2-MPP


SMILES COc1ccccc1N1CCNCC1
InChIKey VNZLQLYBRIOLFZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 192.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Human Adenosine A pKi 7.0 7.0 7.0 Guide to Pharmacology
A1 AA1R Rat Adenosine A pKi 7.14 7.14 7.14 Guide to Pharmacology
A3 AA3R Human Adenosine A pKi 6.54 6.54 6.54 Guide to Pharmacology
A2B AA2BR Rat Adenosine A pKi 5.29 5.29 5.29 Guide to Pharmacology
A3 AA3R Rat Adenosine A pKi 5.19 5.19 5.19 Guide to Pharmacology
A2A AA2AR Rat Adenosine A pKi 6.82 6.82 6.82 Guide to Pharmacology
A3 AA3R Rat Adenosine A pKi 7.0 7.0 7.0 ChEMBL
A1 AA1R Human Adenosine A pKi 6.09 6.09 6.09 ChEMBL
A1 AA1R Human Adenosine A pKd 6.53 6.53 6.53 ChEMBL
A3 AA3R Human Adenosine A pKi 8.18 8.18 8.18 Drug Central
A3 AA3R Rat Adenosine A pKi 8.15 8.15 8.15 Drug Central
A2A AA2AR Human Adenosine A pKi 6.51 6.51 6.51 Guide to Pharmacology
A2A AA2AR Human Adenosine A pKi 6.16 6.89 7.7 ChEMBL
A2A AA2AR Human Adenosine A pKd 7.76 7.76 7.76 ChEMBL
A2B AA2BR Human Adenosine A pKi 4.82 4.82 4.82 Guide to Pharmacology
A3 AA3R Human Adenosine A pKd 6.13 6.13 6.13 ChEMBL
A3 AA3R Human Adenosine A pKi 6.54 6.54 6.54 ChEMBL
A1 AA1R Rat Adenosine A pKi 4.54 7.24 8.29 ChEMBL
A1 AA1R Rat Adenosine A pKd 5.71 5.71 5.71 ChEMBL
A1 AA1R Rat Adenosine A pKi 8.08 8.08 8.08 Drug Central
A2A AA2AR Rat Adenosine A pKi 7.52 7.52 7.52 ChEMBL
A2A AA2AR Rat Adenosine A pKi 8.12 8.12 8.12 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A1 AA1R Human Adenosine A pEC50 5.6 6.51 7.41 ChEMBL
A1 AA1R Human Adenosine A pIC50 8.63 8.63 8.63 ChEMBL
A1 AA1R Human Adenosine A pEC50 8.19 8.19 8.19 Drug Central
A2A AA2AR Human Adenosine A pEC50 8.21 8.21 8.21 Drug Central
A2B AA2BR Human Adenosine A pEC50 8.34 8.34 8.34 Drug Central
A2A AA2AR Human Adenosine A pEC50 4.4 5.98 7.6 ChEMBL
A2B AA2BR Human Adenosine A pEC50 4.29 4.95 7.28 ChEMBL
A3 AA3R Human Adenosine A pEC50 5.98 6.67 7.87 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.94 8.94 8.94 ChEMBL
A1 AA1R Guinea pig Adenosine A pEC50 5.47 5.47 5.47 ChEMBL