GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3036780	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3036780.0	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970.0	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107587	None	16	Human	Functional	pAC50	=	9.7	9.7	3	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	4940	14476	None	26	Human	Functional	pAC50	=	6	6.0	-5	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14476	None	26	Human	Functional	pAC50	=	6	6.0	-5	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	16351	102785	None	36	Human	Functional	pAC50	=	6	6.0	-162	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	16351.0	102785	None	36	Human	Functional	pAC50	=	6	6.0	-162	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102785	None	36	Human	Functional	pAC50	=	6	6.0	-162	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102785	None	36	Human	Functional	pAC50	=	6	6.0	-162	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5	5.0	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5	5.0	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5	5.0	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5	5.0	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	1427	2013	None	42	Human	Functional	pAC50	=	5	5.0	-933	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	None	42	Human	Functional	pAC50	=	5	5.0	-933	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	None	42	Human	Functional	pAC50	=	5	5.0	-933	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	None	42	Human	Functional	pAC50	=	5	5.0	-933	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	None	42	Human	Functional	pAC50	=	5	5.0	-933	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2543	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358.0	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	None	46	Human	Functional	pAC50	=	5.0	5.0	-691	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-23	42	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-23	42	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-23	42	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-23	42	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-23	42	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	104870	98934	None	37	Human	Functional	pAC50	=	5.0	5.0	-56	10	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98934	None	37	Human	Functional	pAC50	=	5.0	5.0	-56	10	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98934	None	37	Human	Functional	pAC50	=	5.0	5.0	-56	10	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	4178	198259	None	39	Human	Functional	pAC50	=	5.0	5.0	-3	2	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	CHEMBL558	198259	None	39	Human	Functional	pAC50	=	5.0	5.0	-3	2	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	54682461	84720	None	41	Human	Functional	pAC50	=	5.0	5.0	-2	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84720	None	41	Human	Functional	pAC50	=	5.0	5.0	-2	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	2520	206466	None	47	Human	Functional	pAC50	=	5.0	5.0	-10	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	206466	None	47	Human	Functional	pAC50	=	5.0	5.0	-10	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	206466	None	47	Human	Functional	pAC50	=	5.0	5.0	-10	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	26987	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	26987.0	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	None	27	Human	Functional	pAC50	=	6.0	6.0	-104	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	1222	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396.0	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	None	37	Human	Functional	pAC50	=	6.0	6.0	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	4993	122423	None	61	Human	Functional	pAC50	=	5.0	5.0	-1	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122423	None	61	Human	Functional	pAC50	=	5.0	5.0	-1	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-229	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	71496458	115628	None	61	Human	Functional	pAC50	=	5.9	5.9	-3	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115628	None	61	Human	Functional	pAC50	=	5.9	5.9	-3	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	447715	199383	None	50	Human	Functional	pAC50	=	4.9	4.9	-13	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	199383	None	50	Human	Functional	pAC50	=	4.9	4.9	-13	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	4452	2762	None	13	Human	Functional	pAC50	=	6.9	6.9	-85	21	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	None	13	Human	Functional	pAC50	=	6.9	6.9	-85	21	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	None	13	Human	Functional	pAC50	=	6.9	6.9	-85	21	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	6.9	6.9	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	6.9	6.9	-6	43	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1385580	29284	None	49	Human	Functional	pAC50	=	5.9	5.9	-141	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29284	None	49	Human	Functional	pAC50	=	5.9	5.9	-141	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615.0	29284	None	49	Human	Functional	pAC50	=	5.9	5.9	-141	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29284	None	49	Human	Functional	pAC50	=	5.9	5.9	-141	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB12877	29284	None	49	Human	Functional	pAC50	=	5.9	5.9	-141	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Functional	pAC50	=	4.9	4.9	-27	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Functional	pAC50	=	4.9	4.9	-141	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Functional	pAC50	=	4.9	4.9	-141	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	16960	14493	None	19	Human	Functional	pAC50	=	4.9	4.9	-1905	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16960.0	14493	None	19	Human	Functional	pAC50	=	4.9	4.9	-1905	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1201287	14493	None	19	Human	Functional	pAC50	=	4.9	4.9	-1905	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB00405	14493	None	19	Human	Functional	pAC50	=	4.9	4.9	-1905	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	4.9	4.9	-97723	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	123606	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	123606.0	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	None	46	Human	Functional	pAC50	=	4.9	4.9	-1071	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	4.9	4.9	-14	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	4.9	4.9	-14	14	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-11	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-11	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	71398	106495	None	32	Human	Functional	pAC50	=	4.9	4.9	-2290	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106495	None	32	Human	Functional	pAC50	=	4.9	4.9	-2290	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	91610	141440	None	61	Human	Functional	pAC50	=	4.9	4.9	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	527	7	2	6	3.5	COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL383634	141440	None	61	Human	Functional	pAC50	=	4.9	4.9	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	527	7	2	6	3.5	COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C	10.1038/s41467-023-40064-9
	11626560	203394	None	56	Human	Functional	pAC50	=	4.9	4.9	-6	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	203394	None	56	Human	Functional	pAC50	=	4.9	4.9	-6	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	1212	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372.0	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-14	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	212	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651.0	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-141	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	5.9	5.9	-26	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	134	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681.0	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	None	19	Human	Functional	pAC50	=	6.9	6.9	-12	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	1890	2759	None	31	Human	Functional	pAC50	=	5.9	5.9	-1	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	None	31	Human	Functional	pAC50	=	5.9	5.9	-1	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	None	31	Human	Functional	pAC50	=	5.9	5.9	-1	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	None	31	Human	Functional	pAC50	=	5.9	5.9	-1	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	None	31	Human	Functional	pAC50	=	5.9	5.9	-1	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	2869	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857.0	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	31703	194829	None	40	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194829	None	40	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194829	None	40	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	21722	17999	None	26	Human	Functional	pAC50	=	4.9	4.9	-9	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17999	None	26	Human	Functional	pAC50	=	4.9	4.9	-9	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	65700	78289	None	22	Human	Functional	pAC50	=	4.9	4.9	-41	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78289	None	22	Human	Functional	pAC50	=	4.9	4.9	-41	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	3081361	93987	None	66	Human	Functional	pAC50	=	4.9	4.9	-22	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93987	None	66	Human	Functional	pAC50	=	4.9	4.9	-22	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	5.8	5.8	-173	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	5.8	5.8	-173	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	5.8	5.8	-173	35	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	610479	15507	None	60	Human	Functional	pAC50	=	4.8	4.8	-1	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15507	None	60	Human	Functional	pAC50	=	4.8	4.8	-1	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Functional	pAC50	=	4.8	4.8	-33	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Functional	pAC50	=	4.8	4.8	-33	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	2782	32008	None	48	Human	Functional	pAC50	=	4.8	4.8	-4466	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	32008	None	48	Human	Functional	pAC50	=	4.8	4.8	-4466	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	32008	None	48	Human	Functional	pAC50	=	4.8	4.8	-4466	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	21772	78430	None	26	Human	Functional	pAC50	=	4.8	4.8	-1000	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL2110816	78430	None	26	Human	Functional	pAC50	=	4.8	4.8	-1000	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	4528	98179	None	50	Human	Functional	pAC50	=	4.8	4.8	-213	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL273575	98179	None	50	Human	Functional	pAC50	=	4.8	4.8	-213	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	1201549	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1201549.0	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	None	17	Human	Functional	pAC50	=	5.8	5.8	-97	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2342	599	None	30	Human	Functional	pAC50	=	5.8	5.8	-3	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	None	30	Human	Functional	pAC50	=	5.8	5.8	-3	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	None	30	Human	Functional	pAC50	=	5.8	5.8	-3	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	None	30	Human	Functional	pAC50	=	5.8	5.8	-3	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	None	30	Human	Functional	pAC50	=	5.8	5.8	-3	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Functional	pAC50	=	5.8	5.8	-79	39	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2583	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999.0	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	None	69	Human	Functional	pAC50	=	4.8	4.8	-8912	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	5.8	5.8	-2	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	5440	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-512	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5440.0	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-512	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-512	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB00372	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-512	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3926	209699	None	30	Human	Functional	pAC50	=	5.8	5.8	-2	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	209699	None	30	Human	Functional	pAC50	=	5.8	5.8	-2	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	2142	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775.0	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	None	36	Human	Functional	pAC50	=	4.8	4.8	-223	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5077	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767.0	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	None	61	Human	Functional	pAC50	=	4.8	4.8	-602	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	60606	61580	None	50	Human	Functional	pAC50	=	4.8	4.8	-7	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	60606.0	61580	None	50	Human	Functional	pAC50	=	4.8	4.8	-7	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61580	None	50	Human	Functional	pAC50	=	4.8	4.8	-7	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	DB00758	61580	None	50	Human	Functional	pAC50	=	4.8	4.8	-7	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	46199646	120571	None	49	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	520	8	4	7	3.4	CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO	10.1038/s41467-023-40064-9
	CHEMBL3544914	120571	None	49	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	520	8	4	7	3.4	CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO	10.1038/s41467-023-40064-9
	5666	103047	None	29	Human	Functional	pAC50	=	4.8	4.8	-7	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL306700	103047	None	29	Human	Functional	pAC50	=	4.8	4.8	-7	5	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	1224	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100.0	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	None	51	Human	Functional	pAC50	=	4.8	4.8	-912	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3704	78218	None	21	Human	Functional	pAC50	=	4.8	4.8	-3	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	CHEMBL2105022	78218	None	21	Human	Functional	pAC50	=	4.8	4.8	-3	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	3198	207971	None	50	Human	Functional	pAC50	=	4.8	4.8	-29	37	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201049	207971	None	50	Human	Functional	pAC50	=	4.8	4.8	-29	37	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL808	207971	None	50	Human	Functional	pAC50	=	4.8	4.8	-29	37	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	4746	207349	None	24	Human	Functional	pAC50	=	4.8	4.8	-15	19	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	207349	None	24	Human	Functional	pAC50	=	4.8	4.8	-15	19	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	207349	None	24	Human	Functional	pAC50	=	4.8	4.8	-15	19	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	228	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005.0	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	None	20	Human	Functional	pAC50	=	5.8	5.8	-316	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	10034073	17168	None	30	Human	Functional	pAC50	=	4.8	4.8	-3	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	1056	13	7	18	6.2	CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1255800	17168	None	30	Human	Functional	pAC50	=	4.8	4.8	-3	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	1056	13	7	18	6.2	CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C	10.1038/s41467-023-40064-9
	445643	97442	None	46	Human	Functional	pAC50	=	4.8	4.8	-2	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97442	None	46	Human	Functional	pAC50	=	4.8	4.8	-2	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	2378	98741	None	64	Human	Functional	pAC50	=	4.8	4.8	-34	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	4	0	2	5.2	c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL277535	98741	None	64	Human	Functional	pAC50	=	4.8	4.8	-34	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	4	0	2	5.2	c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1	10.1038/s41467-023-40064-9
	50905713	102451	None	54	Human	Functional	pAC50	=	4.8	4.8	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	4	2	6	4.5	C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3039502	102451	None	54	Human	Functional	pAC50	=	4.8	4.8	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	4	2	6	4.5	C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1	10.1038/s41467-023-40064-9
	26248	161633	None	72	Human	Functional	pAC50	=	4.8	4.8	-1	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161633	None	72	Human	Functional	pAC50	=	4.8	4.8	-1	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	47936	193531	None	56	Human	Functional	pAC50	=	4.8	4.8	-380	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193531	None	56	Human	Functional	pAC50	=	4.8	4.8	-380	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2448	99377	None	50	Human	Functional	pAC50	=	5.8	5.8	-81	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	2448.0	99377	None	50	Human	Functional	pAC50	=	5.8	5.8	-81	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99377	None	50	Human	Functional	pAC50	=	5.8	5.8	-81	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	DB12401	99377	None	50	Human	Functional	pAC50	=	5.8	5.8	-81	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	4976	206037	None	20	Human	Functional	pAC50	=	5.8	5.8	-199	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	206037	None	20	Human	Functional	pAC50	=	5.8	5.8	-199	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	5.7	5.7	-3	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2855	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717.0	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	None	63	Human	Functional	pAC50	=	4.7	4.7	-9549	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5482	14425	None	55	Human	Functional	pAC50	=	4.7	4.7	-10	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14425	None	55	Human	Functional	pAC50	=	4.7	4.7	-10	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	6127	14505	None	4	Human	Functional	pAC50	=	4.7	4.7	-117	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	6127.0	14505	None	4	Human	Functional	pAC50	=	4.7	4.7	-117	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14505	None	4	Human	Functional	pAC50	=	4.7	4.7	-117	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14505	None	4	Human	Functional	pAC50	=	4.7	4.7	-117	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	3823	50235	None	31	Human	Functional	pAC50	=	4.7	4.7	-47	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50235	None	31	Human	Functional	pAC50	=	4.7	4.7	-47	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50235	None	31	Human	Functional	pAC50	=	4.7	4.7	-47	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2995	206863	None	31	Human	Functional	pAC50	=	4.7	4.7	-7079	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2995.0	206863	None	31	Human	Functional	pAC50	=	4.7	4.7	-7079	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	206863	None	31	Human	Functional	pAC50	=	4.7	4.7	-7079	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	206863	None	31	Human	Functional	pAC50	=	4.7	4.7	-7079	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB01151	206863	None	31	Human	Functional	pAC50	=	4.7	4.7	-7079	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	5.7	5.7	-8	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	5.7	5.7	-8	19	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Functional	pAC50	=	8.6	8.6	-1	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	5.7	5.7	-3	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	5.7	5.7	-3	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	5.7	5.7	-3	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	5.7	5.7	-3	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	5.7	5.7	-194	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	5.7	5.7	-194	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	5.7	5.7	-194	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	5.7	5.7	-194	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	202	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3062316	33583	None	70	Human	Functional	pAC50	=	4.7	4.7	1	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33583	None	70	Human	Functional	pAC50	=	4.7	4.7	1	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL5416410	33583	None	70	Human	Functional	pAC50	=	4.7	4.7	1	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	4.7	4.7	-14	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	4.7	4.7	-14	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	11658860	2344	None	24	Human	Functional	pAC50	=	6.7	6.7	-17	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	None	24	Human	Functional	pAC50	=	6.7	6.7	-17	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	None	24	Human	Functional	pAC50	=	6.7	6.7	-17	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	None	24	Human	Functional	pAC50	=	6.7	6.7	-17	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	None	24	Human	Functional	pAC50	=	6.7	6.7	-17	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	6.7	6.7	-57	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	47510	172649	None	27	Human	Functional	pAC50	=	4.7	4.7	-13	3	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172649	None	27	Human	Functional	pAC50	=	4.7	4.7	-13	3	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	3949	100668	None	35	Human	Functional	pAC50	=	4.7	4.7	-22	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100668	None	35	Human	Functional	pAC50	=	4.7	4.7	-22	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	71398	106495	None	32	Human	Functional	pAC50	=	4.7	4.7	-2290	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106495	None	32	Human	Functional	pAC50	=	4.7	4.7	-2290	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2351	4301	None	35	Human	Functional	pAC50	=	4.7	4.7	-9	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4301	None	35	Human	Functional	pAC50	=	4.7	4.7	-9	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4301	None	35	Human	Functional	pAC50	=	4.7	4.7	-9	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	5311017	120668	None	8	Human	Functional	pAC50	=	4.7	4.7	-32	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5311017.0	120668	None	8	Human	Functional	pAC50	=	4.7	4.7	-32	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3545985	120668	None	8	Human	Functional	pAC50	=	4.7	4.7	-32	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00865	120668	None	8	Human	Functional	pAC50	=	4.7	4.7	-32	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	636403	188375	None	19	Human	Functional	pAC50	=	4.7	4.7	-8	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188375	None	19	Human	Functional	pAC50	=	4.7	4.7	-8	7	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	48041	107137	None	37	Human	Functional	pAC50	=	5.7	5.7	1	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	CHEMBL315838	107137	None	37	Human	Functional	pAC50	=	5.7	5.7	1	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	7.6	7.