oxotremorine-M
SMILES | O=C1CCCN1CC#CC[N+](C)(C)C |
InChIKey | CANZROMYQDHYHR-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 1 |
Hydrogen bond donors | 0 |
Rotatable bonds | 2 |
Molecular weight (Da) | 195.1 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | No |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 5.1 | 5.1 | 5.1 | Guide to Pharmacology |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 4.9 | 4.9 | 4.9 | Guide to Pharmacology |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKd | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 5.1 | 5.1 | 5.1 | Guide to Pharmacology |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 5.2 | 5.2 | 5.2 | Guide to Pharmacology |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.82 | 7.05 | 9.11 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.92 | 5.92 | 5.92 | ChEMBL |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.97 | 6.97 | 6.97 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 4.69 | 4.69 | 4.69 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pEC50 | 6.16 | 6.16 | 6.16 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 8.0 | 8.0 | 8.0 | ChEMBL |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pEC50 | 5.64 | 5.64 | 5.64 | ChEMBL |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pEC50 | 5.75 | 5.75 | 5.75 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pEC50 | 5.13 | 5.13 | 5.13 | ChEMBL |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.2 | 5.63 | 6.5 | ChEMBL |