prazosin


SMILES COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
InChIKey IENZQIKPVFGBNW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Human Endothelin A pKi 10.47 10.47 10.47 Guide to Pharmacology
ETB EDNRB Human Endothelin A pKi 6.86 6.86 6.86 Guide to Pharmacology
ETA EDNRA Human Endothelin A pKi 10.47 10.47 10.47 ChEMBL
ETA EDNRA Rat Endothelin A pKi 10.33 10.4 10.47 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Human Endothelin A pA2 9.2 9.85 10.5 Guide to Pharmacology
ETA EDNRA Human Endothelin A pIC50 9.51 10.16 10.47 ChEMBL
ETB EDNRB Human Endothelin A pIC50 6.29 6.85 7.2 ChEMBL
ETA EDNRA Rat Endothelin A pIC50 8.82 9.46 10.1 ChEMBL
ETB EDNRB Pig Endothelin A pIC50 6.28 6.65 6.96 ChEMBL