sufentanil


SMILES COCC1(CCN(CC1)CCc1cccs1)N(c1ccccc1)C(=O)CC
InChIKey GGCSSNBKKAUURC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 386.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 9.9 9.9 9.9 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 9.1 9.1 9.1 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 9.66 9.66 9.66 ChEMBL
δ OPRD Human Opioid A pKi 7.3 7.3 7.3 PDSP Ki database
κ OPRK Human Opioid A pKi 7.12 7.12 7.12 PDSP Ki database
μ OPRM Human Opioid A pKi 9.52 9.67 9.82 PDSP Ki database
δ OPRD Human Opioid A pKi 8.14 8.14 8.14 Drug Central
μ OPRM Rat Opioid A pKi 8.02 8.02 8.02 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pIC50 9.4 9.4 9.4 ChEMBL
μ OPRM Human Opioid A pEC50 8.82 8.86 8.89 ChEMBL
κ OPRK Human Opioid A pEC50 8.17 8.17 8.17 Drug Central
μ OPRM Human Opioid A pEC50 8.09 8.09 8.09 Drug Central