dexloxiglumide


SMILES CCCCCN(C(=O)[C@H](NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC
InChIKey QNQZBKQEIFTHFZ-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 14
Molecular weight (Da) 460.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.1 8.4 8.7 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.5 8.55 8.6 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.02 8.02 8.02 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pIC50 4.73 4.73 4.73 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 6.47 6.59 6.82 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 7.46 7.46 7.46 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.72 7.72 7.72 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 4.01 4.01 4.01 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.33 7.33 7.33 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL