GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3562	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3562	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3562	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3562	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11693	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1827	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	367	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3824	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	3775	14475	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14475	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	2348	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2136	3095	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5280343	188275	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	188275	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	188275	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	2247	505	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4614	5391	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	CHEMBL1071	5391	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	47936	193422	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193422	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	180	401	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4940	14470	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14470	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	5573	67581	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1325297	67581	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL190044	67581	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	4919	206234	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206234	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3316	31760	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31760	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	21109	74999	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL203266	74999	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	26248	161539	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161539	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	4413	98073	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98073	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	9429	202133	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202133	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3658	4107	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2220	3134	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	68873	43564	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43564	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	443955	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	21158560	112793	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL3305985	112793	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL5292015	194537	0	None	-29	5	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	41684	31221	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31221	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4477	36536	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	36536	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	5284550	41721	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41721	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	3149	12614	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12614	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2333	142335	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2713	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205271	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	154257	178619	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	68617	205527	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205527	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205527	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	216416	111581	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111581	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	5048	3133	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	8924	3133	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102	3133	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL462605	3133	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB11642	3133	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	107771	120248	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120248	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	5803	162227	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162227	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	6127	14499	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14499	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	35061	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	20628	96548	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96548	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	447715	196927	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	196927	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1024	1571	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1571	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1571	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1571	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1571	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	13314	84233	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	84233	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	4450	178228	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178228	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	2335	11848	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	1816	2540	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4976	203579	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203579	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	46780481	107531	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	5210	33338	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33338	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33338	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	47936	193422	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193422	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	1530	2182	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1971	2866	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3000322	3562	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3562	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3562	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3562	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3108	207287	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207287	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	13789	38377	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL1463345	38377	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	26987	949	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	213046	2385	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	43815	186920	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186920	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186920	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	3081361	93934	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	100	3805	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1056	3371	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	60753	194684	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194684	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	187	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2131	57407	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	57407	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	3236	67609	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67609	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	4832	55420	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1619528	55420	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	2705	3842	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3842	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3842	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3842	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3842	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	124	2981	47	None	-11481	24	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	47	None	-11481	24	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	47	None	-11481	24	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	47	None	-11481	24	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	47	None	-11481	24	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2402	3370	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10184653	10997	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	10997	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	127151	35330	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	3022645	35330	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL14370	35330	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	19675	51670	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51670	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3949	100614	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100614	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	54697325	58979	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58979	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	25382	9157	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9157	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	3158	56267	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56267	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1210	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5833	30484	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30484	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	2165	203783	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203783	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203783	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	2564	206184	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL864	206184	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16363	596	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	10133	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	910	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	60606	61560	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2726	919	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2333	142335	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2895	203592	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203592	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	31101	729	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	131411	15392	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15392	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15392	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	5591	157531	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157531	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2905	14498	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14498	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	8612	11260	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1179047	11260	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	2381	663	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	374	663	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7128	663	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1101	663	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00810	663	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	123603	883	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684	883	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	584	883	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	9658	883	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	CHEMBL168815	883	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	23480	124090	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124090	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	2286	3183	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2551	794	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	794	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	794	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	794	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	794	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4942	5718	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5718	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398745	2914	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2166	3123	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3123	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3123	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3123	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3123	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2370	623	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	297	623	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	358	623	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	CHEMBL1482	623	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	DB01019	623	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	319	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	6450551	19211	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL1289926	19211	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	1427	2013	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2200	3131	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3131	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3131	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3131	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3131	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	2540	4401	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4401	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	124087	1389	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2995	204405	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204405	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204405	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4746	204891	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204891	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204891	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	11504295	2923	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2583	3776	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4153	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1224	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	5453	203619	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203619	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	3652	4097	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4097	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4097	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4097	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4097	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	135	2532	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	5284632	67402	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67402	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67402	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	154417	23181	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23181	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2470	3653	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	71496458	115564	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115564	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	657202	12530	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12530	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	54682461	84686	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84686	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	154257	178619	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	1385580	29276	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29276	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29276	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16351	102730	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102730	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4066	204626	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4642	41986	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	41986	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2774	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3868	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	135398737	958	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10798	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10798	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	207523	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207523	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4150	788	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	3294	2006	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2337	3256	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3042	1414	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	1201549	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24821094	67094	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67094	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	636403	188268	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188268	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	2267	559	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	129456	207172	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207172	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	10104167	2059	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2059	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2059	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	42599070	16078	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223804	16078	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	137630848	161116	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161116	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161116	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	10386	161168	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161168	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161168	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	2230	465	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	296	465	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	CHEMBL7303	465	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	DB04365	465	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	2551	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	298	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	488	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	CHEMBL965	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	DB00411	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	49799920	10542	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL1169506	10542	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	11120503	4195	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100163	4195	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	137629935	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44329977	111410	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL327269	111410	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	44589681	185288	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	CHEMBL485913	185288	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	22745278	187063	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	CHEMBL491209	187063	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	2551	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	298	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	488	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	CHEMBL965	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	DB00411	794	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	10104047	21637	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21637	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	137629935	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161020	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191002	123612	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	CHEMBL3618445	123612	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	170332	160976	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160976	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160976	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3652	4097	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	57	4097	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809	4097	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	CHEMBL21536	4097	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	DB15357	4097	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	44303017	200833	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	200833	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	42598829	16080	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223806	16080	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	45786849	157805	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157805	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	44330073	208430	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL99884	208430	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44209166	59556	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL171721	59556	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	44303408	201946	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	201946	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10451242	203114	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	203114	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	122189496	123336	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616500	123336	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	89777356	155882	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4060475	155882	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	53385782	74313	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	CHEMBL2024331	74313	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	424727	161174	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4095774	161174	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117601	161174	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	129456	207172	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207172	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	24967746	16055	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223754	16055	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9820835	116775	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL337676	116775	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	9927975	4189	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100147	4189	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	145973726	164630	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	CHEMBL4216213	164630	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	137629935	161020	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161020	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161020	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191003	123613	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618446	123613	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	137635723	156083	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4062934	156083	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	187	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	294	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	65	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	8593	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	CHEMBL667	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	DB03128	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	294	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	65	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	8593	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	CHEMBL667	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	DB03128	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	137630667	161092	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161092	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161092	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	57230548	173233	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524085	173233	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	44330080	107720	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL319109	107720	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303018	202023	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	202023	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137631026	161150	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161150	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161150	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	137628799	160993	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	160993	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	160993	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189499	123337	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	CHEMBL3616504	123337	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	10686494	100538	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	CHEMBL291351	100538	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	10686494	100538	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100538	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	122191007	123616	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618449	123616	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	42598357	16105	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223863	16105	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42598359	16106	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223864	16106	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25207745	16126	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223941	16126	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	89777060	157121	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4074908	157121	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	5487543	205646	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	205646	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	11725107	100613	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100613	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629887	161010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	161010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	161010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	10375002	24146	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL133905	24146	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	44158142	188670	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	CHEMBL503735	188670	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	5487543	205646	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	CHEMBL81878	205646	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	650899	54414	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1535797	54414	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1609153	54414	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	44158142	188670	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	CHEMBL503735	188670	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	57088082	173234	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524086	173234	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	53414666	159301	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159301	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	178030	21371	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	CHEMBL131428	21371	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	129456	207172	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207172	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	137629935	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	137629935	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161020	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191006	123615	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618448	123615	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	3652	4097	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4097	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4097	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4097	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4097	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	42598360	16104	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223862	16104	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	87934	98081	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL273308	98081	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL542883	98081	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	122191004	123333	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616497	123333	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	122191001	123611	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618444	123611	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	647412	27319	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	CHEMBL1367424	27319	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	137639541	156703	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156703	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	42598358	16102	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223860	16102	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	187	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44303293	201426	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	201426	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	53382542	86313	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86313	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	122191005	123614	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618447	123614	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	2551	794	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	794	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	794	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	794	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	794	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	10426487	2841	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	291	2841	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	CHEMBL99521	2841	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	306	3456	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	3536	3456	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	53930639	3456	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	9577995	3456	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	CHEMBL134641	3456	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	42598591	16077	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223803	16077	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599068	16079	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223805	16079	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25230693	16125	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223940	16125	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	16071018	16054	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL1223753	16054	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16038385	80458	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL2146598	80458	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16123945	80459	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	CHEMBL2146599	80459	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	170332	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3123	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	305	3123	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910	3123	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	CHEMBL550	3123	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	DB01085	3123	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	170332	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160976	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189495	123335	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616499	123335	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122191008	123617	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618450	123617	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303397	102288	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102288	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10104047	21637	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21637	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	10019339	102626	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102626	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	5441	2426	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	9893054	2426	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL3616501	2426	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	187	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	294	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	65	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	8593	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL667	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	DB03128	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	2551	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	298	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	488	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	CHEMBL965	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	DB00411	794	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	59654579	123607	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618440	123607	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122190994	123604	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618436	123604	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303294	201156	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	201156	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	170332	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44303286	201318	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	201318	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	44303286	201318	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	CHEMBL60419	201318	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	170332	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160976	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44253016	80457	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	CHEMBL2146597	80457	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	44303019	100946	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	100946	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	16071018	16054	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223753	16054	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	42598828	16103	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223861	16103	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599071	16124	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223939	16124	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9883040	100537	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100537	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100537	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44303396	201236	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	201236	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	118500	156999	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	156999	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	44303323	163242	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163242	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10104047	21637	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21637	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	71792	78406	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	CHEMBL2111051	78406	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	44303327	163011	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	163011	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	2551	794	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	794	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	794	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	794	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	794	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44330081	208163	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL98255	208163	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303314	100933	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100933	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629744	161175	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161175	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161175	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	644390	40412	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	CHEMBL1482157	40412	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	25010776	55955	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1559151	55955	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1624037	55955	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	137646732	157792	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4083081	157792	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	75356563	156957	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	156957	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	44372610	52543	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL159208	52543	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372301	49802	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL156749	49802	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372633	50308	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL157197	50308	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44372232	119820	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348412	119820	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	10058744	206382	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL87622	206382	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372253	50010	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156925	50010	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	9795428	96488	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	CHEMBL262455	96488	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	5487543	205646	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	205646	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10266025	120166	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL351561	120166	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372580	119781	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348079	119781	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372492	155724	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL405426	155724	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	794	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	298	794	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	488	794	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	CHEMBL965	794	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	DB00411	794	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	10420458	206268	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL86903	206268	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372591	54345	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160858	54345	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372290	54451	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160939	54451	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	794	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	794	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	794	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	794	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	794	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	44372254	53966	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL160554	53966	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10086044	48978	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL156050	48978	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9903828	119493	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345415	119493	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372506	119469	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345205	119469	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372278	49410	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156445	49410	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	44372277	168363	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL434469	168363	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10242016	168299	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL434072	168299	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372289	119476	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345250	119476	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44213237	101921	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101921	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44372647	120020	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL350223	120020	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44371814	51399	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL158180	51399	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372452	119623	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL346580	119623	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9913341	82158	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82158	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82158	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44590172	170318	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444688	170318	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL527216	170318	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590171	178748	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL468609	178748	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554632	178748	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590176	189065	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509614	189065	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555707	189065	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	155566290	176580	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176580	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176580	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11690968	106501	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085072	106501	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140185	106501	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44590179	172717	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450538	172717	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553446	172717	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590167	179024	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL471214	179024	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589495	185980	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486982	185980	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590122	192560	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL521244	192560	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16125400	84663	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84663	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76313456	106509	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085066	106509	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140216	106509	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	162675053	183258	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183258	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	71455968	83926	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206599	83926	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	10397133	107062	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL315676	107062	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71716773	86566	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86566	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	162353372	181387	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181387	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71463135	83934	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206607	83934	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71716773	86566	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86566	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	109018479	181818	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181818	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	76327901	103495	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085084	103495	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	44233675	103378	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084639	103378	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11518068	106506	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085059	106506	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140213	106506	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	44590180	172646	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL449640	172646	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540398	172646	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590175	188632	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL503025	188632	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553433	188632	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	52176747	159031	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159031	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	162353379	180962	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	180962	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	25034111	193418	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL526009	193418	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44590123	183860	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480877	183860	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034111	193418	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL526009	193418	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589497	175293	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL457302	175293	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44233417	86046	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2307674	86046	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10092649	193073	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193073	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	10092649	193073	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193073	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	290	2473	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	4022	2473	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	5926	2473	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL40554	2473	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL74300	2473	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	71450616	83933	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206606	83933	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	11503336	106514	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085071	106514	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140242	106514	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	76309756	103494	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085083	103494	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76313457	103491	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085080	103491	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	13940563	206030	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL8510	206030	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353393	179439	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179439	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	16664965	84902	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84902	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76320693	103493	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085082	103493	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	109035013	180475	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180475	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	76309755	103489	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085079	103489	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76320692	106508	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085065	106508	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140215	106508	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71459691	83932	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206605	83932	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	44590170	188371	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501348	188371	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553431	188371	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	109032820	182875	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182875	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	162353369	180795	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180795	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	44232953	103391	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084663	103391	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	15681301	120320	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL352832	120320	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	15945874	188765	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505452	188765	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	15945874	188765	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505452	188765	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589984	190558	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL518001	190558	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590035	191754	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL519760	191754	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034180	188412	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL502000	188412	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589571	172587	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448904	172587	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589570	172757	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL451040	172757	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10465524	58996	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL169011	58996	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161040	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161040	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161040	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161040	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137408729	190742	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5182783	190742	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	15681299	120479	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	CHEMBL354259	120479	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	156015978	178323	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178323	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178323	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10397356	120716	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL354738	120716	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161040	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161040	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161040	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161040	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162353388	180979	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	180979	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	71459689	83916	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206585	83916	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	168276820	190106	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190106	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190106	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	71454215	83925	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206595	83925	