Ro64-6198


SMILES O=C1NCN(C21CCN(CC2)[C@H]1CC[C@H]2c3c1cccc3CCC2)c1ccccc1
InChIKey JLFMYEAXZNPWBK-REWPJTCUSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 401.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL1 GALR1 Human Galanin A pKi 8.76 9.43 10.1 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pKi 8.53 8.67 8.81 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pKi 8.25 8.75 9.25 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pKi 9.0 9.55 10.1 Guide to Pharmacology
GAL2 GALR2 Mouse Galanin A pKi 8.41 8.41 8.41 Guide to Pharmacology
GAL1 GALR1 Mouse Galanin A pKi 9.34 9.84 10.33 Guide to Pharmacology
GAL3 GALR3 Human Galanin A pKi 7.91 8.13 8.35 Guide to Pharmacology
GAL3 GALR3 Rat Galanin A pKi 8.13 8.48 8.83 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL1 GALR1 Human Galanin A pIC50 9.89 9.89 9.89 Guide to Pharmacology
GAL2 GALR2 Human Galanin A pIC50 7.93 9.0 9.12 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pIC50 8.72 9.02 9.32 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pEC50 8.28 8.28 8.28 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pEC50 9.8 9.8 9.8 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pIC50 8.85 9.43 10.01 Guide to Pharmacology
GAL3 GALR3 Rat Galanin A pIC50 6.96 6.96 6.96 Guide to Pharmacology