pindolol


SMILES OC(COc1cccc2c1cc[nH]2)CNC(C)C
InChIKey JZQKKSLKJUAGIC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 248.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKd 6.78 6.78 6.78 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 7.18 7.18 7.18 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKd 8.58 8.6 8.62 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 9.27 9.27 9.28 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.57 7.64 7.7 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 4.27 4.27 4.27 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 9.4 9.41 9.42 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKd 9.18 9.22 9.27 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.96 7.33 7.65 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 7.2 7.2 7.2 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.04 6.43 7.75 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.0 5.1 5.31 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 5.0 5.01 5.02 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.0 5.77 6.26 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 8.59 8.86 9.28 PDSP Ki database
β2 ADRB2 Guinea pig Adrenoceptors A pKi 8.58 8.76 8.94 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.09 7.46 7.82 PDSP Ki database
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.51 7.51 7.51 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.02 5.03 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.66 5.66 5.66 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 8.32 8.86 9.4 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.39 5.65 5.92 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.58 5.58 5.58 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.7 5.7 5.7 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.37 8.37 8.37 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.03 8.03 8.03 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.6 9.05 9.7 Guide to Pharmacology
β2 ADRB2 Human Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 9.4 9.4 9.4 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKd 8.17 8.17 8.17 Drug Central
β3 ADRB3 Human Adrenoceptors A pKi 7.36 7.36 7.36 PDSP Ki database
β3 ADRB3 Human Adrenoceptors A pKi 7.1 7.1 7.1 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
β2 ADRB2 Rat Adrenoceptors A pKi 9.5 9.5 9.5 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 PDSP Ki database
β1 ADRB1 Rat Adrenoceptors A pKi 9.18 9.18 9.18 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 PDSP Ki database
β1 H0W3H1 Guinea pig Adrenoceptors A pKi 8.14 8.14 8.14 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 7.5 7.5 7.5 ChEMBL
β3 ADRB3 Human Adrenoceptors A pIC50 7.06 7.06 7.06 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 9.04 9.04 9.04 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.32 7.32 7.32 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 9.26 9.26 9.26 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 7.57 7.57 7.57 ChEMBL
β3 ADRB3 Human Adrenoceptors A pEC50 5.6 6.5 7.4 Guide to Pharmacology