cirazoline
SMILES | C1CN=C(N1)COc1ccccc1C1CC1 |
InChIKey | YAORIDZYZDUZCM-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 3 |
Hydrogen bond donors | 1 |
Rotatable bonds | 4 |
Molecular weight (Da) | 216.1 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 6.0 | 6.8 | 7.6 | Guide to Pharmacology |
V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 6.2 | 6.4 | 6.6 | Guide to Pharmacology |
V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 8.33 | 9.12 | 9.82 | ChEMBL |
V1A | V1AR | Human | Vasopressin and oxytocin | A | pKi | 8.3 | 8.4 | 8.5 | Guide to Pharmacology |
V1B | V1BR | Human | Vasopressin and oxytocin | A | pKi | 7.36 | 7.36 | 7.36 | ChEMBL |
V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 6.48 | 6.48 | 6.48 | ChEMBL |
V2 | V2R | Human | Vasopressin and oxytocin | A | pKi | 5.5 | 5.75 | 6.0 | Guide to Pharmacology |
OT | OXYR | Human | Vasopressin and oxytocin | A | pKi | 6.4 | 7.37 | 7.96 | ChEMBL |
OT | OXYR | Rat | Vasopressin and oxytocin | A | pKd | 8.29 | 8.29 | 8.29 | ChEMBL |
OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 7.12 | 7.26 | 7.4 | ChEMBL |
OT | OXYR | Rat | Vasopressin and oxytocin | A | pKi | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
OT | OXYR | Human | Vasopressin and oxytocin | A | pIC50 | 6.43 | 6.83 | 7.23 | ChEMBL |
OT | OXYR | Rat | Vasopressin and oxytocin | A | pIC50 | 7.92 | 7.92 | 7.92 | ChEMBL |