(+)-naloxone


SMILES C=CCN1CC[C@@]23[C@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O
InChIKey UZHSEJADLWPNLE-FCLVOEFKSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 8.7 8.7 8.7 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 7.9 7.9 7.9 Guide to Pharmacology
H3 HRH3 Guinea pig Histamine A pKd 7.6 7.6 7.6 ChEMBL
H3 HRH3 Rat Histamine A pKi 7.25 7.58 7.92 ChEMBL
H3 HRH3 Human Histamine A pKi 8.68 8.68 8.68 ChEMBL
H3 HRH3 Mouse Histamine A pKi 7.6 7.7 7.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database