L-365260


SMILES Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2
InChIKey KDFQABSFVYLGPM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 398.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 8.41 8.78 8.96 ChEMBL
OX1 OX1R Human Orexin A pKd 8.29 8.29 8.29 ChEMBL
OX1 OX1R Human Orexin A pKi 8.7 9.0 9.3 Guide to Pharmacology
OX2 OX2R Human Orexin A pKi 6.89 6.89 6.89 ChEMBL
OX2 OX2R Human Orexin A pKi 6.6850000000000005 6.69 6.69 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX2 OX2R Human Orexin A pKB 6.86 6.86 6.86 Guide to Pharmacology