ONO-3708


SMILES OC(=O)CCC/C=C\C[C@@H]1[C@@H](NC(=O)[C@@H](C2CCCC2)O)C[C@H]2C[C@@H]1C2(C)C
InChIKey SXHUZJPIRVLMHY-AZPSIHDESA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 9
Molecular weight (Da) 391.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 8.4 8.4 8.4 Guide to Pharmacology
H3 HRH3 Guinea pig Histamine A pKd 7.7 7.7 7.7 ChEMBL
H4 HRH4 Human Histamine A pKi 7.84 7.93 8.0 ChEMBL
H3 HRH3 Human Histamine A pKi 8.37 8.39 8.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pEC50 7.05 7.2 7.5 ChEMBL
H3 HRH3 Human Histamine A pEC50 8.13 8.44 9.2 ChEMBL