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	109013312	180134	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180134	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	162658112	181071	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181071	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	11602980	103502	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085091	103502	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	76324336	103497	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085086	103497	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	162353384	181090	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181090	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	71452455	83919	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206588	83919	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	44590125	183861	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480878	183861	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590036	188377	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501419	188377	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	152278786	182752	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182752	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162646559	179640	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4742997	179640	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	25034112	188393	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL501727	188393	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589585	188892	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507375	188892	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555474	188892	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590177	188922	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507874	188922	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554918	188922	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	163938	106918	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	CHEMBL314737	106918	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	152278786	182752	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182752	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162353375	179895	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	179895	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	10262405	57596	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166782	57596	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44234194	103396	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084670	103396	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10262466	98344	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98344	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	76324335	103492	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085081	103492	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10399393	205786	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL83074	205786	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	162658421	181101	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181101	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	156015807	178299	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178299	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178299	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76324334	106477	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085070	106477	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140112	106477	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	156015978	178323	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178323	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178323	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	138578683	184803	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	CHEMBL4851711	184803	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	44265375	206147	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	206147	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	162353386	180980	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	180980	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	44233189	103401	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084678	103401	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	162667844	182533	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182533	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44418764	82159	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82159	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	44590033	183678	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480299	183678	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590166	189416	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL513228	189416	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	76316970	103486	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085076	103486	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10220392	206005	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL84893	206005	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11508710	103500	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085089	103500	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	156493644	185062	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4855467	185062	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	156493614	185400	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4860985	185400	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	168272462	190164	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5173887	190164	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	137630050	161040	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161040	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161040	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161040	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	46830362	7894	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1090097	7894	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	76331543	103503	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085092	103503	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186228	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186228	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186228	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	9990434	106339	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL313918	106339	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44455159	97765	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL271704	97765	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	46682613	181156	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181156	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	162353378	182911	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	182911	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44590174	170057	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444300	170057	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL466271	170057	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590178	172738	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450781	172738	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540400	172738	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	11583262	106497	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085060	106497	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140181	106497	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156493565	184986	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4854289	184986	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	168276820	190106	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190106	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190106	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	10058347	105931	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL312823	105931	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71450615	83931	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206604	83931	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	11819427	57552	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166423	57552	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	47358375	180762	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180762	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	11584660	93268	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93268	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44590182	183151	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL479526	183151	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590034	189977	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL517087	189977	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094791	83257	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83257	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353374	180043	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180043	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	138578970	185667	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4864914	185667	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	71452456	83936	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206609	83936	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	122203596	155806	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155806	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155806	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137637944	155815	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4059829	155815	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	71450617	83937	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206610	83937	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	162353382	181734	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181734	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	11626847	106476	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085068	106476	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140111	106476	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	2551	794	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	298	794	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	488	794	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	CHEMBL965	794	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	DB00411	794	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	10092649	193073	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193073	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	44233419	103399	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084674	103399	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	10092649	193073	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193073	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	164606754	184702	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184702	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184702	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	138578253	186455	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4876599	186455	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	24882532	95117	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95117	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	137638270	156877	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	CHEMBL4071900	156877	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	137647734	157846	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4083681	157846	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	156016041	178247	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178247	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178247	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155806	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155806	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155806	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	76327903	103504	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085093	103504	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	69444105	103487	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085077	103487	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015807	178299	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178299	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178299	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137655063	158973	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096143	158973	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	11552174	103501	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085090	103501	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44589583	172481	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448294	172481	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555471	172481	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590168	172729	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450652	172729	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540399	172729	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589584	188779	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505651	188779	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540144	188779	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094788	141915	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	141915	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353381	180029	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180029	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	44589498	172758	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL451043	172758	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	10419574	58095	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL167438	58095	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76327900	106483	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085061	106483	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140142	106483	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71457771	83929	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206602	83929	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	76320694	103496	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085085	103496	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	71454213	83922	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206591	83922	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	71450662	84006	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207176	84006	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	162649767	180102	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180102	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	71452454	83918	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206587	83918	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	54816802	181272	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181272	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	10081053	57570	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166593	57570	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44233187	86025	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2306159	86025	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	76327902	103499	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085088	103499	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	164606754	184702	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184702	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184702	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	109035056	181323	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181323	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	11619198	106491	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085058	106491	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140170	106491	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015153	178307	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178307	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178307	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162353371	181650	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181650	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	16040727	169443	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL442672	169443	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL495102	169443	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590169	188243	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL499565	188243	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL539885	188243	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590181	173564	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL453248	173564	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL551113	173564	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034110	188766	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505453	188766	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	10376012	58733	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168561	58733	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76320690	106460	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085063	106460	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140092	106460	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	137654353	159016	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096589	159016	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	2986945	95055	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255169	95055	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	2904292	183580	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183580	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	15681300	57563	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166537	57563	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11510358	106484	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085069	106484	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140143	106484	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	58975257	103377	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084638	103377	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	36014865	182670	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182670	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	44233928	86074	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2308786	86074	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	71455969	83930	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206603	83930	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11547053	106465	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085074	106465	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140097	106465	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	71454217	83928	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206601	83928	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	109014373	179802	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179802	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	156016041	178247	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178247	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178247	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	71455966	83921	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206590	83921	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	52176747	159031	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159031	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	15681303	58990	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168991	58990	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44590173	189091	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL510029	189091	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555019	189091	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	156015153	178307	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178307	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178307	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11712408	106522	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085067	106522	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140261	106522	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	108993425	181758	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181758	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	168289751	191810	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	CHEMBL5198423	191810	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	2551	794	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	794	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	794	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	794	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	794	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	1201549	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	333	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	7601	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL1201203	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL438151	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	DB00245	597	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	44590124	169794	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL443925	169794	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	162657046	180843	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4757103	180843	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	76316969	106523	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085075	106523	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140262	106523	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	162353391	180821	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180821	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	76313454	106507	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085064	106507	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140214	106507	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186228	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186228	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186228	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	76309754	106521	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085062	106521	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140260	106521	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	1421986	8265	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1092461	8265	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	11442478	106478	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085073	106478	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140113	106478	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	10109893	82165	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82165	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82165	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	162353376	180427	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180427	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	11820032	98224	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98224	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353377	181165	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181165	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353390	180949	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	180949	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	162670602	182937	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	182937	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	133640439	181373	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181373	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	10240891	206098	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL85678	206098	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	16094783	136567	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136567	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44589496	185981	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486983	185981	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	174174	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	260	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	320	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	CHEMBL517712	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	DB00572	523	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	76309757	103498	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085087	103498	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71463136	83935	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206608	83935	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71459724	84007	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207177	84007	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	302	2977	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2977	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2977	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155806	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155806	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155806	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	71454214	83923	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206592	83923	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10375322	58730	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168545	58730	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71454212	83917	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206586	83917	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	16125704	84664	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84664	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL4755618	214041	39	None	1	2	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at muscarinic M2 receptor (unknown origin)Agonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	11617374	103488	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085078	103488	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	155522355	176409	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176409	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176409	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	49665121	170463	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	CHEMBL4448840	170463	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	162353387	181231	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181231	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	71457770	83927	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206600	83927	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10376182	58756	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168639	58756	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71455965	83920	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206589	83920	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	162353383	182577	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182577	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	162657652	180985	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	180985	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	71463134	83924	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206594	83924	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11519069	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3939	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	25195533	78386	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78386	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78386	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589580	173148	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL452142	173148	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL553448	173148	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	132947	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	132947	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3864	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	25034186	201438	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL540396	201438	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL604842	201438	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589579	189054	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL509515	189054	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL540148	189054	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	11766733	155754	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155754	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155754	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	132947	3864	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3864	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3864	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	10770914	25061	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25061	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44232952	103383	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103383	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10580398	21611	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL131748	21611	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	316	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2835	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2835	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	10109130	133015	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	133015	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140699	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140699	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	69058946	106475	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106475	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106475	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10629559	23751	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL133561	23751	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	10628017	21716	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21716	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939891	169364	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169364	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939891	169364	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	CHEMBL442014	169364	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	9946298	72827	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72827	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406481	72875	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72875	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406573	72974	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72974	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10532418	24605	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL134294	24605	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	25034182	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25034182	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448870	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540359	172584	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16116085	11846	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11846	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11846	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12058	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	11691950	12762	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12762	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12762	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	174174	523	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	260	523	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	320	523	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	CHEMBL517712	523	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	DB00572	523	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	10771937	21693	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21693	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21693	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	25034184	188397	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL501803	188397	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL539887	188397	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589581	188788	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL505751	188788	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL540145	188788	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	14939896	82087	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82087	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82087	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406686	140911	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140911	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	174174	523	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	523	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	523	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	523	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	523	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	44341782	9993	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL114885	9993	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44318928	205763	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	205763	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	44319043	206059	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	206059	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11753447	187351	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493265	187351	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	2166	3123	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	305	3123	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910	3123	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL550	3123	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	DB01085	3123	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	128222	102088	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL302179	102088	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44341878	110340	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL324026	110340	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939893	9534	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9534	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	154734599	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	327	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	4108	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL27673	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	154734599	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2503	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44319071	206019	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	206019	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11556983	187365	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493331	187365	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL538864	187365	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL555476	187365	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	44341782	9993	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL114885	9993	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	44341782	9993	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL114885	9993	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	10789183	104367	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104367	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	206133	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	206133	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44380974	57565	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	CHEMBL166544	57565	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	101720828	97120	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97120	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97120	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97120	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	44381057	58112	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL167587	58112	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44380592	59310	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	CHEMBL170554	59310	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	154734599	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	154734599	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2503	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	101676031	97328	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97328	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97328	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97328	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	319	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1324	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	2705	3842	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3842	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3842	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3842	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3842	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44380973	120731	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	CHEMBL354855	120731	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	44319342	205718	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	205718	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319339	205907	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	205907	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44341864	109211	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL321687	109211	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44380309	58776	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168736	58776	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44298537	101042	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL294613	101042	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	44380837	58440	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	CHEMBL168304	58440	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	44381064	58261	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168235	58261	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	10316726	12028	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12028	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12028	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16144765	96879	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL265592	96879	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44380612	59192	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	CHEMBL170113	59192	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	44341975	9528	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	CHEMBL112208	9528	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	44380613	58495	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	CHEMBL168322	58495	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	154734599	2503	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	327	2503	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	4108	2503	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL27673	2503	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	10049361	206121	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	206121	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913892	205837	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	205837	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	14537191	147989	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	147989	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	10486393	141702	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141702	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141702	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10794142	22936	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL132926	22936	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	1734	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	16086059	80775	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80775	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10722780	22299	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL132377	22299	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355098	24703	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134382	24703	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355099	165251	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL422977	165251	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	11365314	187352	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493266	187352	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	44341764	9954	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL114681	9954	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10402105	110491	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL324855	110491	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	14211056	107163	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316309	107163	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380611	58824	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	CHEMBL168841	58824	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	44380972	120250	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL352334	120250	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	14939888	10162	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	CHEMBL115878	10162	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	44381066	59024	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	CHEMBL169290	59024	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	14939894	10296	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10296	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406598	73025	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	73025	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	129989	451	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	451	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	451	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	71128	96810	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96810	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	66875589	103390	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103390	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589576	189056	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509520	189056	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555706	189056	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44406480	72844	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72844	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44319009	106936	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106936	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11249888	187377	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493465	187377	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537192	100224	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100224	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	189509	106000	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL313227	106000	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44365882	58124	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL167690	58124	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	2028	2979	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2979	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2979	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2979	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2979	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	44406520	135258	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135258	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	15114860	107156	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316282	107156	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	14211057	111425	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL327363	111425	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	10316726	12028	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12028	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12028	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16115945	12297	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12297	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12297	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	10606253	157273	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157273	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939895	82119	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82119	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82119	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10055202	11533	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	CHEMBL11805	11533	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	14939897	96549	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96549	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96549	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44233192	106482	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106482	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106482	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11504490	192602	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL521523	192602	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	11504490	192602	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	CHEMBL521523	192602	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	44589582	171641	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL446587	171641	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL550885	171641	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16042745	185301	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL485932	185301	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL538360	185301	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10557581	21774	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21774	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21774	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10418181	9586	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9586	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9586	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	9843814	127249	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127249	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	14449843	24822	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134488	24822	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	14211049	106988	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL315191	106988	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	2200	3131	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3131	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3131	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3131	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3131	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	44381142	59063	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	CHEMBL169523	59063	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	10653319	24243	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL133993	24243	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44380591	58751	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL168616	58751	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44406521	73906	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73906	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44233190	103402	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103402	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589578	173170	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL452193	173170	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL540401	173170	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	44589577	188968	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL508343	188968	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL540146	188968	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	25132856	187216	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL492437	187216	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537188	136546	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136546	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	14211052	206536	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL88578	206536	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380614	57467	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	CHEMBL165700	57467	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	59993948	73142	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	CHEMBL2011501	73142	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	14537189	162643	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162643	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	14939893	9534	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9534	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10369736	59364	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	CHEMBL170793	59364	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	44381205	57527	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	CHEMBL166232	57527	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	10508599	115229	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL334690	115229	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44381378	57526	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	CHEMBL166229	57526	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	129989	451	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	451	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	451	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	10651844	115489	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115489	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	14914761	9964	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	CHEMBL114738	9964	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	44380975	57607	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	CHEMBL166803	57607	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	44365718	58786	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168786	58786	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	9916852	204919	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL76164	204919	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	44314347	102863	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL305693	102863	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10230930	80634	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	CHEMBL2151158	80634	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	44314697	104180	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL309720	104180	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314564	204808	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL75108	204808	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188467	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188467	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188467	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314328	103711	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308787	103711	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10417432	104874	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311099	104874	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10009554	204711	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL74141	204711	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314698	205152	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL78131	205152	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188467	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188467	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188467	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314329	204556	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL72932	204556	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314699	103179	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308166	103179	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314713	104870	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311054	104870	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164615651	188511	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188511	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188511	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614830	188500	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188500	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188500	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314554	105683	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL312571	105683	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	3009356	105623	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL312344	105623	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	483747	105409	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL311795	105409	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	3009352	96639	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL263555	96639	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	3009353	168025	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL432170	168025	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	1935	3734	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3734	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3734	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3734	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3734	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	164615651	188511	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188511	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188511	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	313	2691	0	None	-	1	Human	6.3	pA2	<	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9862767
