RO 116 1148


SMILES CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2
InChIKey VBFBEYXWJLASJA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 332.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA2 FFAR2 Human Free fatty acid A pEC50 3.1 3.85 4.6 Guide to Pharmacology
FFA3 FFAR3 Human Free fatty acid A pEC50 2.8 3.35 3.9 Guide to Pharmacology
FFA2 FFAR2 Human Free fatty acid A pEC50 8.34 8.34 8.34 Drug Central
FFA3 FFAR3 Human Free fatty acid A pEC50 8.31 8.31 8.31 Drug Central
FFA3 FFAR3 Human Free fatty acid A pEC50 4.92 4.92 4.92 ChEMBL