5-methylurapidil


SMILES COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C
InChIKey HIHZDNKKIUQQSC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 401.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations α1A α1B

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CRF1 CRFR1 Human Corticotropin-releasing factor B1 pKd 7.7 8.25 8.8 Guide to Pharmacology
CRF1 CRFR1 Human Corticotropin-releasing factor B1 pKi 8.7 8.7 8.7 Guide to Pharmacology
CRF2 CRFR2 Human Corticotropin-releasing factor B1 pKd 8.8 8.85 8.9 Guide to Pharmacology
CRF2 CRFR2 Mouse Corticotropin-releasing factor B1 pKd 9.0 9.0 9.0 Guide to Pharmacology
CRF2 CRFR2 Rat Corticotropin-releasing factor B1 pKd 8.6 8.7 8.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CRF1 CRFR1 Human Corticotropin-releasing factor B1 pIC50 9.14 9.14 9.14 Guide to Pharmacology
CRF2 CRFR2 Human Corticotropin-releasing factor B1 pIC50 9.21 9.21 9.21 Guide to Pharmacology