Ro 63-0563


SMILES CNc1cc(cc(n1)NC)NS(=O)(=O)c1ccc(cc1)N
InChIKey PTFNKZLSFWJYFJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Molecular weight (Da) 307.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MT1 MTR1A Human Melatonin A pKi 8.5 8.85 9.2 Guide to Pharmacology
MT2 MTR1B Human Melatonin A pKi 6.8 7.0 7.2 Guide to Pharmacology
MT2 MTR1B Human Melatonin A pKi 6.78 7.06 7.14 ChEMBL
MT1 MTR1A Human Melatonin A pKi 8.51 9.08 9.22 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MT2 MTR1B Human Melatonin A pEC50 6.39 6.39 6.39 ChEMBL
MT1 MTR1A Human Melatonin A pEC50 7.14 7.14 7.14 ChEMBL