acifran


SMILES OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1
InChIKey DFDGRKNOFOJBAJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 218.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Rat Dopamine A pKi 9.0 9.0 9.0 Guide to Pharmacology
D1 DRD1 Bovine Dopamine A pKi 5.26 5.26 5.26 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.26 5.26 5.26 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.17 8.57 8.66 ChEMBL
D3 DRD3 Human Dopamine A pKi 4.92 5.58 7.34 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.33 5.37 5.88 ChEMBL
D1 DRD1 Pig Dopamine A pKi 5.26 5.26 5.26 ChEMBL
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pEC50 6.81 6.81 6.81 ChEMBL