prazosin
SMILES | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 |
InChIKey | IENZQIKPVFGBNW-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 8 |
Hydrogen bond donors | 1 |
Rotatable bonds | 4 |
Molecular weight (Da) | 383.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
ETA | EDNRA | Human | Endothelin | A | pKi | 10.47 | 10.47 | 10.47 | Guide to Pharmacology |
ETB | EDNRB | Human | Endothelin | A | pKi | 6.86 | 6.86 | 6.86 | Guide to Pharmacology |
ETA | EDNRA | Human | Endothelin | A | pKi | 10.47 | 10.47 | 10.47 | ChEMBL |
ETA | EDNRA | Rat | Endothelin | A | pKi | 10.33 | 10.4 | 10.47 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
ETA | EDNRA | Human | Endothelin | A | pA2 | 9.2 | 9.85 | 10.5 | Guide to Pharmacology |
ETA | EDNRA | Human | Endothelin | A | pIC50 | 9.51 | 10.16 | 10.47 | ChEMBL |
ETB | EDNRB | Human | Endothelin | A | pIC50 | 6.29 | 6.85 | 7.2 | ChEMBL |
ETA | EDNRA | Rat | Endothelin | A | pIC50 | 8.82 | 9.46 | 10.1 | ChEMBL |
ETB | EDNRB | Pig | Endothelin | A | pIC50 | 6.28 | 6.65 | 6.96 | ChEMBL |