FK-888
SMILES | O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 |
InChIKey | BFNKQTIJVFGCKQ-PDJGWCFMSA-N |
Chemical properties
Hydrogen bond acceptors | 5 |
Hydrogen bond donors | 2 |
Rotatable bonds | 8 |
Molecular weight (Da) | 588.3 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
NOP | OPRX | Human | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
NOP | OPRX | Human | Opioid | A | pKi | 8.09 | 8.09 | 8.09 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 5.06 | 5.06 | 5.06 | ChEMBL |
κ | OPRK | Human | Opioid | A | pKi | 5.98 | 5.98 | 5.98 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 6.99 | 6.99 | 6.99 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
NOP | OPRX | Human | Opioid | A | pIC50 | 7.52 | 7.52 | 7.52 | ChEMBL |
κ | OPRK | Human | Opioid | A | pIC50 | 5.12 | 5.12 | 5.12 | ChEMBL |
μ | OPRM | Human | Opioid | A | pIC50 | 5.82 | 5.82 | 5.82 | ChEMBL |