GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	46780481	107531	20	None	3	15	Human	9.7	pAC50	=	9.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	3	15	Human	9.7	pAC50	=	9.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	3	15	Human	9.7	pAC50	=	9.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	3	15	Human	9.7	pAC50	=	9.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	4940	14470	35	None	-5	15	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14470	35	None	-5	15	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	16351	102730	47	None	-162	17	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102730	47	None	-162	17	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	1427	2013	54	None	-933	30	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	54	None	-933	30	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	54	None	-933	30	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	54	None	-933	30	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	54	None	-933	30	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2543	3707	68	None	-691	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	68	None	-691	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	68	None	-691	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	68	None	-691	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	68	None	-691	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	2247	505	81	None	-23	42	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	81	None	-23	42	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	81	None	-23	42	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	81	None	-23	42	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	81	None	-23	42	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	104870	98880	47	None	-56	10	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98880	47	None	-56	10	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98880	47	None	-56	10	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	4178	195803	63	None	-3	2	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	CHEMBL558	195803	63	None	-3	2	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	54682461	84686	62	None	-2	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84686	62	None	-2	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	2520	204008	70	None	-10	20	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	204008	70	None	-10	20	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	204008	70	None	-10	20	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	26987	949	33	None	-104	34	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	33	None	-104	34	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	33	None	-104	34	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	33	None	-104	34	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	33	None	-104	34	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	1222	1664	49	None	-5	25	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	49	None	-5	25	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	49	None	-5	25	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	49	None	-5	25	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	49	None	-5	25	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	4993	122357	110	None	-1	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122357	110	None	-1	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	242	470	124	None	-229	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-229	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-229	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-229	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-229	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	71496458	115564	87	None	-3	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115564	87	None	-3	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	447715	196927	68	None	-19	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	196927	68	None	-19	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	4452	2762	19	None	-85	21	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	19	None	-85	21	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	19	None	-85	21	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	16363	596	53	None	-3	21	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	53	None	-3	21	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	53	None	-3	21	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	53	None	-3	21	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	53	None	-3	21	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	135398737	958	93	None	-6	43	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	93	None	-6	43	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	93	None	-6	43	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	93	None	-6	43	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	93	None	-6	43	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1385580	29276	76	None	-141	19	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29276	76	None	-141	19	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29276	76	None	-141	19	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	2402	3370	62	None	-27	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-27	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-27	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-27	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-27	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	216416	111581	48	None	-141	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111581	48	None	-141	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	16960	14487	23	None	-1905	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1201287	14487	23	None	-1905	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	11504295	2923	47	None	-97723	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	47	None	-97723	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	47	None	-97723	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	47	None	-97723	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	47	None	-97723	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	123606	352	70	None	-1071	6	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	70	None	-1071	6	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	70	None	-1071	6	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	70	None	-1071	6	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	70	None	-1071	6	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	2333	142335	97	None	-14	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-14	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2162	41514	100	None	-11	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41514	100	None	-11	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	71398	106439	44	None	-2290	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106439	44	None	-2290	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	91610	141353	96	None	-1	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	527	7	2	6	3.5	COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL383634	141353	96	None	-1	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	527	7	2	6	3.5	COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C	10.1038/s41467-023-40064-9
	11626560	200937	94	None	-6	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200937	94	None	-6	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	1212	1662	50	None	-14	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	50	None	-14	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	50	None	-14	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	50	None	-14	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	50	None	-14	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	212	3806	47	None	-141	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	47	None	-141	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	47	None	-141	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	47	None	-141	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	47	None	-141	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	31101	729	40	None	-26	29	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-26	29	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-26	29	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-26	29	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-26	29	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	134	2514	24	None	-12	18	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	24	None	-12	18	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	24	None	-12	18	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	24	None	-12	18	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	24	None	-12	18	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1613	2348	53	None	-2	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	53	None	-2	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	53	None	-2	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	53	None	-2	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	53	None	-2	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	1890	2759	49	None	-1	24	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	49	None	-1	24	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	49	None	-1	24	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	49	None	-1	24	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	49	None	-1	24	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	2869	4152	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4152	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4152	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4152	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4152	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	31703	194717	63	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194717	63	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194717	63	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	21722	17992	31	None	-9	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17992	31	None	-9	21	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	65700	78260	28	None	-41	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78260	28	None	-41	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	3081361	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	135409453	3773	41	None	-173	35	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	41	None	-173	35	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	41	None	-173	35	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	610479	15500	90	None	-1	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15500	90	None	-1	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	41684	31221	105	None	-33	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31221	105	None	-33	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	2782	32000	67	None	-4466	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	32000	67	None	-4466	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	32000	67	None	-4466	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	21772	78399	31	None	-1000	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL2110816	78399	31	None	-1000	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	4528	98126	80	None	-6	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL273575	98126	80	None	-6	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	1201549	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-97	26	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2342	599	39	None	-3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	39	None	-3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	39	None	-3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	39	None	-3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	39	None	-3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	1353	1911	93	None	-77	39	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	93	None	-77	39	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	93	None	-77	39	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	93	None	-77	39	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	93	None	-77	39	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2583	3776	118	None	-8912	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	118	None	-8912	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	118	None	-8912	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	118	None	-8912	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	118	None	-8912	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	124087	1389	114	None	-2	27	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	114	None	-2	27	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	114	None	-2	27	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	114	None	-2	27	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	114	None	-2	27	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	5440	28724	37	None	-512	16	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28724	37	None	-512	16	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3926	207241	40	None	-2	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207241	40	None	-2	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	2142	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	58	None	-223	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5077	3578	79	None	-602	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	79	None	-602	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	79	None	-602	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	79	None	-602	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	79	None	-602	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	60606	61560	73	None	-7	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	-7	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	46199646	120507	69	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	520	8	4	7	3.4	CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO	10.1038/s41467-023-40064-9
	CHEMBL3544914	120507	69	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	520	8	4	7	3.4	CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO	10.1038/s41467-023-40064-9
	5666	102992	35	None	-7	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL306700	102992	35	None	-7	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	1224	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	83	None	-912	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3704	78189	41	None	-3	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	CHEMBL2105022	78189	41	None	-3	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	3198	205513	76	None	-29	37	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201049	205513	76	None	-29	37	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL808	205513	76	None	-29	37	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	4746	204891	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204891	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204891	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	228	445	28	None	-316	20	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	28	None	-316	20	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	28	None	-316	20	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	28	None	-316	20	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	28	None	-316	20	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	10034073	17161	29	None	-3	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	1056	13	7	18	6.2	CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1255800	17161	29	None	-3	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	1056	13	7	18	6.2	CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C	10.1038/s41467-023-40064-9
	445643	97389	69	None	-2	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	-2	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	2378	98687	103	None	-34	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	4	0	2	5.2	c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL277535	98687	103	None	-34	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	4	0	2	5.2	c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1	10.1038/s41467-023-40064-9
	50905713	102396	76	None	-1	2	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	4	2	6	4.5	C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3039502	102396	76	None	-1	2	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	4	2	6	4.5	C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1	10.1038/s41467-023-40064-9
	26248	161539	102	None	-1	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161539	102	None	-1	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	47936	193422	88	None	-380	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193422	88	None	-380	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2448	99323	70	None	-81	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99323	70	None	-81	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	4976	203579	29	None	-199	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203579	29	None	-199	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205271	82	None	-3	27	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2855	4132	104	None	-9549	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	104	None	-9549	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	104	None	-9549	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	104	None	-9549	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	104	None	-9549	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5482	14420	80	None	-10	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14420	80	None	-10	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	6127	14499	8	None	-117	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14499	8	None	-117	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	3823	50221	42	None	-47	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50221	42	None	-47	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50221	42	None	-47	15	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2995	204405	53	None	-7079	18	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204405	53	None	-7079	18	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204405	53	None	-7079	18	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	154257	178619	67	None	-8	19	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-8	19	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	2389	3331	118	None	-1	29	Human	8.6	pAC50	=	8.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	118	None	-1	29	Human	8.6	pAC50	=	8.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	118	None	-1	29	Human	8.6	pAC50	=	8.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	118	None	-1	29	Human	8.6	pAC50	=	8.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	118	None	-1	29	Human	8.6	pAC50	=	8.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2335	11848	22	None	-3	34	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-3	34	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-3	34	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-3	34	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3158	56267	27	None	-194	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56267	27	None	-194	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	202	1508	77	None	-2	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	77	None	-2	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	77	None	-2	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	77	None	-2	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	77	None	-2	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3062316	33575	121	None	1	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33575	121	None	1	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	2333	142335	97	None	-14	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-14	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	11658860	2344	51	None	-17	11	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	51	None	-17	11	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	51	None	-17	11	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	51	None	-17	11	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	51	None	-17	11	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	3658	4107	53	None	-57	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-57	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-57	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-57	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-57	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	47510	172546	39	None	-13	3	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172546	39	None	-13	3	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	3949	100614	50	None	-22	16	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100614	50	None	-22	16	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	71398	106439	44	None	-2290	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106439	44	None	-2290	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2351	4300	49	None	-9	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4300	49	None	-9	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4300	49	None	-9	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	5311017	120604	11	None	-32	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3545985	120604	11	None	-32	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	636403	188268	22	None	-8	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188268	22	None	-8	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	48041	107081	46	None	1	6	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	CHEMBL315838	107081	46	None	1	6	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	213046	2385	59	None	-1	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	59	None	-1	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	59	None	-1	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	59	None	-1	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	59	None	-1	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2136	3095	30	None	-45	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	30	None	-45	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	30	None	-45	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	30	None	-45	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	30	None	-45	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	54454	5258	88	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5258	88	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	3157	1470	71	None	-10232	21	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	71	None	-10232	21	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	71	None	-10232	21	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	71	None	-10232	21	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	71	None	-10232	21	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	1830	2590	44	None	-416	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	44	None	-416	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	44	None	-416	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	44	None	-416	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	44	None	-416	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	10184665	3991	51	None	-13489	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3991	51	None	-13489	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3991	51	None	-13489	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3991	51	None	-13489	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3991	51	None	-13489	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	3658	4107	53	None	-57	18	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-57	18	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-57	18	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-57	18	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-57	18	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	119570	3159	96	None	-426	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	96	None	-426	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	96	None	-426	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	96	None	-426	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	96	None	-426	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	9911830	19148	100	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1289494	19148	100	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	68873	43564	64	None	-1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43564	64	None	-1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	47979	78210	59	None	-7943	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78210	59	None	-7943	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	104870	98880	47	None	-56	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98880	47	None	-56	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98880	47	None	-56	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	4031	99313	28	None	-39	12	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99313	28	None	-39	12	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	102	4127	48	None	-549	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	48	None	-549	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	48	None	-549	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	48	None	-549	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	48	None	-549	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	45138674	16646	50	None	-1	6	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16646	50	None	-1	6	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	4011	82408	49	None	-46	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82408	49	None	-46	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2780	110529	36	None	-251	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110529	36	None	-251	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2284	3182	33	None	-16	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3182	33	None	-16	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3182	33	None	-16	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3182	33	None	-16	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3182	33	None	-16	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	2286	3183	51	None	-20	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	51	None	-20	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	51	None	-20	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	51	None	-20	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	51	None	-20	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	60753	194684	40	None	-7	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194684	40	None	-7	6	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	4942	5718	50	None	-31	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5718	50	None	-31	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2264	53190	38	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
