FMS586


SMILES O=C(N(CCc1ccncc1)C)Nc1ccc2c(c1)c1CCCCc1n2C(C)C
InChIKey YLNOMVNCZMWDST-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 390.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.8 8.8 8.8 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 7.15 7.15 7.15 ChEMBL
D2 DRD2 Rat Dopamine A pKi 9.0 9.67 10.05 ChEMBL
D2 DRD2 Rat Dopamine A pKd 9.77 9.77 9.77 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.8 9.9 9.97 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.59 9.86 10.07 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 9.04 9.04 9.04 ChEMBL