GW405833


SMILES COc1ccc2c(c1)c(CCN1CCOCC1)c(n2C(=O)c1cccc(c1Cl)Cl)C
InChIKey FSFZRNZSZYDVLI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 446.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB2 CNR2 Human Cannabinoid A pKi 7.46 7.97 8.42 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 5.22 5.59 5.72 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB2 CNR2 Human Cannabinoid A pEC50 7.29 8.24 9.19 ChEMBL
CB1 CNR1 Human Cannabinoid A pEC50 4.79 4.79 4.79 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.0 5.0 5.0 ChEMBL
CB2 CNR2 Human Cannabinoid A pEC50 6.97 6.97 6.97 Guide to Pharmacology