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2136	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768.0	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	None	24	Human	Functional	pAC50	=	5.6	5.6	-45	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	54454	5260	None	48	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5260	None	48	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Functional	pAC50	=	4.6	4.6	-10232	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	1830	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897.0	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	None	33	Human	Functional	pAC50	=	4.6	4.6	-416	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	10184665	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	10184665.0	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3991	None	42	Human	Functional	pAC50	=	4.6	4.6	-13489	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	6.6	6.6	-57	18	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	119570	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	119570.0	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	None	58	Human	Functional	pAC50	=	4.6	4.6	-426	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	9911830	19155	None	57	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1289494	19155	None	57	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	68873	43578	None	39	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43578	None	39	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	47979	78239	None	45	Human	Functional	pAC50	=	4.6	4.6	-7943	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78239	None	45	Human	Functional	pAC50	=	4.6	4.6	-7943	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	104870	98934	None	37	Human	Functional	pAC50	=	4.6	4.6	-56	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98934	None	37	Human	Functional	pAC50	=	4.6	4.6	-56	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98934	None	37	Human	Functional	pAC50	=	4.6	4.6	-56	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	4031	99367	None	27	Human	Functional	pAC50	=	4.6	4.6	-39	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99367	None	27	Human	Functional	pAC50	=	4.6	4.6	-39	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	102	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969.0	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	None	36	Human	Functional	pAC50	=	5.6	5.6	-549	20	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	45138674	16653	None	45	Human	Functional	pAC50	=	5.6	5.6	-1	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16653	None	45	Human	Functional	pAC50	=	5.6	5.6	-1	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	4011	82440	None	34	Human	Functional	pAC50	=	5.6	5.6	-46	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82440	None	34	Human	Functional	pAC50	=	5.6	5.6	-46	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2780	110592	None	24	Human	Functional	pAC50	=	5.6	5.6	-251	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2780.0	110592	None	24	Human	Functional	pAC50	=	5.6	5.6	-251	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110592	None	24	Human	Functional	pAC50	=	5.6	5.6	-251	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13511	110592	None	24	Human	Functional	pAC50	=	5.6	5.6	-251	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2284	3182	None	26	Human	Functional	pAC50	=	5.6	5.6	-16	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3182	None	26	Human	Functional	pAC50	=	5.6	5.6	-16	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3182	None	26	Human	Functional	pAC50	=	5.6	5.6	-16	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3182	None	26	Human	Functional	pAC50	=	5.6	5.6	-16	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3182	None	26	Human	Functional	pAC50	=	5.6	5.6	-16	34	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Functional	pAC50	=	5.6	5.6	-20	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	60753	194796	None	31	Human	Functional	pAC50	=	4.6	4.6	-7	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194796	None	31	Human	Functional	pAC50	=	4.6	4.6	-7	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	4942	5720	None	27	Human	Functional	pAC50	=	4.6	4.6	-31	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4942.0	5720	None	27	Human	Functional	pAC50	=	4.6	4.6	-31	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5720	None	27	Human	Functional	pAC50	=	4.6	4.6	-31	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB12278	5720	None	27	Human	Functional	pAC50	=	4.6	4.6	-31	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2264	53206	None	25	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
	CHEMBL1598608	53206	None	25	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	349	2	1	4	1.5	CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21	10.1038/s41467-023-40064-9
	2351	3286	None	44	Human	Functional	pAC50	=	4.6	4.6	-457	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	2820	3286	None	44	Human	Functional	pAC50	=	4.6	4.6	-457	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	5035	3286	None	44	Human	Functional	pAC50	=	4.6	4.6	-457	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	CHEMBL81	3286	None	44	Human	Functional	pAC50	=	4.6	4.6	-457	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	DB00481	3286	None	44	Human	Functional	pAC50	=	4.6	4.6	-457	27	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	5994	4643	None	51	Human	Functional	pAC50	=	4.6	4.6	-9	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4643	None	51	Human	Functional	pAC50	=	4.6	4.6	-9	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	64139	84819	None	58	Human	Functional	pAC50	=	4.6	4.6	-2	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	CHEMBL223228	84819	None	58	Human	Functional	pAC50	=	4.6	4.6	-2	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Functional	pAC50	=	4.6	4.6	-102	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Functional	pAC50	=	4.6	4.6	-102	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Functional	pAC50	=	4.6	4.6	-102	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	5.6	5.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	5.6	5.6	-1	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	1056	3371	None	67	Human	Functional	pAC50	=	4.6	4.6	-51	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	None	67	Human	Functional	pAC50	=	4.6	4.6	-51	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	None	67	Human	Functional	pAC50	=	4.6	4.6	-51	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	None	67	Human	Functional	pAC50	=	4.6	4.6	-51	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	None	67	Human	Functional	pAC50	=	4.6	4.6	-51	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	46220502	112646	None	60	Human	Functional	pAC50	=	4.6	4.6	-91	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112646	None	60	Human	Functional	pAC50	=	4.6	4.6	-91	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	9417	133581	None	40	Human	Functional	pAC50	=	4.6	4.6	-346	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133581	None	40	Human	Functional	pAC50	=	4.6	4.6	-346	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133581	None	40	Human	Functional	pAC50	=	4.6	4.6	-346	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	54684141	210459	None	52	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL973	210459	None	52	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	2218	15289	None	20	Human	Functional	pAC50	=	5.5	5.5	-3	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15289	None	20	Human	Functional	pAC50	=	5.5	5.5	-3	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	72106	78221	None	44	Human	Functional	pAC50	=	5.5	5.5	3	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78221	None	44	Human	Functional	pAC50	=	5.5	5.5	3	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	25102847	78250	None	62	Human	Functional	pAC50	=	5.5	5.5	-2	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78250	None	62	Human	Functional	pAC50	=	5.5	5.5	-2	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	1210	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036.0	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	None	42	Human	Functional	pAC50	=	4.5	4.5	-524	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	72095	78302	None	14	Human	Functional	pAC50	=	4.5	4.5	-	1	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	246	6	2	3	1.8	C#CCOc1ccc(N)cc1C(=O)NCCCC	10.1038/s41467-023-40064-9
	CHEMBL2107094	78302	None	14	Human	Functional	pAC50	=	4.5	4.5	-	1	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	246	6	2	3	1.8	C#CCOc1ccc(N)cc1C(=O)NCCCC	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	2	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	19675	51685	None	37	Human	Functional	pAC50	=	6.5	6.5	-4	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51685	None	37	Human	Functional	pAC50	=	6.5	6.5	-4	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-7	29	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10802	None	64	Human	Functional	pAC50	=	6.5	6.5	10	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10802	None	64	Human	Functional	pAC50	=	6.5	6.5	10	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	209982	None	33	Human	Functional	pAC50	=	6.5	6.5	-10	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	19861.0	209982	None	33	Human	Functional	pAC50	=	6.5	6.5	-10	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	209982	None	33	Human	Functional	pAC50	=	6.5	6.5	-10	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	DB00719	209982	None	33	Human	Functional	pAC50	=	6.5	6.5	-10	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	2274	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917.0	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	None	38	Human	Functional	pAC50	=	5.5	5.5	-5	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	1530	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827.0	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	None	36	Human	Functional	pAC50	=	6.5	6.5	-5	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1816	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205.0	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	None	64	Human	Functional	pAC50	=	6.5	6.5	-53	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	1209	1658	None	52	Human	Functional	pAC50	=	5.5	5.5	-3	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	None	52	Human	Functional	pAC50	=	5.5	5.5	-3	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	None	52	Human	Functional	pAC50	=	5.5	5.5	-3	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	None	52	Human	Functional	pAC50	=	5.5	5.5	-3	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	None	52	Human	Functional	pAC50	=	5.5	5.5	-3	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5906	14501	None	15	Human	Functional	pAC50	=	4.5	4.5	-3	4	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	5906.0	14501	None	15	Human	Functional	pAC50	=	4.5	4.5	-3	4	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14501	None	15	Human	Functional	pAC50	=	4.5	4.5	-3	4	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	DB00610	14501	None	15	Human	Functional	pAC50	=	4.5	4.5	-3	4	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	22323	15305	None	29	Human	Functional	pAC50	=	5.4	5.4	-2	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15305	None	29	Human	Functional	pAC50	=	5.4	5.4	-2	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15305	None	29	Human	Functional	pAC50	=	5.4	5.4	-2	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	1234	189330	None	32	Human	Functional	pAC50	=	5.4	5.4	-13	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189330	None	32	Human	Functional	pAC50	=	5.4	5.4	-13	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189330	None	32	Human	Functional	pAC50	=	5.4	5.4	-13	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	2220	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400.0	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	None	58	Human	Functional	pAC50	=	7.4	7.4	6	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	104850	3330	None	58	Human	Functional	pAC50	=	5.4	5.4	-338	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	None	58	Human	Functional	pAC50	=	5.4	5.4	-338	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	None	58	Human	Functional	pAC50	=	5.4	5.4	-338	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	None	58	Human	Functional	pAC50	=	5.4	5.4	-338	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	None	58	Human	Functional	pAC50	=	5.4	5.4	-338	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4066	207084	None	54	Human	Functional	pAC50	=	5.4	5.4	-239	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4066.0	207084	None	54	Human	Functional	pAC50	=	5.4	5.4	-239	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	207084	None	54	Human	Functional	pAC50	=	5.4	5.4	-239	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	207084	None	54	Human	Functional	pAC50	=	5.4	5.4	-239	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2585	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2585.0	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	None	59	Human	Functional	pAC50	=	5.4	5.4	-724	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	5.4	5.4	-3	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	5.4	5.4	-3	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	5.4	5.4	-3	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	2105	3054	None	28	Human	Functional	pAC50	=	8.3	8.3	-2	25	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	None	28	Human	Functional	pAC50	=	8.3	8.3	-2	25	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	None	28	Human	Functional	pAC50	=	8.3	8.3	-2	25	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	None	28	Human	Functional	pAC50	=	8.3	8.3	-2	25	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	None	28	Human	Functional	pAC50	=	8.3	8.3	-2	25	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	1043	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223.0	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	None	6	Human	Functional	pAC50	=	7.4	7.4	-54	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	4640	78295	None	23	Human	Functional	pAC50	=	6.4	6.4	-3	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78295	None	23	Human	Functional	pAC50	=	6.4	6.4	-3	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	5453	206077	None	58	Human	Functional	pAC50	=	5.4	5.4	-93	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	206077	None	58	Human	Functional	pAC50	=	5.4	5.4	-93	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.4	5.4	-2570	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.4	5.4	-2570	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.4	5.4	-2570	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.4	5.4	-2570	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.4	5.4	-2570	23	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2795	14500	None	28	Human	Functional	pAC50	=	5.4	5.4	1	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	5	1	2	3.5	CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1201313	14500	None	28	Human	Functional	pAC50	=	5.4	5.4	1	4	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	5	1	2	3.5	CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	5.4	5.4	-120	21	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	5.4	5.4	-120	21	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	2407	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227.0	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	None	50	Human	Functional	pAC50	=	6.3	6.3	-138	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	2267	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2267.0	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-190	14	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2435	3590	None	59	Human	Functional	pAC50	=	6.3	6.3	-23	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	None	59	Human	Functional	pAC50	=	6.3	6.3	-23	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	None	59	Human	Functional	pAC50	=	6.3	6.3	-23	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	None	59	Human	Functional	pAC50	=	6.3	6.3	-23	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	None	59	Human	Functional	pAC50	=	6.3	6.3	-23	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	4150	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019.0	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	None	26	Human	Functional	pAC50	=	5.3	5.3	-72	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5329102	194838	None	50	Human	Functional	pAC50	=	5.3	5.3	-6	37	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194838	None	50	Human	Functional	pAC50	=	5.3	5.3	-6	37	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2601	3780	None	25	Human	Functional	pAC50	=	6.3	6.3	-154	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	None	25	Human	Functional	pAC50	=	6.3	6.3	-154	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	None	25	Human	Functional	pAC50	=	6.3	6.3	-154	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	None	25	Human	Functional	pAC50	=	6.3	6.3	-154	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	None	25	Human	Functional	pAC50	=	6.3	6.3	-154	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	5284550	41735	None	12	Human	Functional	pAC50	=	5.3	5.3	-251	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5284550.0	41735	None	12	Human	Functional	pAC50	=	5.3	5.3	-251	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL108947	41735	None	12	Human	Functional	pAC50	=	5.3	5.3	-251	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41735	None	12	Human	Functional	pAC50	=	5.3	5.3	-251	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	DB09167	41735	None	12	Human	Functional	pAC50	=	5.3	5.3	-251	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-691	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-691	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	4886	14115	None	19	Human	Functional	pAC50	=	4.3	4.3	-19	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1198	14115	None	19	Human	Functional	pAC50	=	4.3	4.3	-19	5	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	135398745	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135398745.0	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-1	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	6.3	6.3	-107	32	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	5311507	194927	None	32	Human	Functional	pAC50	=	6.3	6.3	-4	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	5311507.0	194927	None	32	Human	Functional	pAC50	=	6.3	6.3	-4	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194927	None	32	Human	Functional	pAC50	=	6.3	6.3	-4	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB01624	194927	None	32	Human	Functional	pAC50	=	6.3	6.3	-4	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	3337	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	3337.0	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	65801	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	66264	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	91452	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL87493	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	DB00574	208825	None	14	Human	Functional	pAC50	=	5.3	5.3	-1	6	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	3151	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3151.0	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	None	65	Human	Functional	pAC50	=	6.3	6.3	-38	24	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	20628	96601	None	25	Human	Functional	pAC50	=	6.3	6.3	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96601	None	25	Human	Functional	pAC50	=	6.3	6.3	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	55645	84404	None	3	Human	Functional	pAC50	=	5.3	5.3	-3090	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	55645.0	84404	None	3	Human	Functional	pAC50	=	5.3	5.3	-3090	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84404	None	3	Human	Functional	pAC50	=	5.3	5.3	-3090	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	209	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748.0	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3057	None	57	Human	Functional	pAC50	=	6.2	6.2	-47	25	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5.2	5.2	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5.2	5.2	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5.2	5.2	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5.2	5.2	-19	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	9429	204590	None	44	Human	Functional	pAC50	=	5.2	5.2	-602	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	9429.0	204590	None	44	Human	Functional	pAC50	=	5.2	5.2	-602	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	204590	None	44	Human	Functional	pAC50	=	5.2	5.2	-602	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	204590	None	44	Human	Functional	pAC50	=	5.2	5.2	-602	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	4450	178333	None	41	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178333	None	41	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	1400	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658.0	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	None	46	Human	Functional	pAC50	=	5.2	5.2	-7	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	1343	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519.0	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	None	43	Human	Functional	pAC50	=	6.2	6.2	-112	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3042	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	3042.0	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	None	26	Human	Functional	pAC50	=	5.2	5.2	-501	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	7.2	7.2	-4	12	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54841	205585	None	33	Human	Functional	pAC50	=	5.2	5.2	-3	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	205585	None	33	Human	Functional	pAC50	=	5.2	5.2	-3	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	55645	84404	None	3	Human	Functional	pAC50	=	5.2	5.2	-3090	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	55645.0	84404	None	3	Human	Functional	pAC50	=	5.2	5.2	-3090	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84404	None	3	Human	Functional	pAC50	=	5.2	5.2	-3090	11	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.2	6.2	-229	33	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2865	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854.0	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	None	47	Human	Functional	pAC50	=	7.2	7.2	3	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	3947	208853	None	39	Human	Functional	pAC50	=	5.2	5.2	-10	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL87708	208853	None	39	Human	Functional	pAC50	=	5.2	5.2	-10	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	131411	15398	None	50	Human	Functional	pAC50	=	5.2	5.2	-2	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15398	None	50	Human	Functional	pAC50	=	5.2	5.2	-2	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15398	None	50	Human	Functional	pAC50	=	5.2	5.2	-2	10	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	168871	89164	None	10	Human	Functional	pAC50	=	6.2	6.2	-52	13	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89164	None	10	Human	Functional	pAC50	=	6.2	6.2	-52	13	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	2318	154946	None	18	Human	Functional	pAC50	=	5.2	5.2	-10	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154946	None	18	Human	Functional	pAC50	=	5.2	5.2	-10	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	150	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226.0	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	None	14	Human	Functional	pAC50	=	8.1	8.1	-1	17	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	7.2	7.2	-4	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	68867	78202	None	29	Human	Functional	pAC50	=	7.2	7.2	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	68867.0	78202	None	29	Human	Functional	pAC50	=	7.2	7.2	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78202	None	29	Human	Functional	pAC50	=	7.2	7.2	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	DB08810	78202	None	29	Human	Functional	pAC50	=	7.2	7.2	-1	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	118422671	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562.0	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301.0	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194.0	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL2365658	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL3526436	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	None	41	Human	Functional	pAC50	=	5.2	5.2	-2344	23	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	213	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533.0	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	None	34	Human	Functional	pAC50	=	6.1	6.1	-3	21	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	44112	121354	None	36	Human	Functional	pAC50	=	5.1	5.1	-301	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121354	None	36	Human	Functional	pAC50	=	5.1	5.1	-301	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Functional	pAC50	=	5.1	5.1	-27	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	2762	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587.0	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	7318	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL1241	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	DB00792	3863	None	23	Human	Functional	pAC50	=	5.1	5.1	-234	9	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	3936	52504	None	58	Human	Functional	pAC50	=	5.1	5.1	-4	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	3	0	4	3.8	COc1cccc(N(C)C(=S)Oc2ccc3c(c2)CCCC3)n1	10.1038/s41467-023-40064-9
