LTE4


SMILES CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N
InChIKey OTZRAYGBFWZKMX-FRFVZSDQSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 18
Molecular weight (Da) 439.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Human Leukotriene A pKi 7.05 7.42 7.8 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pKi 6.5 6.5 6.5 Guide to Pharmacology
oxoglutarate OXGR1 Mouse Oxoglutarate A pKd 8.6 8.6 8.6 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Human Leukotriene A pEC50 6.98 6.98 6.98 ChEMBL
CysLT1 CLTR1 Human Leukotriene A pEC50 6.62 6.67 7.24 Guide to Pharmacology
CysLT1 CLTR1 Human Leukotriene A pIC50 6.56 6.76 6.97 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pEC50 6.53 6.53 6.53 ChEMBL
CysLT2 CLTR2 Human Leukotriene A pEC50 5.64 6.3 7.11 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pIC50 6.15 5.94 6.16 Guide to Pharmacology
P2Y12 P2Y12 Human P2Y A pEC50 8.89 8.89 8.89 ChEMBL
GPR17 GPR17 Mouse A orphans A pEC50 9.51 9.51 9.51 Guide to Pharmacology