GR 159897


SMILES COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1
InChIKey BANYJBHWTOJQDU-GDLZYMKVSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 414.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.33 8.33 8.33 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKd 8.77 8.77 8.77 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.12 8.12 8.12 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.68 7.74 7.8 ChEMBL