	CHEMBL1591365	52504	None	58	Human	Functional	pAC50	=	5.1	5.1	-4	2	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	3	0	4	3.8	COc1cccc(N(C)C(=S)Oc2ccc3c(c2)CCCC3)n1	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	5.1	5.1	-128	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	5.1	5.1	-128	12	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	214	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566.0	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	None	43	Human	Functional	pAC50	=	6.1	6.1	-7	28	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2393	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078.0	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	None	46	Human	Functional	pAC50	=	5.1	5.1	-56	8	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	191	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170.0	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	None	60	Human	Functional	pAC50	=	7.1	7.1	1	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Functional	pAC50	=	7.1	7.1	-3	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Functional	pAC50	=	7.1	7.1	-3	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Functional	pAC50	=	7.1	7.1	-3	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Functional	pAC50	=	7.1	7.1	-3	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Functional	pAC50	=	7.1	7.1	-3	22	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2477	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	2477.0	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-173	20	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	1024	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	162639143	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	5284373	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	760	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL160	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB00091	1289	None	44	Human	Functional	pAC50	=	5.1	5.1	-141	6	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	3191	102913	None	65	Human	Functional	pAC50	=	5.1	5.1	-48	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	3191.0	102913	None	65	Human	Functional	pAC50	=	5.1	5.1	-48	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102913	None	65	Human	Functional	pAC50	=	5.1	5.1	-48	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	DB11742	102913	None	65	Human	Functional	pAC50	=	5.1	5.1	-48	33	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	17676	7074	None	25	Human	Functional	pAC50	=	6.1	6.1	-199	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	17676.0	7074	None	25	Human	Functional	pAC50	=	6.1	6.1	-199	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7074	None	25	Human	Functional	pAC50	=	6.1	6.1	-199	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7074	None	25	Human	Functional	pAC50	=	6.1	6.1	-199	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01063	7074	None	25	Human	Functional	pAC50	=	6.1	6.1	-199	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5.1	5.1	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5.1	5.1	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5.1	5.1	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5.1	5.1	-19	17	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	441074	19421	None	48	Human	Functional	pAC50	=	5.1	5.1	-4	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19421	None	48	Human	Functional	pAC50	=	5.1	5.1	-4	11	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	2398	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801.0	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	None	43	Human	Functional	pAC50	=	6.1	6.1	-123	36	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-158	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4418	34231	None	58	Human	Functional	pAC50	=	5.0	5.0	-165	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	4418.0	34231	None	58	Human	Functional	pAC50	=	5.0	5.0	-165	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34231	None	58	Human	Functional	pAC50	=	5.0	5.0	-165	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	DB12092	34231	None	58	Human	Functional	pAC50	=	5.0	5.0	-165	18	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	3149	12618	None	11	Human	Functional	pAC50	=	6.0	6.0	3	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12618	None	11	Human	Functional	pAC50	=	6.0	6.0	3	26	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	65981	18461	None	59	Human	Functional	pAC50	=	5.0	5.0	2	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1272	18461	None	59	Human	Functional	pAC50	=	5.0	5.0	2	3	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	5803	162321	None	58	Human	Functional	pAC50	=	5.0	5.0	-2	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162321	None	58	Human	Functional	pAC50	=	5.0	5.0	-2	8	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	6.0	6.0	-6	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	6.0	6.0	-6	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	6.0	6.0	-6	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	6.0	6.0	-6	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	6.0	6.0	-6	38	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Functional	pAC50	=	6.0	6.0	-9	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Functional	pAC50	=	6.0	6.0	-9	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Functional	pAC50	=	6.0	6.0	-9	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Functional	pAC50	=	6.0	6.0	-9	15	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	3689	102826	None	36	Human	Functional	pAC50	=	5.0	5.0	-1380	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102826	None	36	Human	Functional	pAC50	=	5.0	5.0	-1380	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102826	None	36	Human	Functional	pAC50	=	5.0	5.0	-1380	16	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	65709	59901	None	35	Human	Functional	pAC50	=	5.0	5.0	-4	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1729803	59901	None	35	Human	Functional	pAC50	=	5.0	5.0	-4	13	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	124	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636.0	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	None	32	Human	Functional	pAC50	=	7.0	7.0	-177	24	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	5.0	5.0	-14	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	5.0	5.0	-14	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	5.0	5.0	-14	30	Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	10531	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10531.0	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	None	13	Human	Functional	pAC50	=	6	6.0	-100	29	Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	5	139	None	45	Human	Functional	pEC50	=	9.6	9.6	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5202	139	None	45	Human	Functional	pEC50	=	9.6	9.6	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.6	9.6	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	DB08839	139	None	45	Human	Functional	pEC50	=	9.6	9.6	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	45	Human	Functional	pEC50	=	9.5	9.5	-15	26	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	168289382	191902	None	0	Human	Functional	pEC50	=	9.3	9.3	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191902	None	0	Human	Functional	pEC50	=	9.3	9.3	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168289382	191902	None	0	Human	Functional	pEC50	=	9.3	9.3	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191902	None	0	Human	Functional	pEC50	=	9.3	9.3	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	107	141	None	65	Human	Functional	pEC50	=	9.3	9.3	6309	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	1833	141	None	65	Human	Functional	pEC50	=	9.3	9.3	6309	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	CHEMBL8165	141	None	65	Human	Functional	pEC50	=	9.3	9.3	6309	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.bmcl.2014.07.062
	5	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-15	26	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5202	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	CHEMBL39	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	DB08839	139	None	45	Mouse	Functional	pEC50	=	9.3	9.3	2	26	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.9b01061
	5	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5202	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	DB08839	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-15	26	Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	11247569	201876	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	CHEMBL591223	201876	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	434	4	2	4	5.2	COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C	10.1021/jm9007328
	1524	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	197	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	3822	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	3822.0	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	88	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	CHEMBL51	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	DB12465	2181	None	61	Human	Functional	pEC50	=	9.0	9.0	1	18	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2013.02.020
	5	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-15	26	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	5202	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-15	26	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-15	26	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	DB08839	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-15	26	Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	5	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-15	26	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	5202	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-15	26	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-15	26	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	DB08839	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-15	26	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	439280	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	168291775	192015	None	0	Human	Functional	pEC50	=	8.8	8.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	192015	None	0	Human	Functional	pEC50	=	8.8	8.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168291775	192015	None	0	Human	Functional	pEC50	=	8.8	8.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	192015	None	0	Human	Functional	pEC50	=	8.8	8.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-15	26	Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	4376990	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193118	None	4	Human	Functional	pEC50	=	8.8	8.8	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	145	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	1832	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	DB14010	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.2c00129
	145	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	1832	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	DB14010	140	None	16	Human	Functional	pEC50	=	8.8	8.8	3	12	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.1c00577
	145	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	1832	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	DB14010	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	5	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-15	26	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	120083	None	57	Human	Functional	pEC50	=	8.7	8.7	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120083	None	57	Human	Functional	pEC50	=	8.7	8.7	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120083	None	57	Human	Functional	pEC50	=	8.7	8.7	-9	9	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	152743520	190088	None	1	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5170895	190088	None	1	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11695000	89105	None	0	Human	Functional	pEC50	=	8	8.0	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89105	None	0	Human	Functional	pEC50	=	8	8.0	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89105	None	0	Human	Functional	pEC50	=	8	8.0	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	24773649	94880	None	0	Human	Functional	pEC50	=	8	8.0	-2	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94880	None	0	Human	Functional	pEC50	=	8	8.0	-2	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	122180957	121837	None	0	Human	Functional	pEC50	=	8.0	8.0	20	2	Partial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	CHEMBL3589578	121837	None	0	Human	Functional	pEC50	=	8.0	8.0	20	2	Partial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2A receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	10105208	62519	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62519	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	17954204	63959	None	17	Human	Functional	pEC50	=	7	7.0	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63959	None	17	Human	Functional	pEC50	=	7	7.0	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	24773816	94909	None	0	Human	Functional	pEC50	=	7	7.0	-12	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94909	None	0	Human	Functional	pEC50	=	7	7.0	-12	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	23395431	94966	None	0	Human	Functional	pEC50	=	7	7.0	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94966	None	0	Human	Functional	pEC50	=	7	7.0	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	24773650	154787	None	2	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154787	None	2	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	10105208	62519	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62519	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	22368315	63787	None	0	Human	Functional	pEC50	=	7	7.0	-12	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63787	None	0	Human	Functional	pEC50	=	7	7.0	-12	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	9994008	166244	None	0	Human	Functional	pEC50	=	7	7.0	-9	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166244	None	0	Human	Functional	pEC50	=	7	7.0	-9	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	96783829	192911	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	CHEMBL5174204	192911	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	CHEMBL5221436	192911	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assay	ChEMBL	218	2	2	1	2.6	Fc1cccc2[nH]cc(C[C@H]3CCCN3)c12	10.1021/acsmedchemlett.2c00128
	24773897	94911	None	2	Human	Functional	pEC50	=	6	6.0	-251	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL253807	94911	None	2	Human	Functional	pEC50	=	6	6.0	-251	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	134265705	164186	None	0	Human	Functional	pEC50	=	4	4.0	-1621	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	164186	None	0	Human	Functional	pEC50	=	4	4.0	-1621	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265590	164853	None	0	Human	Functional	pEC50	=	4	4.0	-309	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164853	None	0	Human	Functional	pEC50	=	4	4.0	-309	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	118733794	120737	None	0	Human	Functional	pEC50	=	6	6.0	-15	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120737	None	0	Human	Functional	pEC50	=	6	6.0	-15	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120737	None	0	Human	Functional	pEC50	=	6	6.0	-15	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	118733818	120729	None	0	Human	Functional	pEC50	=	6.0	6.0	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120729	None	0	Human	Functional	pEC50	=	6.0	6.0	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120729	None	0	Human	Functional	pEC50	=	6.0	6.0	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	24826871	91146	None	0	Human	Functional	pEC50	=	6.0	6.0	-85	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397907	91146	None	0	Human	Functional	pEC50	=	6.0	6.0	-85	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	157114558	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5187568	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221884	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	24826963	91149	None	0	Human	Functional	pEC50	=	6.0	6.0	-74	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397910	91149	None	0	Human	Functional	pEC50	=	6.0	6.0	-74	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168941703	196195	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	227	1	1	2	2.6	Cc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5418595	196195	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	227	1	1	2	2.6	Cc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	11176570	91154	None	1	Human	Functional	pEC50	=	7.0	7.0	-6	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397915	91154	None	1	Human	Functional	pEC50	=	7.0	7.0	-6	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	157114558	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5187568	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221884	192973	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1O	10.1021/acsmedchemlett.1c00694
	18735309	207891	None	0	Human	Functional	pEC50	=	6.0	6.0	-21	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	207891	None	0	Human	Functional	pEC50	=	6.0	6.0	-21	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	24826787	91131	None	0	Human	Functional	pEC50	=	7.0	7.0	-6	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397892	91131	None	0	Human	Functional	pEC50	=	7.0	7.0	-6	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	122442268	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168276822	190232	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5173321	190232	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	168941477	194997	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	229	2	2	3	1.9	COc1cccc2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5394639	194997	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	229	2	2	3	1.9	COc1cccc2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	44412405	77810	None	0	Human	Functional	pEC50	=	6.0	6.0	-5	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77810	None	0	Human	Functional	pEC50	=	6.0	6.0	-5	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	122442268	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138440	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	58911579	91130	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397891	91130	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162644827	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162644827	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183729	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162657367	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45485781	199847	None	0	Human	Functional	pEC50	=	6.0	6.0	-23	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	CHEMBL569342	199847	None	0	Human	Functional	pEC50	=	6.0	6.0	-23	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	5	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-15	26	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-15	26	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-15	26	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-15	26	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	122180976	121856	None	1	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	CHEMBL3589597	121856	None	1	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	122180977	121857	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL3589598	121857	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	168941574	195420	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2c(C3=CCCNC3)n[nH]c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5403370	195420	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2c(C3=CCCNC3)n[nH]c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5080051	217150	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL		None	None	None		Oc1cccc2[nH]cc(CCN3CCC3)c12	10.1021/acsmedchemlett.2c00129
