Z-360


SMILES O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O
InChIKey VIJCCFFEBCOOIE-JOCHJYFZSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 520.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 8.53 8.53 8.53 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.34 8.34 8.34 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 8.43 8.43 8.43 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 ChEMBL
D5 DRD5 Human Dopamine A pKi 8.05 8.05 8.05 ChEMBL
H1 HRH1 Human Histamine A pKi 8.43 8.43 8.43 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.75 7.75 7.75 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.34 8.34 8.34 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.53 8.53 8.53 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.37 9.45 9.52 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.5 8.51 8.52 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.25 8.28 8.3 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.1 8.37 8.53 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.66 7.66 7.66 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.58 7.77 7.96 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.1 7.32 7.55 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.74 7.74 7.74 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.6 7.6 7.6 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 9.19 9.19 9.19 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 6.6 6.6 6.6 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 8.36 8.36 8.36 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 7.74 7.74 7.74 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 8.05 8.05 8.05 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.43 8.43 8.43 PDSP Ki database
H3 HRH3 Human Histamine A pKi 6.0 6.0 6.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.34 8.34 8.34 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.86 6.86 6.86 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.52 8.52 8.52 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.35 8.35 8.35 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 7.66 7.66 7.66 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.11 8.11 8.11 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
D1 DRD1 Human Dopamine A pKi 8.11 8.11 8.11 Drug Central
D2 DRD2 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Human Dopamine A pKi 8.08 8.08 8.08 Drug Central
D4 DRD4 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
D5 DRD5 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
H1 HRH1 Human Histamine A pKi 8.07 8.07 8.07 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.52 8.52 8.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pIC50 6.06 7.53 9.0 ChEMBL
H1 HRH1 Rat Histamine A pIC50 8.05 8.05 8.05 Drug Central
H1 HRH1 Rat Histamine A pIC50 8.97 8.97 8.97 ChEMBL