FK-888


SMILES O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2
InChIKey BFNKQTIJVFGCKQ-PDJGWCFMSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 588.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.82 7.82 7.82 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.82 7.82 7.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.77 7.77 7.77 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 6.42 7.36 8.32 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.82 7.82 7.82 ChEMBL