	3906894	102034	None	22	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	102034	None	22	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	168941653	196860	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	264	1	1	1	3.7	CN1CCC=C(c2c[nH]c3c(Cl)c(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5433583	196860	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	264	1	1	1	3.7	CN1CCC=C(c2c[nH]c3c(Cl)c(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	10401602	123135	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123135	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44383397	59260	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Functional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	CHEMBL170319	59260	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Functional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional antagonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	11437171	83523	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83523	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	162657367	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183788	None	0	Human	Functional	pEC50	=	7.0	7.0	-42	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168272608	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162670523	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44412404	77797	None	4	Human	Functional	pEC50	=	6.0	6.0	-10	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77797	None	4	Human	Functional	pEC50	=	6.0	6.0	-10	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	168272608	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192902	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162670523	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183856	None	0	Human	Functional	pEC50	=	7.0	7.0	-41	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45485779	199963	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570023	199963	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	168282376	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168941574	195420	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2c(C3=CCCNC3)n[nH]c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5403370	195420	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2c(C3=CCCNC3)n[nH]c2c1	10.1021/acsmedchemlett.3c00444
	168282376	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192995	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24849050	78331	None	1	Human	Functional	pEC50	=	6.9	6.9	-5	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78331	None	1	Human	Functional	pEC50	=	6.9	6.9	-5	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	162659049	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162659049	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183799	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11302765	84282	None	4	Human	Functional	pEC50	=	5.9	5.9	-74	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84282	None	4	Human	Functional	pEC50	=	5.9	5.9	-74	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	122442251	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	3906894	102034	None	22	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	102034	None	22	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	5	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.2c00716
	5202	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.2c00716
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.2c00716
	DB08839	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs by ONE-Glo reagent based luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jnatprod.2c00716
	5	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	5202	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	DB08839	139	None	45	Human	Functional	pEC50	=	7.9	7.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	168941477	194997	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	229	2	2	3	1.9	COc1cccc2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5394639	194997	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	229	2	2	3	1.9	COc1cccc2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL4790446	216558	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	216558	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4790446	216558	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	216558	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	168941556	196480	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)cc(F)cc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5424784	196480	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)cc(F)cc23)C1	10.1021/acsmedchemlett.3c00444
	1621	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	17	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	5761	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	CHEMBL263881	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	DB04829	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	46233391	201656	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	454	4	2	4	5.4	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)c1	10.1021/jm9007328
	CHEMBL589769	201656	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	454	4	2	4	5.4	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)c1	10.1021/jm9007328
	168280534	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5183493	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221899	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	168280534	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5183493	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221899	192977	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1C(F)(F)F	10.1021/acsmedchemlett.1c00694
	122442251	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	107992	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	72197306	102543	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL2393231	102543	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL3040287	102543	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	276	2	2	6	-0.0	CNc1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	107992	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	33	Human	Functional	pEC50	=	5.9	5.9	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	118733762	120708	None	0	Human	Functional	pEC50	=	5.9	5.9	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120708	None	0	Human	Functional	pEC50	=	5.9	5.9	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120708	None	0	Human	Functional	pEC50	=	5.9	5.9	-93	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	53324327	56866	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56866	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	16115517	84872	None	0	Human	Functional	pEC50	=	6.9	6.9	-87	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84872	None	0	Human	Functional	pEC50	=	6.9	6.9	-87	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11206703	91126	None	0	Human	Functional	pEC50	=	6.9	6.9	-40	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91126	None	0	Human	Functional	pEC50	=	6.9	6.9	-40	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	168268736	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168268736	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192898	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	57799306	89143	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89143	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89143	None	0	Human	Functional	pEC50	=	6.9	6.9	-47	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	9881119	207931	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	207931	None	0	Human	Functional	pEC50	=	6.9	6.9	-4	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	5	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	11160564	63324	None	2	Human	Functional	pEC50	=	6.9	6.9	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63324	None	2	Human	Functional	pEC50	=	6.9	6.9	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	11608308	64330	None	3	Human	Functional	pEC50	=	6.9	6.9	-42	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64330	None	3	Human	Functional	pEC50	=	6.9	6.9	-42	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	24773809	94935	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94935	None	0	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	3991761	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183437	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222058	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	728636	114368	None	3	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	3	2	1	2.4	CC[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330646	114368	None	3	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	3	2	1	2.4	CC[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	16115388	137453	None	0	Human	Functional	pEC50	=	6.9	6.9	2	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137453	None	0	Human	Functional	pEC50	=	6.9	6.9	2	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	3991761	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183437	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222058	193005	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	2	2	2	3.6	COc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	11514226	89144	None	0	Human	Functional	pEC50	=	6.9	6.9	-114	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89144	None	0	Human	Functional	pEC50	=	6.9	6.9	-114	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89144	None	0	Human	Functional	pEC50	=	6.9	6.9	-114	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11609026	89161	None	0	Human	Functional	pEC50	=	6.9	6.9	-38	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89161	None	0	Human	Functional	pEC50	=	6.9	6.9	-38	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89161	None	0	Human	Functional	pEC50	=	6.9	6.9	-38	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	71562661	87341	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87341	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	1621	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	17	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	5761	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	CHEMBL263881	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	DB04829	2429	None	10	Human	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acs.jmedchem.2c00702
	439280	120083	None	57	Human	Functional	pEC50	=	6.9	6.9	-9	9	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	6971044	120083	None	57	Human	Functional	pEC50	=	6.9	6.9	-9	9	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	CHEMBL350221	120083	None	57	Human	Functional	pEC50	=	6.9	6.9	-9	9	Agonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting methodAgonist activity at 5-HT2A receptor (unknown origin) expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding incubated for 30 mins by liquid scintillation counting method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.07.030
	46884102	8064	None	1	Human	Functional	pEC50	=	6.9	6.9	-128	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091106	8064	None	1	Human	Functional	pEC50	=	6.9	6.9	-128	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	5	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	5202	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	DB08839	139	None	45	Human	Functional	pEC50	=	6.9	6.9	-15	26	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.2c00702
	46230099	201768	None	0	Human	Functional	pEC50	=	6.9	6.9	-70	3	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	201768	None	0	Human	Functional	pEC50	=	6.9	6.9	-70	3	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	71562661	87341	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87341	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	118733808	120720	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120720	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120720	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	11414184	83531	None	0	Human	Functional	pEC50	=	6.9	6.9	-5	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83531	None	0	Human	Functional	pEC50	=	6.9	6.9	-5	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	166	3359	None	19	Human	Functional	pEC50	=	6.9	6.9	-36	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3359	None	19	Human	Functional	pEC50	=	6.9	6.9	-36	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	6.9	6.9	-36	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	134265622	164848	None	0	Human	Functional	pEC50	=	5.9	5.9	-223	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164848	None	0	Human	Functional	pEC50	=	5.9	5.9	-223	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	46228422	202492	None	0	Human	Functional	pEC50	=	5.9	5.9	-60	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	202492	None	0	Human	Functional	pEC50	=	5.9	5.9	-60	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	168277051	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168277051	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192946	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295524	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205848	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222868	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168276542	190421	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5176147	190421	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	168295524	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205848	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222868	193139	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	2	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168280316	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	168280316	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192972	None	0	Human	Functional	pEC50	=	5.9	5.9	-41	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	11608308	64330	None	3	Human	Functional	pEC50	=	6.9	6.9	-42	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL181076	64330	None	3	Human	Functional	pEC50	=	6.9	6.9	-42	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	71681897	91153	None	0	Human	Functional	pEC50	=	5.9	5.9	-87	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	CHEMBL2397914	91153	None	0	Human	Functional	pEC50	=	5.9	5.9	-87	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	53324165	56817	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56817	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	9901086	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL4743049	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168290116	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193251	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222481	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168290116	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193251	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222481	193073	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	292	3	3	2	3.7	Oc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	44572657	12471	None	5	Human	Functional	pEC50	=	5.9	5.9	-263	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12471	None	5	Human	Functional	pEC50	=	5.9	5.9	-263	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12471	None	5	Human	Functional	pEC50	=	5.9	5.9	-263	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	12370465	12678	None	15	Human	Functional	pEC50	=	5.9	5.9	-109	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12678	None	15	Human	Functional	pEC50	=	5.9	5.9	-109	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12678	None	15	Human	Functional	pEC50	=	5.9	5.9	-109	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	9901086	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL4743049	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187737	None	28	Human	Functional	pEC50	=	6.9	6.9	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168288579	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5197871	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222382	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	168288579	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5197871	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222382	193052	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	3	2	3.8	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	11949706	202511	None	0	Human	Functional	pEC50	=	5.8	5.8	-1445	2	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595645	202511	None	0	Human	Functional	pEC50	=	5.8	5.8	-1445	2	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	16743289	59588	None	2	Human	Functional	pEC50	=	6.8	6.8	-724	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL171774	59588	None	2	Human	Functional	pEC50	=	6.8	6.8	-724	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	168283046	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168941768	196057	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	212	1	2	1	2.9	Cc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5416033	196057	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	212	1	2	1	2.9	Cc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	5	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	168283046	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	193001	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	118733806	120719	None	0	Human	Functional	pEC50	=	5.8	5.8	-46	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120719	None	0	Human	Functional	pEC50	=	5.8	5.8	-46	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120719	None	0	Human	Functional	pEC50	=	5.8	5.8	-46	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	24826957	91151	None	0	Human	Functional	pEC50	=	6.8	6.8	-24	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397912	91151	None	0	Human	Functional	pEC50	=	6.8	6.8	-24	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572804	12627	None	0	Human	Functional	pEC50	=	5.8	5.8	-48	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12627	None	0	Human	Functional	pEC50	=	5.8	5.8	-48	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12627	None	0	Human	Functional	pEC50	=	5.8	5.8	-48	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL4757837	216555	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	216555	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4757837	216555	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	216555	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	1621	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	17	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	5761	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	CHEMBL263881	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	DB04829	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	5	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	7153	98073	None	55	Human	Functional	pEC50	=	6.8	6.8	-1	4	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	98073	None	55	Human	Functional	pEC50	=	6.8	6.8	-1	4	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	22292784	64615	None	16	Human	Functional	pEC50	=	6.8	6.8	-5	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64615	None	16	Human	Functional	pEC50	=	6.8	6.8	-5	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	11952353	202316	None	0	Human	Functional	pEC50	=	5.8	5.8	-1071	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	202316	None	0	Human	Functional	pEC50	=	5.8	5.8	-1071	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	168268703	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168268703	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192885	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	122442263	138444	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	46884137	8444	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093698	8444	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	72197481	102457	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393240	102457	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3039632	102457	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	168280955	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5184449	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221926	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168280955	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5184449	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221926	192984	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	168288855	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5194467	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222402	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	11658860	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	22292784	64615	None	16	Human	Functional	pEC50	=	6.8	6.8	-5	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64615	None	16	Human	Functional	pEC50	=	6.8	6.8	-5	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	168280043	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	3568612	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	10329912	62571	None	7	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	CHEMBL178252	62571	None	7	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	24773979	130237	None	20	Human	Functional	pEC50	=	5.8	5.8	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130237	None	20	Human	Functional	pEC50	=	5.8	5.8	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	24773978	154505	None	0	Human	Functional	pEC50	=	5.8	5.8	-7	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL398926	154505	None	0	Human	Functional	pEC50	=	5.8	5.8	-7	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	168288855	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5194467	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222402	193057	None	0	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Cl)ccc1O	10.1021/acsmedchemlett.1c00694
	168280043	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192968	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	1621	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	17	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	5761	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	CHEMBL263881	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	DB04829	2429	None	10	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/acsmedchemlett.4c00058
	9991444	62652	None	1	Human	Functional	pEC50	=	7.8	7.8	-4	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62652	None	1	Human	Functional	pEC50	=	7.8	7.8	-4	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	3568612	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	193104	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	45484663	200824	None	0	Dog	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nnc2c3c(nc(Cc4ccccc4)n12)CCNCC3	10.1016/j.bmcl.2009.07.063
	CHEMBL576631	200824	None	0	Dog	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nnc2c3c(nc(Cc4ccccc4)n12)CCNCC3	10.1016/j.bmcl.2009.07.063
	10329912	62571	None	7	Human	Functional	pEC50	=	5.8	5.8	-3	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178252	62571	None	7	Human	Functional	pEC50	=	5.8	5.8	-3	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	24773979	130237	None	20	Human	Functional	pEC50	=	5.8	5.8	-4	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL367796	130237	None	20	Human	Functional	pEC50	=	5.8	5.8	-4	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	44572755	12463	None	0	Human	Functional	pEC50	=	5.8	5.8	-70	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12463	None	0	Human	Functional	pEC50	=	5.8	5.8	-70	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12463	None	0	Human	Functional	pEC50	=	5.8	5.8	-70	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	11427139	84721	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84721	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44315993	172980	None	0	Human	Functional	pEC50	=	6.8	6.8	-16	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172980	None	0	Human	Functional	pEC50	=	6.8	6.8	-16	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	168941556	196480	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)cc(F)cc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5424784	196480	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)cc(F)cc23)C1	10.1021/acsmedchemlett.3c00444