	CHEMBL1598608	53190	38	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
	2351	3286	64	None	-457	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	2820	3286	64	None	-457	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	5035	3286	64	None	-457	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	CHEMBL81	3286	64	None	-457	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	DB00481	3286	64	None	-457	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	5994	4641	88	None	-9	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4641	88	None	-9	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	64139	84785	96	None	-2	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	CHEMBL223228	84785	96	None	-2	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	43815	186920	64	None	-102	20	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186920	64	None	-102	20	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186920	64	None	-102	20	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	5591	157531	90	None	-1	17	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157531	90	None	-1	17	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	1056	3371	116	None	-51	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	116	None	-51	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	116	None	-51	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	116	None	-51	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	116	None	-51	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	46220502	112583	84	None	-91	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112583	84	None	-91	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	9417	133512	54	None	-346	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133512	54	None	-346	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133512	54	None	-346	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	54684141	208000	82	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL973	208000	82	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	2218	15283	23	None	-3	12	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15283	23	None	-3	12	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	72106	78192	60	None	3	3	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78192	60	None	3	3	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	25102847	78221	93	None	-2	10	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78221	93	None	-2	10	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	1210	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	51	None	-524	22	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	72095	78273	20	None	-	1	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	246	6	2	3	1.8	C#CCOc1ccc(N)cc1C(=O)NCCCC	10.1038/s41467-023-40064-9
	CHEMBL2107094	78273	20	None	-	1	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	246	6	2	3	1.8	C#CCOc1ccc(N)cc1C(=O)NCCCC	10.1038/s41467-023-40064-9
	3294	2006	111	None	2	23	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	111	None	2	23	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	111	None	2	23	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	111	None	2	23	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	111	None	2	23	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	19675	51670	43	None	-4	15	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51670	43	None	-4	15	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2337	3256	77	None	-7	29	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	77	None	-7	29	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	77	None	-7	29	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	77	None	-7	29	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	77	None	-7	29	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10798	104	None	10	20	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10798	104	None	10	20	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	207523	50	None	-10	10	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207523	50	None	-10	10	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	2274	3173	58	None	-5	36	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	58	None	-5	36	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	58	None	-5	36	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	58	None	-5	36	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	58	None	-5	36	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	1530	2182	50	None	-5	25	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	50	None	-5	25	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	50	None	-5	25	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	50	None	-5	25	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	50	None	-5	25	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1816	2540	102	None	-53	12	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	102	None	-53	12	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	102	None	-53	12	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	102	None	-53	12	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	102	None	-53	12	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	1209	1658	75	None	-3	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	75	None	-3	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	75	None	-3	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	75	None	-3	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	75	None	-3	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5906	14495	23	None	-3	4	Human	4.5	pAC50	=	4.5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14495	23	None	-3	4	Human	4.5	pAC50	=	4.5	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	22323	15299	32	None	-2	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15299	32	None	-2	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15299	32	None	-2	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	1234	189221	56	None	-13	10	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189221	56	None	-13	10	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189221	56	None	-13	10	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	2220	3134	82	None	6	17	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	6	17	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	6	17	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	6	17	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	6	17	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	104850	3330	96	None	-323	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	96	None	-323	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	96	None	-323	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	96	None	-323	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	96	None	-323	27	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4066	204626	78	None	-239	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-239	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2585	803	103	None	-724	33	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	103	None	-724	33	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	103	None	-724	33	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	103	None	-724	33	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	103	None	-724	33	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	72093	35061	9	None	-3	28	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-3	28	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-3	28	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	2105	3054	37	None	-2	25	Human	8.3	pAC50	=	8.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	37	None	-2	25	Human	8.3	pAC50	=	8.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	37	None	-2	25	Human	8.3	pAC50	=	8.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	37	None	-2	25	Human	8.3	pAC50	=	8.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	37	None	-2	25	Human	8.3	pAC50	=	8.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	1043	1582	14	None	-81	22	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	14	None	-81	22	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	14	None	-81	22	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	14	None	-81	22	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	14	None	-81	22	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	4640	78266	30	None	-3	11	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78266	30	None	-3	11	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	5453	203619	102	None	-93	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203619	102	None	-93	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	2470	3653	50	None	-2570	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-2570	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-2570	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-2570	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-2570	23	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2795	14494	37	None	1	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	5	1	2	3.5	CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1201313	14494	37	None	1	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	5	1	2	3.5	CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl	10.1038/s41467-023-40064-9
	25382	9157	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9157	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	2407	3372	76	None	-138	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	76	None	-138	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	76	None	-138	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	76	None	-138	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	76	None	-138	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	2267	559	71	None	-190	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	71	None	-190	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	71	None	-190	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	71	None	-190	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	71	None	-190	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2435	3590	83	None	-23	21	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	83	None	-23	21	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	83	None	-23	21	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	83	None	-23	21	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	83	None	-23	21	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	4150	788	39	None	-72	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	39	None	-72	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	39	None	-72	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	39	None	-72	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	39	None	-72	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5329102	194726	86	None	-6	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194726	86	None	-6	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2601	3780	33	None	-154	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	33	None	-154	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	33	None	-154	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	33	None	-154	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	33	None	-154	17	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	5284550	41721	15	None	-251	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41721	15	None	-251	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	2540	4401	111	None	-691	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4401	111	None	-691	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	4886	14110	28	None	-19	5	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1198	14110	28	None	-19	5	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	135398745	2914	112	None	-1	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	112	None	-1	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	112	None	-1	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	112	None	-1	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	1971	2866	38	None	-107	32	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	38	None	-107	32	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	38	None	-107	32	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	38	None	-107	32	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	38	None	-107	32	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	5311507	194815	41	None	-4	12	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194815	41	None	-4	12	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	3337	206367	27	None	-1	6	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	65801	206367	27	None	-1	6	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	66264	206367	27	None	-1	6	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	91452	206367	27	None	-1	6	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL87493	206367	27	None	-1	6	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	3151	1462	97	None	-38	24	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	97	None	-38	24	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	97	None	-38	24	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	97	None	-38	24	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	97	None	-38	24	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	20628	96548	28	None	-1	13	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96548	28	None	-1	13	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	55645	84370	8	None	-3090	11	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84370	8	None	-3090	11	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	209	3057	97	None	-47	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3057	97	None	-47	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3057	97	None	-47	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3057	97	None	-47	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3057	97	None	-47	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	9429	202133	58	None	-602	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202133	58	None	-602	18	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	4450	178228	69	None	-9	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178228	69	None	-9	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	1400	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	70	None	-7	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	1343	1889	62	None	-112	12	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	62	None	-112	12	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	62	None	-112	12	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	62	None	-112	12	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	62	None	-112	12	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3042	1414	35	None	-501	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	35	None	-501	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	35	None	-501	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	35	None	-501	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	35	None	-501	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	37	778	60	None	-4	12	Human	7.2	pAC50	=	7.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-4	12	Human	7.2	pAC50	=	7.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-4	12	Human	7.2	pAC50	=	7.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-4	12	Human	7.2	pAC50	=	7.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-4	12	Human	7.2	pAC50	=	7.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54841	203127	52	None	-3	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	203127	52	None	-3	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	55645	84370	8	None	-3090	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84370	8	None	-3090	11	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	242	470	124	None	-229	33	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-229	33	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-229	33	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-229	33	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-229	33	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2865	4143	73	None	3	20	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	73	None	3	20	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	73	None	3	20	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	73	None	3	20	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	73	None	3	20	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	3947	206395	53	None	-10	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL87708	206395	53	None	-10	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	131411	15392	70	None	-2	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15392	70	None	-2	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15392	70	None	-2	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	168871	89130	14	None	-52	13	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-52	13	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	2318	154856	29	None	-10	15	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154856	29	None	-10	15	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	150	2509	21	None	-1	17	Human	8.1	pAC50	=	8.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	21	None	-1	17	Human	8.1	pAC50	=	8.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	21	None	-1	17	Human	8.1	pAC50	=	8.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	21	None	-1	17	Human	8.1	pAC50	=	8.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	21	None	-1	17	Human	8.1	pAC50	=	8.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	135	2532	43	None	-4	33	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	43	None	-4	33	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	43	None	-4	33	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	43	None	-4	33	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	43	None	-4	33	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	68867	78173	38	None	-1	13	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78173	38	None	-1	13	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	2726	919	68	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	68	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	68	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	68	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	68	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	118422671	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	65	None	-2344	23	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	213	3853	55	None	-12	22	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	55	None	-12	22	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	55	None	-12	22	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	55	None	-12	22	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	55	None	-12	22	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	44112	121290	48	None	-301	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121290	48	None	-301	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2402	3370	62	None	-27	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-27	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-27	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-27	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-27	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	2762	3863	31	None	-234	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587	3863	31	None	-234	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	7318	3863	31	None	-234	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL1241	3863	31	None	-234	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	DB00792	3863	31	None	-234	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	3936	52488	94	None	-4	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	3	0	4	3.8	COc1cccc(N(C)C(=S)Oc2ccc3c(c2)CCCC3)n1	10.1038/s41467-023-40064-9
	CHEMBL1591365	52488	94	None	-4	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	3	0	4	3.8	COc1cccc(N(C)C(=S)Oc2ccc3c(c2)CCCC3)n1	10.1038/s41467-023-40064-9
