JNJ 7777120


SMILES CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl
InChIKey HUQJRYMLJBBEDO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 277.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations H4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 9.2 9.2 9.2 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.7 8.7 8.7 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 9.1 9.1 9.1 Guide to Pharmacology
δ OPRD Human Opioid A pKi 8.89 8.89 8.89 ChEMBL
μ OPRM Rat Opioid A pKi 7.82 8.0 8.09 ChEMBL
μ OPRM Rat Opioid A pKd 7.66 8.36 9.05 ChEMBL
κ OPRK Rat Opioid A pKd 6.2 6.2 6.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Mouse Opioid A pIC50 6.35 8.07 9.57 ChEMBL
δ OPRD Human Opioid A pEC50 5.86 7.94 10.7 ChEMBL
μ OPRM Human Opioid A pEC50 5.86 6.21 6.89 ChEMBL
μ OPRM Rat Opioid A pIC50 7.38 7.38 7.38 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 5.36 7.06 8.77 ChEMBL