JCF 109


SMILES O=N(=O)c1ccccc1S(=O)(=O)NC[C@@H]1CC[C@H](CC1)CNc1ccc2c(c1)cccc2
InChIKey BPBPTEVVRMSHTB-WGSAOQKQSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 453.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 6.7 6.7 6.7 Guide to Pharmacology
κ OPRK Human Opioid A pKi 6.9 6.9 6.9 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.7 9.7 9.7 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 8.18 8.18 8.18 Guide to Pharmacology
μ OPRM Rhesus macaque Opioid A pKi 10.7 10.85 11.0 ChEMBL
μ OPRM Rat Opioid A pKi 9.3 9.3 9.3 ChEMBL
μ OPRM Human Opioid A pKi 9.7 9.7 9.7 PDSP Ki database
δ OPRD Human Opioid A pKi 6.73 6.73 6.73 PDSP Ki database
κ OPRK Human Opioid A pKi 6.93 6.93 6.93 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 6.23 6.23 6.23 PDSP Ki database
δ A0A286XTF2 Guinea pig Opioid A pKi 6.85 6.85 6.85 PDSP Ki database
μ OPRM Human Opioid A pKi 9.7 9.7 9.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pEC50 10.52 10.52 10.52 Guide to Pharmacology