Ro 63-0563


SMILES CNc1cc(cc(n1)NC)NS(=O)(=O)c1ccc(cc1)N
InChIKey PTFNKZLSFWJYFJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Molecular weight (Da) 307.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pKi 9.35 9.35 9.35 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.99 7.99 7.99 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 9.5 9.5 9.5 Guide to Pharmacology
α1A ADA1A Rat Adrenoceptors A pKi 8.12 8.12 8.12 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pIC50 8.92 8.92 8.92 ChEMBL
α1D ADA1D Rat Adrenoceptors A pIC50 7.64 7.64 7.64 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pIC50 7.76 7.76 7.76 ChEMBL