piclidenoson
SMILES | CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I |
InChIKey | HUJXGQILHAUCCV-MOROJQBDSA-N |
Chemical properties
Hydrogen bond acceptors | 9 |
Hydrogen bond donors | 4 |
Rotatable bonds | 5 |
Molecular weight (Da) | 510.1 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 8.3 | 8.65 | 9.0 | Guide to Pharmacology |
CRF1 | CRFR1 | Rat | Corticotropin-releasing factor | B1 | pKi | 8.6 | 8.8 | 9.0 | ChEMBL |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 8.07 | 8.74 | 9.42 | PDSP Ki database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 7.5 | 8.44 | 9.08 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pIC50 | 7.73 | 7.73 | 7.73 | ChEMBL |