dexniguldipine


SMILES COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C
InChIKey SVJMLYUFVDMUHP-MGBGTMOVSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 609.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Human Vasopressin and oxytocin A pKi 8.3 8.3 8.3 Guide to Pharmacology
V1B V1BR Human Vasopressin and oxytocin A pKi 8.0 8.0 8.0 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 7.6 7.9 8.2 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKi 9.4 9.4 9.4 Guide to Pharmacology
V1A V1AR Rat Vasopressin and oxytocin A pKi 8.5 8.5 8.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database