	2520	204008	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	204008	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	204008	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	1935	3734	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3734	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3734	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3734	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3734	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	1979	77326	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77326	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	123603	883	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684	883	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	584	883	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	9658	883	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	CHEMBL168815	883	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2370	623	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	623	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	623	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	623	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	623	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	1273	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1754	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2166	3123	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3123	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3123	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3123	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3123	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5831	215963	0	None	-1	5	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	21158560	112793	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112793	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	13637	579	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Determined in a functional M2-GIRK assay, measuring potentiation of acetylcholine (EC<sub>20</sub>) mediated M<sub>2</sub>R activation; Positive cooperativity >1Determined in a functional M2-GIRK assay, measuring potentiation of acetylcholine (EC<sub>20</sub>) mediated M<sub>2</sub>R activation; Positive cooperativity >1	Guide to Pharmacology	584	5	3	7	2.8	C[C@H](NC(=O)C1=CN(C2=NC(N3C[C@@H](O)[C@H](O)C3)=C(F)C=C2C1=O)C4=C(F)C=C(F)C=C4F)C(F)(F)C(F)(F)F	39463278
	10101670	1509	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	7635	1509	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	CHEMBL32985	1509	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	10104167	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	10104167	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	6937	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	6937	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	CHEMBL3121473	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	CHEMBL3121473	2059	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	288	252	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	288	252	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	6979053	252	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	6979053	252	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	286	251	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	286	251	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	6954180	251	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	6954180	251	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	18381	217707	0	None	-1	4	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	469	4	2	6	3.2	CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1Cl	None
	11434515	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11519741	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11519741	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	4484	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	4484	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	7449	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	7449	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	CHEMBL1194325	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	CHEMBL1194325	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	DB08897	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	DB08897	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	1935	3734	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	2551	3734	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	6687	3734	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	CHEMBL95	3734	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	DB00382	3734	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	154059	3637	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	2457	3637	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	7483	3637	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	CHEMBL1734	3637	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	DB01591	3637	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	11693	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	11693	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	4302	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	4302	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	7459	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	7459	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	CHEMBL1201335	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	CHEMBL1201335	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	DB00986	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	DB00986	1827	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200

Get vendors

Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		3000322	3562	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	3562	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	3562	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	3562	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		11434515	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		11519741	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4484	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		7449	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1194325	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		DB08897	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		367	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		5487427	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		8592	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL1900528	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL3305968	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL4650755	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		DB01409	3824	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		11693	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	1827	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		25897919	55652	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	55652	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	55652	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	55652	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		25897919	55652	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	55652	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	55652	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	55652	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		11693	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	1827	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		2705	3842	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	3842	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	3842	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	3842	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	3842	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		3157	1470	71	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		242	470	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		133	2496	52	None	-	42	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	2496	52	None	-	42	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	2496	52	None	-	42	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	2496	52	None	-	42	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	2496	52	None	-	42	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL1630575	56343	0	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
		441383	20333	57	None	-7	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	20333	57	None	-7	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		2335	11848	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		4919	206234	23	None	-3	8	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL86715	206234	23	None	-3	8	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		3652	4097	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	4097	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	4097	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	4097	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	4097	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		3152	188411	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	188411	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		2200	3131	46	None	-35	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		328	3131	46	None	-35	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		4848	3131	46	None	-35	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		CHEMBL9967	3131	46	None	-35	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		DB00670	3131	46	None	-35	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		1613	2348	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		43815	186920	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL1708	186920	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL490	186920	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		1209	1658	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	1658	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	1658	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	1658	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	1658	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		5994	4641	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
		CHEMBL103	4641	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
		2200	3131	46	None	-35	12	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		328	3131	46	None	-35	12	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		4848	3131	46	None	-35	12	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		CHEMBL9967	3131	46	None	-35	12	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		DB00670	3131	46	None	-35	12	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		5050	78200	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL2105300	78200	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
		31315	93408	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL245807	93408	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		5353853	17986	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	17986	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	17986	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL3039583	210949	0	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		3775	14475	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201232	14475	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
		4097	14482	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201264	14482	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		2774	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		5593	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		7319	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		CHEMBL1200604	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB00809	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB01199	3868	95	None	-1	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		2402	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	3370	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		15387	45822	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	45822	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		1273	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		3450	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		356	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		6172	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		67425	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL360055	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		DB00483	1754	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		4904	155521	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL404215	155521	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4209	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		176870	195485	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
		CHEMBL553	195485	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
		4209	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3678	94792	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	94792	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		460612	206044	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		6918992	206044	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL852	206044	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		5282592	14476	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1201235	14476	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
		16222096	80483	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		CHEMBL2146883	80483	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		6918456	14515	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
		CHEMBL1201772	14515	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
		103	4153	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2444	14478	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	14478	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		1201549	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		333	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7601	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201203	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL438151	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00245	597	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		24958200	8574	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
		CHEMBL1094636	8574	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
		5523	3851	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		8286	3851	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1237044	3851	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		DB00193	3851	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		5426	178685	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
		CHEMBL468	178685	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		3627	44129	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	44129	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		3447	206376	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
		CHEMBL87563	206376	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
		2247	505	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		20299	14505	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1201354	14505	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		1712	2492	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	2492	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	2492	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	2492	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	2492	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4594	42872	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
		CHEMBL1503	42872	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
		5584	203211	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	203211	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		4735	195115	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	195115	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	195115	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		2166	3123	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		305	3123	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		5910	3123	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		CHEMBL550	3123	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		DB01085	3123	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		2745	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		5572	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		66007	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		7315	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1490	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		DB00376	3861	42	None	-46	8	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		154417	23181	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1331216	23181	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		5311064	1366	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		534	1366	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		806	1366	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		CHEMBL493682	1366	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		2286	3183	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		2247	505	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2480	19440	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		CHEMBL129529	19440	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		49803313	112586	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL3301622	112586	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
		3344	198318	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	198318	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		54758501	139067	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	139067	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		6127	14499	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1201340	14499	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		72287	61061	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	61061	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL4743867	214033	14	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		71109	78206	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		CHEMBL2105453	78206	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		24821094	67094	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1873475	67094	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		62867	3129	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	3129	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	3129	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	3129	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		3103	41658	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	41658	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		9571107	167519	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	167519	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		2337	3256	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5591	157531	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	157531	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		1224	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		40973	46035	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		CHEMBL1533	46035	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		3606	203488	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL6615	203488	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		180	401	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		1599	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	2341	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		135400189	44575	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
		CHEMBL1520	44575	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
		135398737	958	93	None	-22	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-22	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-22	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-22	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-22	89	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		4417	55562	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1439099	55562	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1620794	55562	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL5292015	194537	0	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
		6077	150698	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	150698	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		40466968	207036	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		60947	207036	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL916	207036	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL5291995	194536	0	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		41049	106760	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
		CHEMBL314437	106760	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
		18609376	204359	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		6279	204359	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL717	204359	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		3294	2006	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		1726	2497	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		1993	2497	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		7438	2497	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		CHEMBL978	2497	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		DB06709	2497	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		5440	28724	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	28724	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		193962	103793	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	103793	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		9853053	120519	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	120519	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		24821094	67094	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1873475	67094	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		2895	203592	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL669	203592	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		121515	199099	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL588934	199099	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		443869	78141	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	78141	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		432824	78264	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
		CHEMBL2106996	78264	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
		10180	98869	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	98869	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		208898	66199	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	66199	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		4761	13441	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1193	13441	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1580221	13441	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		1547484	940	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	940	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	940	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	940	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	940	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		151537	162664	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		41867	162664	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL417	162664	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		9324	9238	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL110691	9238	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		5039	63183	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		CHEMBL1790041	63183	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		5284632	67402	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1888176	67402	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL3084748	67402	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4642	41986	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1495	41986	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		7099	195522	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	195522	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		9419	35922	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	35922	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		4940	14470	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1201210	14470	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		4021	100480	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
		CHEMBL290916	100480	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
		9429	202133	58	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	202133	58	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		3152	188411	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	188411	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		22530	56130	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	56130	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	56130	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		5351322	94791	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	94791	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		708857	56184	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1626223	56184	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
		9400	14491	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
		CHEMBL1201302	14491	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
		2726	919	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3180	14473	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201217	14473	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		1712095	195392	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL551978	195392	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		25295	13620	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	13620	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		31101	729	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		22323	15299	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	15299	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	15299	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		4098	32505	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	32505	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	32505	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		316	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		317	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		71183	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL3140030	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL376897	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		DB00462	2835	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		2039	2982	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		5749	2982	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		7257	2982	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		CHEMBL1201286	2982	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		DB00219	2982	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		2293	3186	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		329	3186	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		4934	3186	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		CHEMBL1180725	3186	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		DB00782	3186	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		25897919	55652	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	55652	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	55652	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	55652	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		6917866	167437	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		CHEMBL4297364	167437	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		2784	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		351	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		366	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		676	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL620	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		DB00771	952	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		174174	523	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		260	523	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		320	523	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		CHEMBL517712	523	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		DB00572	523	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		2286	3183	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		68778	115205	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL334491	115205	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
		1548955	88581	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	88581	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	88581	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		100	3805	58	None	-19	55	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2637	3805	58	None	-19	55	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5452	3805	58	None	-19	55	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL479	3805	58	None	-19	55	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB00679	3805	58	None	-19	55	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		242	470	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3607	36382	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		CHEMBL144673	36382	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		93154	5436	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	5436	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		2898	32651	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL141305	32651	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
		2805	161890	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	161890	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		12555	17961	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	17961	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		6726	1280	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	1280	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	1280	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	1280	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	1280	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		2749	344	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	344	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	344	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	344	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	344	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		132999	179101	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
		CHEMBL471737	179101	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
		3354	41784	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		CHEMBL1493	41784	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		3166	169420	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	169420	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		5354	155656	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	155656	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		6075	150108	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	150108	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		191	403	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		213046	2385	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		115163	57303	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
		CHEMBL1650818	57303	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
		5583	13044	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL119	13044	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4601	206747	35	None	-2	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	206747	35	None	-2	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	206747	35	None	-2	16	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		160883	55264	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		CHEMBL1618102	55264	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		16960	14487	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1201287	14487	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		5511	5488	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1076211	5488	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		2333	142335	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
		CHEMBL388590	142335	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
		124087	1389	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3055	1433	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	1433	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	1433	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	1433	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	1433	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		135	2532	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		60663	175669	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	175669	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	175669	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	175669	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		3000322	3562	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	3562	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	3562	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	3562	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		3053	205134	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	205134	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		43082	60283	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	60283	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		11519069	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		11519070	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4816	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7354	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187833	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB09076	3939	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		11693	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	1827	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		10470	2488	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		1689	2488	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4057	2488	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL524004	2488	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB04843	2488	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		180	401	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		4886	14110	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1198	14110	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		4919	206234	23	None	-3	8	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL86715	206234	23	None	-3	8	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		6918558	14514	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201764	14514	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		2771	195017	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		40	1547	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	1547	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	1547	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	1547	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	1547	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		1909	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	2822	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		54697325	58979	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		CHEMBL1689772	58979	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		7019	167976	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	167976	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	167976	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		3474	38101	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		CHEMBL146095	38101	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		104903	56344	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	56344	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		1530	2182	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		3827	2182	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		7206	2182	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		CHEMBL534	2182	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		DB00920	2182	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		5330286	67571	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		CHEMBL189963	67571	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		2580	78395	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	78395	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		3634	84108	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL22077	84108	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		2398	954	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	954	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	954	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	954	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	954	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		1427	2013	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	2013	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	2013	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	2013	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	2013	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		4908	188806	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		CHEMBL506	188806	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		1086	1590	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	1590	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	1590	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	1590	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	1590	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		187	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		10071196	3124	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		5142	3124	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		8423	3124	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		CHEMBL2111101	3124	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		DB05316	3124	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		187	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		319	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	1324	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		2762	3863	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	3863	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	3863	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	3863	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	3863	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		11057	176149	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	176149	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	176149	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	176149	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		187	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		2993	114692	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	114692	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	114692	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		70695647	78213	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL2105618	78213	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		11154555	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	800	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		25151352	140606	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	140606	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		4167	14500	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	14500	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4167	14500	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	14500	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		174174	523	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		260	523	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		320	523	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		CHEMBL517712	523	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		DB00572	523	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		277	1301	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	1301	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	1301	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	1301	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	1301	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2710	84308	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	84308	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		4921596	98782	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		60063	98782	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		CHEMBL278255	98782	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		3601	14503	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	14503	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		16351	102730	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	102730	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		1210	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1213	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		2725	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		33036	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		4411	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		616	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		6976	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		716121	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1201353	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1554789	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL505	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB01114	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB13679	918	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		5039	63183	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		CHEMBL1790041	63183	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		2337	3256	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		3158	56267	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		135565596	109269	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
		CHEMBL3218576	109269	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
		2107	3055	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	3055	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	3055	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	3055	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	3055	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		3158	56267	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2220	3134	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		27400	3134	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		93	3134	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL294951	3134	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB06153	3134	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		5568	197500	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	197500	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	197500	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	197500	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		11976	920	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	920	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	920	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	920	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		3162	4235	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1004	4235	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		21722	17992	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	17992	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		3336	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	95001	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1273	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		3450	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		356	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		6172	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		67425	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL360055	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		DB00483	1754	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		2905	14498	50	None	-	4	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1201338	14498	50	None	-	4	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
		65863	14465	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	14465	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		2774	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		5593	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		7319	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		CHEMBL1200604	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB00809	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB01199	3868	95	None	-1	9	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		2865	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		1935	3734	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		2551	3734	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		6687	3734	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL95	3734	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00382	3734	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		1971	2866	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	2866	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	2866	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	2866	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	2866	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		3157	1470	71	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-	10	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		2600	3779	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		19861	207523	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL946	207523	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		4976	203579	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL668	203579	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		448537	160250	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	160250	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		71329	179269	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
		CHEMBL473	179269	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
