prazosin


SMILES COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
InChIKey IENZQIKPVFGBNW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1A α1B α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Human Endothelin A pKi 10.47 10.47 10.47 Guide to Pharmacology
ETB EDNRB Human Endothelin A pKi 6.86 6.86 6.86 Guide to Pharmacology
ETA EDNRA Human Endothelin A pKi 10.47 10.47 10.47 ChEMBL
ETA EDNRA Rat Endothelin A pKi 10.33 10.4 10.47 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Human Endothelin A pA2 9.2 9.85 10.5 Guide to Pharmacology
ETA EDNRA Human Endothelin A pIC50 9.51 10.16 10.47 ChEMBL
ETB EDNRB Human Endothelin A pIC50 6.29 6.85 7.2 ChEMBL
ETA EDNRA Rat Endothelin A pIC50 8.82 9.46 10.1 ChEMBL
ETB EDNRB Pig Endothelin A pIC50 6.28 6.65 6.96 ChEMBL