naltrexone


SMILES O=C1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O
InChIKey DQCKKXVULJGBQN-XFWGSAIBSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 341.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FPR2/ALX FPR2 Human Formylpeptide A pKd 6.37 6.37 6.37 Guide to Pharmacology
FPR1 FPR1 Human Formylpeptide A pKd 8.52 8.52 8.52 ChEMBL
FPR1 FPR1 Human Formylpeptide A pKi 7.38 7.38 7.38 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FPR1 FPR1 Human Formylpeptide A pEC50 10.1 10.15 10.2 Guide to Pharmacology
FPR1 FPR1 Mouse Formylpeptide A pEC50 4.7 4.7 4.7 Guide to Pharmacology
FPR1 FPR1 Human Formylpeptide A pEC50 7.7 7.85 8.0 ChEMBL
FPR1 FPR1 Human Formylpeptide A pIC50 7.7 7.7 7.7 ChEMBL
FPR2/ALX FPR2 Human Formylpeptide A pEC50 4.69 4.69 4.69 ChEMBL