		27901	78207	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	78207	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4822	45032	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	45032	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		26987	949	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3236	67609	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1902981	67609	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		1371	1923	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		24199	1923	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		323	1923	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1201325	1923	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		DB06787	1923	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		3047788	78196	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL2105148	78196	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		2865	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		135398737	958	93	None	-22	89	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-22	89	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-22	89	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-22	89	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-22	89	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		1613	2348	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		115368	3056	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	3056	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	3056	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	3056	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	3056	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		124087	1389	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		1979	77326	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL20835	77326	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		12488	1657	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	1657	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	1657	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	1657	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		3033538	1319	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		7155	1319	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		781	1319	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1201216	1319	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		DB00298	1319	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		237	204865	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	204865	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	204865	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	204865	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		21855	84246	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	84246	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		2771	195017	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		34040	28085	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	28085	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		6834	205552	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL811	205552	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		3000322	3562	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	3562	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	3562	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	3562	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		2705	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		2705	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	3842	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		1605	2342	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		3957	2342	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		7216	2342	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		CHEMBL998	2342	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		DB00455	2342	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		1224	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	1432	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		2551	794	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		298	794	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		488	794	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL965	794	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB00411	794	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		2683	102888	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	102888	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	102888	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		5205	78187	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	78187	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		1227	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	2489	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2337	3256	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		1560	2309	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		5359371	2309	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		7209	2309	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1254682	2309	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		DB00504	2309	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		1353	1911	93	None	-5011	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-5011	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-5011	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-5011	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-5011	83	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		2028	2979	80	None	-8	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		359	2979	80	None	-8	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		4634	2979	80	None	-8	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		CHEMBL1231	2979	80	None	-8	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		DB01062	2979	80	None	-8	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		1400	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	1957	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		180	401	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		98941	46950	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	46950	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		9880	30941	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL139835	30941	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		54697325	58979	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		CHEMBL1689772	58979	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		26987	949	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		25102847	78221	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		CHEMBL2105717	78221	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		3055	1433	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	1433	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	1433	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	1433	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	1433	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		5832	14460	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL1201146	14460	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		9417	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	133512	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		135	2532	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1726	2497	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		1993	2497	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		7438	2497	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		CHEMBL978	2497	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		DB06709	2497	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		2520	204008	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	204008	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	204008	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2284	3182	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		10104167	2059	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		6937	2059	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		CHEMBL3121473	2059	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		10104167	2059	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		6937	2059	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		CHEMBL3121473	2059	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		405242	11967	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1182967	11967	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL274413	11967	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		23657685	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1195729	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1203986	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		23657685	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1195729	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1203986	13819	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		44435840	13820	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1195736	13820	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL555247	13820	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		44435840	13820	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1195736	13820	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL555247	13820	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		11600184	12303	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		CHEMBL1184960	12303	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		CHEMBL380572	12303	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		23657683	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1195234	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1203985	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		23657683	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1195234	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1203985	13748	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		44435838	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1190118	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1203984	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		44435838	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1190118	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1203984	13067	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		23657687	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1190117	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL540132	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		23657687	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1190117	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL540132	13066	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		10653182	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		CHEMBL265482	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		CHEMBL281080	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		2370	623	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		297	623	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		358	623	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		CHEMBL1482	623	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		DB01019	623	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		167962	4069	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		362	4069	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		CHEMBL31599	4069	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		10653182	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		CHEMBL265482	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		CHEMBL281080	99139	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		2166	3123	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		305	3123	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		5910	3123	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL550	3123	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		DB01085	3123	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		10437519	106921	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31475	106921	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		76328902	106518	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121475	106518	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140248	106518	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL5287096	194613	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL5315302	194613	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		44408941	11815	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1182020	11815	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL206666	11815	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		118714969	120843	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3337859	120843	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3558417	120843	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		46878254	14238	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1199299	14238	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL607178	14238	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		60138187	106448	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138192	106448	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121479	106448	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139879	106448	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		135544402	113108	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		135597270	113108	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202147	113108	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33142	113108	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		11613432	12308	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1184988	12308	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL382243	12308	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44265572	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL262448	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL27743	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44265572	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL262448	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL27743	98672	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		10077281	104107	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL30939	104107	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8653	104107	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		44318743	105949	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
		CHEMBL312920	105949	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
		118714976	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337863	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558421	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		76328902	106518	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121475	106518	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140248	106518	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		118714976	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337863	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558421	120845	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		187	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		11828809	11958	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1182934	11958	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL273255	11958	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		134207697	174279	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4549515	174279	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		10438106	99657	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202149	99657	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL284370	99657	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		44279262	106074	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
		CHEMBL31336	106074	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
		10795567	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		CHEMBL285598	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		CHEMBL303052	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		10795567	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		CHEMBL285598	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		CHEMBL303052	99835	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		187	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		167962	4069	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		362	4069	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		CHEMBL31599	4069	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		405252	11934	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182747	11934	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL263972	11934	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		1273	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		3450	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		356	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		6172	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		67425	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		CHEMBL360055	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		DB00483	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		1273	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		3450	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		356	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		6172	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		67425	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		CHEMBL360055	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		DB00483	1754	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		168294767	193019	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10865495	18070	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL126655	18070	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL8898	18070	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		10865495	18070	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL126655	18070	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8898	18070	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		167962	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		362	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		CHEMBL31599	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		10699850	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL168760	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL286892	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL5272950	193740	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	166	2	1	3	0.5	O=C1C[C@@H](Cc2cnc[nH]2)CO1	10.1021/acs.jnatprod.2c01079
		10699850	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL168760	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL286892	100028	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		60138189	106520	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138190	106520	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121476	106520	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140252	106520	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		11007357	11085	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177962	11085	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL8721	11085	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		10795468	11737	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181455	11737	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171664	11737	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		170332	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		2370	623	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		297	623	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		358	623	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		CHEMBL1482	623	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		DB01019	623	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		167962	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		362	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		CHEMBL31599	4069	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		170332	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		167962	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		362	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		CHEMBL31599	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		405254	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL269205	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL31380	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		167962	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		362	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		CHEMBL31599	4069	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		405254	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL269205	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31380	106182	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44319261	12345	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL1185324	12345	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL407440	12345	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		10629136	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		CHEMBL30376	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		CHEMBL68151	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		10629136	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		CHEMBL30376	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		CHEMBL68151	102351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		10985389	11974	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1183013	11974	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL275988	11974	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		187	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		294	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		65	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		8593	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		CHEMBL667	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		DB03128	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		44408892	75152	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL203627	75152	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44265578	17962	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL126103	17962	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL268194	17962	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		44265578	17962	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL126103	17962	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL268194	17962	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		137629935	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		10257778	116783	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202150	116783	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33774	116783	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		137629935	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		44318815	12351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185416	12351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL412670	12351	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		10974720	17985	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL126199	17985	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL9071	17985	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		10974720	17985	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL126199	17985	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL9071	17985	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		76325356	106512	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3120178	106512	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140233	106512	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		405246	11969	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182976	11969	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL274564	11969	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		302	2977	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		4630	2977	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		CHEMBL7634	2977	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		187	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10676698	11736	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181450	11736	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171388	11736	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		187	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10604576	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		CHEMBL303002	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31162	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		10604576	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		CHEMBL303002	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		CHEMBL31162	105328	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		21158560	112793	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3305985	112793	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11527805	12307	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		CHEMBL1184985	12307	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		CHEMBL381913	12307	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		11535022	11807	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		CHEMBL1181943	11807	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		CHEMBL199636	11807	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		60138188	106450	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138191	106450	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121478	106450	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139897	106450	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		44265574	11087	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1177964	11087	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8764	11087	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		405250	11839	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		CHEMBL1182178	11839	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		CHEMBL216974	11839	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		76328904	106451	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121480	106451	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139898	106451	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		11585610	12309	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1184995	12309	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL382659	12309	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		11757557	100113	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL1202151	100113	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL287536	100113	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		44279470	102325	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
		CHEMBL30361	102325	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
		11094083	11088	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		CHEMBL1177968	11088	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		CHEMBL8855	11088	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		11613432	12308	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1184988	12308	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL382243	12308	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		10747747	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		CHEMBL280535	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		CHEMBL304129	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		10747747	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		CHEMBL280535	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		CHEMBL304129	99077	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		44408941	11815	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1182020	11815	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL206666	11815	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		10483419	111346	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32689	111346	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL539621	111346	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		10771150	11738	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181457	11738	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171776	11738	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		44278967	99770	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL285136	99770	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		137629935	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		44279153	107011	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31533	107011	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		137629935	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		2230	465	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		296	465	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		CHEMBL7303	465	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		DB04365	465	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		9987754	11081	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177947	11081	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL8449	11081	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		10007510	109695	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL1202152	109695	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32278	109695	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL5287159	194619	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
		CHEMBL5315392	194619	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
		118714979	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337866	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558422	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10319023	111343	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32688	111343	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		118714979	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337866	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558422	120846	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10770828	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL165814	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31895	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10770828	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL165814	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31895	107591	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		154734599	2503	12	None	-	11	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		327	2503	12	None	-	11	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		4108	2503	12	None	-	11	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		CHEMBL27673	2503	12	None	-	11	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		44319052	12070	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183674	12070	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL311649	12070	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		44319054	12074	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183713	12074	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL314491	12074	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		11115491	11925	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1182715	11925	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL262449	11925	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		44265538	11089	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177969	11089	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8900	11089	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		2520	204008	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		CHEMBL1280	204008	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		CHEMBL6966	204008	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		118720626	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355097	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558555	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44318760	12341	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185295	12341	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL405691	12341	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		44279242	105582	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
		CHEMBL31221	105582	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
		118720626	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355097	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558555	120852	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		118714974	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337862	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558420	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44265563	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		CHEMBL285811	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		CHEMBL8491	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		44265563	99860	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL285811	99860	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8491	99860	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		118714974	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337862	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558420	120844	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44265563	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL285811	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8491	99860	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		118714971	120839	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		CHEMBL3337860	120839	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		CHEMBL3558367	120839	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		44319263	12354	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		CHEMBL1185419	12354	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		CHEMBL412718	12354	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		10556700	12239	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184494	12239	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL352356	12239	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10843180	11733	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181400	11733	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169638	11733	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		118714981	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337867	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558423	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11828771	16738	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL124330	16738	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8729	16738	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		118714981	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337867	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558423	120847	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11115442	12342	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1185309	12342	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL406431	12342	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		11828771	16738	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL124330	16738	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8729	16738	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		168057	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		7634	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		CHEMBL28407	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		44318758	12317	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1185047	12317	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL385915	12317	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		76321739	106449	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121477	106449	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139896	106449	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		10699593	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL282782	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL353262	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10699593	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL282782	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL353262	99413	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		168057	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		7634	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		CHEMBL28407	1212	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		44279691	99741	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL284962	99741	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10909212	12371	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		CHEMBL1185516	12371	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		CHEMBL418702	12371	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		44319178	12407	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1185797	12407	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL433343	12407	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		405242	11967	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1182967	11967	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL274413	11967	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		23657556	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1190116	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL540131	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		118714972	114589	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		CHEMBL3337861	114589	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		10442337	203948	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL69305	203948	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		118714972	114589	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		CHEMBL3337861	114589	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		10461289	112704	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202148	112704	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33044	112704	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		10442081	102608	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL304142	102608	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
		168927	140169	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
		CHEMBL380352	140169	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
		168927	140169	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
		CHEMBL380352	140169	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
		10009514	202169	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
		CHEMBL609382	202169	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
		10974913	11091	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		CHEMBL1177971	11091	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		CHEMBL9017	11091	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		44408892	75152	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL203627	75152	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44279471	99993	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
		CHEMBL286686	99993	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
		10032676	11732	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181399	11732	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169633	11732	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10077592	116582	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33656	116582	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		44265498	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL32676	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL8669	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44265498	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL32676	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8669	111323	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		76328904	106451	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121480	106451	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139898	106451	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		10009225	96513	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL262632	96513	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8531	96513	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		10009225	96513	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL262632	96513	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8531	96513	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		10747449	12246	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184538	12246	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354750	12246	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10461019	12240	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184498	12240	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL352486	12240	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10101670	1509	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		7635	1509	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		CHEMBL32985	1509	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		118720628	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355098	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558556	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10509176	12245	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184534	12245	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354673	12245	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		118720628	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355098	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558556	120853	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		23657556	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1190116	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL540131	13065	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		76325356	106512	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3120178	106512	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140233	106512	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		11505653	12310	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1185000	12310	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL382846	12310	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		118714977	114590	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		CHEMBL3337865	114590	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		118714977	114590	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		CHEMBL3337865	114590	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		10963807	11080	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1177938	11080	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL7902	11080	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		44319265	12344	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185319	12344	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL407071	12344	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		10794637	11728	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181384	11728	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169133	11728	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		44381306	11729	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181388	11729	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169342	11729	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10843237	12244	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184525	12244	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354103	12244	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		11104735	11082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1177953	11082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL8518	11082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		10676884	11731	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181392	11731	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169475	11731	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10509365	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31452	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL352323	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10509365	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31452	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL352323	106881	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL5285668	194630	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL5315497	194630	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		10069369	99704	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL284672	99704	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10348407	16296	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL122499	16296	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL267482	16296	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		10348407	16296	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL122499	16296	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL267482	16296	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		10818763	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL169001	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31518	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10818763	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL169001	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31518	106987	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		11422540	202134	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
		CHEMBL609120	202134	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
		10261985	203949	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL69306	203949	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		11671915	11803	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1181935	11803	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL197604	11803	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		134207690	174645	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4558206	174645	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		11756054	110864	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL32609	110864	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		10747380	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		CHEMBL31103	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		CHEMBL68393	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		10747380	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		CHEMBL31103	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		CHEMBL68393	104867	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		10077281	104107	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL30939	104107	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL8653	104107	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10509354	11727	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181373	11727	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL168613	11727	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		1935	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		2551	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		6687	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		CHEMBL95	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		DB00382	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		11083080	11086	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		CHEMBL1177963	11086	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		CHEMBL8763	11086	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		1935	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		2551	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		6687	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		CHEMBL95	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		DB00382	3734	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		53382542	86313	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
		CHEMBL2313377	86313	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
		134207682	173644	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4534301	173644	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		10055492	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL31376	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL3350263	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		11504244	106519	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138185	106519	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121474	106519	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140249	106519	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		10055492	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL31376	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL3350263	106177	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		10818794	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		CHEMBL30264	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		CHEMBL73114	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		10818794	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		CHEMBL30264	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		CHEMBL73114	102167	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		71717892	89078	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL2311018	89078	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL2365146	89078	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		76321739	106449	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121477	106449	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139896	106449	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		60138189	106520	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138190	106520	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121476	106520	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140252	106520	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138187	106448	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138192	106448	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121479	106448	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139879	106448	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		405244	12343	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1185313	12343	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL406691	12343	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		60138188	106450	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138191	106450	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121478	106450	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139897	106450	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		11768033	11951	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182845	11951	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL269592	11951	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		10843266	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		CHEMBL32530	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		CHEMBL68936	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		10985526	18821	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL127933	18821	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8983	18821	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		10985526	18821	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL127933	18821	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8983	18821	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		10843266	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		CHEMBL32530	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		CHEMBL68936	110563	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		11353863	202135	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL609124	202135	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		2551	794	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		298	794	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		488	794	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		CHEMBL965	794	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		DB00411	794	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		132986	99613	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
		CHEMBL284055	99613	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
		405248	11945	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		CHEMBL1182821	11945	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		CHEMBL268195	11945	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		10509706	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		CHEMBL262124	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		CHEMBL303624	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		10509706	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		CHEMBL262124	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		CHEMBL303624	96440	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		10348116	104818	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
		CHEMBL31097	104818	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
		44319180	12078	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183728	12078	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL315340	12078	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		118714967	120842	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3337858	120842	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3558416	120842	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		46878256	14164	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1198561	14164	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL607179	14164	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		11115574	11084	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1177955	11084	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL8532	11084	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		2230	465	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		296	465	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		CHEMBL7303	465	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		DB04365	465	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		11636025	11809	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1181949	11809	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL201016	11809	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		170332	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		170332	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		10748143	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL2111531	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL284393	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		10748143	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL2111531	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL284393	99662	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		11504244	106519	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138185	106519	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121474	106519	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140249	106519	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		10767691	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL171215	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31915	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10767691	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL171215	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31915	107759	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10050814	109793	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL32329	109793	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
		102070733	120841	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337857	120841	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558415	120841	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		44340802	62131	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
		CHEMBL177732	62131	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
		11331580	202136	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
		CHEMBL609125	202136	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
