LY320135


SMILES COc1ccc2c(c1)oc(c2C(=O)c1ccc(cc1)C#N)c1ccc(cc1)OC
InChIKey RYNSGDFWBJWWSZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 383.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 9.49 9.49 9.49 Guide to Pharmacology
κ OPRK Human Opioid A pKi 6.89 6.89 6.89 Guide to Pharmacology
μ OPRM Human Opioid A pKi 6.59 6.59 6.59 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 7.82 7.82 7.82 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 9.04 9.04 9.04 ChEMBL
μ OPRM Rat Opioid A pKi 7.44 7.54 7.82 ChEMBL
δ OPRD Human Opioid A pKi 9.49 9.49 9.49 ChEMBL
μ OPRM Human Opioid A pKi 6.58 6.58 6.58 ChEMBL
κ OPRK Human Opioid A pKi 5.47 6.18 6.89 ChEMBL
κ OPRK Rat Opioid A pKi 7.47 7.47 7.47 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Mouse Opioid A pIC50 9.2 9.36 9.51 ChEMBL
μ OPRM Rat Opioid A pIC50 5.63 7.41 8.01 ChEMBL
δ OPRD Human Opioid A pEC50 9.4 9.66 9.92 ChEMBL
δ OPRD Human Opioid A pIC50 9.64 9.64 9.64 ChEMBL
μ OPRM Human Opioid A pIC50 8.68 8.68 8.68 ChEMBL
κ OPRK Human Opioid A pIC50 7.7 7.7 7.7 ChEMBL