	168288743	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	11658860	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.8	6.8	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442273	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733824	120733	None	0	Human	Functional	pEC50	=	5.8	5.8	-75	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416065	120733	None	0	Human	Functional	pEC50	=	5.8	5.8	-75	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546960	120733	None	0	Human	Functional	pEC50	=	5.8	5.8	-75	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	16115654	137061	None	0	Human	Functional	pEC50	=	6.8	6.8	-27	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	137061	None	0	Human	Functional	pEC50	=	6.8	6.8	-27	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	168288743	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	193056	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	1355	2011	None	45	Human	Functional	pEC50	=	6.8	6.8	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	2011	None	45	Human	Functional	pEC50	=	6.8	6.8	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.8	6.8	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.8	6.8	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	122442273	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138443	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11630623	89133	None	0	Human	Functional	pEC50	=	5.8	5.8	-151	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89133	None	0	Human	Functional	pEC50	=	5.8	5.8	-151	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89133	None	0	Human	Functional	pEC50	=	5.8	5.8	-151	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	44572749	12441	None	0	Human	Functional	pEC50	=	6.8	6.8	-32	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12441	None	0	Human	Functional	pEC50	=	6.8	6.8	-32	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12441	None	0	Human	Functional	pEC50	=	6.8	6.8	-32	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	168290300	192095	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5201317	192095	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11983273	78025	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	78025	None	0	Human	Functional	pEC50	=	6.8	6.8	-2	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	25084025	12705	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12705	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12705	None	0	Human	Functional	pEC50	=	5.8	5.8	-117	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	168280082	191302	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5189232	191302	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	168941766	197177	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	251	1	2	2	2.7	Fc1ccc(Cl)c2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5440436	197177	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	251	1	2	2	2.7	Fc1ccc(Cl)c2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	122442263	138444	None	0	Human	Functional	pEC50	=	7.8	7.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	7.8	7.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	7.8	7.8	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168941715	196900	None	0	Human	Functional	pEC50	=	7.8	7.8	-8	3	Agonist activity at 5-HT2A receptor (unknown origin)Agonist activity at 5-HT2A receptor (unknown origin)	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5434434	196900	None	0	Human	Functional	pEC50	=	7.8	7.8	-8	3	Agonist activity at 5-HT2A receptor (unknown origin)Agonist activity at 5-HT2A receptor (unknown origin)	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	11160564	63324	None	2	Human	Functional	pEC50	=	6.8	6.8	-7	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63324	None	2	Human	Functional	pEC50	=	6.8	6.8	-7	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	168276542	190421	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5176147	190421	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	391	6	1	4	4.1	COc1cc(CCNC2CCOc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	11221167	84714	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84714	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	168268771	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	168268771	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192900	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	11737032	85050	None	0	Human	Functional	pEC50	=	5.8	5.8	-47	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	85050	None	0	Human	Functional	pEC50	=	5.8	5.8	-47	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	145709	114366	None	19	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2c(Cl)cccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330643	114366	None	19	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2c(Cl)cccc12	10.1016/j.bmcl.2014.07.062
	1534	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	44622849	199247	None	0	Dog	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nc2c3c(nc(Cc4ccccc4)n2n1)CCNCC3	10.1016/j.bmcl.2009.07.063
	CHEMBL565547	199247	None	0	Dog	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5-HT2A receptor in dog bladder stripAgonist activity at 5-HT2A receptor in dog bladder strip	ChEMBL	293	2	1	5	1.7	Cc1nc2c3c(nc(Cc4ccccc4)n2n1)CCNCC3	10.1016/j.bmcl.2009.07.063
	44315697	207963	None	0	Human	Functional	pEC50	=	6.7	6.7	-8	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	207963	None	0	Human	Functional	pEC50	=	6.7	6.7	-8	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	118733810	120721	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120721	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120721	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	3568128	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	193042	None	0	Human	Functional	pEC50	=	5.7	5.7	-4	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	11716185	89098	None	0	Human	Functional	pEC50	=	5.7	5.7	-70	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337497	89098	None	0	Human	Functional	pEC50	=	5.7	5.7	-70	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2364998	89098	None	0	Human	Functional	pEC50	=	5.7	5.7	-70	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	44572800	12657	None	2	Human	Functional	pEC50	=	5.7	5.7	-190	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12657	None	2	Human	Functional	pEC50	=	5.7	5.7	-190	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12657	None	2	Human	Functional	pEC50	=	5.7	5.7	-190	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	170453288	196449	None	2	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5424175	196449	None	2	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	9822580	202976	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	404	3	2	3	5.1	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1	10.1021/jm9007328
	CHEMBL598808	202976	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation countingActivity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting	ChEMBL	404	3	2	3	5.1	Cn1ncc(Br)c1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1	10.1021/jm9007328
	14107683	178231	None	20	Mouse	Functional	pEC50	=	7.7	7.7	-5	2	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178231	None	20	Mouse	Functional	pEC50	=	7.7	7.7	-5	2	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	1534	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103095	None	23	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	14107683	178231	None	20	Mouse	Functional	pEC50	=	7.7	7.7	-5	2	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178231	None	20	Mouse	Functional	pEC50	=	7.7	7.7	-5	2	Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	9991444	62652	None	1	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62652	None	1	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	11291	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	4980	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	11658860	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-17	11	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-17	11	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-17	11	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-17	11	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-17	11	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	170453288	196449	None	2	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5424175	196449	None	2	Human	Functional	pEC50	=	6.7	6.7	-6	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	168295545	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205884	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222933	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	168295545	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5205884	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222933	193153	None	0	Human	Functional	pEC50	=	5.7	5.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	3	2	1	5.3	Fc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	44573004	12524	None	0	Human	Functional	pEC50	=	5.7	5.7	-52	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12524	None	0	Human	Functional	pEC50	=	5.7	5.7	-52	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12524	None	0	Human	Functional	pEC50	=	5.7	5.7	-52	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	58911582	91133	None	0	Human	Functional	pEC50	=	6.7	6.7	-16	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397894	91133	None	0	Human	Functional	pEC50	=	6.7	6.7	-16	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	3071387	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	3939391	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	162656326	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4757142	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802987	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	3071387	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192879	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	3939391	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	193059	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	162656326	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4757142	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802987	183783	None	0	Human	Functional	pEC50	=	5.7	5.7	-6	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	216	2860	None	26	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2860	None	26	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2860	None	26	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	11447552	62548	None	2	Human	Functional	pEC50	=	6.7	6.7	-30	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62548	None	2	Human	Functional	pEC50	=	6.7	6.7	-30	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	10465263	64353	None	37	Human	Functional	pEC50	=	6.7	6.7	-19	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64353	None	37	Human	Functional	pEC50	=	6.7	6.7	-19	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773895	94910	None	0	Human	Functional	pEC50	=	6.7	6.7	-25	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94910	None	0	Human	Functional	pEC50	=	6.7	6.7	-25	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	152	364	None	24	Human	Functional	pEC50	=	8.7	8.7	-1	5	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	2107	364	None	24	Human	Functional	pEC50	=	8.7	8.7	-1	5	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	CHEMBL275854	364	None	24	Human	Functional	pEC50	=	8.7	8.7	-1	5	Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1016/j.bmcl.2018.04.059
	145	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	1832	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	DB14010	140	None	16	Human	Functional	pEC50	=	8.7	8.7	3	12	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	5	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	14107683	178231	None	20	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acsmedchemlett.4c00058
	CHEMBL4648350	178231	None	20	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acsmedchemlett.4c00058
	14107683	178231	None	20	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acsmedchemlett.4c00058
	CHEMBL4648350	178231	None	20	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acsmedchemlett.4c00058
	5	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	146	135	None	50	Human	Functional	pEC50	=	8.6	8.6	851	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	164682	135	None	50	Human	Functional	pEC50	=	8.6	8.6	851	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	CHEMBL275628	135	None	50	Human	Functional	pEC50	=	8.6	8.6	851	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	10.1016/j.bmcl.2014.07.062
	90489020	190982	None	8	Human	Functional	pEC50	=	8.6	8.6	14	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5184791	190982	None	8	Human	Functional	pEC50	=	8.6	8.6	14	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	168941564	195265	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5399727	195265	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	50878551	90779	None	28	Human	Functional	pEC50	=	8.6	8.6	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90779	None	28	Human	Functional	pEC50	=	8.6	8.6	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	156836209	188682	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4873240	188682	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL5028766	188682	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	220	4	1	1	2.8	CCN(C)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	122442260	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	85542158	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at 5-HT2A receptor (unknown origin)Agonist activity at 5-HT2A receptor (unknown origin)	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at 5-HT2A receptor (unknown origin)Agonist activity at 5-HT2A receptor (unknown origin)	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at 5-HT2A receptor (unknown origin)Agonist activity at 5-HT2A receptor (unknown origin)	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	122442263	138444	None	0	Human	Functional	pEC50	=	6.7	6.7	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	6.7	6.7	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	6.7	6.7	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	53317924	56867	None	0	Human	Functional	pEC50	=	5.7	5.7	-10	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56867	None	0	Human	Functional	pEC50	=	5.7	5.7	-10	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	58911534	91143	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397904	91143	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	4646586	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168268773	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4401618	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	27559	205867	None	7	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	205867	None	7	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168268773	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192901	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4646586	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193122	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	4401618	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193132	None	2	Human	Functional	pEC50	=	6.7	6.7	9	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	11595191	89094	None	0	Human	Functional	pEC50	=	5.7	5.7	-51	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89094	None	0	Human	Functional	pEC50	=	5.7	5.7	-51	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89094	None	0	Human	Functional	pEC50	=	5.7	5.7	-51	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	23492	114364	None	42	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	1	2	1.7	Cn1cc(CCN)c2ccccc21	10.1016/j.bmcl.2014.07.062
	CHEMBL3330641	114364	None	42	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	1	2	1.7	Cn1cc(CCN)c2ccccc21	10.1016/j.bmcl.2014.07.062
	57799324	89126	None	0	Human	Functional	pEC50	=	7.7	7.7	-9	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337501	89126	None	0	Human	Functional	pEC50	=	7.7	7.7	-9	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365359	89126	None	0	Human	Functional	pEC50	=	7.7	7.7	-9	2	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	122442260	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138441	None	0	Human	Functional	pEC50	=	7.7	7.7	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168941519	195345	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	231	1	1	2	2.4	CN1CCC=C(c2n[nH]c3cc(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5401711	195345	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	231	1	1	2	2.4	CN1CCC=C(c2n[nH]c3cc(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	27559	205867	None	7	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	205867	None	7	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	122442286	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	146025686	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183865	None	0	Human	Functional	pEC50	=	6.7	6.7	-21	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442286	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.7	6.7	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168294789	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5208018	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222900	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	44572759	12466	None	0	Human	Functional	pEC50	=	5.7	5.7	-83	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12466	None	0	Human	Functional	pEC50	=	5.7	5.7	-83	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12466	None	0	Human	Functional	pEC50	=	5.7	5.7	-83	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	168294789	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5208018	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5222900	193145	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(F)ccc1O	10.1021/acsmedchemlett.1c00694
	22241625	196520	None	0	Human	Functional	pEC50	=	5.7	5.7	-63	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	CHEMBL5425772	196520	None	0	Human	Functional	pEC50	=	5.7	5.7	-63	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	146025688	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	168941768	196057	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	212	1	2	1	2.9	Cc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5416033	196057	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	212	1	2	1	2.9	Cc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	24826867	91129	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397890	91129	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	146025687	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	11291	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	4980	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	4	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.4c00058
	10472780	63303	None	0	Human	Functional	pEC50	=	7.7	7.7	2	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179244	63303	None	0	Human	Functional	pEC50	=	7.7	7.7	2	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	141	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	6089	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	CHEMBL12420	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	DB01488	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.2c00129
	141	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	6089	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	CHEMBL12420	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	DB01488	1427	None	18	Human	Functional	pEC50	=	7.7	7.7	1	15	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/acsmedchemlett.1c00577
	146025687	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183821	None	0	Human	Functional	pEC50	=	7.7	7.7	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	16115513	136489	None	0	Human	Functional	pEC50	=	6.7	6.7	-43	2	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL373531	136489	None	0	Human	Functional	pEC50	=	6.7	6.7	-43	2	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11447552	62548	None	2	Human	Functional	pEC50	=	6.7	6.7	-30	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62548	None	2	Human	Functional	pEC50	=	6.7	6.7	-30	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	44412150	77762	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77762	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	46228433	202196	None	6	Human	Functional	pEC50	=	5.7	5.7	-87	2	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	CHEMBL593547	202196	None	6	Human	Functional	pEC50	=	5.7	5.7	-87	2	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	22241625	196520	None	0	Human	Functional	pEC50	=	5.7	5.7	-63	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	CHEMBL5425772	196520	None	0	Human	Functional	pEC50	=	5.7	5.7	-63	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	146025688	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183800	None	0	Human	Functional	pEC50	=	5.7	5.7	-81	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	168274581	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168274581	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192923	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168285159	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168285159	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	193023	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	85542158	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	27559	205867	None	7	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	205867	None	7	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168273192	190525	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190525	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	168297263	192521	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5208046	192521	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	1534	103095	None	23	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	9287	103095	None	23	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL30713	103095	None	23	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	27559	205867	None	7	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	205867	None	7	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	168273192	190525	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190525	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	168297263	192521	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL5208046	192521	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	377	6	1	4	3.7	COc1cc(CCNC2COc3ccccc32)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	53321947	56814	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56814	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	85542158	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	146025685	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	122442293	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442250	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	146025685	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183765	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	122442293	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138429	None	0	Human	Functional	pEC50	=	5.6	5.6	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	53325935	56813	None	0	Human	Functional	pEC50	=	5.6	5.6	-436	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56813	None	0	Human	Functional	pEC50	=	5.6	5.6	-436	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	44572172	12550	None	0	Human	Functional	pEC50	=	6.6	6.6	-47	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12550	None	0	Human	Functional	pEC50	=	6.6	6.6	-47	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12550	None	0	Human	Functional	pEC50	=	6.6	6.6	-47	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	122442250	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	46228438	202441	None	0	Human	Functional	pEC50	=	6.6	6.6	-2344	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	202441	None	0	Human	Functional	pEC50	=	6.6	6.6	-2344	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	134265663	163774	None	0	Human	Functional	pEC50	=	6.6	6.6	-204	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163774	None	0	Human	Functional	pEC50	=	6.6	6.6	-204	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	168281505	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168281505	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192989	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44572180	12566	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12566	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12566	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	14515725	87344	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87344	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	168941461	197064	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)ccc(F)c23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5437921	197064	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	265	1	1	2	3.1	CN1CCC=C(c2n[nH]c3c(Cl)ccc(F)c23)C1	10.1021/acsmedchemlett.3c00444
