SR120819A


SMILES CN(C[C@@H]1CC[C@@H](CC1)C/N=C(/c1ccc(cc1)C[C@H](C(=O)N1CCCC1)NC(=O)[C@H](NS(=O)(=O)c1ccc2c(c1)cccc2)Cc1ccccc1)\N)C
InChIKey GKKPXBHNFVDHAQ-GWOGJWAKSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 15
Molecular weight (Da) 750.4

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 6.1 6.1 6.1 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.3 8.3 8.3 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.28 7.28 7.28 ChEMBL
μ OPRM Rat Opioid A pKi 7.75 8.67 9.8 ChEMBL
δ OPRD Human Opioid A pKi 5.22 5.37 5.56 ChEMBL
μ OPRM Human Opioid A pKi 8.34 8.82 9.54 ChEMBL
μ OPRM Rat Opioid A pKi 8.28 9.03 9.62 PDSP Ki database
μ OPRM Bovine Opioid A pKi 9.17 9.17 9.17 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.3 6.3 6.3 PDSP Ki database
μ OPRM Mouse Opioid A pKi 9.03 9.1 9.17 PDSP Ki database
δ F1N083 Bovine Opioid A pKi 6.3 6.3 6.3 PDSP Ki database
κ OPRK Human Opioid A pKi 5.69 5.69 5.69 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.29 5.46 5.63 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pIC50 7.44 7.44 7.44 ChEMBL
δ OPRD Mouse Opioid A pIC50 6.55 7.31 7.58 ChEMBL
μ OPRM Rat Opioid A pIC50 7.25 8.79 9.37 ChEMBL
μ OPRM Rat Opioid A pEC50 6.78 6.88 6.98 ChEMBL
δ OPRD Human Opioid A pEC50 6.03 6.03 6.03 ChEMBL
μ OPRM Human Opioid A pIC50 7.18 7.84 8.49 ChEMBL
μ OPRM Human Opioid A pEC50 7.21 7.68 7.85 ChEMBL