NAN 190


SMILES COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2
InChIKey SJDOMIRMMUGQQK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 393.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 5.0 5.0 5.0 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 6.39 6.39 6.39 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.35 6.35 6.35 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.3 5.3 5.3 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.52 5.52 5.52 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 4.0 4.0 4.0 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 6.32 6.51 6.7 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 5.77 5.77 5.77 ChEMBL