	11291	3220	None	14	Human	Functional	pEC50	=	7.6	7.6	-2	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3220	None	14	Human	Functional	pEC50	=	7.6	7.6	-2	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	7.6	7.6	-2	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	71562661	87341	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87341	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	14515725	87344	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87344	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	24773894	63000	None	2	Human	Functional	pEC50	=	5.6	5.6	-9	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178566	63000	None	2	Human	Functional	pEC50	=	5.6	5.6	-9	2	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	168275195	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	17654	116863	None	60	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL337825	116863	None	60	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	11658860	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	71562661	87341	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87341	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	168275195	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192932	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802359	216549	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	118713118	114370	None	2	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	206	3	2	1	2.6	CCC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330648	114370	None	2	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	206	3	2	1	2.6	CCC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	44572808	12710	None	0	Human	Functional	pEC50	=	6.6	6.6	-74	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12710	None	0	Human	Functional	pEC50	=	6.6	6.6	-74	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12710	None	0	Human	Functional	pEC50	=	6.6	6.6	-74	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	11658860	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802359	216549	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	46230097	201822	None	0	Human	Functional	pEC50	=	6.6	6.6	-15	3	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	201822	None	0	Human	Functional	pEC50	=	6.6	6.6	-15	3	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	112485369	114369	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	222	3	2	1	3.1	CCC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330647	114369	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	222	3	2	1	3.1	CCC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	44412388	78214	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78214	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	5	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	5202	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	DB08839	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	172445373	195170	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs in presence of serotonin by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs in presence of serotonin by ONE-Glo reagent based luciferase assay	ChEMBL	244	1	3	3	1.7	CC1=N[C@H](C(=O)O)Cc2c[nH]c3c(O)ccc1c23	10.1021/acs.jnatprod.2c00716
	CHEMBL5398022	195170	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs in presence of serotonin by ONE-Glo reagent based luciferase assayAgonist activity at N-terminal HA-tagged human 5HT2A receptor transfected in CHO-K1 cells co-expressing C-terminal EYFP measured for 5.5 hrs in presence of serotonin by ONE-Glo reagent based luciferase assay	ChEMBL	244	1	3	3	1.7	CC1=N[C@H](C(=O)O)Cc2c[nH]c3c(O)ccc1c23	10.1021/acs.jnatprod.2c00716
	23652278	62651	None	11	Human	Functional	pEC50	=	6.6	6.6	-16	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62651	None	11	Human	Functional	pEC50	=	6.6	6.6	-16	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773814	94912	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94912	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	24773900	123499	None	6	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123499	None	6	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	4312735	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	134265618	164150	None	0	Human	Functional	pEC50	=	5.6	5.6	-204	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164150	None	0	Human	Functional	pEC50	=	5.6	5.6	-204	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	24773894	63000	None	2	Human	Functional	pEC50	=	5.6	5.6	-9	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178566	63000	None	2	Human	Functional	pEC50	=	5.6	5.6	-9	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	11780383	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL1288870	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5169776	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	11780383	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL1288870	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5169776	19058	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	264	1	3	2	3.1	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	4312735	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192983	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	45485751	200111	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	CHEMBL570937	200111	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	162653458	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.6	6.6	-17	11	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	162645074	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168272754	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168272754	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192903	None	0	Human	Functional	pEC50	=	7.6	7.6	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	166	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	162653458	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183772	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10465263	64353	None	37	Human	Functional	pEC50	=	6.6	6.6	-19	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64353	None	37	Human	Functional	pEC50	=	6.6	6.6	-19	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL4783435	216557	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803467	216557	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	162645074	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183730	None	0	Human	Functional	pEC50	=	5.6	5.6	-177	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4783435	216557	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803467	216557	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	50942111	56863	None	0	Human	Functional	pEC50	=	5.6	5.6	-27	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56863	None	0	Human	Functional	pEC50	=	5.6	5.6	-27	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	23652278	62651	None	11	Human	Functional	pEC50	=	6.6	6.6	-16	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62651	None	11	Human	Functional	pEC50	=	6.6	6.6	-16	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53325938	56822	None	0	Human	Functional	pEC50	=	5.6	5.6	-32	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56822	None	0	Human	Functional	pEC50	=	5.6	5.6	-32	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	168294447	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5206761	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222789	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	9794638	120853	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	CHEMBL355474	120853	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	168294447	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5206761	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222789	193125	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	2	3	3	3.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	166	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	7.6	7.6	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	50878551	90779	None	28	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90779	None	28	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	72197485	102544	None	0	Human	Functional	pEC50	=	7.6	7.6	1	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393244	102544	None	0	Human	Functional	pEC50	=	7.6	7.6	1	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040288	102544	None	0	Human	Functional	pEC50	=	7.6	7.6	1	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	168294430	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	5031728	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5191733	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222389	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	168294430	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193116	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	5031728	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5191733	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222389	193054	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	5202	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	DB08839	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-15	26	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.4c00058
	20976025	141174	None	29	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2014.07.062
	CHEMBL382635	141174	None	29	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2014.07.062
	146464681	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183463	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221759	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	146464681	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183463	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221759	192958	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	2	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	168295067	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295067	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193131	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	172469352	197023	None	0	Human	Functional	pEC50	=	5.5	5.5	-288	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5437030	197023	None	0	Human	Functional	pEC50	=	5.5	5.5	-288	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	168295538	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	168295538	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193148	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	145966293	164549	None	0	Human	Functional	pEC50	=	5.5	5.5	-85	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164549	None	0	Human	Functional	pEC50	=	5.5	5.5	-85	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	172469352	197023	None	0	Human	Functional	pEC50	=	5.5	5.5	-288	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5437030	197023	None	0	Human	Functional	pEC50	=	5.5	5.5	-288	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	16115652	83524	None	0	Human	Functional	pEC50	=	6.5	6.5	-26	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83524	None	0	Human	Functional	pEC50	=	6.5	6.5	-26	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	1355	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-4	6	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	72197309	102553	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL2393234	102553	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	CHEMBL3040350	102553	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	318	4	1	6	0.8	CCN(CC)c1nc(N2CCN(C)CC2)nc2c1CCNCC2	10.1016/j.ejmech.2013.02.020
	162643473	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4764937	216556	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803300	216556	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	162643473	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183721	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162658689	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4764937	216556	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803300	216556	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	162658689	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183796	None	0	Human	Functional	pEC50	=	6.5	6.5	-47	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733826	120707	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416066	120707	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546874	120707	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	168941678	195526	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	242	2	1	2	2.9	COc1cccc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5405349	195526	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	242	2	1	2	2.9	COc1cccc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	53325937	56821	None	0	Human	Functional	pEC50	=	8.5	8.5	7	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56821	None	0	Human	Functional	pEC50	=	8.5	8.5	7	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	168293874	192288	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192288	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192288	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192288	None	0	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168941548	196083	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	233	1	2	2	2.6	Clc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5416604	196083	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	233	1	2	2	2.6	Clc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	168273228	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5178632	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221423	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	168941728	197186	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	228	2	2	2	2.6	COc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5440705	197186	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	228	2	2	2	2.6	COc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	168273228	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5178632	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221423	192908	None	0	Human	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44389646	64904	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64904	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	74405184	186162	None	8	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	230	6	1	1	3.4	CCCN(CC)CCc1c[nH]c2ccccc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4871007	186162	None	8	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	230	6	1	1	3.4	CCCN(CC)CCc1c[nH]c2ccccc12	10.1021/acsmedchemlett.1c00577
	168280365	191385	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5190617	191385	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	11658860	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-17	11	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-17	11	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-17	11	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-17	11	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-17	11	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	3288856	192922	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5176057	192922	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221496	192922	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL4749189	216551	None	26	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	216551	None	26	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	70683433	74484	None	0	Human	Functional	pEC50	=	5.5	5.5	-169	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74484	None	0	Human	Functional	pEC50	=	5.5	5.5	-169	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74484	None	0	Human	Functional	pEC50	=	5.5	5.5	-169	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	11499800	89141	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89141	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89141	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL4749189	216551	None	26	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	216551	None	26	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	45485742	200279	None	0	Human	Functional	pEC50	=	6.5	6.5	-30	3	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	200279	None	0	Human	Functional	pEC50	=	6.5	6.5	-30	3	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	24773651	154947	None	0	Human	Functional	pEC50	=	7.5	7.5	-5	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154947	None	0	Human	Functional	pEC50	=	7.5	7.5	-5	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	168292007	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	24773728	94913	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94913	None	0	Human	Functional	pEC50	=	6.5	6.5	-15	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	168292007	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	193097	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	44225654	187296	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assayAgonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL492301	187296	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assayAgonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	53321948	56820	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56820	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	44404886	72249	None	0	Human	Functional	pEC50	=	7.5	7.5	19	2	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL198124	72249	None	0	Human	Functional	pEC50	=	7.5	7.5	19	2	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	85542158	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	172444062	195485	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	CHEMBL5404610	195485	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	168941654	195567	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5406172	195567	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	85542158	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	5.5	5.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	168941654	195567	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5406172	195567	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	172444062	195485	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	CHEMBL5404610	195485	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	16115511	84871	None	0	Human	Functional	pEC50	=	5.5	5.5	-72	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84871	None	0	Human	Functional	pEC50	=	5.5	5.5	-72	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	44572207	12706	None	0	Human	Functional	pEC50	=	6.5	6.5	-25	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12706	None	0	Human	Functional	pEC50	=	6.5	6.5	-25	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12706	None	0	Human	Functional	pEC50	=	6.5	6.5	-25	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL4795286	216559	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	216559	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4795286	216559	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	216559	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168282202	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192993	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	25070582	61474	None	27	Dog	Functional	pEC50	=	5.5	5.5	-316	9	Agonist activity at 5HT2A receptor in dog femoral arteryAgonist activity at 5HT2A receptor in dog femoral artery	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61474	None	27	Dog	Functional	pEC50	=	5.5	5.5	-316	9	Agonist activity at 5HT2A receptor in dog femoral arteryAgonist activity at 5HT2A receptor in dog femoral artery	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	168289654	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168290156	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168289654	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	193068	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168290156	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	193074	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10624	70324	None	12	Human	Functional	pEC50	=	5.5	5.5	-46	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	10624.0	70324	None	12	Human	Functional	pEC50	=	5.5	5.5	-46	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70324	None	12	Human	Functional	pEC50	=	5.5	5.5	-46	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70324	None	12	Human	Functional	pEC50	=	5.5	5.5	-46	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	DB11664	70324	None	12	Human	Functional	pEC50	=	5.5	5.5	-46	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	10332474	59675	None	0	Human	Functional	pEC50	=	6.5	6.5	-1513	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL172159	59675	None	0	Human	Functional	pEC50	=	6.5	6.5	-1513	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	44572168	12488	None	0	Human	Functional	pEC50	=	6.5	6.5	-31	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12488	None	0	Human	Functional	pEC50	=	6.5	6.5	-31	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12488	None	0	Human	Functional	pEC50	=	6.5	6.5	-31	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	168295285	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5208963	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222859	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	162658803	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168295285	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5208963	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222859	193138	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	274	1	2	2	2.9	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	162658803	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183798	None	0	Human	Functional	pEC50	=	6.5	6.5	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	172456366	196390	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	274	2	2	1	4.2	C1=C(c2c[nH]c3cccc(-c4ccccc4)c23)CNCC1	10.1021/acsmedchemlett.3c00444