	2169	44847	35	None	-128	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44847	35	None	-128	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	214	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-7	28	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2393	3334	82	None	-128	9	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	82	None	-128	9	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	82	None	-128	9	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	82	None	-128	9	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	82	None	-128	9	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	191	403	98	None	1	36	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	98	None	1	36	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	98	None	1	36	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	98	None	1	36	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	98	None	1	36	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	103	4153	61	None	-3	22	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	61	None	-3	22	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	61	None	-3	22	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	61	None	-3	22	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	61	None	-3	22	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2477	745	59	None	-173	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	745	59	None	-173	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	745	59	None	-173	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	745	59	None	-173	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	745	59	None	-173	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	1024	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	162639143	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	5284373	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	760	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL160	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB00091	1289	71	None	-141	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	3191	102858	97	None	-48	33	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102858	97	None	-48	33	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	17676	7072	29	None	-199	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7072	29	None	-199	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7072	29	None	-199	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	4046	2483	33	None	-19	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-19	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-19	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-19	17	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	441074	19414	82	None	-4	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19414	82	None	-4	11	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	2398	954	62	None	-123	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	62	None	-123	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	62	None	-123	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	62	None	-123	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	62	None	-123	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	180	401	56	None	-158	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-158	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-158	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-158	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-158	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4418	34222	85	None	-165	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34222	85	None	-165	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	3149	12614	15	None	3	26	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12614	15	None	3	26	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	65981	18454	102	None	2	3	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1272	18454	102	None	2	3	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	5803	162227	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162227	84	None	-2	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	100	3805	58	None	-6	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	58	None	-6	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	58	None	-6	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	58	None	-6	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	58	None	-6	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2895	203592	41	None	-9	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203592	41	None	-9	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	3689	102771	55	None	-1380	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102771	55	None	-1380	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102771	55	None	-1380	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	65709	59881	39	None	-4	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1729803	59881	39	None	-4	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	124	2981	47	None	-177	24	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	47	None	-177	24	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	47	None	-177	24	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	47	None	-177	24	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	47	None	-177	24	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	68617	205527	62	None	-14	30	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205527	62	None	-14	30	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205527	62	None	-14	30	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	10531	1420	21	None	-100	25	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	21	None	-100	25	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	21	None	-100	25	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	21	None	-100	25	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	21	None	-100	25	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	5	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-19	26	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	168289382	191793	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191793	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168289382	191793	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191793	0	None	1	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	107	141	121	None	6309	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	1833	141	121	None	6309	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	CHEMBL8165	141	121	None	6309	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	5	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	72	None	-19	26	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	72	None	2	26	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	11247569	199420	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL591223	199420	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	1524	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	197	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	3822	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	88	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	CHEMBL51	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	DB12465	2181	96	None	1	18	Human	9.0	pEC50	=	9.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	5	139	72	None	-19	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	5202	139	72	None	-19	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	CHEMBL39	139	72	None	-19	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	DB08839	139	72	None	-19	26	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	439280	120019	107	None	-9	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	107	None	-9	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	107	None	-9	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	168291775	191906	0	None	1	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	191906	0	None	1	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168291775	191906	0	None	1	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	191906	0	None	1	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	5202	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	CHEMBL39	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	DB08839	139	72	None	-19	26	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	4376990	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	5	None	-3	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	145	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	1832	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	CHEMBL7257	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	DB14010	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	145	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	1832	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	CHEMBL7257	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	DB14010	140	49	None	6	11	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	5	139	72	None	-19	26	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	72	None	-19	26	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	72	None	-19	26	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	72	None	-19	26	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	120019	107	None	-9	9	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	107	None	-9	9	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	107	None	-9	9	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	152743520	189979	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5170895	189979	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11695000	89071	0	None	-17	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89071	0	None	-17	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89071	0	None	-17	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	24773649	94827	0	None	-2	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94827	0	None	-2	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	122180957	121772	0	None	20	2	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	CHEMBL3589578	121772	0	None	20	2	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	10105208	62499	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62499	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	17954204	63938	23	None	-7	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63938	23	None	-7	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	24773816	94856	0	None	-12	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94856	0	None	-12	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	23395431	94913	0	None	-10	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94913	0	None	-10	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	24773650	154697	2	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154697	2	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	10105208	62499	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62499	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	22368315	63766	0	None	-12	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63766	0	None	-12	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	9994008	166149	0	None	-9	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166149	0	None	-9	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	96783829	192802	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	CHEMBL5174204	192802	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	CHEMBL5221436	192802	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	24773897	94858	3	None	-251	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL253807	94858	3	None	-251	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	134265705	164091	0	None	-1621	3	Human	4.0	pEC50	=	4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	164091	0	None	-1621	3	Human	4.0	pEC50	=	4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265590	164758	0	None	-309	3	Human	4.0	pEC50	=	4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164758	0	None	-309	3	Human	4.0	pEC50	=	4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	118733794	120673	0	None	-15	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120673	0	None	-15	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120673	0	None	-15	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	118733818	120665	0	None	-93	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120665	0	None	-93	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120665	0	None	-93	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	24826871	91112	0	None	-85	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397907	91112	0	None	-85	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	157114558	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5187568	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221884	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	24826963	91115	0	None	-74	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397910	91115	0	None	-74	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	11176570	91120	1	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397915	91120	1	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	157114558	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5187568	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221884	192864	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	18735309	205433	0	None	-21	3	Human	6.0	pEC50	=	6.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	205433	0	None	-21	3	Human	6.0	pEC50	=	6.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	24826787	91097	0	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397892	91097	0	None	-6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	122442268	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168276822	190123	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5173321	190123	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	44412405	77781	0	None	-5	3	Human	6.0	pEC50	=	6.0	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77781	0	None	-5	3	Human	6.0	pEC50	=	6.0	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	122442268	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	0	None	-7	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	58911579	91096	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397891	91096	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162644827	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162644827	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	0	None	-16	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162657367	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45485781	197391	0	None	-23	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	CHEMBL569342	197391	0	None	-23	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	5	139	72	None	-19	26	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	72	None	-19	26	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	72	None	-19	26	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	72	None	-19	26	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	122180976	121791	2	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	CHEMBL3589597	121791	2	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	122180977	121792	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL3589598	121792	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5080051	214662	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL		None	None	None		Oc1cccc2[nH]cc(CCN3CCC3)c12	10.1021/acsmedchemlett.2c00129
	3906894	101979	24	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	101979	24	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	10401602	123069	0	None	-3	3	Human	7.0	pEC50	=	7.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123069	0	None	-3	3	Human	7.0	pEC50	=	7.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44383397	59242	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Functional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	CHEMBL170319	59242	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Functional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	11437171	83490	0	None	-2	3	Human	7.0	pEC50	=	7.0	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83490	0	None	-2	3	Human	7.0	pEC50	=	7.0	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	162657367	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	0	None	-42	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168272608	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162670523	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44412404	77768	6	None	-10	3	Human	6.0	pEC50	=	6.0	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77768	6	None	-10	3	Human	6.0	pEC50	=	6.0	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	168272608	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	0	None	-3	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162670523	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	0	None	-41	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45485779	197507	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570023	197507	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	168282376	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168282376	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192886	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24849050	78300	2	None	-5	3	Human	6.9	pEC50	=	6.9	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78300	2	None	-5	3	Human	6.9	pEC50	=	6.9	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	162659049	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162659049	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183693	0	None	-13	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11302765	84248	4	None	-74	3	Human	5.9	pEC50	=	5.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84248	4	None	-74	3	Human	5.9	pEC50	=	5.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	122442251	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	3906894	101979	24	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	101979	24	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	5	139	72	None	-19	26	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	5202	139	72	None	-19	26	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	CHEMBL39	139	72	None	-19	26	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	DB08839	139	72	None	-19	26	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	CHEMBL4790446	214071	2	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	214071	2	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4790446	214071	2	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	214071	2	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	1621	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	17	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	5761	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	CHEMBL263881	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	DB04829	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	46233391	199200	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	454	4	2	4	5.4	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)c1	10.1021/jm9007328
	CHEMBL589769	199200	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	454	4	2	4	5.4	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)c1	10.1021/jm9007328
	168280534	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5183493	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221899	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	168280534	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5183493	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221899	192868	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	122442251	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	107992	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	72197306	102488	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL2393231	102488	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL3040287	102488	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	107992	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	49	None	-6	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	118733762	120644	0	None	-93	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120644	0	None	-93	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120644	0	None	-93	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	53324327	56850	0	None	-2	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56850	0	None	-2	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	16115517	84838	0	None	-87	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84838	0	None	-87	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11206703	91092	0	None	-40	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91092	0	None	-40	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	168268736	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168268736	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	0	None	-3	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	57799306	89109	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89109	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89109	0	None	-47	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	9881119	205473	0	None	-4	3	Human	6.9	pEC50	=	6.9	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	205473	0	None	-4	3	Human	6.9	pEC50	=	6.9	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	5	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	11160564	63304	4	None	-7	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63304	4	None	-7	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	11608308	64309	4	None	-42	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64309	4	None	-42	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	24773809	94882	0	None	-15	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94882	0	None	-15	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	3991761	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183437	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222058	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	728636	114304	5	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	3	2	1	2.4	CC[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330646	114304	5	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	3	2	1	2.4	CC[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	16115388	137366	0	None	2	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137366	0	None	2	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	3991761	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183437	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222058	192896	2	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	11514226	89110	0	None	-114	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89110	0	None	-114	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89110	0	None	-114	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11609026	89127	0	None	-38	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89127	0	None	-38	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89127	0	None	-38	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	71562661	87307	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	1621	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	17	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	5761	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	CHEMBL263881	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	DB04829	2429	17	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	439280	120019	107	None	-9	9	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	6971044	120019	107	None	-9	9	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	CHEMBL350221	120019	107	None	-9	9	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	46884102	8062	1	None	-128	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091106	8062	1	None	-128	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	5	