hexahydrosiladifenidol


SMILES O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1
InChIKey QTBCATBNRIYMPB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 331.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.6 6.7 6.8 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.7 7.85 8.0 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.5 7.1 7.7 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.8 7.0 7.2 Guide to Pharmacology
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.7 6.75 6.8 Guide to Pharmacology
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 7.4 7.4 7.4 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.4 7.65 7.9 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.46 7.9 8.38 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.11 7.22 7.33 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.0 8.0 8.0 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.22 7.64 8.14 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.2 7.2 7.2 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.92 7.11 7.3 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.85 7.85 7.85 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 7.61 7.61 7.61 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.4 8.4 8.4 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.6 6.6 6.6 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database