	CHEMBL5422786	196390	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	274	2	2	1	4.2	C1=C(c2c[nH]c3cccc(-c4ccccc4)c23)CNCC1	10.1021/acsmedchemlett.3c00444
	92042921	120734	None	0	Human	Functional	pEC50	=	6.5	6.5	-104	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416067	120734	None	0	Human	Functional	pEC50	=	6.5	6.5	-104	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546961	120734	None	0	Human	Functional	pEC50	=	6.5	6.5	-104	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	44572178	12565	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12565	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12565	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	122442309	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	3572096	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168274213	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	3572096	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	193007	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	122442309	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138434	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168274213	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192919	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	44316017	207910	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	207910	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	24826869	91136	None	0	Human	Functional	pEC50	=	7.4	7.4	-9	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91136	None	0	Human	Functional	pEC50	=	7.4	7.4	-9	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	162652937	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162652937	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183768	None	0	Human	Functional	pEC50	=	7.4	7.4	-22	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	164108	None	0	Human	Functional	pEC50	=	7.4	7.4	-194	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	164108	None	0	Human	Functional	pEC50	=	7.4	7.4	-194	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	16115269	138216	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138216	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	168280142	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	168280142	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192970	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	172448061	195947	None	0	Human	Functional	pEC50	=	6.4	6.4	-39	2	Agonist activity at N-terminal HA-tagged human 5HT2A receptorAgonist activity at N-terminal HA-tagged human 5HT2A receptor	ChEMBL	233	5	2	3	2.2	NC[C@@H]1C[C@@H]1c1cc(O)ccc1OCC1CC1	10.1016/j.bmcl.2024.129654
	CHEMBL5413973	195947	None	0	Human	Functional	pEC50	=	6.4	6.4	-39	2	Agonist activity at N-terminal HA-tagged human 5HT2A receptorAgonist activity at N-terminal HA-tagged human 5HT2A receptor	ChEMBL	233	5	2	3	2.2	NC[C@@H]1C[C@@H]1c1cc(O)ccc1OCC1CC1	10.1016/j.bmcl.2024.129654
	16115644	137047	None	0	Human	Functional	pEC50	=	6.4	6.4	-21	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	137047	None	0	Human	Functional	pEC50	=	6.4	6.4	-21	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	92042919	120731	None	0	Human	Functional	pEC50	=	6.4	6.4	-89	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416063	120731	None	0	Human	Functional	pEC50	=	6.4	6.4	-89	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546958	120731	None	0	Human	Functional	pEC50	=	6.4	6.4	-89	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44316027	207980	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	207980	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	122442263	138444	None	0	Human	Functional	pEC50	=	7.4	7.4	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	7.4	7.4	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	7.4	7.4	-15	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	6092	114363	None	7	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	4	2	1	2.3	CCNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330640	114363	None	7	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	188	4	2	1	2.3	CCNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	24826788	91132	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397893	91132	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162659286	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	162665030	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168280026	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	4407909	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4407909	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192975	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	168280026	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192967	None	0	Human	Functional	pEC50	=	6.4	6.4	10	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	162665030	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183833	None	0	Human	Functional	pEC50	=	6.4	6.4	-38	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162659286	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-12	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	57888255	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183371	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221840	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	57888255	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183371	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221840	192966	None	0	Human	Functional	pEC50	=	6.4	6.4	19	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	234	1	2	1	3.4	CCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	77379	19053	None	44	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1288716	19053	None	44	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	11291	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	11291	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	4980	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acs.jnatprod.9b01061
	854024	140647	None	46	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cc(F)ccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL381160	140647	None	46	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2cc(F)ccc12	10.1016/j.bmcl.2014.07.062
	53317923	56862	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56862	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	44412389	78125	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78125	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	172445742	197396	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	239	0	1	3	2.6	Cc1cc2nc3c(nc2cc1C)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	CHEMBL5394878	197396	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	239	0	1	3	2.6	Cc1cc2nc3c(nc2cc1C)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	CHEMBL5498883	197396	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	239	0	1	3	2.6	Cc1cc2nc3c(nc2cc1C)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	166	3359	None	19	Human	Functional	pEC50	=	6.4	6.4	-36	5	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3359	None	19	Human	Functional	pEC50	=	6.4	6.4	-36	5	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	6.4	6.4	-36	5	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	118733774	120714	None	0	Human	Functional	pEC50	=	5.4	5.4	-43	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120714	None	0	Human	Functional	pEC50	=	5.4	5.4	-43	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120714	None	0	Human	Functional	pEC50	=	5.4	5.4	-43	3	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	4239160	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5177505	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221421	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	4239160	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5177505	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221421	192907	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	2	1	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	5132936	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	5132936	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192942	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	44626357	200008	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570274	200008	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	164513426	195281	None	0	Human	Functional	pEC50	=	7.4	7.4	4	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	2	2	2.2	C[C@@H]1C=C(c2c[nH]c3ncccc23)CNC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5399968	195281	None	0	Human	Functional	pEC50	=	7.4	7.4	4	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	2	2	2.2	C[C@@H]1C=C(c2c[nH]c3ncccc23)CNC1	10.1021/acsmedchemlett.3c00566
	44412403	77827	None	0	Human	Functional	pEC50	=	6.4	6.4	-7	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77827	None	0	Human	Functional	pEC50	=	6.4	6.4	-7	3	Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	10015414	63505	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63505	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	107992	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	122461993	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	107992	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	33	Human	Functional	pEC50	=	6.4	6.4	-6	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	122461993	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138446	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	18735305	207391	None	0	Human	Functional	pEC50	=	6.4	6.4	-19	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	207391	None	0	Human	Functional	pEC50	=	6.4	6.4	-19	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	122442254	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572798	12654	None	1	Human	Functional	pEC50	=	6.4	6.4	-131	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12654	None	1	Human	Functional	pEC50	=	6.4	6.4	-131	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12654	None	1	Human	Functional	pEC50	=	6.4	6.4	-131	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	122442254	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.4	6.4	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122180976	121856	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	CHEMBL3589597	121856	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	379	8	1	4	3.8	COc1cccc(CNCCc2cc(OC)c(Br)cc2OC)c1	10.1021/acs.jmedchem.2c00702
	26714	75818	None	43	Human	Functional	pEC50	=	7.4	7.4	89	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL1522572	75818	None	43	Human	Functional	pEC50	=	7.4	7.4	89	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL204839	75818	None	43	Human	Functional	pEC50	=	7.4	7.4	89	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	46830177	8063	None	22	Human	Functional	pEC50	=	6.4	6.4	-190	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091105	8063	None	22	Human	Functional	pEC50	=	6.4	6.4	-190	2	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12518	None	0	Human	Functional	pEC50	=	5.4	5.4	-58	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12518	None	0	Human	Functional	pEC50	=	5.4	5.4	-58	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12518	None	0	Human	Functional	pEC50	=	5.4	5.4	-58	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	11231392	84928	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84928	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168280082	191302	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5189232	191302	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	340	7	1	6	2.6	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	168279029	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	162657053	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	162657053	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183787	None	0	Human	Functional	pEC50	=	6.3	6.3	-38	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168279029	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192963	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	122442254	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-33	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572176	12564	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12564	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12564	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	168941519	195345	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	231	1	1	2	2.4	CN1CCC=C(c2n[nH]c3cc(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5401711	195345	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	231	1	1	2	2.4	CN1CCC=C(c2n[nH]c3cc(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	11313985	91117	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91117	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL4802921	216554	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	122180977	121857	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL3589598	121857	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	365	7	2	4	3.5	COc1cc(CCNCc2cccc(O)c2)c(OC)cc1Br	10.1021/acs.jmedchem.2c00702
	CHEMBL4802921	216554	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442272	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442272	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138435	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	17087	114367	None	31	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	CHEMBL3330644	114367	None	31	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	190	3	2	2	1.7	COc1cccc2c(CCN)c[nH]c12	10.1016/j.bmcl.2014.07.062
	77158	19054	None	38	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1288717	19054	None	38	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2014.07.062
	156836218	188711	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL4877402	188711	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	CHEMBL5028990	188711	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	248	6	1	1	3.6	CCCN(CC)CCc1c[nH]c2ccc(F)cc12	10.1021/acsmedchemlett.1c00577
	5	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	166	3359	None	19	Human	Functional	pEC50	=	7.3	7.3	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3359	None	19	Human	Functional	pEC50	=	7.3	7.3	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	7.3	7.3	-36	5	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	6088	119906	None	24	Human	Functional	pEC50	=	7.3	7.3	100	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	CHEMBL348588	119906	None	24	Human	Functional	pEC50	=	7.3	7.3	100	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1016/j.bmcl.2014.07.062
	46884138	8445	None	0	Human	Functional	pEC50	=	6.3	6.3	-100	3	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8445	None	0	Human	Functional	pEC50	=	6.3	6.3	-100	3	Agonist activity at 5HT2A receptorAgonist activity at 5HT2A receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	10331841	169307	None	5	Human	Functional	pEC50	=	6.3	6.3	-46	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169307	None	5	Human	Functional	pEC50	=	6.3	6.3	-46	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	44572810	12659	None	0	Human	Functional	pEC50	=	6.3	6.3	-95	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12659	None	0	Human	Functional	pEC50	=	6.3	6.3	-95	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12659	None	0	Human	Functional	pEC50	=	6.3	6.3	-95	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	44572170	12469	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12469	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12469	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	168291896	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4752798	216552	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	216552	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4752798	216552	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	216552	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	169307	None	5	Human	Functional	pEC50	=	6.3	6.3	-46	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169307	None	5	Human	Functional	pEC50	=	6.3	6.3	-46	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168282109	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442270	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11209786	137327	None	0	Human	Functional	pEC50	=	6.3	6.3	-36	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137327	None	0	Human	Functional	pEC50	=	6.3	6.3	-36	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	44572761	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	168282109	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192992	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	53321865	56864	None	0	Human	Functional	pEC50	=	5.3	5.3	-138	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56864	None	0	Human	Functional	pEC50	=	5.3	5.3	-138	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	168291896	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	193094	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168941548	196083	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	233	1	2	2	2.6	Clc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5416604	196083	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	233	1	2	2	2.6	Clc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	11151653	91135	None	0	Human	Functional	pEC50	=	7.3	7.3	-6	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91135	None	0	Human	Functional	pEC50	=	7.3	7.3	-6	3	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	168290300	192095	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5201317	192095	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay	ChEMBL	314	7	1	4	3.0	COc1cc(CCNCc2ccccc2F)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	134265620	164501	None	0	Human	Functional	pEC50	=	7.3	7.3	-426	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164501	None	0	Human	Functional	pEC50	=	7.3	7.3	-426	3	Agonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	168941715	196900	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5434434	196900	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	168291130	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168941715	196900	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5434434	196900	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2A receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	168291130	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	193085	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	157292621	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	157292621	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	44573014	12525	None	0	Human	Functional	pEC50	=	6.3	6.3	-13	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12525	None	0	Human	Functional	pEC50	=	6.3	6.3	-13	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12525	None	0	Human	Functional	pEC50	=	6.3	6.3	-13	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	14515725	87344	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87344	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	14515725	87344	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87344	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	16115271	79139	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79139	None	0	Human	Functional	pEC50	=	7.3	7.3	-5	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	4543677	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192899	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168268706	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	46228430	202194	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	202194	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44573018	12648	None	0	Human	Functional	pEC50	=	6.2	6.2	-64	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12648	None	0	Human	Functional	pEC50	=	6.2	6.2	-64	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12648	None	0	Human	Functional	pEC50	=	6.2	6.2	-64	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	168268706	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192866	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	162676555	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	44572802	12448	None	1	Human	Functional	pEC50	=	6.2	6.2	-123	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12448	None	1	Human	Functional	pEC50	=	6.2	6.2	-123	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12448	None	1	Human	Functional	pEC50	=	6.2	6.2	-123	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	53324629	56815	None	0	Human	Functional	pEC50	=	6.2	6.2	4	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56815	None	0	Human	Functional	pEC50	=	6.2	6.2	4	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	162676555	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183895	None	0	Human	Functional	pEC50	=	6.2	6.2	-22	2	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	172466550	196777	None	0	Human	Functional	pEC50	=	6.2	6.2	-25	3	Agonist activity at 5-HT2A (unknown origin)Agonist activity at 5-HT2A (unknown origin)	ChEMBL	271	0	2	2	3.5	Oc1cc2c3c(c1Cl)-c1ccccc1CC3NCC2	10.1016/j.ejmech.2023.115414
	CHEMBL5432040	196777	None	0	Human	Functional	pEC50	=	6.2	6.2	-25	3	Agonist activity at 5-HT2A (unknown origin)Agonist activity at 5-HT2A (unknown origin)	ChEMBL	271	0	2	2	3.5	Oc1cc2c3c(c1Cl)-c1ccccc1CC3NCC2	10.1016/j.ejmech.2023.115414
	168275014	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	15760	113142	None	27	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL331241	113142	None	27	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	10.1016/j.bmcl.2014.07.062
	72197484	102549	None	0	Human	Functional	pEC50	=	8.2	8.2	1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102549	None	0	Human	Functional	pEC50	=	8.2	8.2	1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102549	None	0	Human	Functional	pEC50	=	8.2	8.2	1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	12833	67682	None	11	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	208	2	2	1	2.7	CC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL1906905	67682	None	11	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	208	2	2	1	2.7	CC(N)Cc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2014.07.062
	72197486	102558	None	0	Human	Functional	pEC50	=	8.2	8.2	1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102558	None	0	Human	Functional	pEC50	=	8.2	8.2	1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102558	None	0	Human	Functional	pEC50	=	8.2	8.2	1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	11291	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	4980	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.2c00129
	11291	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	4980	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	8.2	8.2	-2	4	Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayAgonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00577
