zinterol


SMILES OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C
InChIKey XJBCFFLVLOPYBV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 8
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 7.6 7.66 7.72 ChEMBL
OX1 OX1R Human Orexin A pKd 7.57 7.57 7.57 ChEMBL
OX2 OX2R Human Orexin A pKi 5.68 5.88 6.1 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.5 6.5 6.5 ChEMBL
OX1 OX1R Human Orexin A pKi 7.25 7.25 7.25 Guide to Pharmacology
OX2 OX2R Human Orexin A pKi 5.35 5.35 5.35 Guide to Pharmacology
OX1 OX1R Rat Orexin A pKi 6.4 6.4 6.4 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKB 7.9 7.9 7.9 Guide to Pharmacology
OX2 OX2R Human Orexin A pKB 6.0 6.0 6.0 Guide to Pharmacology