VU0422288
SMILES | Clc1ccc(nc1)Oc1ccc(cc1Cl)NC(=O)c1ccccn1 |
InChIKey | MZRLPXFGQKQHST-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 1 |
Rotatable bonds | 4 |
Molecular weight (Da) | 359.0 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pEC50 | 6.9 | 6.9 | 6.9 | ChEMBL |
mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pEC50 | 6.83 | 6.83 | 6.83 | ChEMBL |
mGlu7 | GRM7 | Rat | Metabotropic glutamate | C | pEC50 | 6.84 | 6.84 | 6.84 | ChEMBL |
mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pEC50 | 6.97 | 6.97 | 6.97 | ChEMBL |
mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pKB | 6.7 | 6.7 | 6.7 | Guide to Pharmacology |
mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pEC50 | 6.9 | 6.9 | 6.9 | ChEMBL |