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	5202	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	CHEMBL39	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	DB08839	139	72	None	-19	26	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	46230099	199312	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	199312	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	71562661	87307	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	118733808	120656	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120656	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120656	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	11414184	83498	0	None	-5	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83498	0	None	-5	3	Human	6.9	pEC50	=	6.9	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	166	3359	18	None	-36	4	Human	6.9	pEC50	=	6.9	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3359	18	None	-36	4	Human	6.9	pEC50	=	6.9	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3359	18	None	-36	4	Human	6.9	pEC50	=	6.9	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	134265622	164753	0	None	-223	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164753	0	None	-223	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	46228422	200036	0	None	-60	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	200036	0	None	-60	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	168277051	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168277051	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192837	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295524	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205848	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222868	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168276542	190312	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5176147	190312	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	168295524	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205848	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222868	193030	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168280316	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	168280316	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192863	0	None	-41	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	11608308	64309	4	None	-42	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL181076	64309	4	None	-42	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	71681897	91119	0	None	-87	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	CHEMBL2397914	91119	0	None	-87	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	53324165	56801	0	None	-2	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56801	0	None	-2	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	9901086	187631	33	None	-95	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	33	None	-95	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168290116	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193251	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222481	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168290116	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193251	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222481	192964	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	44572657	12467	6	None	-263	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12467	6	None	-263	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12467	6	None	-263	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	12370465	12674	18	None	-109	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12674	18	None	-109	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12674	18	None	-109	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	9901086	187631	33	None	-95	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	33	None	-95	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168288579	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5197871	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222382	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	168288579	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5197871	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222382	192943	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	11949706	200055	0	None	-1445	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595645	200055	0	None	-1445	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	16743289	59569	3	None	-724	2	Human	6.8	pEC50	=	6.8	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL171774	59569	3	None	-724	2	Human	6.8	pEC50	=	6.8	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	168283046	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	168283046	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192892	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	118733806	120655	0	None	-46	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120655	0	None	-46	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120655	0	None	-46	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	24826957	91117	0	None	-24	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397912	91117	0	None	-24	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572804	12623	1	None	-48	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12623	1	None	-48	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12623	1	None	-48	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL4757837	214068	1	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	214068	1	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4757837	214068	1	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	214068	1	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	72	None	-19	26	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	7153	98020	77	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	98020	77	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	22292784	64594	15	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64594	15	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	11952353	199860	0	None	-1071	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	199860	0	None	-1071	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	168268703	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168268703	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192776	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	122442263	138357	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	46884137	8442	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093698	8442	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	72197481	102402	0	None	4	2	Human	6.8	pEC50	=	6.8	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393240	102402	0	None	4	2	Human	6.8	pEC50	=	6.8	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3039632	102402	0	None	4	2	Human	6.8	pEC50	=	6.8	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	168280955	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5184449	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221926	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168280955	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5184449	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221926	192875	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168288855	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5194467	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222402	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	11658860	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	22292784	64594	15	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64594	15	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	168280043	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	3568612	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	10329912	62551	8	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	CHEMBL178252	62551	8	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	24773979	130169	21	None	-4	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130169	21	None	-4	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	24773978	154416	1	None	-7	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL398926	154416	1	None	-7	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	168288855	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5194467	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222402	192948	0	None	-2	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	168280043	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192859	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	9991444	62632	1	None	-4	3	Human	7.8	pEC50	=	7.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62632	1	None	-4	3	Human	7.8	pEC50	=	7.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	3568612	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	192995	2	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	45484663	198368	0	None	-	1	Dog	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nnc2c3c(nc(Cc4ccccc4)n12)CCNCC3	10.1016/j.bmcl.2009.07.063
	CHEMBL576631	198368	0	None	-	1	Dog	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nnc2c3c(nc(Cc4ccccc4)n12)CCNCC3	10.1016/j.bmcl.2009.07.063
	10329912	62551	8	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178252	62551	8	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	24773979	130169	21	None	-4	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL367796	130169	21	None	-4	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	44572755	12459	1	None	-70	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12459	1	None	-70	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12459	1	None	-70	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	11427139	84687	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84687	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44315993	172877	0	None	-16	3	Human	6.8	pEC50	=	6.8	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172877	0	None	-16	3	Human	6.8	pEC50	=	6.8	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	168288743	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	11658860	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	51	None	-17	11	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442273	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733824	120669	0	None	-75	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416065	120669	0	None	-75	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546960	120669	0	None	-75	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	16115654	136974	0	None	-27	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136974	0	None	-27	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	168288743	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	1355	2011	88	None	-4	6	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	2011	88	None	-4	6	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	2011	88	None	-4	6	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	2011	88	None	-4	6	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	122442273	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11630623	89099	0	None	-151	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89099	0	None	-151	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89099	0	None	-151	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	44572749	12437	1	None	-32	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12437	1	None	-32	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12437	1	None	-32	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	168290300	191986	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5201317	191986	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11983273	77996	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	77996	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	25084025	12701	1	None	-117	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12701	1	None	-117	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12701	1	None	-117	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	168280082	191193	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5189232	191193	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	122442263	138357	0	None	-15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-15	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11160564	63304	4	None	-7	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63304	4	None	-7	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	168276542	190312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5176147	190312	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	11221167	84680	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84680	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	168268771	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	168268771	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192791	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	11737032	85016	0	None	-47	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	85016	0	None	-47	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	145709	114302	25	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2c(Cl)cccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330643	114302	25	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2c(Cl)cccc12	10.1016/j.bmcl.2014.07.062
	1534	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	44622849	196791	0	None	-	1	Dog	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nc2c3c(nc(Cc4ccccc4)n2n1)CCNCC3	10.1016/j.bmcl.2009.07.063
	CHEMBL565547	196791	0	None	-	1	Dog	5.8	pEC50	=	5.8	Functional	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nc2c3c(nc(Cc4ccccc4)n2n1)CCNCC3	10.1016/j.bmcl.2009.07.063
	44315697	205505	0	None	-8	3	Human	6.7	pEC50	=	6.7	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	205505	0	None	-8	3	Human	6.7	pEC50	=	6.7	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	118733810	120657	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120657	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120657	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	3568128	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	1	None	-4	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	11716185	89064	0	None	-70	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337497	89064	0	None	-70	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2364998	89064	0	None	-70	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	44572800	12653	3	None	-190	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12653	3	None	-190	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12653	3	None	-190	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	9822580	200520	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	404	3	2	3	5.1	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1	10.1021/jm9007328
	CHEMBL598808	200520	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	404	3	2	3	5.1	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1	10.1021/jm9007328
	14107683	178126	22	None	-2	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178126	22	None	-2	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	1534	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	53	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	14107683	178126	22	None	-2	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178126	22	None	-2	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	9991444	62632	1	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62632	1	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	11658860	2344	51	None	-17	11	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2344	51	None	-17	11	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2344	51	None	-17	11	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2344	51	None	-17	11	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2344	51	None	-17	11	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	168295545	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205884	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222933	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	168295545	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205884	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222933	193044	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	44573004	12520	1	None	-52	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12520	1	None	-52	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12520	1	None	-52	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	58911582	91099	0	None	-16	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397894	91099	0	None	-16	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	3071387	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	3939391	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	162656326	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4757142	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802987	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	3071387	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192770	1	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	3939391	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	192950	1	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	162656326	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4757142	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802987	183677	0	None	-6	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	216	2860	32	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2860	32	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2860	32	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	11447552	62528	4	None	-30	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62528	4	None	-30	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	10465263	64332	63	None	-19	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64332	63	None	-19	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773895	94857	0	None	-25	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94857	0	None	-25	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	152	364	29	None	-1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	2107	364	29	None	-1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	CHEMBL275854	364	29	None	-1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	5	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	72	None	-19	26	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	146	135	85	None	851	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	164682	135	85	None	851	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	CHEMBL275628	135	85	None	851	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	90489020	190873	9	None	14	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5184791	190873	9	None	14	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	50878551	90745	61	None	-1	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90745	61	None	-1	3	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	156836209	188575	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4873240	188575	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL5028766	188575	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	122442260	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	138357	0	None	-15	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-15	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-15	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	53317924	56851	0	None	-10	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56851	0	None	-10	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	58911534	91109	0	None	-7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397904	91109	0	None	-7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	4646586	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168268773	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4401618	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	27559	203409	11	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	11	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168268773	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192792	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4646586	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193013	2	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	4401618	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193023	5	None	9	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	11595191	89060	0	None	-51	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89060	0	None	-51	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89060	0	None	-51	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	23492	114300	60	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	1	2	1.7	Cn1cc(CCN)c2ccccc21	10.1016/j.bmcl.2014.07.062
	CHEMBL3330641	114300	60	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	1	2	1.7	Cn1cc(CCN)c2ccccc21	10.1016/j.bmcl.2014.07.062
