L-703,606


SMILES Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2
InChIKey WSLTYZVXORBNLB-KAYWLYCHSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 508.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.85 8.85 8.85 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 9.06 9.06 9.06 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 9.06 9.06 9.06 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.63 5.63 5.63 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.52 8.52 8.52 ChEMBL