		367	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		5487427	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		8592	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL1900528	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL3305968	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL4650755	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		DB01409	3824	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		367	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		5487427	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		8592	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL1900528	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL3305968	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL4650755	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		DB01409	3824	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		11434515	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		11519741	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		4484	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		7449	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		CHEMBL1194325	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		DB08897	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		10143956	13911	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1196359	13911	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL556635	13911	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		11693	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		3494	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		4302	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		7459	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		CHEMBL1201335	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		DB00986	1827	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		11434515	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11519741	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		4484	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		7449	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		CHEMBL1194325	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		DB08897	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		44233403	13901	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL1196247	13901	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL556222	13901	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44233401	13624	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		CHEMBL1194321	13624	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		CHEMBL551327	13624	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		11852298	14026	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197251	14026	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL564057	14026	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		155566290	176580	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	176580	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	176580	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		367	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		5487427	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		8592	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL1900528	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL3305968	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL4650755	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		DB01409	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		367	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		5487427	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		8592	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL1900528	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL3305968	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL4650755	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		DB01409	3824	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		44232930	196693	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL564747	196693	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44232931	196381	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL562642	196381	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		44232927	195337	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL551729	195337	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		44236098	195648	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL556426	195648	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44233177	13900	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1196246	13900	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL556221	13900	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44232685	14029	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL1197273	14029	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL564765	14029	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		20735153	13623	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1194314	13623	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL551063	13623	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		11489419	13618	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL1194274	13618	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL549784	13618	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		44233173	14020	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197216	14020	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL562890	14020	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44236340	13792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1195513	13792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL554725	13792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		688566	195883	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL558910	195883	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		49800047	14483	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201024	14483	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201268	14483	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		44232683	13626	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL1194336	13626	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL551731	13626	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		44236336	14013	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL1197131	14013	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL560327	14013	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		11693	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		3494	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		4302	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		7459	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		CHEMBL1201335	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		DB00986	1827	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		9913341	82158	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL216927	82158	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL553058	82158	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		44236101	14028	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197261	14028	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL564515	14028	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44236099	195555	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL554699	195555	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		10007638	120876	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401648	120876	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559195	120876	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		67548926	120878	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401649	120878	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559201	120878	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		9809330	115999	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		CHEMBL335542	115999	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		44232681	14015	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197156	14015	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL561187	14015	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		10325942	120879	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401650	120879	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559202	120879	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		10143954	13619	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1194286	13619	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL549986	13619	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		44236332	14017	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197183	14017	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL561870	14017	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		10143718	63134	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779131	63134	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789435	63134	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		44235871	196572	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL563887	196572	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		50925542	19177	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289653	19177	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		10165877	63130	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779133	63130	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789396	63130	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		11725334	117776	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401641	117776	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		155566290	176580	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	176580	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	176580	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		9928017	62339	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779033	62339	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		11569908	14001	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197028	14001	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL559106	14001	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		1201549	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		52942402	19219	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289983	19219	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		44303019	100946	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL294082	100946	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		10229167	63125	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779136	63125	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789385	63125	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14590398	101866	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL300660	101866	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590401	187978	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL49721	187978	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054136	60359	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17460	60359	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		13810575	98582	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
		CHEMBL276771	98582	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
		14590398	101866	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL300660	101866	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		14590401	187978	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL49721	187978	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		44333541	4752	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103785	4752	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		60691	101551	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		CHEMBL29835	101551	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		24739387	188157	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL498556	188157	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL4639128	214022	17	None	-	0	Human	5.0	pIC50	=	5	Binding	Cross screening panelCross screening panel	ChEMBL		None	None	None		COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1	10.6019/CHEMBL4630907
		44275628	11994	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183229	11994	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL285803	11994	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		10354348	98882	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
		CHEMBL279105	98882	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
		67549179	117780	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401645	117780	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
		10784004	13387	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1192621	13387	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL543890	13387	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		137630050	161040	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		2774	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		5593	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		7319	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		CHEMBL1200604	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB00809	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB01199	3868	95	None	-1	9	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		1224	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		100	3805	58	None	-19	55	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-19	55	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-19	55	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-19	55	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-19	55	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		124087	1389	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		135	2532	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10782321	12124	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		CHEMBL1184098	12124	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		CHEMBL332405	12124	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		10080742	206366	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL87485	206366	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		2284	3182	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		10594386	11418	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180249	11418	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL118553	11418	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		2230	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		296	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		CHEMBL7303	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		DB04365	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		9946632	62349	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779043	62349	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
		44302901	101056	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
		CHEMBL294726	101056	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
		6726	1280	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		2683	102888	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		10547222	114786	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333940	114786	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44236338	13910	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1196358	13910	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL556634	13910	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		52948443	19193	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289758	19193	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		2551	794	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		298	794	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		488	794	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		CHEMBL965	794	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		DB00411	794	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		3652	4097	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		57	4097	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		60809	4097	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		CHEMBL21536	4097	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		DB15357	4097	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		14590397	187697	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL49525	187697	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054141	162484	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		CHEMBL416723	162484	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		9815331	203107	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		14590397	187697	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL49525	187697	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		9815331	203107	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		11793999	12115	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184074	12115	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL331516	12115	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		18456768	63135	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779134	63135	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789445	63135	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2200	3131	46	None	-31	12	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		328	3131	46	None	-31	12	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		4848	3131	46	None	-31	12	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		CHEMBL9967	3131	46	None	-31	12	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		DB00670	3131	46	None	-31	12	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		13271739	98526	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL276282	98526	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14054138	98826	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL278701	98826	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		53853235	78681	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		CHEMBL2112432	78681	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		10829928	12402	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		CHEMBL1185758	12402	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		CHEMBL431688	12402	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		15730	71118	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	71118	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		10827157	11437	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL1180317	11437	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL121552	11437	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		52947552	19107	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289201	19107	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52943921	19124	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289315	19124	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942610	19327	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290635	19327	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		46891076	6708	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1083618	6708	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		441383	20333	57	None	-7	16	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-7	16	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		9944783	62343	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779037	62343	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2551	794	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	794	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		10567372	12131	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	12131	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	12131	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	12131	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44302788	200622	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL59939	200622	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		122203596	155806	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10760249	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		CHEMBL1180285	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		CHEMBL120119	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		10760249	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL1180285	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL120119	11423	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		67547950	120877	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401655	120877	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3559199	120877	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		54586723	62344	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779038	62344	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10686494	100538	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
		CHEMBL291351	100538	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
		10393952	63129	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779140	63129	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789389	63129	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		9798900	63136	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779047	63136	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1789446	63136	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		107867	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		13578548	101362	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296988	101362	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		107867	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	2974	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		13578548	101362	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296988	101362	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		67548544	120882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401656	120882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3559205	120882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		3088389	23114	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13308	23114	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		2551	794	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		298	794	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		488	794	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		CHEMBL965	794	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		DB00411	794	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		2247	505	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		44303294	201156	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60331	201156	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		4735	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	195115	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		11057	176149	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		2812	4779	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		10518821	12127	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184108	12127	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL332645	12127	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		44302793	199729	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
		CHEMBL59347	199729	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
		10664532	12112	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184064	12112	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL330892	12112	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		52945272	19208	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289866	19208	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		52943721	19289	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290410	19289	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		379653	101683	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL299344	101683	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578572	186899	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL48980	186899	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054140	98940	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL279528	98940	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		5487543	205646	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
		CHEMBL81878	205646	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
		24750278	89424	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
		CHEMBL237067	89424	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
		379653	101683	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL299344	101683	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578572	186899	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL48980	186899	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		14590400	177462	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL46390	177462	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		3071772	98420	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL275537	98420	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		14590400	177462	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL46390	177462	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10638050	11415	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL116601	11415	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180202	11415	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10848032	206093	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85645	206093	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		44342270	9930	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		CHEMBL114484	9930	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		3652	4097	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		57	4097	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		60809	4097	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		CHEMBL21536	4097	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		DB15357	4097	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		44303286	201318	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		CHEMBL60419	201318	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		3071780	18790	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
		CHEMBL12781	18790	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
		44275648	11984	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183077	11984	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL278618	11984	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		13621567	98160	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL27384	98160	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL440085	98160	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		10757736	14504	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120135	14504	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		10567372	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10567372	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	12131	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44302834	202710	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61700	202710	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		4098	32505	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		10516408	11441	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180330	11441	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL122353	11441	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10240891	206098	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85678	206098	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		44303424	200487	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL59862	200487	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
		9815331	203107	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	203107	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		324	1925	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		6436265	1925	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		CHEMBL277642	1925	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		10300661	63137	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779135	63137	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789451	63137	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		13578571	101124	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
		CHEMBL295214	101124	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
		13578571	101124	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
		CHEMBL295214	101124	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
		10610375	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL1180284	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL120109	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		10610375	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		CHEMBL1180284	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		CHEMBL120109	11422	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		11820032	98224	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
		CHEMBL274329	98224	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
		3013846	188239	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		CHEMBL499519	188239	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		2745	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		5572	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		66007	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		7315	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		CHEMBL1490	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		DB00376	3861	42	None	-46	8	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		306	3456	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		3536	3456	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		53930639	3456	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		9577995	3456	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		CHEMBL134641	3456	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		2230	465	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		296	465	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		CHEMBL7303	465	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		DB04365	465	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		44275626	11165	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178434	11165	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL28033	11165	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		163388532	190358	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
		CHEMBL5177023	190358	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
		CHEMBL4800073	214054	5	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2	ChEMBL		None	None	None		C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4cnccc4c3)ccc2[nH]1	10.6019/CHEMBL5212743
		44356367	118492	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
		CHEMBL341447	118492	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
		122203596	155806	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		137630050	161040	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10684720	12094	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1183926	12094	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL324712	12094	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		2551	794	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		298	794	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		488	794	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		CHEMBL965	794	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		DB00411	794	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		19816	57585	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL166736	57585	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		52946249	19088	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289082	19088	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		10420458	206268	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL86903	206268	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		71454411	78449	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL2111621	78449	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		44302741	202655	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61412	202655	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		4011	82408	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		10521205	11429	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180298	11429	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120599	11429	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		9903030	62348	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779042	62348	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
		46871844	6812	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1083925	6812	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		46871665	6595	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
		CHEMBL1083108	6595	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
		1273	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		3450	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		356	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		6172	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		67425	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		CHEMBL360055	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		DB00483	1754	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		25897919	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		657309	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		CHEMBL1464005	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		CHEMBL1621597	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		44236334	14012	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197117	14012	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL559931	14012	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		44233175	14019	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197209	14019	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL562655	14019	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		25897919	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		657309	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1464005	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1621597	55652	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		52947320	19248	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290184	19248	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
		939077	195068	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL549577	195068	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44303323	163242	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL418491	163242	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		10785471	113716	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL332320	113716	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		14590403	188395	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
		CHEMBL50176	188395	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
		13810574	59694	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17228	59694	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		14590403	188395	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
		CHEMBL50176	188395	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
		302	2977	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		4630	2977	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL7634	2977	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		24739886	187869	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL496376	187869	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		14590396	172542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL44838	172542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590396	172542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL44838	172542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		19716	9267	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL11081	9267	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		10356006	205649	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL81895	205649	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		10515352	106175	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL313749	106175	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		122203596	155806	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10019339	102626	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL304247	102626	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		1935	3734	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		2551	3734	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		6687	3734	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		CHEMBL95	3734	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		DB00382	3734	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		1935	3734	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		2551	3734	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		6687	3734	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		CHEMBL95	3734	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		DB00382	3734	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		2750	204061	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		5282593	55258	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1319362	55258	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1618018	55258	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		10808719	12132	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184120	12132	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL333125	12132	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		10399393	205786	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL83074	205786	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		4212	198679	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL1417019	198679	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL58	198679	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		154734599	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		327	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		4108	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		CHEMBL27673	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		154734599	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		327	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		4108	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		CHEMBL27673	2503	12	None	1	11	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		10546275	15202	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL121059	15202	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		10133281	62346	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779040	62346	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		9857572	62342	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779036	62342	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		13578549	101274	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296317	101274	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		10678449	22653	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL132698	22653	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		13578549	101274	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296317	101274	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10846833	49805	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
		CHEMBL15675	49805	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
		3071773	19408	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL12937	19408	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		44275683	99282	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL281944	99282	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL541666	99282	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		10593954	13076	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1190178	13076	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL540316	13076	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		10358345	11442	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180331	11442	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL122354	11442	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		9996901	117777	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401642	117777	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		3236	67609	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		CHEMBL1902981	67609	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		10641009	11426	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180292	11426	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120472	11426	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		10726038	119432	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
		CHEMBL344892	119432	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
		44333603	109647	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		CHEMBL322378	109647	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		3072503	4866	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL104355	4866	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		3072518	5246	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106344	5246	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		2398	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		10663572	13159	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1190784	13159	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL541584	13159	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		44303396	201236	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL60374	201236	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		9974222	11921	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1182709	11921	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL262198	11921	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		10778750	163958	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL420781	163958	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		52942628	19087	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289081	19087	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942401	19218	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289982	19218	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		44275767	97617	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL27096	97617	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL540136	97617	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		52945255	19307	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290520	19307	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		46891179	6417	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1082365	6417	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		118728611	117779	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401644	117779	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		10267601	12129	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1184116	12129	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL332980	12129	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		44302775	202796	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL62247	202796	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		10573693	11430	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180305	11430	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL120963	11430	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		3158	56267	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		10220392	206005	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL84893	206005	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		4841	67427	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1889399	67427	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1909073	67427	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		44303314	100933	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL293982	100933	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		54585743	62350	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779044	62350	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		44275682	11991	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183197	11991	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL284208	11991	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		191	403	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		3823	50221	42	None	-44	10	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	50221	42	None	-44	10	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	50221	42	None	-44	10	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		44302900	202798	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
		CHEMBL62251	202798	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
		44302813	101930	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL301041	101930	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		137630050	161040	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		2028	2979	80	None	-8	10	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	2979	80	None	-8	10	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	2979	80	None	-8	10	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	2979	80	None	-8	10	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	2979	80	None	-8	10	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		44303327	163011	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		CHEMBL417560	163011	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		10539130	106730	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL314420	106730	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		10567192	12096	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1183934	12096	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL324936	12096	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		10567372	12131	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	12131	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	12131	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	12131	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10777692	11427	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180296	11427	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL120539	11427	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		68617	205527	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		54585742	62337	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779031	62337	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		54582845	63131	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779139	63131	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789405	63131	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		10451242	203114	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL64029	203114	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		10262466	98344	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL275104	98344	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		122203596	155806	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10538337	12111	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL1184062	12111	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL330885	12111	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		67547652	117782	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401647	117782	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
		154734599	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		327	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		4108	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		CHEMBL27673	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		11678378	120886	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401654	120886	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3559211	120886	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		54586745	63140	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779138	63140	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789461	63140	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		134688371	14429	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		13765	14429	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		CHEMBL1200623	14429	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		3652	46244	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		CHEMBL1535	46244	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		50925541	19159	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289545	19159	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		50925543	19178	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289654	19178	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		10119939	63128	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1777827	63128	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789388	63128	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		155522355	176409	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	176409	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	176409	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		9967590	62141	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1777826	62141	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		174174	523	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		260	523	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		320	523	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		CHEMBL517712	523	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		DB00572	523	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		2551	794	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		298	794	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		488	794	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		CHEMBL965	794	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		DB00411	794	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		10208972	63132	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779129	63132	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789429	63132	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		52942458	19247	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290183	19247	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		10094518	101393	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL297224	101393	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		10096508	177023	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
		CHEMBL46315	177023	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
		11725107	100613	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL291872	100613	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		10094518	101393	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL297224	101393	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10096508	177023	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
		CHEMBL46315	177023	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
		3072508	107488	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL318517	107488	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		14054145	98628	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL277078	98628	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL5076569	214449	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		44302727	101918	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL300987	101918	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		10176679	133609	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		CHEMBL37132	133609	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		10797864	26145	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
		CHEMBL135645	26145	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
		52947254	19207	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289865	19207	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		52949961	19348	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290752	19348	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		3072505	108572	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL320291	108572	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		2551	794	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	794	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2274	3173	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		3652	4097	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	4097	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	4097	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	4097	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	4097	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		24882193	188649	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL503468	188649	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		3198	205513	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		54586743	63141	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779130	63141	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		CHEMBL1789462	63141	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		13578551	101284	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296405	101284	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578551	101284	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296405	101284	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		9882189	167434	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
		CHEMBL4297224	167434	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
		9882189	167434	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
		CHEMBL4297224	167434	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
