strychnine


SMILES O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3
InChIKey QMGVPVSNSZLJIA-FVWCLLPLSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 334.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7XP6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CRF1 CRFR1 Human Corticotropin-releasing factor B1 pKd 7.3 7.55 7.8 Guide to Pharmacology
CRF2 CRFR2 Mouse Corticotropin-releasing factor B1 pKd 9.0 9.05 9.1 Guide to Pharmacology
CRF2 CRFR2 Rat Corticotropin-releasing factor B1 pKd 8.3 8.35 8.4 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database