prazosin
SMILES | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 |
InChIKey | IENZQIKPVFGBNW-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 8 |
Hydrogen bond donors | 1 |
Rotatable bonds | 4 |
Molecular weight (Da) | 383.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKd | 7.7 | 8.25 | 8.8 | Guide to Pharmacology |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
CRF2 | CRFR2 | Human | Corticotropin-releasing factor | B1 | pKd | 8.8 | 8.85 | 8.9 | Guide to Pharmacology |
CRF2 | CRFR2 | Mouse | Corticotropin-releasing factor | B1 | pKd | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
CRF2 | CRFR2 | Rat | Corticotropin-releasing factor | B1 | pKd | 8.6 | 8.7 | 8.8 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pIC50 | 9.14 | 9.14 | 9.14 | Guide to Pharmacology |
CRF2 | CRFR2 | Human | Corticotropin-releasing factor | B1 | pIC50 | 9.21 | 9.21 | 9.21 | Guide to Pharmacology |