	57799324	89092	0	None	-9	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337501	89092	0	None	-9	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365359	89092	0	None	-9	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	122442260	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-4	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	27559	203409	11	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	11	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	122442286	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	146025686	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	0	None	-21	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442286	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-13	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168294789	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5208018	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222900	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	44572759	12462	1	None	-83	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12462	1	None	-83	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12462	1	None	-83	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	168294789	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5208018	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222900	193036	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	146025688	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	24826867	91095	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397890	91095	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	146025687	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	10472780	63283	0	None	2	2	Human	7.7	pEC50	=	7.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179244	63283	0	None	2	2	Human	7.7	pEC50	=	7.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	141	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	6089	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	CHEMBL12420	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	DB01488	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	141	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	6089	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	CHEMBL12420	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	DB01488	1427	35	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	146025687	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	0	None	-12	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	16115513	136402	0	None	-43	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL373531	136402	0	None	-43	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11447552	62528	4	None	-30	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62528	4	None	-30	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	44412150	77733	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77733	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	46228433	199740	8	None	-87	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	CHEMBL593547	199740	8	None	-87	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	146025688	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	0	None	-81	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	168274581	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168274581	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192814	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168285159	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168285159	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	27559	203409	11	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	11	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168273192	190416	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190416	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	168297263	192412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5208046	192412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	1534	103040	53	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	9287	103040	53	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL30713	103040	53	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	27559	203409	11	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	11	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168273192	190416	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190416	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	168297263	192412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5208046	192412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	53321947	56798	0	None	-3	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56798	0	None	-3	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	146025685	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	122442293	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442250	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	146025685	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183659	0	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	122442293	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	0	None	-20	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	53325935	56797	0	None	-436	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56797	0	None	-436	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	44572172	12546	0	None	-47	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12546	0	None	-47	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12546	0	None	-47	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	122442250	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	46228438	199985	0	None	-2344	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	199985	0	None	-2344	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	134265663	163679	0	None	-204	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163679	0	None	-204	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	168281505	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168281505	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192880	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44572180	12562	1	None	-199	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12562	1	None	-199	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12562	1	None	-199	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	14515725	87310	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	11291	3220	26	None	-2	4	Human	7.6	pEC50	=	7.6	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3220	26	None	-2	4	Human	7.6	pEC50	=	7.6	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3220	26	None	-2	4	Human	7.6	pEC50	=	7.6	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	71562661	87307	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	14515725	87310	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	0	None	-1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	24773894	62980	3	None	-9	2	Human	5.6	pEC50	=	5.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178566	62980	3	None	-9	2	Human	5.6	pEC50	=	5.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	168275195	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	17654	116799	95	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL337825	116799	95	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	11658860	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	71562661	87307	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	168275195	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192823	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802359	214062	1	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	118713118	114306	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	206	3	2	1	2.6	CCC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330648	114306	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	206	3	2	1	2.6	CCC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	44572808	12706	0	None	-74	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12706	0	None	-74	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12706	0	None	-74	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	11658860	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802359	214062	1	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	46230097	199366	0	None	-15	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	199366	0	None	-15	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	112485369	114305	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	222	3	2	1	3.1	CCC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330647	114305	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	222	3	2	1	3.1	CCC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	44412388	78185	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78185	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	23652278	62631	17	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62631	17	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773814	94859	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94859	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773900	123432	8	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123432	8	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	4312735	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	134265618	164055	0	None	-204	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164055	0	None	-204	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	24773894	62980	3	None	-9	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178566	62980	3	None	-9	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	11780383	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL1288870	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5169776	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	11780383	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL1288870	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5169776	19051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	4312735	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	1	None	-2	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	45485751	197655	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	CHEMBL570937	197655	0	None	-1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	162653458	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	51	None	-17	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	162645074	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168272754	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168272754	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192794	0	None	-6	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	166	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	162653458	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10465263	64332	63	None	-19	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64332	63	None	-19	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL4783435	214070	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803467	214070	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	162645074	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	0	None	-177	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4783435	214070	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803467	214070	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	50942111	56847	0	None	-27	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56847	0	None	-27	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	23652278	62631	17	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62631	17	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53325938	56806	0	None	-32	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56806	0	None	-32	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	168294447	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5206761	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222789	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	9794638	120789	0	None	-46	2	Human	6.6	pEC50	=	6.6	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	CHEMBL355474	120789	0	None	-46	2	Human	6.6	pEC50	=	6.6	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	168294447	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5206761	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222789	193016	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	166	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	18	None	-36	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	50878551	90745	61	None	-1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90745	61	None	-1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	72197485	102489	0	None	1	7	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393244	102489	0	None	1	7	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040288	102489	0	None	1	7	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	168294430	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	5031728	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5191733	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222389	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	168294430	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193007	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	5031728	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5191733	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222389	192945	2	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	20976025	141087	46	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2014.07.062
	CHEMBL382635	141087	46	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2014.07.062
	146464681	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183463	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221759	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	146464681	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183463	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221759	192849	0	None	3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	168295067	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295067	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193022	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295538	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168295538	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193039	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	145966293	164454	0	None	-85	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164454	0	None	-85	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	16115652	83491	0	None	-26	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83491	0	None	-26	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	1355	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	2011	88	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	72197309	102498	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL2393234	102498	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL3040350	102498	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	162643473	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4764937	214069	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803300	214069	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	162643473	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162658689	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4764937	214069	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803300	214069	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	162658689	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	0	None	-47	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733826	120643	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416066	120643	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546874	120643	0	None	-5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	53325937	56805	0	None	7	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56805	0	None	7	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	168293874	192179	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192179	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	0	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168273228	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5178632	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221423	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	168273228	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5178632	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221423	192799	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44389646	64883	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64883	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	74405184	186056	8	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	230	6	1	1	3.4	CCCN(CC)CCc1c[nH]c2ccccc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4871007	186056	8	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	230	6	1	1	3.4	CCCN(CC)CCc1c[nH]c2ccccc12	10.1021/acsmedchemlett.1c00577
	168280365	191276	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5190617	191276	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11658860	2344	51	None	-17	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	51	None	-17	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	51	None	-17	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	51	None	-17	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	51	None	-17	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	3288856	192813	2	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5176057	192813	2	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221496	192813	2	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL4749189	214064	31	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	214064	31	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	70683433	74458	1	None	-169	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74458	1	None	-169	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74458	1	None	-169	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	11499800	89107	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89107	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89107	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL4749189	214064	31	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	214064	31	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	45485742	197823	0	None	-30	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	197823	0	None	-30	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	24773651	154857	0	None	-5	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154857	0	None	-5	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	168292007	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	24773728	94860	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94860	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	168292007	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	192988	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	44225654	187190	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assayAgonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL492301	187190	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assayAgonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	53321948	56804	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56804	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	44404886	72225	0	None	19	2	Human	7.5	pEC50	=	7.5	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL198124	72225	0	None	19	2	Human	7.5	pEC50	=	7.5	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	16115511	84837	0	None	-72	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84837	0	None	-72	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	44572207	12702	0	None	-25	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12702	0	None	-25	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12702	0	None	-25	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL4795286	214072	0	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	214072	0	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4795286	214072	0	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	214072	0	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168282202	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	25070582	61454	28	None	-316	9	Dog	5.5	pEC50	=	5.5	Functional	Agonist activity at 5HT2A receptor in dog femoral arteryAgonist activity at 5HT2A receptor in dog femoral artery	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	28	None	-316	9	Dog	5.5	pEC50	=	5.5	Functional	Agonist activity at 5HT2A receptor in dog femoral arteryAgonist activity at 5HT2A receptor in dog femoral artery	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	168289654	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168290156	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168289654	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	192959	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168290156	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	192965	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10624	70300	19	None	-46	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70300	19	None	-46	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70300	19	None	-46	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	10332474	59655	0	None	-1513	2	Human	6.5	pEC50	=	6.5	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL172159	59655	0	None	-1513	2	Human	6.5	pEC50	=	6.5	Functional	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	44572168	12484	1	None	-31	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12484	1	None	-31	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12484	1	None	-31	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	168295285	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5208963	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222859	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	162658803	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168295285	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5208963	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222859	193029	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	162658803	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183692	0	None	-38	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	92042921	120670	0	None	-104	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416067	120670	0	None	-104	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546961	120670	0	None	-104	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	44572178	12561	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12561	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12561	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	122442309	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	3572096	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168274213	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	3572096	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	1	None	-2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	122442309	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168274213	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192810	0	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	44316017	205452	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	205452	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	24826869	91102	0	None	-9	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91102	0	None	-9	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	162652937	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162652937	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	164013	0	None	-194	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	164013	0	None	-194	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	16115269	138129	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138129	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	168280142	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	168280142	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192861	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	16115644	136960	0	None	-21	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136960	0	None	-21	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	92042919	120667	0	None	-89	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416063	120667	0	None	-89	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546958	120667	0	None	-89	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44316027	205522	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	205522	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	122442263	138357	0	None	-15	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	0	None	-15	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	0	None	-15	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	6092	114299	14	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	4	2	1	2.3	CCNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330640	114299	14	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	4	2	1	2.3	CCNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	24826788	91098	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397893	91098	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162659286	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	162665030	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168280026	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	4407909	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4407909	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	1	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	168280026	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192858	0	None	10	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	162665030	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183727	0	None	-38	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162659286	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	0	None	-12	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	57888255	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183371	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221840	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	57888255	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183371	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221840	192857	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	77379	19046	75	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1288716	19046	75	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	11291	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	11291	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	26	None	-2	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	854024	140560	77	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cc(F)ccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL381160	140560	77	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cc(F)ccc12	10.1016/j.bmcl.2014.07.062
