amitriptyline


SMILES CN(CCC=C1c2ccccc2CCc2c1cccc2)C
InChIKey KRMDCWKBEZIMAB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 277.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations 5-HT6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
RXFP1 RXFP1 Human Relaxin family peptide A pKd 6.99 6.99 6.99 Guide to Pharmacology
RXFP2 RXFP2 Human Relaxin family peptide A pKi 6.0 6.0 6.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
RXFP1 RXFP1 Human Relaxin family peptide A pEC50 8.22 8.22 8.22 Guide to Pharmacology
RXFP2 RXFP2 Human Relaxin family peptide A pEC50 6.0 6.0 6.0 Guide to Pharmacology