GPCRdb

trazodone

SMILES	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
InChIKey	PHLBKPHSAVXXEF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	6
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	371.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.65	6.7	6.75	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.93	6.93	6.93	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.38	7.38	7.38	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.93	6.97	7.02	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.08	6.08	6.08	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.97	6.97	6.97	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.4	7.4	7.4	Guide to Pharmacology
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.7	7.95	8.2	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	ChEMBL
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.7	7.87	8.22	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.35	7.46	7.57	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.1	7.1	7.1	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.17	7.17	7.17	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.72	6.98	7.13	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.6	6.6	6.6	Guide to Pharmacology
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.4	6.55	6.7	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.33	7.33	7.33	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.7	6.27	6.71	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.65	6.65	6.65	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.75	5.75	5.75	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
CB₂	CNR2	Human	Cannabinoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	8.27	8.27	8.27	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	5.43	5.43	5.43	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.38	5.42	5.46	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.26	8.26	8.26	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	5.9	5.9	5.9	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKi	6.45	6.45	6.45	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.23	8.23	8.23	Drug Central
D₄	DRD4	Human	Dopamine	A	pKi	6.15	6.15	6.15	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.21	8.21	8.21	Drug Central
D₅	DRD5	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
EP₃	PE2R3	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
EP₄	PE2R4	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	7.38	7.38	7.38	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	7.54	7.54	7.54	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	5.96	6.31	6.66	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.21	8.21	8.21	Drug Central
H₂	HRH2	Human	Histamine	A	pKi	5.48	5.48	5.48	PDSP Ki database
H₂	HRH2	Human	Histamine	A	pKi	8.26	8.26	8.26	Drug Central
H₃	HRH3	Guinea pig	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₄	HRH4	Human	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.33	7.33	7.33	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.21	7.21	7.21	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.89	6.89	6.89	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.82	6.82	6.82	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.47	6.47	6.47	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.14	6.14	6.14	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.75	6.75	6.75	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.55	6.55	6.55	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.81	6.81	6.81	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.0	5.0	5.0	PDSP Ki database

Showing 1 to 78 of 78 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.51	6.51	6.51	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.11	6.11	6.11	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.87	5.87	5.87	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.61	7.16	7.7	ChEMBL
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pIC50	8.11	8.11	8.11	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.97	6.97	6.97	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.04	7.04	7.04	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.35	5.35	5.35	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.43	5.43	5.43	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.44	6.44	6.44	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.65	4.65	4.65	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.93	6.93	6.93	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.02	8.02	8.02	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.16	8.16	8.16	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.96	6.96	6.96	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.58	6.58	6.58	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.04	6.04	6.04	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.41	6.41	6.41	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.71	5.71	5.71	ChEMBL

Showing 1 to 19 of 19 entries

Join us

Cite us

Main reference

trazodone

Chemical properties

Drug properties

Database connections

Bioactivities