	53317923	56846	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56846	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	44412389	78096	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78096	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	166	3359	18	None	-36	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3359	18	None	-36	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3359	18	None	-36	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	118733774	120650	0	None	-43	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120650	0	None	-43	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120650	0	None	-43	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	4239160	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5177505	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221421	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	4239160	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5177505	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221421	192798	2	None	-4	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	5132936	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	5132936	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192833	1	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	44626357	197552	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570274	197552	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	44412403	77798	0	None	-7	3	Human	6.4	pEC50	=	6.4	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77798	0	None	-7	3	Human	6.4	pEC50	=	6.4	Functional	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	10015414	63485	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63485	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	107992	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	122461993	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	107992	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	49	None	-6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	122461993	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	18735305	204933	0	None	-19	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	204933	0	None	-19	3	Human	6.4	pEC50	=	6.4	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	122442254	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572798	12650	2	None	-131	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12650	2	None	-131	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12650	2	None	-131	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	122442254	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-33	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122180976	121791	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	CHEMBL3589597	121791	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	26714	75791	73	None	89	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL1522572	75791	73	None	89	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL204839	75791	73	None	89	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	46830177	8061	30	None	-190	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091105	8061	30	None	-190	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12514	1	None	-58	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12514	1	None	-58	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12514	1	None	-58	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	11231392	84894	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84894	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168280082	191193	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5189232	191193	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	168279029	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	162657053	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	162657053	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	0	None	-38	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168279029	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192854	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	122442254	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	0	None	-33	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572176	12560	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12560	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12560	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	11313985	91083	0	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91083	0	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL4802921	214067	2	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	122180977	121792	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL3589598	121792	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL4802921	214067	2	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442272	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442272	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	17087	114303	39	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330644	114303	39	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	77158	19047	56	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1288717	19047	56	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2014.07.062
	156836218	188604	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4877402	188604	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL5028990	188604	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	5	139	72	None	-19	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	72	None	-19	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	72	None	-19	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	72	None	-19	26	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	166	3359	18	None	-36	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3359	18	None	-36	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3359	18	None	-36	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	6088	119842	56	None	100	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL348588	119842	56	None	100	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	46884138	8443	0	None	-100	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8443	0	None	-100	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	10331841	169204	6	None	-46	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169204	6	None	-46	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	44572810	12655	2	None	-95	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12655	2	None	-95	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12655	2	None	-95	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	44572170	12465	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12465	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12465	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	168291896	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4752798	214065	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	214065	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4752798	214065	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	214065	0	None	-3	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	169204	6	None	-46	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169204	6	None	-46	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168282109	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442270	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11209786	137240	0	None	-36	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137240	0	None	-36	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	44572761	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12680	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	168282109	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192883	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	53321865	56848	0	None	-138	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56848	0	None	-138	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	168291896	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	0	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	11151653	91101	0	None	-6	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91101	0	None	-6	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	168290300	191986	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5201317	191986	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	134265620	164406	0	None	-426	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164406	0	None	-426	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	168291130	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168291130	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192976	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	157292621	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	157292621	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	192971	0	None	-5	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	44573014	12521	1	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12521	1	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12521	1	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	14515725	87310	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	14515725	87310	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	16115271	79108	0	None	-5	3	Human	7.3	pEC50	=	7.3	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79108	0	None	-5	3	Human	7.3	pEC50	=	7.3	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	4543677	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	1	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168268706	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	46228430	199738	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	199738	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44573018	12644	1	None	-64	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12644	1	None	-64	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12644	1	None	-64	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	168268706	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192757	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	162676555	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	44572802	12444	2	None	-123	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12444	2	None	-123	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12444	2	None	-123	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	53324629	56799	0	None	4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56799	0	None	4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	162676555	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183789	0	None	-22	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	168275014	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	15760	113079	57	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL331241	113079	57	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1016/j.bmcl.2014.07.062
	72197484	102494	0	None	1	9	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102494	0	None	1	9	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102494	0	None	1	9	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	12833	67661	17	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	208	2	2	1	2.7	CC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1906905	67661	17	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	208	2	2	1	2.7	CC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	72197486	102503	0	None	1	8	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102503	0	None	1	8	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102503	0	None	1	8	Human	8.2	pEC50	=	8.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	11291	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	4980	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	CHEMBL65547	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	11291	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	4980	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	CHEMBL65547	3220	26	None	-2	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	152743520	189979	1	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5170895	189979	1	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	18735313	204934	1	None	-93	3	Human	6.2	pEC50	=	6.2	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	204934	1	None	-93	3	Human	6.2	pEC50	=	6.2	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	168275014	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192820	0	None	-3	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	11493484	89070	0	None	-141	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89070	0	None	-141	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89070	0	None	-141	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11666237	89112	0	None	-35	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89112	0	None	-35	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89112	0	None	-35	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	10064386	63317	4	None	-30	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63317	4	None	-30	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44572806	12654	1	None	-38	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12654	1	None	-38	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12654	1	None	-38	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11658860	2344	51	None	-17	11	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2344	51	None	-17	11	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2344	51	None	-17	11	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2344	51	None	-17	11	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2344	51	None	-17	11	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	146025684	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	9859257	205123	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	205123	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	11695000	89071	0	None	-17	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89071	0	None	-17	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89071	0	None	-17	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	53323196	56849	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56849	0	None	3	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	11777150	62605	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62605	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	1355	2011	88	None	-4	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	2011	88	None	-4	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	2011	88	None	-4	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	2011	88	None	-4	6	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	10036629	64637	0	None	-7	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64637	0	None	-7	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	9990808	122772	0	None	-10	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122772	0	None	-10	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	11949710	199902	0	None	-67	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199902	0	None	-67	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	146025684	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	0	None	-14	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168276822	190123	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5173321	190123	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	44404883	72062	32	None	-21	3	Human	6.2	pEC50	=	6.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197664	72062	32	None	-21	3	Human	6.2	pEC50	=	6.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	24826790	91094	0	None	-12	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397889	91094	0	None	-12	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	57888169	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	57888169	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	192907	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	143111395	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177927	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221502	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442300	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	143111395	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177927	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221502	192815	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	53324630	56803	0	None	-128	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56803	0	None	-128	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	45485725	197827	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	197827	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	122442300	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	0	None	-4	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572751	12499	1	None	-87	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12499	1	None	-87	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12499	1	None	-87	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	122442286	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	25070582	61454	28	None	-6	9	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	28	None	-6	9	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	122442286	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	0	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	72197311	102491	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393236	102491	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040299	102491	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	118733820	120666	0	None	-4	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416062	120666	0	None	-4	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546957	120666	0	None	-4	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL5078999	214598	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL		None	None	None		COc1ccc2[nH]cc(CCN3CCC3)c2c1	10.1021/acsmedchemlett.2c00129
	1355	2011	88	None	-4	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	142	2011	88	None	-4	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	CHEMBL478	2011	88	None	-4	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	DB12110	2011	88	None	-4	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	1150	3878	121	None	41	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	125	3878	121	None	41	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	CHEMBL6640	3878	121	None	41	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	DB08653	3878	121	None	41	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	5	139	72	None	-19	26	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	72	None	-19	26	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	72	None	-19	26	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	72	None	-19	26	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	46228437	199984	1	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	199984	1	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	5	139	72	None	-19	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	72	None	-19	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	72	None	-19	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	72	None	-19	26	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	46230098	199329	0	None	-34	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199329	0	None	-34	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	24826786	91086	0	None	-19	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397881	91086	0	None	-19	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	168	3982	15	None	-66	5	Human	6.1	pEC50	=	6.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3982	15	None	-66	5	Human	6.1	pEC50	=	6.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3982	15	None	-66	5	Human	6.1	pEC50	=	6.