	152743520	190088	None	1	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5170895	190088	None	1	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	326	8	1	5	2.9	COc1cc(CCNCc2ccccc2OC)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	172467300	196796	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptorAgonist activity at human 5HT2A receptor	ChEMBL	251	2	1	2	3.1	CC1(C)Cc2cc(Cl)cc([C@H]3C[C@H]3CN)c2O1	10.1016/j.bmcl.2024.129654
	CHEMBL5432430	196796	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptorAgonist activity at human 5HT2A receptor	ChEMBL	251	2	1	2	3.1	CC1(C)Cc2cc(Cl)cc([C@H]3C[C@H]3CN)c2O1	10.1016/j.bmcl.2024.129654
	18735313	207392	None	1	Human	Functional	pEC50	=	6.2	6.2	-93	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	207392	None	1	Human	Functional	pEC50	=	6.2	6.2	-93	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	168275014	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192929	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	11493484	89104	None	0	Human	Functional	pEC50	=	6.2	6.2	-141	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89104	None	0	Human	Functional	pEC50	=	6.2	6.2	-141	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89104	None	0	Human	Functional	pEC50	=	6.2	6.2	-141	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11666237	89146	None	0	Human	Functional	pEC50	=	6.2	6.2	-35	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89146	None	0	Human	Functional	pEC50	=	6.2	6.2	-35	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89146	None	0	Human	Functional	pEC50	=	6.2	6.2	-35	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	10064386	63337	None	2	Human	Functional	pEC50	=	7.2	7.2	-30	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63337	None	2	Human	Functional	pEC50	=	7.2	7.2	-30	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	168941678	195526	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	242	2	1	2	2.9	COc1cccc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5405349	195526	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	242	2	1	2	2.9	COc1cccc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	44572806	12658	None	0	Human	Functional	pEC50	=	6.2	6.2	-38	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12658	None	0	Human	Functional	pEC50	=	6.2	6.2	-38	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12658	None	0	Human	Functional	pEC50	=	6.2	6.2	-38	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11658860	2344	None	24	Human	Functional	pEC50	=	6.2	6.2	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2344	None	24	Human	Functional	pEC50	=	6.2	6.2	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2344	None	24	Human	Functional	pEC50	=	6.2	6.2	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.2	6.2	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.2	6.2	-17	11	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	146025684	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	9859257	207581	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	207581	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	11695000	89105	None	0	Human	Functional	pEC50	=	7.2	7.2	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89105	None	0	Human	Functional	pEC50	=	7.2	7.2	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89105	None	0	Human	Functional	pEC50	=	7.2	7.2	-17	3	Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	53323196	56865	None	0	Human	Functional	pEC50	=	7.2	7.2	3	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56865	None	0	Human	Functional	pEC50	=	7.2	7.2	3	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	11777150	62625	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62625	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	1355	2011	None	45	Human	Functional	pEC50	=	7.2	7.2	-4	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	2011	None	45	Human	Functional	pEC50	=	7.2	7.2	-4	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	7.2	7.2	-4	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	2011	None	45	Human	Functional	pEC50	=	7.2	7.2	-4	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	10036629	64658	None	0	Human	Functional	pEC50	=	7.2	7.2	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64658	None	0	Human	Functional	pEC50	=	7.2	7.2	-7	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	9990808	122838	None	0	Human	Functional	pEC50	=	7.2	7.2	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122838	None	0	Human	Functional	pEC50	=	7.2	7.2	-10	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	11949710	202358	None	0	Human	Functional	pEC50	=	6.2	6.2	-67	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	202358	None	0	Human	Functional	pEC50	=	6.2	6.2	-67	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	146025684	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183741	None	0	Human	Functional	pEC50	=	6.2	6.2	-14	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168276822	190232	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5173321	190232	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	324	6	1	5	2.8	COc1cc(CCNC2COc3ccccc32)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	44404883	72086	None	24	Human	Functional	pEC50	=	6.2	6.2	-21	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197664	72086	None	24	Human	Functional	pEC50	=	6.2	6.2	-21	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	24826790	91128	None	0	Human	Functional	pEC50	=	7.2	7.2	-12	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397889	91128	None	0	Human	Functional	pEC50	=	7.2	7.2	-12	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	57888169	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	57888169	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	193016	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	172460365	197485	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	279	0	1	3	3.3	Clc1cc2nc3c(nc2cc1Cl)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	CHEMBL5418999	197485	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	279	0	1	3	3.3	Clc1cc2nc3c(nc2cc1Cl)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	CHEMBL5499631	197485	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assayAgonist activity at 5-HT2A receptor in HEK293 cells assessed as calcium mobilisation by Fluo-4 dye based assay	ChEMBL	279	0	1	3	3.3	Clc1cc2nc3c(nc2cc1Cl)[C@@H]1CCC(C3)N1	10.1021/acs.jmedchem.3c01059
	143111395	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177927	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221502	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442300	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	143111395	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177927	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221502	192924	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	248	2	2	1	3.8	CCCC1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	53324630	56819	None	0	Human	Functional	pEC50	=	6.2	6.2	-128	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56819	None	0	Human	Functional	pEC50	=	6.2	6.2	-128	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	45485725	200283	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	200283	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	168941537	196049	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	240	2	2	1	3.7	CC(C)c1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5415797	196049	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	240	2	2	1	3.7	CC(C)c1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	122442300	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168941653	196860	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	264	1	1	1	3.7	CN1CCC=C(c2c[nH]c3c(Cl)c(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	CHEMBL5433583	196860	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	264	1	1	1	3.7	CN1CCC=C(c2c[nH]c3c(Cl)c(F)ccc23)C1	10.1021/acsmedchemlett.3c00444
	44572751	12503	None	0	Human	Functional	pEC50	=	7.2	7.2	-87	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12503	None	0	Human	Functional	pEC50	=	7.2	7.2	-87	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12503	None	0	Human	Functional	pEC50	=	7.2	7.2	-87	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	122442286	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	25070582	61474	None	27	Human	Functional	pEC50	=	7.2	7.2	-6	9	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61474	None	27	Human	Functional	pEC50	=	7.2	7.2	-6	9	Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	122442286	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168941564	195265	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5399727	195265	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	217	1	2	2	2.1	Fc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	72197311	102546	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393236	102546	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040299	102546	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	2	1	7	0.5	CN1CCN(c2nc3c(c(N4CCSCC4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	118733820	120730	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416062	120730	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546957	120730	None	0	Human	Functional	pEC50	=	6.2	6.2	-4	2	Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL5078999	217086	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay	ChEMBL		None	None	None		COc1ccc2[nH]cc(CCN3CCC3)c2c1	10.1021/acsmedchemlett.2c00129
	168941463	196635	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	232	1	2	1	3.2	Clc1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5428466	196635	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	232	1	2	1	3.2	Clc1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	168941766	197177	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	251	1	2	2	2.7	Fc1ccc(Cl)c2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5440436	197177	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	251	1	2	2	2.7	Fc1ccc(Cl)c2[nH]nc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	1355	2011	None	45	Human	Functional	pEC50	=	8.1	8.1	-4	6	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	142	2011	None	45	Human	Functional	pEC50	=	8.1	8.1	-4	6	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	8.1	8.1	-4	6	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	DB12110	2011	None	45	Human	Functional	pEC50	=	8.1	8.1	-4	6	Agonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2013.02.020
	1043	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	149	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	8223	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	8223.0	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	CHEMBL442	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	DB00696	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	1150	3878	None	72	Human	Functional	pEC50	=	8.1	8.1	41	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	125	3878	None	72	Human	Functional	pEC50	=	8.1	8.1	41	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	CHEMBL6640	3878	None	72	Human	Functional	pEC50	=	8.1	8.1	41	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	DB08653	3878	None	72	Human	Functional	pEC50	=	8.1	8.1	41	3	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.bmcl.2014.07.062
	5	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-15	26	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	1043	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	149	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	8223	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	8223.0	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	CHEMBL442	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	DB00696	1582	None	6	Human	Functional	pEC50	=	8.1	8.1	-54	22	Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assayAgonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1021/acsmedchemlett.4c00058
	46228437	202440	None	1	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	202440	None	1	Human	Functional	pEC50	=	7.2	7.2	-6	3	Agonist activity against human 5HT2A receptor by FLIPR assayAgonist activity against human 5HT2A receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	5	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-15	26	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-15	26	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-15	26	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-15	26	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	46230098	201785	None	0	Human	Functional	pEC50	=	7.2	7.2	-34	4	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	201785	None	0	Human	Functional	pEC50	=	7.2	7.2	-34	4	Agonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	24826786	91120	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397881	91120	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Agonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2A receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	168941728	197186	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	228	2	2	2	2.6	COc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5440705	197186	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	228	2	2	2	2.6	COc1cccc2[nH]cc(C3=CCCNC3)c12	10.1021/acsmedchemlett.3c00444
	168	3982	None	15	Human	Functional	pEC50	=	6.1	6.1	-66	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3982	None	15	Human	Functional	pEC50	=	6.1	6.1	-66	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3982	None	15	Human	Functional	pEC50	=	6.1	6.1	-66	5	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	168291564	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122838	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122838	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	168291564	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	193092	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168941538	195747	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	243	2	1	3	2.3	COc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5410020	195747	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assayAgonist activity at 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with RLuc-fused Galphaq/GFP2/Gy9/Gbeta3 assessed as Gaq hetero trimeric G protein activation incubated for 30 mins using coelenterazine 400a as a substrate by BRET assay	ChEMBL	243	2	1	3	2.3	COc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	4305260	191134	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191134	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	4305260	191134	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191134	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	44572174	12551	None	0	Human	Functional	pEC50	=	6.1	6.1	-208	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12551	None	0	Human	Functional	pEC50	=	6.1	6.1	-208	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12551	None	0	Human	Functional	pEC50	=	6.1	6.1	-208	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	168941537	196049	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	240	2	2	1	3.7	CC(C)c1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5415797	196049	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	240	2	2	1	3.7	CC(C)c1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	168941538	195747	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	243	2	1	3	2.3	COc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5410020	195747	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	243	2	1	3	2.3	COc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	168286640	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168286640	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162652983	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183769	None	0	Human	Functional	pEC50	=	6.1	6.1	-37	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	1355	2011	None	45	Human	Functional	pEC50	=	7.1	7.1	-4	6	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	142	2011	None	45	Human	Functional	pEC50	=	7.1	7.1	-4	6	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	7.1	7.1	-4	6	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	DB12110	2011	None	45	Human	Functional	pEC50	=	7.1	7.1	-4	6	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	190006	114365	None	15	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	CHEMBL3330642	114365	None	15	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	174	2	2	1	2.0	Cc1ccc2c(CCN)c[nH]c2c1	10.1016/j.bmcl.2014.07.062
	9901086	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL4743049	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	162658153	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183791	None	0	Human	Functional	pEC50	=	6.1	6.1	-28	3	Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	9901086	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL4743049	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187737	None	28	Human	Functional	pEC50	=	7.1	7.1	-95	6	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	11264955	207419	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	207419	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	53317925	56868	None	0	Human	Functional	pEC50	=	6.1	6.1	-91	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56868	None	0	Human	Functional	pEC50	=	6.1	6.1	-91	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	168941703	196195	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	227	1	1	2	2.6	Cc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	CHEMBL5418595	196195	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	227	1	1	2	2.6	Cc1ccnc2[nH]cc(C3=CCCN(C)C3)c12	10.1021/acsmedchemlett.3c00444
	122442251	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	72197668	102550	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393246	102550	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040325	102550	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	7	Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	44572164	12687	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12687	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12687	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	168291006	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	168291006	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	193084	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	122442251	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	6.1	6.1	-47	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	53325936	56818	None	0	Human	Functional	pEC50	=	5.1	5.1	-436	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56818	None	0	Human	Functional	pEC50	=	5.1	5.1	-436	3	Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	16115381	83476	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83476	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	168941463	196635	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	232	1	2	1	3.2	Clc1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	CHEMBL5428466	196635	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assayAgonist activity at RLuc-fused 5-HT2A (unknown origin) expressed in HEK293T cells co-transfected with mVenus-fused beta arrestin-2/GRK2 assessed as beta arrestin-2 recruitment incubated for 30 mins using coelenterazine h as a substrate by BRET assay	ChEMBL	232	1	2	1	3.2	Clc1ccc2[nH]cc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00444
	168277089	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179053	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221673	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	168277089	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179053	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221673	192948	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	3	4	1.8	Cn1ccnc1C1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	20026449	87340	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87340	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	11264345	130467	None	3	Human	Functional	pEC50	=	6.1	6.1	-38	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130467	None	3	Human	Functional	pEC50	=	6.1	6.1	-38	3	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442275	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	20026449	87340	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87340	None	1	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	3549735	192316	None	0	Human	Functional	pEC50	=	5.1	5.1	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192316	None	0	Human	Functional	pEC50	=	5.1	5.1	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442275	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138448	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168268877	190079	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	190079	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	14107683	178231	None	20	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178231	None	20	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	168268877	190079	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	190079	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	14107683	178231	None	20	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	CHEMBL4648350	178231	None	20	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assayAgonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay	ChEMBL	190	3	3	2	1.6	CNCCc1c[nH]c2cccc(O)c12	10.1021/acs.jnatprod.9b01061
	12834	210385	None	21	Human	Functional	pEC50	=	8.1	8.1	18	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	CHEMBL96816	210385	None	21	Human	Functional	pEC50	=	8.1	8.1	18	2	Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayAgonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2014.07.062
	90489020	190982	None	8	Human	Functional	pEC50	=	8.1	8.1	14	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	CHEMBL5184791	190982	None	8	Human	Functional	pEC50	=	8.1	8.1	14	2	Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayAgonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay	ChEMBL	312	7	2	5	2.6	COc1cc(CCNCc2ccccc2O)c(OC)cc1C#N	10.1021/acs.jmedchem.2c00702
	9881885	64130	None	0	Human	Functional	pEC50	=	7.1	7.1	-15	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64130	None	0	Human	Functional	pEC50	=	7.1	7.1	-15	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44389645	64202	None	0	Human	Functional	pEC50	=	7.1	7.1	-26	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64202	None	0	Human	Functional	pEC50	=	7.1	7.1	-26	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10036629	64658	None	0	Human	Functional	pEC50	=	7.1	7.1	-7	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64658	None	0	Human	Functional	pEC50	=	7.1	7.1	-7	3	Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	146464686	192106	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201492	192106	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	3549735	192316	None	0	Human	Functional	pEC50	=	5.1	5.1	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192316	None	0	Human	Functional	pEC50	=	5.1	5.1	-6	2	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	3356430	193155	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193155	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193155	None	0	Human	Functional	pEC50	=

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Ligand source activities (1 row/activity)