doxazosin


SMILES COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2
InChIKey RUZYUOTYCVRMRZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 451.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pKi 8.5 8.8 9.1 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 8.3 8.7 9.1 Guide to Pharmacology
α1D ADA1D Rat Adrenoceptors A pKd 8.97 8.97 8.97 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 9.51 9.51 9.51 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 9.38 9.38 9.38 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 9.0 9.1 9.2 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 8.69 8.69 8.69 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.2 9.2 9.2 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.4 8.96 9.49 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.55 6.55 6.55 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.5 8.95 9.27 ChEMBL
α1A ADA1A Human Adrenoceptors A pKd 7.59 7.59 7.59 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.14 6.14 6.14 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.63 6.63 6.63 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 5.72 5.72 5.72 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 9.0 9.0 9.0 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 8.5 8.5 8.5 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.06 8.06 8.06 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.03 8.03 8.03 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.4 8.85 9.3 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 9.12 9.12 9.12 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pIC50 6.12 6.12 6.12 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.81 8.97 9.13 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.47 8.47 8.47 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.43 6.43 6.43 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.26 6.26 6.26 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 5.56 5.56 5.56 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.06 8.06 8.06 Drug Central