AS96


SMILES C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C
InChIKey ZGPHNPBSZODLNU-GFMRDNFCSA-N

Chemical properties

Hydrogen bond acceptors 11
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 530.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 8.5 8.5 8.5 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 7.52 7.52 7.52 Guide to Pharmacology
α2B ADA2B Rat Adrenoceptors A pKi 8.32 8.32 8.32 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.53 7.94 8.35 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 6.54 6.54 6.54 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.67 7.67 7.67 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.08 8.08 8.08 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.54 8.54 8.54 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.55 4.55 4.55 ChEMBL