MeTRH


SMILES O=C(N1CCC[C@H]1C(=O)N)[C@@H](NC(=O)[C@@H]1CCC(=O)N1C)Cc1[nH]cnc1
InChIKey DJLHRAHTTSWYAW-AVGNSLFASA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 376.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Human Cannabinoid A pKi 8.0 8.0 8.0 Guide to Pharmacology
CB2 CNR2 Human Cannabinoid A pKi 8.5 8.5 8.5 Guide to Pharmacology
CB1 CNR1 Mouse Cannabinoid A pKi 8.89 8.89 8.89 ChEMBL
CB1 CNR1 Rat Cannabinoid A pKi 8.04 8.04 8.04 ChEMBL
CB2 CNR2 Human Cannabinoid A pKi 8.02 8.31 8.54 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 8.02 8.39 8.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Rat Cannabinoid A pIC50 6.55 6.55 6.55 ChEMBL
CB2 CNR2 Human Cannabinoid A pEC50 7.66 7.98 8.3 ChEMBL
CB1 CNR1 Human Cannabinoid A pEC50 7.45 7.74 8.3 ChEMBL