		3072510	5365	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106936	5365	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10761219	11431	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180309	11431	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL121298	11431	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		2337	3256	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		2745	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		5572	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		66007	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		7315	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		CHEMBL1490	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		DB00376	3861	42	None	-46	8	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		2551	794	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		298	794	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		488	794	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		CHEMBL965	794	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		DB00411	794	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		154734599	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		327	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		4108	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		CHEMBL27673	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		154734599	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		327	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		4108	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		CHEMBL27673	2503	12	None	1	11	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		24996645	70426	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
		CHEMBL1945848	70426	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
		44275767	97617	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL27096	97617	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL540136	97617	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		290	2473	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		4022	2473	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		5926	2473	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		CHEMBL40554	2473	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		CHEMBL74300	2473	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		15685990	58083	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL167335	58083	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		11498	3019	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		4995951	3019	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		CHEMBL59898	3019	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		1971	2866	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		11695697	117781	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401646	117781	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		54583839	62341	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779035	62341	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		277	1301	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2286	3183	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		118728610	117775	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401640	117775	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
		3067217	61298	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
		CHEMBL17671	61298	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
		3072506	5324	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106782	5324	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		3072512	5363	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106932	5363	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		10639739	11649	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		CHEMBL1181055	11649	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		CHEMBL154087	11649	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		6918276	15611	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	15611	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		10759393	84385	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL2112589	84385	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL2219563	84385	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		25014630	83539	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		CHEMBL2203713	83539	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		44275648	11984	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183077	11984	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL278618	11984	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		1548953	207679	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		154734599	2503	12	None	1	11	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		327	2503	12	None	1	11	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		4108	2503	12	None	1	11	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		CHEMBL27673	2503	12	None	1	11	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		3072515	5194	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106082	5194	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		202718	87324	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
		CHEMBL2332280	87324	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
		4601	206747	35	None	-2	16	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-2	16	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-2	16	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		3072507	5249	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106348	5249	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		1726	2497	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	2497	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		13621567	98160	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL27384	98160	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL440085	98160	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		10595006	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL1180343	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL123099	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		10595006	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL1180343	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL123099	11445	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		10777343	206169	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL86288	206169	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		52946359	19123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289314	19123	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		44275683	99282	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL281944	99282	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL541666	99282	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		9308	17754	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		9308	17754	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		10611310	12123	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184096	12123	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL332335	12123	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		316	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		46890977	6732	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
		CHEMBL1083723	6732	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
		46871666	7069	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		CHEMBL1084993	7069	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		10208897	63127	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779049	63127	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789387	63127	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10246307	117778	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401643	117778	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
		316	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		317	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		71183	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		CHEMBL3140030	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		CHEMBL376897	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		DB00462	2835	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		11306852	14025	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		CHEMBL1197250	14025	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		CHEMBL563996	14025	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		11539632	70561	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		CHEMBL194837	70561	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		9946010	62340	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779034	62340	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10053614	120880	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401651	120880	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559203	120880	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		14075467	101480	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL297818	101480	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14075467	101480	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL297818	101480	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		107867	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		302	2977	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		4630	2977	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		CHEMBL7634	2977	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		3071778	163285	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL418712	163285	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		3072509	5572	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107673	5572	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		107867	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	2974	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		10333583	206050	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85264	206050	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10686988	12189	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		CHEMBL1184244	12189	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		CHEMBL340780	12189	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		155522355	176409	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	176409	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	176409	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		10852843	11924	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1182713	11924	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL262303	11924	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		44304805	203022	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		CHEMBL345233	203022	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		CHEMBL63325	203022	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		10132599	62338	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779032	62338	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10755733	11428	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL1180297	11428	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL120581	11428	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		4189	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		316	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	2835	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44275682	11991	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183197	11991	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL284208	11991	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		3072514	5419	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107254	5419	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		19718	204824	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL75358	204824	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		9308	17754	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		10688349	12136	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184138	12136	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL334194	12136	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		54583840	62351	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779045	62351	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		10591874	13316	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1192001	13316	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL543177	13316	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		2230	465	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		296	465	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		CHEMBL7303	465	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		DB04365	465	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		11811722	10065	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		CHEMBL115280	10065	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		5310989	200877	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL60142	200877	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		3042	1414	35	None	-28	14	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	1414	35	None	-28	14	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	1414	35	None	-28	14	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	1414	35	None	-28	14	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	1414	35	None	-28	14	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		44275680	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178406	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL26932	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		10660	14416	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		10826990	206156	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL86197	206156	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		44302879	202718	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61774	202718	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		10522202	11434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180312	11434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL121385	11434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		44303018	202023	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60833	202023	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		3055247	18931	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL12858	18931	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10755732	12121	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184092	12121	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL332181	12121	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		5747382	109203	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	109203	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10549581	11449	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180349	11449	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL123198	11449	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		135398737	958	93	None	-22	89	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-22	89	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-22	89	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-22	89	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-22	89	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		167962	4069	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		10563152	206070	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL85460	206070	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		72548703	161567	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	161567	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		10082470	52717	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		CHEMBL15944	52717	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		CHEMBL308608	52717	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		9804849	67456	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		CHEMBL189118	67456	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		44275626	11165	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178434	11165	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL28033	11165	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		10522336	15130	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL120972	15130	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44303397	102288	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL303360	102288	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		9308	17754	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		44275680	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178406	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL26932	11163	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		107867	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		14054139	161767	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		CHEMBL413966	161767	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		107867	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	2974	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		52950036	19158	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289544	19158	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52943879	19349	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290753	19349	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
		11569926	63133	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779048	63133	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789434	63133	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14054137	98885	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL279135	98885	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		44268378	21951	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
		CHEMBL13206	21951	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
		14590394	180886	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL47575	180886	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590394	180886	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL47575	180886	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		316	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	2835	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		176	398	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		154734599	2503	12	None	1	11	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		327	2503	12	None	1	11	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		4108	2503	12	None	1	11	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		CHEMBL27673	2503	12	None	1	11	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		10937901	9910	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		CHEMBL114379	9910	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		10058347	105931	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL312823	105931	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10035533	205703	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL82378	205703	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10854880	11421	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180282	11421	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL120080	11421	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		3071774	21548	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13166	21548	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		1726	2497	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	2497	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		5487543	205646	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL81878	205646	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		43815	186920	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL1708	186920	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL490	186920	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		3071777	163286	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL418714	163286	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10636001	11425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180290	11425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL120329	11425	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		5648	78411	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2107687	78411	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2111176	78411	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		1734	116	10	None	-9	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		307	116	10	None	-9	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL168067	116	10	None	-9	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		3071779	16822	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
		CHEMBL12472	16822	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
		15685982	56526	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL163661	56526	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		13578552	160177	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
		CHEMBL410928	160177	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
		13578552	160177	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
		CHEMBL410928	160177	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
		9905467	11436	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180316	11436	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL121520	11436	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		6075	150108	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		3072501	107269	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	107269	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		154059	3637	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		2457	3637	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		7483	3637	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1734	3637	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		DB01591	3637	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		2335	11848	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	11848	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	11848	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	11848	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		3071775	97216	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL268499	97216	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		3071771	21094	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
		CHEMBL13122	21094	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
		2230	465	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		296	465	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		CHEMBL7303	465	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		DB04365	465	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		44575653	181644	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
		CHEMBL477542	181644	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
		52943696	19265	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290294	19265	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		14374296	101653	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL299142	101653	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578554	172425	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
		CHEMBL44773	172425	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
		14374296	101653	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL299142	101653	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578554	172425	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
		CHEMBL44773	172425	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
		6410685	109256	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321808	109256	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
		13578555	176680	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
		CHEMBL45983	176680	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
		14590399	101278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296365	101278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054144	60433	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17519	60433	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14590399	101278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296365	101278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578555	176680	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
		CHEMBL45983	176680	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
		10851853	12188	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184242	12188	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL340561	12188	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		71450872	78679	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL2112418	78679	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		10058744	206382	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL87622	206382	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10397133	107062	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL315676	107062	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10487582	28229	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL137384	28229	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		24180125	95656	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		CHEMBL257991	95656	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		44303017	200833	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL60101	200833	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		52947553	19108	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289202	19108	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		122203596	155806	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		3072513	6262	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL108163	6262	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		78319901	159234	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		CHEMBL4098877	159234	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		118728611	117779	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401644	117779	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		60691	101551	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		CHEMBL29835	101551	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		15685977	120343	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL353023	120343	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		2726	919	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		137630050	161040	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10499832	12135	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184134	12135	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL334093	12135	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		10782462	12114	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1184068	12114	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL330999	12114	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		14660293	52653	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
		CHEMBL15936	52653	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
		3072504	5812	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	5812	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		44333819	4713	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103529	4713	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
		2200	3131	46	None	-31	12	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		328	3131	46	None	-31	12	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		4848	3131	46	None	-31	12	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		CHEMBL9967	3131	46	None	-31	12	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		DB00670	3131	46	None	-31	12	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		10707175	206151	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL86150	206151	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		1210	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		10187216	63138	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779128	63138	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789452	63138	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14590402	101087	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL294919	101087	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590402	101087	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL294919	101087	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13269694	59448	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17120	59448	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14054135	61518	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17709	61518	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		10511551	25831	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL135328	25831	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		3072502	4926	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL104681	4926	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		24871823	92529	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
		CHEMBL2431819	92529	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
		3071776	24549	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13426	24549	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10806268	12137	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184139	12137	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL334245	12137	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		15181802	12165	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL1184199	12165	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL338611	12165	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		10666533	11432	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL1180310	11432	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL121299	11432	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		14058518	11162	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL1178388	11162	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL25649	11162	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		10592484	11435	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180314	11435	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL121476	11435	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		1212	1662	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		11256587	2462	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		8580	2462	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL518924	2462	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		DB05501	2462	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		9966959	62347	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779041	62347	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		44333822	4665	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103189	4665	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		10048670	107458	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL318316	107458	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		57345320	3832	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9882	3832	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL3091687	3832	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		3055	1433	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		313	1433	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		7163	1433	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		CHEMBL936	1433	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		DB01231	1433	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		44302755	202676	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61494	202676	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		10854879	11417	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180239	11417	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL118241	11417	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		1273	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	1754	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		1016	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3191	102858	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		44303293	201426	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60479	201426	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		44235638	195314	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
		CHEMBL551525	195314	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
		52945165	19141	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289432	19141	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942497	19266	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290295	19266	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		3233138	19288	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290409	19288	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		52949883	19326	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290634	19326	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		57396813	71545	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1949930	71545	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1963007	71545	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		10085070	205984	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL84726	205984	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		52946068	19233	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
		CHEMBL1290077	19233	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
		52947416	19306	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290519	19306	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
		46891488	7173	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		CHEMBL1085507	7173	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		14054142	59518	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17155	59518	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		10143858	63139	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779132	63139	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789454	63139	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10164137	63126	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779137	63126	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789386	63126	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2200	3131	46	None	-31	12	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		328	3131	46	None	-31	12	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		4848	3131	46	None	-31	12	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		CHEMBL9967	3131	46	None	-31	12	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		DB00670	3131	46	None	-31	12	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		14590395	101518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
		CHEMBL298078	101518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
		14590395	101518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
		CHEMBL298078	101518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
		16005860	187406	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		CHEMBL493677	187406	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		67547662	120885	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401653	120885	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559210	120885	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		42636350	82593	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
		CHEMBL2178953	82593	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
		9990434	106339	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL313918	106339	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		180	401	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		1530	2182	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10778462	206008	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL84919	206008	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		302	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		4630	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL7634	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		302	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		4630	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		CHEMBL7634	2977	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		44265375	206147	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL8610	206147	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL5070958	214249	3	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		54584800	62345	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779039	62345	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		2166	3123	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		305	3123	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		5910	3123	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		CHEMBL550	3123	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		DB01085	3123	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		10610448	206125	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85936	206125	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		13271741	59532	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17162	59532	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		13271742	59651	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17213	59651	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		10392705	120881	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401652	120881	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559204	120881	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		2230	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		296	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		CHEMBL7303	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		DB04365	465	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		44303408	201946	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60777	201946	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		49853884	90683	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
		CHEMBL2391353	90683	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
		44302728	198713	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL58228	198713	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		14058518	11162	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL1178388	11162	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL25649	11162	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		44302776	102350	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL303758	102350	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		10614695	12157	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184188	12157	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL338280	12157	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		10569816	11459	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL1180367	11459	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL124173	11459	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		10248541	182899	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
		CHEMBL479224	182899	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
		237	204865	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	204865	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	204865	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	204865	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		2200	3131	46	None	-35	12	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		328	3131	46	None	-35	12	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		4848	3131	46	None	-35	12	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		CHEMBL9967	3131	46	None	-35	12	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		DB00670	3131	46	None	-35	12	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		25147683	62352	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779046	62352	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		164612037	185377	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	185377	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	192968	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	193031	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10457079	10030	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	10030	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		688566	195883	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
		CHEMBL558910	195883	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
		137630050	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10387775	78492	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		CHEMBL2111842	78492	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		156015807	178299	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162677523	183674	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4756833	183674	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4802932	183674	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		10387775	78492	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		CHEMBL2111842	78492	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		162649253	183645	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4748004	183645	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4802611	183645	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156015900	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015900	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	178321	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		122203596	155806	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		156015807	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		122203596	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		122203596	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		4120	5934	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL107979	5934	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL293927	5934	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		156015807	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		137630050	161040	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		162677523	183674	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4756833	183674	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4802932	183674	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156014820	178305	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4646116	178305	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4650998	178305	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156015978	178323	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		14753629	13668	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1194660	13668	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553066	13668	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		10101246	9546	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	9546	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		162654942	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4754371	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802913	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		162649253	183645	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4748004	183645	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4802611	183645	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156016041	178247	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162645430	183627	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4744233	183627	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802409	183627	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		324	1925	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		6436265	1925	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		CHEMBL277642	1925	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		14753632	13508	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1193564	13508	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL544993	13508	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		14753634	13727	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1195059	13727	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553783	13727	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156015153	178307	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	178307	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	178307	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10125445	76028	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		CHEMBL205654	76028	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		71716224	86956	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323444	86956	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		14753624	13736	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1195123	13736	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553894	13736	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156016041	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156016041	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		15038486	85768	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
		CHEMBL22923	85768	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
		15038486	85768	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		CHEMBL22923	85768	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		71718669	86958	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323446	86958	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		44457850	98958	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL279712	98958	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		167962	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		167962	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		76315655	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		76315655	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261153	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261153	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3138747	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3138747	106205	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		11957991	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		11957991	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261155	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261155	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139843	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139843	106446	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		167962	4069	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		162654942	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4754371	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802913	183671	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		156015153	178307	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	178307	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	178307	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015978	178323	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457838	161881	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL415038	161881	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		156014820	178305	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4646116	178305	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4650998	178305	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		162677513	183744	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4789147	183744	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4803695	183744	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156015153	178307	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	178307	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	178307	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		174174	523	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		260	523	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		320	523	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		CHEMBL517712	523	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		DB00572	523	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		5861	11285	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1179176	11285	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL63452	11285	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156015978	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457835	83386	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL21942	83386	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		44457839	83994	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22071	83994	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		3636	11147	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1178342	11147	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL21823	11147	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		14753627	13706	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1194941	13706	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL553562	13706	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		44373048	52530	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
		CHEMBL159189	52530	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
		44457833	94787	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
		CHEMBL25334	94787	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
		167962	4069	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		76312112	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76312112	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261148	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261148	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139732	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139732	106440	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		76315655	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		76315655	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261152	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261152	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139166	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139166	106335	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		76312110	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76312110	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261144	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261144	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139691	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139691	106437	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		10365181	18557	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		CHEMBL127587	18557	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		44373347	119565	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
		CHEMBL346049	119565	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
		137628879	160972	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	160972	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	160972	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	160972	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		44457825	163193	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL418189	163193	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		324	1925	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	1925	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	1925	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		11968014	12758	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
		CHEMBL1187846	12758	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
		156015978	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457832	85623	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22829	85623	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		162645430	183627	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4744233	183627	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802409	183627	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		162645520	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4742721	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802414	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		44457828	161880	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL415037	161880	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		44373093	54103	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
		CHEMBL160666	54103	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
		57664406	2398	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		6938	2398	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089376	2398	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		156016041	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162677513	183744	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4789147	183744	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4803695	183744	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156016041	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162645520	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4742721	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802414	183628	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		137628879	160972	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	160972	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	160972	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	160972	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		324	1925	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	1925	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	1925	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		156015807	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10055202	11533	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