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	168291564	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122772	0	None	-10	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122772	0	None	-10	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	168291564	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4305260	191025	1	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191025	1	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	4305260	191025	1	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191025	1	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	44572174	12547	0	None	-208	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12547	0	None	-208	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12547	0	None	-208	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	168286640	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168286640	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192928	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162652983	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	0	None	-37	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	1355	2011	88	None	-4	6	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	142	2011	88	None	-4	6	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	CHEMBL478	2011	88	None	-4	6	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	DB12110	2011	88	None	-4	6	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	190006	114301	24	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL3330642	114301	24	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	9901086	187631	33	None	-95	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	33	None	-95	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	162658153	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	0	None	-28	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	9901086	187631	33	None	-95	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	33	None	-95	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	11264955	204961	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	204961	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	53317925	56852	0	None	-91	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56852	0	None	-91	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	122442251	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	72197668	102495	0	None	-4	7	Human	7.1	pEC50	=	7.1	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393246	102495	0	None	-4	7	Human	7.1	pEC50	=	7.1	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040325	102495	0	None	-4	7	Human	7.1	pEC50	=	7.1	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	44572164	12683	0	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12683	0	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12683	0	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	168291006	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	168291006	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	192975	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	122442251	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	0	None	-47	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	53325936	56802	0	None	-436	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56802	0	None	-436	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	16115381	83443	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83443	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	168277089	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179053	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221673	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	168277089	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179053	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221673	192839	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	20026449	87306	1	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87306	1	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	11264345	130399	5	None	-38	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130399	5	None	-38	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442275	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	20026449	87306	1	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87306	1	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	3549735	192207	2	None	-6	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192207	2	None	-6	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442275	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168268877	189970	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189970	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	14107683	178126	22	None	2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178126	22	None	2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	168268877	189970	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189970	0	None	-2	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	14107683	178126	22	None	2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178126	22	None	2	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	12834	207926	26	None	18	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL96816	207926	26	None	18	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	90489020	190873	9	None	14	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5184791	190873	9	None	14	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	9881885	64109	0	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64109	0	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44389645	64181	0	None	-26	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64181	0	None	-26	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10036629	64637	0	None	-7	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64637	0	None	-7	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	146464686	191997	0	None	8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201492	191997	0	None	8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	3549735	192207	2	None	-6	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192207	2	None	-6	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	3356430	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442250	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	3356430	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	2	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442250	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	0	None	-12	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	1	None	-20	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168277801	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176879	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221724	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168294156	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	146464686	191997	0	None	8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201492	191997	0	None	8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	168277801	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176879	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221724	192844	0	None	-1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168294156	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	0	None	-1	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442272	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442272	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442260	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168280365	191276	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5190617	191276	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11264345	130399	5	None	-38	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL368016	130399	5	None	-38	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1016/j.bmcl.2004.12.080
	168295069	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5208635	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222843	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	122442260	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	0	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168295069	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5208635	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222843	193027	0	None	3	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	11579853	89085	0	None	-70	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337504	89085	0	None	-70	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365200	89085	0	None	-70	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	11448649	83433	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83433	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	11949712	202161	0	None	-870	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	202161	0	None	-870	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	11300712	141686	0	None	-72	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141686	0	None	-72	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	168271458	190608	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180800	190608	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	11652452	89126	0	None	-26	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89126	0	None	-26	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89126	0	None	-26	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	168271458	190608	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180800	190608	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	168284944	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192557	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222162	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	46937339	74209	0	None	-42	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	74209	0	None	-42	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	168284944	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192557	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222162	192913	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	19219	119245	30	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2[nH]cc(CCN)c12	10.1016/j.bmcl.2014.07.062
	CHEMBL343529	119245	30	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2[nH]cc(CCN)c12	10.1016/j.bmcl.2014.07.062
	11291	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	11291	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	26	None	-1	4	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	17954204	63938	23	None	-7	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63938	23	None	-7	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL5094489	215497	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL		None	None	None		c1ccc2c(CCN3CCC3)c[nH]c2c1	10.1021/acsmedchemlett.2c00129
	118733802	120653	0	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120653	0	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120653	0	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	16115267	84793	0	None	-5	3	Human	7.0	pEC50	=	7.0	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84793	0	None	-5	3	Human	7.0	pEC50	=	7.0	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	44572166	12460	0	None	-30	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12460	0	None	-30	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12460	0	None	-30	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	168276733	192831	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180401	192831	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221642	192831	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	4995534	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188386	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221773	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	4995534	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188386	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221773	192852	1	None	-2	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	122442307	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	71682217	91118	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	91118	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	230	4119	25	None	-93	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4119	25	None	-93	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4119	25	None	-93	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL4742882	214063	2	None	1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802403	214063	2	None	1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	122442307	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL4742882	214063	2	None	1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802403	214063	2	None	1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	162650400	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	162668367	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442281	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770058	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771388	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	122442281	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770058	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771388	138352	0	None	-5	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	162668367	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	0	None	-43	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162650400	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	0	None	-346	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	16047544	12648	8	None	-72	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12648	8	None	-72	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12648	8	None	-72	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	24773900	123432	8	None	-1	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	123432	8	None	-1	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	122442310	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	11492162	72053	3	None	-9	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	72053	3	None	-9	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	46230100	199319	0	None	-38	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	199319	0	None	-38	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	122442310	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	72197483	102502	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	340	3	1	5	2.3	c1ccc(Cc2nc3c(c(N4CCSCC4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393242	102502	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	340	3	1	5	2.3	c1ccc(Cc2nc3c(c(N4CCSCC4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040360	102502	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	340	3	1	5	2.3	c1ccc(Cc2nc3c(c(N4CCSCC4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	24826868	91082	1	None	-10	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91082	1	None	-10	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	10017556	161878	0	None	-1	3	Human	7.0	pEC50	=	7.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161878	0	None	-1	3	Human	7.0	pEC50	=	7.0	Functional	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	4363390	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5184885	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221904	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	162669436	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162669436	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	0	None	-23	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	4363390	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5184885	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221904	192870	2	None	21	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	134265732	163807	0	None	-776	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163807	0	None	-776	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265675	164367	0	None	-13	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	164367	0	None	-13	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	44420682	137608	0	None	-3	3	Human	6.0	pEC50	=	6	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137608	0	None	-3	3	Human	6.0	pEC50	=	6	Functional	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	11750471	201117	0	None	-	1	Human	9.6	pIC50	=	9.6	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL603078	201117	0	None	-	1	Human	9.6	pIC50	=	9.6	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	175	3655	44	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorCompound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00483-2
	68186	3655	44	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorCompound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00483-2
	CHEMBL79834	3655	44	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorCompound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00483-2
	156014242	177187	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	647	11	2	7	5.5	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	CHEMBL4635010	177187	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	647	11	2	7	5.5	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCC(c4noc5cc(F)ccc45)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	11684204	200598	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.5	COc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL599226	200598	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.5	COc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11453346	201091	1	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL602874	201091	1	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11774776	201215	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	430	5	2	5	4.5	COc1ccc(NC(=O)Nc2ccc(OC)c(-c3c(Br)cnn3C)c2)cc1	10.1021/jm9007328
	CHEMBL603609	201215	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	430	5	2	5	4.5	COc1ccc(NC(=O)Nc2ccc(OC)c(-c3c(Br)cnn3C)c2)cc1	10.1021/jm9007328
	11294575	200597	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	478	4	2	4	5.3	COc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL599225	200597	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	478	4	2	4	5.3	COc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11625339	201111	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	392	4	2	4	4.7	COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	CHEMBL603061	201111	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	392	4	2	4	4.7	COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	11429246	202291	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	390	4	2	4	5.0	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	CHEMBL610208	202291	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	390	4	2	4	5.0	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	168286940	192281	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5205903	192281	0	None	-	1	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	145993172	166996	0	None	1	3	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	423	6	0	5	3.8	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4287980	166996	0	None	1	3	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	423	6	0	5	3.8	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	25207724	178279	21	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	413	8	2	3	4.3	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1	10.1021/acs.jmedchem.0c00002
	CHEMBL4644559	178279	21	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	413	8	2	3	4.3	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1	10.1021/acs.jmedchem.0c00002
	CHEMBL4650860	178279	21	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	413	8	2	3	4.3	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1	10.1021/acs.jmedchem.0c00002
	11683556	200420	58	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	436	4	2	4	4.8	COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL598172	200420	58	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	436	4	2	4	4.8	COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	2389	3331	118	None	-1	29	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	5073	3331	118	None	-1	29	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	96	3331	118	None	-1	29	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	CHEMBL85	3331	118	None	-1	29	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	DB00734	3331	118	None	-1	29	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	2389	3331	118	None	-1	29	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	5073	3331	118	None	-1	29	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	96	3331	118	None	-1	29	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	CHEMBL85	3331	118	None	-1	29	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	DB00734	3331	118	None	-1	29	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assayAntagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated for 24 hrs followed by 5-HT addition by HTRF assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2019.07.050
	11247569	199420	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL591223	199420	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11567937	200982	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2cccc(F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL602064	200982	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2cccc(F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11519011	201090	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	502	4	2	4	6.2	COc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL602873	201090	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	502	4	2	4	6.2	COc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	10595416	177383	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	371	7	0	4	4.0	COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC	10.1021/acs.jmedchem.0c01058
	CHEMBL4638006	177383	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	371	7	0	4	4.0	COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC	10.1021/acs.jmedchem.0c01058
	10595416	177383	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	371	7	0	4	4.0	COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC	10.1021/acs.jmedchem.0c01058
	CHEMBL4638006	177383	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	371	7	0	4	4.0	COc1cccc(C(=O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC	10.1021/acs.jmedchem.0c01058
	156020283	178084	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	646	11	2	8	4.8	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(c4nsc5ccccc45)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	CHEMBL4647697	178084	0	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	646	11	2	8	4.8	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(c4nsc5ccccc45)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	11675550	200421	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	392	4	2	4	4.7	COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	CHEMBL598173	200421	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	392	4	2	4	4.7	COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Cl)cnn1C	10.1021/jm9007328
	11710154	201464	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	356	4	2	4	4.4	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C	10.1021/jm9007328
	CHEMBL605001	201464	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	356	4	2	4	4.4	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1ccnn1C	10.1021/jm9007328
	11719283	201744	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	446	5	2	4	5.7	COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C(C)C	10.1021/jm9007328
	CHEMBL606622	201744	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	446	5	2	4	5.7	COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(Br)cnn1C(C)C	10.1021/jm9007328
	145988497	167191	0	None	7	3	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	411	6	0	5	3.6	O=C1C2CCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4291387	167191	0	None	7	3	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	411	6	0	5	3.6	O=C1C2CCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	129186554	157818	0	None	2	6	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	408	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4083333	157818	0	None	2	6	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	408	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	11154832	200419	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	436	4	2	4	4.8	COc1ccc(NC(=O)Nc2cc(F)cc(F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL598171	200419	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	436	4	2	4	4.8	COc1ccc(NC(=O)Nc2cc(F)cc(F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11719622	201387	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	462	5	2	4	6.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C(C)C	10.1021/jm9007328
	CHEMBL604586	201387	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	462	5	2	4	6.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C(C)C	10.1021/jm9007328
	11431347	201672	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.8	COc1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL606178	201672	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.8	COc1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11166827	200588	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	448	5	2	4	5.5	CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL599193	200588	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	448	5	2	4	5.5	CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11328744	200589	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	462	5	2	4	5.9	CC(C)Oc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL599194	200589	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	462	5	2	4	5.9	CC(C)Oc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	11531833	200844	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2ccccc2F)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL601097	200844	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	418	4	2	4	4.6	COc1ccc(NC(=O)Nc2ccccc2F)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	135507495	201587	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	420	3	3	4	4.9	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1O	10.1021/jm9007328
	CHEMBL605636	201587	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	420	3	3	4	4.9	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1O	10.1021/jm9007328
	11374796	201675	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.5	COc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL606191	201675	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	468	4	2	4	5.5	COc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	162646896	179572	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR method	ChEMBL	421	6	0	5	4.2	O=C1COc2ccccc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	CHEMBL4741908	179572	0	None	-3	3	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR method	ChEMBL	421	6	0	5	4.2	O=C1COc2ccccc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	11627746	197400	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Agonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulationAgonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	517	7	2	5	5.6	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1	10.1016/j.bmcl.2009.07.073
