FR260010
| SMILES | Cc1ncn(c1)c1cccc(c1)Nc1ncnc2c1CCc1c2cccc1 |
| InChIKey | LFKNMCJSJZOQJF-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 5 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 3 |
| Molecular weight (Da) | 353.2 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| DP2 | PD2R2 | Human | Prostanoid | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| DP2 | PD2R2 | Human | Prostanoid | A | pKd | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
| TP | TA2R | Human | Prostanoid | A | pKi | 8.0 | 8.0 | 8.0 | Guide to Pharmacology |
| DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
| DP2 | PD2R2 | Mouse | Prostanoid | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| DP1 | PD2R | Human | Prostanoid | A | pKi | 8.3 | 8.3 | 8.3 | Drug Central |
| TP | TA2R | Human | Prostanoid | A | pKi | 8.03 | 8.03 | 8.03 | Drug Central |
| DP1 | PD2R | Human | Prostanoid | A | pKi | 4.96 | 4.96 | 4.96 | ChEMBL |
| DP2 | PD2R2 | Human | Prostanoid | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| DP2 | PD2R2 | Human | Prostanoid | A | pKi | 6.47 | 6.99 | 8.37 | ChEMBL |
| TP | TA2R | Human | Prostanoid | A | pKi | 7.75 | 8.45 | 9.24 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| DP2 | PD2R2 | Rat | Prostanoid | A | pIC50 | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
| DP2 | PD2R2 | Rat | Prostanoid | A | pIC50 | 8.14 | 8.14 | 8.14 | Drug Central |
| DP1 | PD2R | Human | Prostanoid | A | pIC50 | 4.48 | 4.48 | 4.48 | ChEMBL |
| DP2 | PD2R2 | Human | Prostanoid | A | pIC50 | 6.12 | 6.9 | 7.68 | ChEMBL |
| TP | TA2R | Human | Prostanoid | A | pIC50 | 7.85 | 7.98 | 8.08 | ChEMBL |