		CHEMBL11805	11533	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
		10365181	18557	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		CHEMBL127587	18557	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		15038486	85768	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		CHEMBL22923	85768	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		167962	4069	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		44373067	51905	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL158589	51905	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		9979830	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		9979830	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL1190002	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL1190002	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL539879	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL539879	13047	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		156015807	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015978	178323	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		11957991	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		11957991	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261154	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261154	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139733	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139733	106441	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		76319430	106443	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2262220	106443	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139826	106443	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		76330179	106444	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261145	106444	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139827	106444	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		14753637	13489	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1193366	13489	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL544759	13489	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		324	1925	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	1925	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	1925	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		71720488	86953	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323441	86953	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		44457844	85815	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
		CHEMBL22962	85815	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
		44457834	84717	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22278	84717	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		137628879	160972	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	160972	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	160972	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	160972	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		156015153	178307	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	178307	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	178307	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		76308444	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76308444	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261149	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261149	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139712	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139712	106438	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		71716836	86954	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323442	86954	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		10318189	54231	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL160755	54231	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
		324	1925	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		6436265	1925	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		CHEMBL277642	1925	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		44373049	52566	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL159237	52566	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		9916852	204919	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		CHEMBL76164	204919	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		9916852	204919	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL76164	204919	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		367	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		5487427	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		8592	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL1900528	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL3305968	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL4650755	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		DB01409	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		367	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		5487427	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		8592	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL1900528	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL3305968	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL4650755	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		DB01409	3824	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		59291417	112823	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298595	112823	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307168	112823	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		688566	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
		CHEMBL558910	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
		71452756	79541	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114068	79541	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		44378845	57157	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL164705	57157	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
		44378762	119928	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL349497	119928	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44324892	111565	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328094	111565	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		688566	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
		CHEMBL558910	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
		688566	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
		CHEMBL558910	195883	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
		44325018	206874	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90700	206874	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44378811	120101	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL350956	120101	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		23056	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		318	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		3260	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL12980	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		25005841	112820	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298599	112820	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307130	112820	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		16065402	67927	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910848	67927	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
		71454563	79656	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115128	79656	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		10143956	13911	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1196359	13911	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL556635	13911	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		367	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		5487427	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		8592	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL1900528	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL3305968	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL4650755	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		DB01409	3824	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		155566290	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155550632	176529	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4540949	176529	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597071	176529	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155566290	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	176580	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		316	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	2835	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44343733	13432	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		CHEMBL119294	13432	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		9827782	103553	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL308566	103553	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
		15407089	207452	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL94189	207452	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10457079	10030	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	10030	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		155566290	176580	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	176580	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	176580	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		164611865	188476	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856113	188476	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028107	188476	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155525097	170950	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4455570	170950	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155567380	176408	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4589047	176408	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596064	176408	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155521894	176425	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451383	176425	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596183	176425	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155550436	176501	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4569639	176501	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596780	176501	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		11434515	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11519741	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		4484	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		7449	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		CHEMBL1194325	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		DB08897	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11852298	14026	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197251	14026	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL564057	14026	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		44378875	57189	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL164935	57189	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44379051	58088	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL167396	58088	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10461523	120249	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL352291	120249	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44379021	120260	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL352380	120260	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		367	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		5487427	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		8592	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL1900528	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL3305968	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL4650755	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		DB01409	3824	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		44274333	11146	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		CHEMBL1178341	11146	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		CHEMBL21812	11146	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		11431874	74280	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		CHEMBL2023762	74280	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		CHEMBL2023764	74280	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		155566290	176580	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4582879	176580	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4597498	176580	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164622681	188562	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864727	188562	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028712	188562	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164616463	188514	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		CHEMBL4859378	188514	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		CHEMBL5028381	188514	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		137630050	161040	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		9827782	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL308566	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		9827782	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL308566	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		15453419	207461	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL94247	207461	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		9827782	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL308566	103553	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		140844407	176632	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4519930	176632	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597916	176632	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		155539713	176360	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4515788	176360	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595691	176360	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44431393	88024	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234440	88024	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
		59291241	112815	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298596	112815	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307116	112815	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		9809330	115999	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		CHEMBL335542	115999	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		15407088	206993	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL91404	206993	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44292486	181511	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL47650	181511	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		16065403	67935	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
		CHEMBL1910856	67935	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
		316	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	2835	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		44610056	123991	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
		CHEMBL3629360	123991	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
		10274019	204251	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71124	204251	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378846	57167	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL164762	57167	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		164622945	188565	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL4871700	188565	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL5028723	188565	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		155523648	176593	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4454300	176593	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597576	176593	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		15463388	165692	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL424530	165692	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		49800047	14483	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201024	14483	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201268	14483	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		367	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		5487427	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		8592	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL1900528	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL3305968	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL4650755	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		DB01409	3824	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		11519069	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		11519070	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		4816	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		7354	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		CHEMBL1187833	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		DB09076	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		164615275	188507	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4861252	188507	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028304	188507	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		367	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		5487427	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		8592	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL1900528	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL3305968	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL4650755	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		DB01409	3824	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		25195533	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL2103803	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL2110584	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		9984928	204683	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL73893	204683	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44325048	111557	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328059	111557	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		9984928	204683	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL73893	204683	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44379026	120302	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL352739	120302	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		14537188	136546	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
		CHEMBL37372	136546	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
		9867847	204258	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL71147	204258	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		9867847	204258	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL71147	204258	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
		25195533	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		CHEMBL2103803	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		CHEMBL2110584	78386	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		155556290	176456	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4554682	176456	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596434	176456	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44337753	109001	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
		CHEMBL321214	109001	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
		316	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		317	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		71183	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		CHEMBL3140030	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		CHEMBL376897	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		DB00462	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		164626501	188596	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874955	188596	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028936	188596	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		316	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		317	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		71183	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		CHEMBL3140030	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		CHEMBL376897	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		DB00462	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		316	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		317	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		71183	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		CHEMBL3140030	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		CHEMBL376897	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		DB00462	2835	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		140844416	176606	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4516342	176606	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597717	176606	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		23056	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		318	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		3260	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		CHEMBL12980	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		156014450	178251	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4636083	178251	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650652	178251	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		164617895	188525	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852868	188525	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028466	188525	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164627113	188602	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4878646	188602	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028981	188602	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164611189	188471	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4851514	188471	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028061	188471	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164614083	188491	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4855492	188491	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028231	188491	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015648	178315	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4641328	178315	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4651078	178315	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL5074599	214319	2	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL		None	None	None		COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CNC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)s2)cc1OC	10.1021/acs.jmedchem.1c00204
		9937474	170470	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4448933	170470	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
		9937474	170470	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4448933	170470	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44378842	57423	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL165375	57423	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44378601	168583	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL435849	168583	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		15407074	57424	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL165377	57424	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44379050	161508	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL412814	161508	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10109130	133015	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL370232	133015	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9894236	60229	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL174070	60229	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		15392110	105485	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL312085	105485	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		164618444	188529	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852186	188529	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028499	188529	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164625454	188591	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862735	188591	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028885	188591	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		11798681	11149	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		CHEMBL1178344	11149	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		CHEMBL21905	11149	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		59291493	112822	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298600	112822	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307158	112822	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		164627445	188607	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4876453	188607	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028997	188607	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164628529	188614	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL4876725	188614	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL5029058	188614	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		10101246	9546	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	9546	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		164624669	188586	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4870127	188586	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028837	188586	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		688566	195883	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL558910	195883	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		164624066	188580	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864987	188580	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028806	188580	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155560305	176253	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4568151	176253	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4594890	176253	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		164610746	188467	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854886	188467	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028038	188467	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164621305	188552	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863285	188552	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028642	188552	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015900	178321	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	178321	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	178321	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		10324012	204706	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL74117	204706	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		10324012	204706	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL74117	204706	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		132947	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		361	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		CHEMBL265256	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		155519740	170406	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
		CHEMBL4448108	170406	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
		156015724	178274	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4643159	178274	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650839	178274	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		164610955	188469	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL4858398	188469	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL5028048	188469	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		132947	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		361	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		CHEMBL265256	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		164619001	188536	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4871153	188536	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028529	188536	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		132947	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		361	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		CHEMBL265256	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		44311771	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL421113	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311771	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL421113	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311771	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL421113	164232	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		164628352	188613	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4878717	188613	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029051	188613	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44312007	169165	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL440491	169165	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44312007	169165	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL440491	169165	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		15463387	56535	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL163777	56535	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		44378810	57431	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL165439	57431	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		44378876	58136	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL167816	58136	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44378952	119900	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL349142	119900	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		132947	3864	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		361	3864	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		CHEMBL265256	3864	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		132947	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		361	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		CHEMBL265256	3864	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		164612662	188482	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4847898	188482	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028154	188482	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44292836	101317	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		CHEMBL296633	101317	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		372625	101147	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL295388	101147	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		164613559	188486	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856659	188486	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028196	188486	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		372625	101147	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL295388	101147	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		367	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		5487427	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		8592	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL1900528	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL3305968	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL4650755	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		DB01409	3824	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		316	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	2835	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		164619973	188541	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862996	188541	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028571	188541	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		174174	523	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		260	523	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		320	523	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		CHEMBL517712	523	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		DB00572	523	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		44311784	204479	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72408	204479	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		174174	523	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		260	523	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		320	523	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		CHEMBL517712	523	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		DB00572	523	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		44311784	204479	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72408	204479	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		137630050	161040	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089543	161040	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4097258	161040	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4116470	161040	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		164617401	188520	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL4852646	188520	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL5028427	188520	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		155543944	176334	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4567026	176334	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595467	176334	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44311717	204489	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72494	204489	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311717	204489	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72494	204489	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		155535606	172052	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
		CHEMBL4471882	172052	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
		9953227	204197	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL70828	204197	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		10628017	21716	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL131865	21716	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		44311718	204471	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72363	204471	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311760	204499	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72551	204499	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44292858	101347	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
		CHEMBL296895	101347	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
		44311718	204471	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72363	204471	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311760	204499	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72551	204499	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		164623076	188567	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872608	188567	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028732	188567	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		939077	195068	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL549577	195068	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		9809222	114093	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL332703	114093	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44378764	57246	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
		CHEMBL165035	57246	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
		10291977	72898	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200401	72898	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44344122	110417	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324484	110417	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		15870384	59237	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
		CHEMBL170298	59237	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
		134272442	176488	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4457734	176488	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596671	176488	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		137630050	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		44312024	204561	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72957	204561	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		137630050	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		44312024	204561	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72957	204561	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		25897919	55652	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		657309	55652	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1464005	55652	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1621597	55652	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		155554568	176609	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4548432	176609	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597724	176609	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		316	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		6604314	30979	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
		CHEMBL1398637	30979	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
		11434515	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		11519741	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		4484	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		7449	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		CHEMBL1194325	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		DB08897	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		316	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	2835	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		11766733	155754	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL1202003	155754	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL405739	155754	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		44344164	10985	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117351	10985	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44311823	204204	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL70860	204204	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311823	204204	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL70860	204204	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		688520	35415	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL1437876	35415	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3289390	35415	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		44311987	204602	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL73245	204602	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		59291402	112786	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298588	112786	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305766	112786	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		44311987	204602	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL73245	204602	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		16116083	12296	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL1184884	12296	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375969	12296	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		129486	100155	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
		CHEMBL287868	100155	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
		25897919	55652	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		657309	55652	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1464005	55652	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1621597	55652	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		367	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		5487427	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		8592	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL1900528	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL3305968	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL4650755	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		DB01409	3824	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		155520948	176429	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4450188	176429	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596191	176429	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44379040	120112	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL351079	120112	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		302	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		302	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	2977	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		9851621	59179	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL170033	59179	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44382606	120795	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355511	120795	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44232952	103383	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084650	103383	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		10009554	204711	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
		CHEMBL74141	204711	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
		10009554	204711	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
		CHEMBL74141	204711	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
		44215377	12092	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL118391	12092	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		137630050	161040	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089543	161040	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4097258	161040	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4116470	161040	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		156015807	178299	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	178299	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	178299	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44344216	13230	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL119131	13230	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44344106	113072	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL331214	113072	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44343862	10511	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116777	10511	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		10771937	21693	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL1202004	21693	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL131846	21693	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		316	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	2835	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		164616706	188515	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4850130	188515	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028391	188515	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015042	178234	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		CHEMBL4645845	178234	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650549	178234	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		44311785	204737	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL74352	204737	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311785	204737	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL74352	204737	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44312451	104786	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL310912	104786	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		15407073	119960	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL349720	119960	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44379055	120515	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
		CHEMBL354534	120515	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
		44312451	104786	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL310912	104786	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44312450	204836	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL75448	204836	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		154734599	2503	12	None	1	11	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		327	2503	12	None	1	11	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		4108	2503	12	None	1	11	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		CHEMBL27673	2503	12	None	1	11	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		CHEMBL5289667	194475	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	959	21	2	5	13.8	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		156015978	178323	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	178323	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	178323	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		25006208	112825	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298763	112825	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307197	112825	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		44431384	148860	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394137	148860	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44344145	11016	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117414	11016	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		56667296	176641	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4461243	176641	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597972	176641	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10470	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		1689	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		4057	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		CHEMBL524004	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		DB04843	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		155512178	176489	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4436930	176489	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596672	176489	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		174174	523	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		260	523	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		320	523	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		CHEMBL517712	523	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		DB00572	523	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		174174	523	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		260	523	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		320	523	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		CHEMBL517712	523	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		DB00572	523	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		10393100	56531	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL163714	56531	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44267748	12935	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11892	12935	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		137628879	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		137628879	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	160972	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		44324655	168139	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL433011	168139	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44343761	111292	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL326561	111292	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		134272452	176674	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4448944	176674	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4598232	176674	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		316	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	2835	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		11223598	106525	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		CHEMBL3084413	106525	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		CHEMBL3140264	106525	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		16125331	136962	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374452	136962	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		122203596	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		174174	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		260	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		320	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		CHEMBL517712	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		DB00572	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		174174	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		260	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		320	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		CHEMBL517712	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		DB00572	523	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		122203596	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		16115945	12297	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1184886	12297	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376057	12297	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		303	2978	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	2978	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	2978	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	2978	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		44344132	110360	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324116	110360	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		25897919	55652	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		657309	55652	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL1464005	55652	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL1621597	55652	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		9946298	72827	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200171	72827	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10291366	140699	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381623	140699	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		25897919	55652	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		657309	55652	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		CHEMBL1464005	55652	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		CHEMBL1621597	55652	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		122203596	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		CHEMBL4059733	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		CHEMBL4066481	155806	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		156016041	178247	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	178247	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	178247	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10291366	140699	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL381623	140699	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		456615	102746	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL305026	102746	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44378689	56525	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL163658	56525	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44378958	9249	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL110744	9249	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		456615	102746	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL305026	102746	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44312083	204487	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL72455	204487	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		59291259	112473	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298591	112473	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		174174	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		10919522	78918	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
		CHEMBL2112957	78918	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
		44325017	206857	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90638	206857	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		59291413	112787	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298589	112787	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305767	112787	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		44325047	207262	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL93017	207262	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		16115947	11849	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182214	11849	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL222259	11849	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		164620907	188548	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4865939	188548	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028619	188548	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10474247	101404	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL297276	101404	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		44344078	110771	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL326057	110771	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9894173	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL12098	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		10163651	163233	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL418446	163233	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
