NMRA-140


SMILES CCc1cc(F)c2c(c1)c(C)c(c(n2)N1CCC(CC1)NC1CCOCC1)c1onc(n1)C
InChIKey CQOJHAJWCDJEAT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 453.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.89 7.89 7.89 ChEMBL
κ OPRK Human Opioid A pKi 8.41 8.41 8.41 ChEMBL
μ OPRM Human Opioid A pKi 8.8 8.8 8.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pEC50 7.43 7.43 7.43 ChEMBL
κ OPRK Human Opioid A pEC50 7.74 7.74 7.74 ChEMBL
μ OPRM Human Opioid A pEC50 7.79 7.79 7.79 ChEMBL