AFDX384


SMILES CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC
InChIKey MZDYABXXPZNUCT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 478.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.92 7.92 7.92 Guide to Pharmacology
κ OPRK Human Opioid A pKi 7.0 7.0 7.0 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.33 9.33 9.33 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.15 8.15 8.15 Drug Central
μ OPRM Human Opioid A pKi 8.03 8.03 8.03 Drug Central
δ OPRD Human Opioid A pKi 8.1 8.1 8.1 Drug Central
δ OPRD Human Opioid A pKi 7.92 8.11 8.3 ChEMBL
κ OPRK Human Opioid A pKi 7.0 7.0 7.0 ChEMBL
μ OPRM Human Opioid A pKi 9.33 9.41 9.5 ChEMBL
κ OPRK Guinea pig Opioid A pKi 8.08 8.08 8.08 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.3 8.3 8.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pIC50 8.5 8.6 8.77 ChEMBL