INCB3344


SMILES CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2
InChIKey MZEOSVPWMSEFPW-UTWBDPIXSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Molecular weight (Da) 577.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Human Cannabinoid A pKi 6.0 6.25 6.5 Guide to Pharmacology
CB1 CNR1 Rat Cannabinoid A pKi 6.41 6.54 6.67 ChEMBL
CB2 CNR2 Human Cannabinoid A pKi 6.52 7.08 7.8 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 5.96 6.88 7.89 ChEMBL
CB1 CNR1 Rat Cannabinoid A pKi 6.51 6.51 6.51 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Rat Cannabinoid A pEC50 6.5 6.71 6.92 ChEMBL
CB2 CNR2 Human Cannabinoid A pEC50 6.58 6.86 7.14 ChEMBL
CB1 CNR1 Human Cannabinoid A pEC50 7.12 7.12 7.12 ChEMBL