MRS1132


SMILES O=c1c(Cl)c(oc2c1cccc2)c1ccccc1
InChIKey FHXDSQYFCFWKAW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 256.0

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pKi 5.3 5.3 5.3 ChEMBL
H2 HRH2 Human Histamine A pKi 5.2 5.2 5.2 ChEMBL
H2 HRH2 Rat Histamine A pKd 4.94 4.94 4.94 ChEMBL
H2 HRH2 Guinea pig Histamine A pKd 5.3 5.3 5.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H2 HRH2 Human Histamine A pEC50 6.4 6.4 6.4 Guide to Pharmacology
H2 HRH2 Human Histamine A pEC50 6.72 6.72 6.72 ChEMBL
H1 HRH1 Human Histamine A pEC50 4.8 4.8 4.8 ChEMBL
H2 HRH2 Guinea pig Histamine A pEC50 6.21 6.46 6.72 ChEMBL