FK-888


SMILES O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2
InChIKey BFNKQTIJVFGCKQ-PDJGWCFMSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 588.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 8.1 8.1 8.1 Guide to Pharmacology
NOP OPRX Human Opioid A pKi 8.09 8.09 8.09 ChEMBL
δ OPRD Human Opioid A pKi 5.06 5.06 5.06 ChEMBL
κ OPRK Human Opioid A pKi 5.98 5.98 5.98 ChEMBL
μ OPRM Human Opioid A pKi 6.99 6.99 6.99 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pIC50 7.52 7.52 7.52 ChEMBL
κ OPRK Human Opioid A pIC50 5.12 5.12 5.12 ChEMBL
μ OPRM Human Opioid A pIC50 5.82 5.82 5.82 ChEMBL