	CHEMBL569475	197400	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Agonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulationAgonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	517	7	2	5	5.6	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1	10.1016/j.bmcl.2009.07.073
	164143991	190154	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	432	9	1	4	3.8	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCF)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5173703	190154	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	432	9	1	4	3.8	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCF)cc2)CC1	10.1016/j.ejmech.2022.114246
	156011636	177421	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	613	10	2	7	3.9	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(C(=O)OC(C)(C)C)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	CHEMBL4638548	177421	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	613	10	2	7	3.9	CN1CCC(N(Cc2ccc(F)cc2)C(=O)NCc2ccc(OCC(O)CN3CCN(C(=O)OC(C)(C)C)CC3)cc2)CC1	10.1021/acs.jmedchem.0c00002
	168282398	191205	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	482	9	1	4	4.7	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5189473	191205	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	482	9	1	4	4.7	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCCCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	11656729	200685	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	536	4	2	4	6.5	COc1ccc(NC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL599828	200685	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	536	4	2	4	6.5	COc1ccc(NC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	44608359	157344	39	None	-1	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	424	4	0	7	3.2	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	CHEMBL4077702	157344	39	None	-1	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	424	4	0	7	3.2	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	168276428	190116	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	490	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)(F)C(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5173149	190116	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	490	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OC(F)(F)C(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	129186534	159696	0	None	-3	6	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	426	4	0	6	3.9	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	CHEMBL4104261	159696	0	None	-3	6	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	426	4	0	6	3.9	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	145991244	166802	0	None	-1	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	411	6	0	5	3.4	CC1(C)C2C(=O)N(CCCCN3CCN(c4cccc5sccc45)CC3)C(=O)C21	10.1016/j.ejmech.2017.12.099
	CHEMBL4284353	166802	0	None	-1	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	411	6	0	5	3.4	CC1(C)C2C(=O)N(CCCCN3CCN(c4cccc5sccc45)CC3)C(=O)C21	10.1016/j.ejmech.2017.12.099
	22733860	186878	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	357	6	1	4	3.7	COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL489624	186878	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	357	6	1	4	3.7	COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	135398745	2914	112	None	-1	33	Human	7.0	pIC50	=	7	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2015.07.030
	47	2914	112	None	-1	33	Human	7.0	pIC50	=	7	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2015.07.030
	CHEMBL715	2914	112	None	-1	33	Human	7.0	pIC50	=	7	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2015.07.030
	DB00334	2914	112	None	-1	33	Human	7.0	pIC50	=	7	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2015.07.030
	168286241	191561	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	441	9	1	3	5.1	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	CHEMBL5194786	191561	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	441	9	1	3	5.1	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	24861189	199973	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	328	6	2	3	3.2	CCNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	CHEMBL595133	199973	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	328	6	2	3	3.2	CCNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	145993577	167386	0	None	-85	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	453	6	0	5	4.9	O=C1CC2(CCCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4295055	167386	0	None	-85	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	453	6	0	5	4.9	O=C1CC2(CCCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	156017859	177889	0	None	-5	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	CHEMBL4644742	177889	0	None	-5	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	127050764	140261	0	None	-10	2	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	435	8	1	4	4.9	CC(=O)Nc1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805600	140261	0	None	-10	2	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	435	8	1	4	4.9	CC(=O)Nc1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	145976732	163510	0	None	-9	3	Human	7.0	pIC50	=	7.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4202443	163510	0	None	-9	3	Human	7.0	pIC50	=	7.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	156021344	178169	0	None	-691	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sc(F)cc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4649106	178169	0	None	-691	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sc(F)cc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	24861190	201668	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	342	7	2	3	3.5	CCCNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	CHEMBL606150	201668	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	342	7	2	3	3.5	CCCNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	1524	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	197	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	3822	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	88	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	CHEMBL51	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	DB12465	2181	96	None	1	18	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2014.12.045
	156018685	177867	0	None	-2	6	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n2c1	10.1016/j.bmcl.2020.127027
	CHEMBL4644391	177867	0	None	-2	6	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n2c1	10.1016/j.bmcl.2020.127027
	22733860	186878	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	357	6	1	4	3.7	COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL489624	186878	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	357	6	1	4	3.7	COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	129186544	161074	0	None	-3	6	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	CHEMBL4087132	161074	0	None	-3	6	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	CHEMBL4116744	161074	0	None	-3	6	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	168286241	191561	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	441	9	1	3	5.1	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	CHEMBL5194786	191561	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	441	9	1	3	5.1	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	242	470	124	None	-229	33	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	34	470	124	None	-229	33	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795	470	124	None	-229	33	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	CHEMBL1112	470	124	None	-229	33	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	DB01238	470	124	None	-229	33	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	127050765	140214	0	None	-45	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805077	140214	0	None	-45	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	127051040	140279	0	None	-66	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	491	12	1	4	5.9	CCCCCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805826	140279	0	None	-66	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	491	12	1	4	5.9	CCCCCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	127051038	140312	0	None	-41	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	421	8	1	4	4.1	NC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3806169	140312	0	None	-41	3	Human	6.0	pIC50	=	6.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	421	8	1	4	4.1	NC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	24861188	199736	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	314	5	2	3	2.8	CNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	CHEMBL593527	199736	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assayAntagonist activity at human 5HT2A receptor expressed in CHO cells assessed as inhibition of (R)-(-)-DOI hydrochloride-induced intracellular calcium mobilization by FLIPR assay	ChEMBL	314	5	2	3	2.8	CNCCc1cccc2[nH]cc(S(=O)(=O)c3ccccc3)c12	10.1016/j.bmc.2009.09.023
	129186530	156226	0	None	6	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	426	4	1	9	1.7	Cc1nc2n(c(=O)c1CCN1CCN(c3ncnc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4064609	156226	0	None	6	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	426	4	1	9	1.7	Cc1nc2n(c(=O)c1CCN1CCN(c3ncnc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	156015526	177598	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	514	9	2	3	5.3	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C(=S)NC(C)C)CC2)cc1	10.1021/acs.jmedchem.0c00002
	CHEMBL4640741	177598	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assayAntagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium flux preincubated for 1 hr followed by serotonin hydrochloride addition by calcium 6 dye based FLIPR assay	ChEMBL	514	9	2	3	5.3	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C(=S)NC(C)C)CC2)cc1	10.1021/acs.jmedchem.0c00002
	145987659	167249	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	421	5	0	5	3.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4292655	167249	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	421	5	0	5	3.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	145963961	164403	0	None	-51	6	Human	7.0	pIC50	=	7.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4213342	164403	0	None	-51	6	Human	7.0	pIC50	=	7.0	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	71528204	86969	0	None	-8128	3	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human 5-HT2A receptor assessed as decrease in agonist-induced intracellular calcium mobilization preincubated for 10 mins prior to agonist addition measured by FLIPR analysisAntagonist activity at human 5-HT2A receptor assessed as decrease in agonist-induced intracellular calcium mobilization preincubated for 10 mins prior to agonist addition measured by FLIPR analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86969	0	None	-8128	3	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human 5-HT2A receptor assessed as decrease in agonist-induced intracellular calcium mobilization preincubated for 10 mins prior to agonist addition measured by FLIPR analysisAntagonist activity at human 5-HT2A receptor assessed as decrease in agonist-induced intracellular calcium mobilization preincubated for 10 mins prior to agonist addition measured by FLIPR analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	137630811	161110	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	CHEMBL4082150	161110	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	CHEMBL4117087	161110	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	168291367	191950	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	532	7	1	4	4.7	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Br)c2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5200788	191950	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	532	7	1	4	4.7	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Br)c2)CC1	10.1016/j.ejmech.2022.114246
	129186528	157465	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	442	4	0	6	4.2	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	CHEMBL4079251	157465	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	442	4	0	6	4.2	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	11519589	200272	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	544	6	2	4	7.4	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCc1ccc(Cl)cc1	10.1021/jm9007328
	CHEMBL597151	200272	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	544	6	2	4	7.4	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCc1ccc(Cl)cc1	10.1021/jm9007328
	9931850	205581	7	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorCompound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor	ChEMBL	418	8	0	3	5.4	CCC(=O)N(C1CCCCCCC1)C1CCN(CCCOc2ccc(F)cc2)CC1	10.1016/s0960-894x(00)00483-2
	CHEMBL81377	205581	7	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorCompound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor	ChEMBL	418	8	0	3	5.4	CCC(=O)N(C1CCCCCCC1)C1CCN(CCCOc2ccc(F)cc2)CC1	10.1016/s0960-894x(00)00483-2
	156017237	177761	0	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	853	21	0	11	8.5	COc1c(OCCOCCOCCOc2ccc(C3CCN(c4ccn5c(CC6CC6)nnc5c4Cl)CC3)cc2)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL4642761	177761	0	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	853	21	0	11	8.5	COc1c(OCCOCCOCCOc2ccc(C3CCN(c4ccn5c(CC6CC6)nnc5c4Cl)CC3)cc2)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	156017237	177761	0	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	853	21	0	11	8.5	COc1c(OCCOCCOCCOc2ccc(C3CCN(c4ccn5c(CC6CC6)nnc5c4Cl)CC3)cc2)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL4642761	177761	0	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	853	21	0	11	8.5	COc1c(OCCOCCOCCOc2ccc(C3CCN(c4ccn5c(CC6CC6)nnc5c4Cl)CC3)cc2)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c01058
	168279444	191177	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	488	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Cl)c2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5188950	191177	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	488	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Cl)c2)CC1	10.1016/j.ejmech.2022.114246
	168285828	191548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	440	5	1	4	4.1	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc3c(c2)CCC(C)(C)O3)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5194545	191548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	440	5	1	4	4.1	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc3c(c2)CCC(C)(C)O3)CC1	10.1016/j.ejmech.2022.114246
	162643405	181751	0	None	-38	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR method	ChEMBL	434	6	1	6	3.5	O=c1[nH]c(=O)n(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc12	10.1016/j.ejmech.2020.112572
	CHEMBL4777475	181751	0	None	-38	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) assessed as decrease in intracellular calcium flux preincubated with calcium followed by compound challenge and measured after 10 mins by FLIPR method	ChEMBL	434	6	1	6	3.5	O=c1[nH]c(=O)n(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc12	10.1016/j.ejmech.2020.112572
	145965041	164255	0	None	-10	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3ccc4ccsc4c3)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4211473	164255	0	None	-10	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3ccc4ccsc4c3)CC2)n1	10.1016/j.bmcl.2018.01.038
	71457756	83902	0	None	-66	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	396	5	0	5	4.7	COc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL2206440	83902	0	None	-66	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	396	5	0	5	4.7	COc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1	10.1021/acs.jmedchem.0c01058
	156011035	177148	0	None	-6	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	437	7	0	8	3.3	COc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	CHEMBL4634009	177148	0	None	-6	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	437	7	0	8	3.3	COc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	145989181	167228	0	None	-1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2ccc3ccsc3c2)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4292250	167228	0	None	-1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2ccc3ccsc3c2)CC1	10.1016/j.ejmech.2017.12.099
	71566778	165206	21	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT2AAntagonist activity at human 5-HT2A	ChEMBL	394	10	1	6	2.7	CCCCOc1c(OC)cc(C(=O)NCC2(N(C)C)CCOCC2)cc1OC	10.1021/acs.jmedchem.7b00956
	CHEMBL4228903	165206	21	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT2AAntagonist activity at human 5-HT2A	ChEMBL	394	10	1	6	2.7	CCCCOc1c(OC)cc(C(=O)NCC2(N(C)C)CCOCC2)cc1OC	10.1021/acs.jmedchem.7b00956
	71457756	83902	0	None	-66	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	396	5	0	5	4.7	COc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1	10.1021/acs.jmedchem.0c01058
	CHEMBL2206440	83902	0	None	-66	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assayAntagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated for 1 hr by Fluo-4 dye based fluorescence assay	ChEMBL	396	5	0	5	4.7	COc1ccccc1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1	10.1021/acs.jmedchem.0c01058
	145963830	164123	0	None	-3	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2A receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	164123	0	None	-3	2	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2A receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	156015516	177563	0	None	-18	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	485	6	0	7	4.1	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Br)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4640409	177563	0	None	-18	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	485	6	0	7	4.1	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Br)cccn12	10.1016/j.bmcl.2020.127027
	127048532	140232	0	None	-3	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(F)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805262	140232	0	None	-3	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(F)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	145988038	167176	0	None	-85	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	413	6	0	5	4.0	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	CHEMBL4291215	167176	0	None	-85	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	413	6	0	5	4.0	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	145975393	163774	0	None	-14	2	Human	6.9	pIC50	=	6.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4205772	163774	0	None	-14	2	Human	6.9	pIC50	=	6.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	168279444	191177	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	488	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Cl)c2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5188950	191177	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrsInverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 120 hrs	ChEMBL	488	7	1	4	4.6	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)c(Cl)c2)CC1	10.1016/j.ejmech.2022.114246
	168295984	192220	0	None	1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	192220	0	None	1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2A receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	122187394	123039	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	367	5	2	6	2.6	OCCN1CCN(c2nc(Nc3ccccc3F)c3ccccc3n2)CC1	10.1016/j.bmcl.2015.07.030
	CHEMBL3609165	123039	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAntagonist activity against 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as reduction in [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	367	5	2	6	2.6	OCCN1CCN(c2nc(Nc3ccccc3F)c3ccccc3n2)CC1	10.1016/j.bmcl.2015.07.030
	168280341	191156	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	427	9	1	3	4.7	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	CHEMBL5188595	191156	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	427	9	1	3	4.7	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CC(N(C)C)C2)cc1	10.1016/j.ejmech.2022.114246
	127049850	140235	0	None	-23	2	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	469	8	1	4	5.0	CNC(=O)c1ccc(Cl)c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805327	140235	0	None	-23	2	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	469	8	1	4	5.0	CNC(=O)c1ccc(Cl)c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	1524	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	197	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	3822	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	88	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	CHEMBL51	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	DB12465	2181	96	None	1	18	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulationAntagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm401895u
	168289739	191847	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	429	8	1	5	3.5	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)nn2)C2CCN(C)CC2)cc1	10.1016/j.ejmech.2022.114246
	CHEMBL5199061	191847	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assayAntagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated for 15 mins by FLIPR assay	ChEMBL	429	8	1	5	3.5	CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)nn2)C2CCN(C)CC2)cc1	10.1016/j.ejmech.2022.114246
	127049848	140297	0	None	-15	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(C)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3806047	140297	0	None	-15	3	Human	5.9	pIC50	=	5.9	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(C)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	156010883	177144	0	None	-15	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(Cl)cn12	10.1016/j.bmcl.2020.127027
	CHEMBL4633978	177144	0	None	-15	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(Cl)cn12	10.1016/j.bmcl.2020.127027
	127049863	140252	0	None	-1	6	Human	7.8	pIC50	=	7.8	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805518	140252	0	None	-1	6	Human	7.8	pIC50	=	7.8	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	156011666	177306	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	409	6	0	7	3.4	O=c1n(CCCCN2CCC(c3cc(F)cc4oncc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4636764	177306	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayAntagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assay	ChEMBL	409	6	0	7	3.4	O=c1n(CCCCN2CCC(c3cc(F)cc4oncc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	17956720	200212	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	488	4	2	4	6.0	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OC(F)(F)F	10.1021/jm9007328
	CHEMBL596735	200212	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	488	4	2	4	6.0	Cn1ncc(Br)c1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OC(F)(F)F	10.1021/jm9007328
	145976348	163741	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1cncc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2018.01.038
	CHEMBL4205326	163741	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assayAntagonistic activity at human 5-HT2A receptor assessed as calcium flux after 10 mins by FLIPR assay	ChEMBL

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)