SB 243213


SMILES O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C
InChIKey ZETBBVYSBABLHL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 428.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 8.6 8.6 8.6 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 6.1 6.12 6.12 ChEMBL
H1 HRH1 Human Histamine A pKi 4.16 4.16 4.16 ChEMBL
H2 HRH2 Human Histamine A pKi 4.15 4.15 4.15 ChEMBL
H3 HRH3 Rat Histamine A pKi 8.6 8.67 8.9 ChEMBL
H3 HRH3 Guinea pig Histamine A pKd 6.98 6.98 6.98 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database