1-arylmethylpyrrolidin-2-yl ethanol amine


SMILES N#Cc1cccc(c1)CN1CCC[C@@H]1[C@@H](CNC(Cc1cc2c(s1)cccc2)(C)C)O
InChIKey HCLQARMRCPEALF-DNQXCXABSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 433.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 9.0 9.0 9.0 Guide to Pharmacology
κ OPRK Human Opioid A pKi 10.5 10.5 10.5 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.7 9.7 9.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pIC50 9.5 9.5 9.5 Guide to Pharmacology