GPCRdb

phenoxybenzamine

SMILES	ClCCN(C(COc1ccccc1)C)Cc1ccccc1
InChIKey	QZVCTJOXCFMACW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	8
Molecular weight (Da)	303.1

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	α_2A

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.89	7.89	7.89	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	6.85	6.85	6.85	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.4	8.4	8.4	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.45	7.45	7.45	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.46	8.46	8.46	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.0	5.0	5.0	PDSP Ki database

Showing 1 to 8 of 8 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.6	4.85	5.1	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	7.2	7.2	7.2	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.14	8.14	8.14	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.2	8.2	8.2	Drug Central

Showing 1 to 4 of 4 entries