L-779,976


SMILES NC[C@@H]1CCC[C@H](C1)CNC(=O)[C@@H]([C@H](c1c[nH]c2c1cccc2)C)NC(=O)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2
InChIKey DDVPVAOEMZRZQU-JONNCTARSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 5
Rotatable bonds 8
Molecular weight (Da) 585.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.8 5.9 6.0 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 4.8 4.8 4.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 5.6 5.6 5.6 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 4.4 4.4 4.4 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 4.4 4.4 4.4 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.32 4.32 4.32 ChEMBL