		9894173	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL12098	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		9894173	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
		CHEMBL12098	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
		10163651	163233	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	163233	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		9894173	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
		CHEMBL12098	15150	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
		15407073	119960	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL349720	119960	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44267782	98520	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL276239	98520	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267782	98520	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		CHEMBL276239	98520	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		20689406	111361	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		CHEMBL326990	111361	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		174174	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		260	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		320	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		CHEMBL517712	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		DB00572	523	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		134272503	176411	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4545504	176411	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596068	176411	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		174174	523	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10486393	141702	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202000	141702	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL385625	141702	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL5270870	193657	0	None	-6	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	507	12	2	4	6.8	NCCCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		164618698	188533	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862098	188533	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028512	188533	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015645	178298	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4638411	178298	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650970	178298	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		11691950	12762	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		CHEMBL1187853	12762	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		CHEMBL524097	12762	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		16116085	11846	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182201	11846	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL219786	11846	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		44311786	103050	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL307234	103050	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311786	103050	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL307234	103050	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		463517	203702	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL67563	203702	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		10180872	103129	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL307810	103129	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378951	57430	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL165434	57430	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44267696	11031	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11756	11031	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44343902	11136	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117817	11136	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9938599	58713	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL168483	58713	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		174174	523	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		260	523	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		320	523	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		CHEMBL517712	523	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		DB00572	523	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		10180872	103129	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL307810	103129	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		155522355	176409	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4451030	176409	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4596065	176409	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		134272501	176581	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4483083	176581	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597500	176581	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44325052	206960	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL91232	206960	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		25897919	55652	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		657309	55652	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1464005	55652	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1621597	55652	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		137630050	161040	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	161040	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	161040	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	161040	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		127044	78910	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
		CHEMBL2112942	78910	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
		16115797	138155	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376870	138155	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155522355	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		155522355	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	176409	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		122203596	155806	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10437400	194285	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL52852	194285	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		44344248	114092	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL332702	114092	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9872651	165114	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL422740	165114	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL5289601	194472	0	None	-1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	973	22	2	5	14.1	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		145148382	176614	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4590868	176614	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597793	176614	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		316	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	2835	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		44311762	163472	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL420008	163472	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
		44311762	163472	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL420008	163472	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
		5284632	67402	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		CHEMBL1888176	67402	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		CHEMBL3084748	67402	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		316	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		164620270	188542	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869723	188542	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028587	188542	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44343901	110314	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL323850	110314	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		59291327	112817	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3298597	112817	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3307126	112817	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		59291513	112818	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3298598	112818	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3307127	112818	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		316	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	2835	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44325034	206839	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90507	206839	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		25897919	55652	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		657309	55652	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		CHEMBL1464005	55652	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		CHEMBL1621597	55652	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		10275847	203999	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL69595	203999	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378597	57416	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL165337	57416	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44379052	120431	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL353842	120431	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10119364	43250	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	43250	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		44406481	72875	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200319	72875	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		71462570	82566	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
		CHEMBL2178569	82566	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
		44337326	7968	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
		CHEMBL109051	7968	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
		174174	523	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		260	523	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		320	523	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		CHEMBL517712	523	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		DB00572	523	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		156015153	178307	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	178307	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	178307	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		118719922	115775	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354068	115775	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44343900	10512	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116781	10512	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		59291527	112463	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298333	112463	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL5281043	194099	0	None	-17	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	479	10	2	4	6.1	NCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155530273	176351	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		CHEMBL4463636	176351	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		CHEMBL4595649	176351	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		156014880	178231	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636351	178231	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650536	178231	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		174174	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		260	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		320	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		CHEMBL517712	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		DB00572	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		44311716	165132	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL422770	165132	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311716	165132	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL422770	165132	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		174174	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		260	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		320	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		CHEMBL517712	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		DB00572	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		16115943	11847	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182205	11847	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL220393	11847	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155560140	176347	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4565234	176347	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595575	176347	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		174174	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		260	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		320	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		CHEMBL517712	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		DB00572	523	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		44343735	11090	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117797	11090	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44378807	58150	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		CHEMBL167932	58150	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		4134	72686	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL1996652	72686	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2106570	72686	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		10269503	167080	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL428962	167080	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		14939896	82087	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201996	82087	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL216566	82087	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		10096939	164820	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL421864	164820	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44295932	189345	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51256	189345	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44344156	10129	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115681	10129	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9807612	59072	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169565	59072	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44383342	59484	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL171411	59484	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		16065135	67925	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910846	67925	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
		11693	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		3494	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		4302	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		7459	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		CHEMBL1201335	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		DB00986	1827	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		140844401	176687	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4539799	176687	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4598363	176687	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		174174	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		260	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		320	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		CHEMBL517712	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		DB00572	523	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		16125541	137207	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374989	137207	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		155513986	176487	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4439675	176487	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596667	176487	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		101882890	115776	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354069	115776	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		14939894	10296	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL116172	10296	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		302	2977	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		4630	2977	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL7634	2977	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL5284000	194239	0	None	-6	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	493	11	2	4	6.6	NCCCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		71128	96810	25	None	-3	7	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
		CHEMBL26505	96810	25	None	-3	7	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
		14210083	156712	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	156712	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		44378763	120503	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL354461	120503	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44344215	13281	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL119168	13281	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		16721019	87986	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234258	87986	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		10061124	78906	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
		CHEMBL2112938	78906	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
		44324891	111564	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328093	111564	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		155559741	176287	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4562770	176287	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595125	176287	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		444015	14016	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL1197177	14016	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		44295617	189649	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51510	189649	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44431389	146151	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL391977	146151	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		174174	523	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		260	523	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		320	523	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		CHEMBL517712	523	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		DB00572	523	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		59291421	112777	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298592	112777	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305620	112777	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		164609302	188463	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846958	188463	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027951	188463	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14210083	156712	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4070155	156712	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		324	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		6436265	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		CHEMBL277642	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		324	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		6436265	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		CHEMBL277642	1925	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		324	1925	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		6436265	1925	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		CHEMBL277642	1925	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		10104167	2059	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	2059	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	2059	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44627746	14042	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197392	14042	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569760	14042	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		122203596	155806	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	155806	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	155806	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		52941205	55269	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		CHEMBL1256938	55269	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		CHEMBL1618160	55269	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		316	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		156015246	178239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4648144	178239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650567	178239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		71452793	79655	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115127	79655	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		444015	14016	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL1197177	14016	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118719921	115774	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354067	115774	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		455657	204005	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL69642	204005	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		455656	204010	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL69670	204010	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		24841480	183899	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		135398737	958	93	None	-22	89	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	958	93	None	-22	89	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	958	93	None	-22	89	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	958	93	None	-22	89	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	958	93	None	-22	89	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		135398745	2914	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	2914	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	2914	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	2914	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		44406527	140649	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381469	140649	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2551	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		298	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		488	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		CHEMBL965	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		DB00411	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		46855274	113718	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323285	113718	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		155536739	172215	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		CHEMBL4473985	172215	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		44385509	61063	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL176400	61063	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
		2551	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		298	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		488	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		CHEMBL965	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		DB00411	794	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		16086067	81317	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL215894	81317	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		10248403	103420	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
		CHEMBL3084867	103420	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
		44309209	204323	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71483	204323	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		301	2534	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		9571002	2534	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL151938	2534	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		118500	156999	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4073256	156999	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
		25147647	182139	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
		CHEMBL478226	182139	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
		11798126	41972	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL149484	41972	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		137630848	161116	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4061390	161116	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117131	161116	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		302	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		302	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	2977	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		56593934	65695	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		CHEMBL1834350	65695	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		73352414	92532	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
		CHEMBL2432038	92532	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
		16125648	84735	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222874	84735	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		15065550	205117	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
		CHEMBL77793	205117	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
		72064	78401	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2110892	78401	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
		11131099	120261	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352404	120261	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		302	2977	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	2977	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	2977	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		44593619	187460	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493980	187460	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		73346334	92541	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
		CHEMBL2432048	92541	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
		44295616	188793	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50584	188793	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267766	161319	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL412421	161319	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		44267766	161319	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
		CHEMBL412421	161319	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
		134688371	14429	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		13765	14429	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		CHEMBL1200623	14429	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		164621085	188549	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869980	188549	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028630	188549	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		639794	98769	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL278129	98769	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		3652	46244	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		CHEMBL1535	46244	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		44400175	67769	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL190815	67769	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44295878	191790	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51982	191790	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		71128	96810	25	None	-17	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL26505	96810	25	None	-17	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		16124706	137522	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL375420	137522	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
		303	2978	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		4629	2978	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		8595	2978	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		CHEMBL44674	2978	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		10871551	120511	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL354523	120511	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		44593618	187459	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493979	187459	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		71718669	86958	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323446	86958	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		11012712	57829	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		CHEMBL167027	57829	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		167962	4069	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		9931930	108600	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL320465	108600	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		11079969	163857	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL420662	163857	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44267713	15605	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12215	15605	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		16125400	84663	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222449	84663	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		71456286	79598	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2114430	79598	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		10380647	154434	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
		CHEMBL39900	154434	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
		15050949	203976	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL69458	203976	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		11498	3019	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		4995951	3019	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		CHEMBL59898	3019	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		15888011	204313	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71431	204313	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		44267718	17013	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12542	17013	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL5285607	194304	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1052	21	1	13	10.0	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		155521383	176426	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4450522	176426	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596184	176426	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		71741394	120835	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	120835	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	120835	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		10474247	101404	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL297276	101404	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		15678852	102217	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302923	102217	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	4097	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		57	4097	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		60809	4097	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL21536	4097	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		DB15357	4097	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		2028	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		359	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		4634	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		CHEMBL1231	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		DB01062	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		14964495	12613	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	12613	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		11526446	201804	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
		CHEMBL606904	201804	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
		16086064	79960	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL212645	79960	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		5747382	109203	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	109203	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		44309208	165649	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL424416	165649	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		14964496	8964	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	8964	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10339062	36287	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		CHEMBL144580	36287	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		474188	31649	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL140490	31649	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10595006	11445	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL1180343	11445	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL123099	11445	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		53414666	159301	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4099673	159301	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
		574782	102151	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
		CHEMBL302557	102151	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
		2274	3173	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44379508	58164	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
		CHEMBL168145	58164	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
		11034265	120373	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
		CHEMBL353290	120373	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
		162353386	180980	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4758635	180980	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		46227555	14131	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198062	14131	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL594376	14131	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		44443734	94239	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL250031	94239	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		36014865	182670	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
		CHEMBL4789054	182670	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
		16125682	84289	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL221401	84289	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44299635	100569	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL291562	100569	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		164623185	188570	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864101	188570	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028743	188570	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		137640511	157066	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4074104	157066	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		16125593	84741	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222916	84741	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		3198	205513	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		73345823	89815	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377392	89815	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
		11722587	12936	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1189204	12936	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL538266	12936	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		26987	949	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		6063	949	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		671	949	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		CHEMBL1626	949	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		DB00283	949	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		71575447	86202	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		CHEMBL2312361	86202	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		44299599	167805	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL430587	167805	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		44313166	103101	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL307628	103101	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		2337	3256	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		11061341	78919	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112958	78919	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44295787	189086	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50998	189086	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267759	11750	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11816	11750	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		10163651	163233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	163233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		15870389	120794	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355510	120794	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		277	1301	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2286	3183	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		2745	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		5572	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		66007	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		7315	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		CHEMBL1490	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		DB00376	3861	42	None	-46	8	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		44431388	87319	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233202	87319	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44431380	87985	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234257	87985	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16065136	67926	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910847	67926	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
		140844418	176410	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4576060	176410	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596067	176410	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		140844397	176598	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4567385	176598	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597612	176598	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		140844405	176642	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4474694	176642	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597973	176642	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10316726	12028	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL1183364	12028	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL292857	12028	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		164614994	188502	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4850553	188502	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028287	188502	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155528270	176391	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4461081	176391	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595943	176391	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44325080	111571	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328120	111571	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44392966	66099	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL183903	66099	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		11808040	168395	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL434684	168395	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		75167447	178286	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634230	178286	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650933	178286	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44233190	103402	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084679	103402	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		324	1925	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		6436265	1925	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		CHEMBL277642	1925	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		154417	93260	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	93260	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		10418181	9586	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL112500	9586	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201995	9586	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		205895	11868	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	11868	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		154059	3637	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		2457	3637	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		7483	3637	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		CHEMBL1734	3637	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		DB01591	3637	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		3652	4097	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		57	4097	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		60809	4097	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		CHEMBL21536	4097	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		DB15357	4097	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		155515662	169964	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4441786	169964	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		2200	3131	46	None	-31	12	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		328	3131	46	None	-31	12	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		4848	3131	46	None	-31	12	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		CHEMBL9967	3131	46	None	-31	12	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		DB00670	3131	46	None	-31	12	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		154059	3637	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		2457	3637	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		7483	3637	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		CHEMBL1734	3637	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		DB01591	3637	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		44308910	203742	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL67814	203742	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		9794266	157151	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4075227	157151	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
		44318817	169114	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL440138	169114	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		16086065	79797	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL211976	79797	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		3072501	107269	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	107269	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		5747382	109203	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	109203	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		71716224	86956	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323444	86956	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		71451002	79710	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		CHEMBL2115494	79710	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		71451002	79710	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		CHEMBL2115494	79710	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		657347	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL105457	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL387632	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		72190449	92272	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426676	92272	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		657347	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL105457	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL387632	5076	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		44274302	77067	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL20732	77067	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		2166	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		305	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		5910	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		CHEMBL550	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		DB01085	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		44448419	12336	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185266	12336	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL403592	12336	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		44295713	189748	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51588	189748	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		71459604	83793	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205811	83793	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		463319	119396	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL344607	119396	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		1971	2866	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		14967772	13413	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1192807	13413	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL544107	13413	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		688567	63034	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL1788199	63034	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		10251468	94069	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		CHEMBL249006	94069	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		12963076	196625	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL564226	196625	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		109018479	181818	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
		CHEMBL4778178	181818	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		145961125	161546	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128667	161546	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		71463063	83801	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205825	83801	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		44318928	205763	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
		CHEMBL82859	205763	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
		250	3386	8	None	-35481	12	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		5311416	3386	8	None	-35481	12	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		CHEMBL69733	3386	8	None	-35481	12	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		24865895	96005	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL259662	96005	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL390842	96005	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		44274469	80608	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21509	80608	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		44406321	72778	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL199981	72778	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		6918276	15611	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	15611	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		60138186	120836	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	120836	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	120836	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	120836	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44267712	162023	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL415975	162023	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		1548953	207679	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	207679	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		71452387	83803	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
		CHEMBL2205829	83803	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
		71452387	83803	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
		CHEMBL2205829	83803	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
		11006792	78922	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112961	78922	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		11501540	133603	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		CHEMBL371293	133603	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		44406598	73025	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200957	73025	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44383238	120627	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL354636	120627	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
		59291452	112776	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298590	112776	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305615	112776	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL5279174	194016	0	None	-16	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.7	C#CCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155541812	173050	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
		CHEMBL4519301	173050	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
		164623942	188579	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4873621	188579	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028796	188579	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		156020548	178178	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4649224	178178	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		10759971	65253	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL182761	65253	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		44627748	14094	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL1197705	14094	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL583027	14094	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		15050960	102327	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303622	102327	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		2381	663	48	None	-15	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		374	663	48	None	-15	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		7128	663	48	None	-15	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL1101	663	48	None	-15	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		DB00810	663	48	None	-15	8	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		156021441	178154	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648939	178154	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44308912	102833	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL305531	102833	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
		155562285	175842	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
		CHEMBL4585326	175842	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
		44296044	194670	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL53190	194670	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		14964499	169389	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	169389	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15196354	119270	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		CHEMBL343697	119270	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		137630994	161140	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4103375	161140	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4117267	161140	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		10421982	206041	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		CHEMBL85190	206041	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		16086061	80218	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		CHEMBL213709	80218	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		10597259	119257	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
		CHEMBL343644	119257	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
		14964499	169389	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	169389	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		14964506	113316	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	113316	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		137629935	161020	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		118710670	120833	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	120833	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	120833	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		2551	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		298	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		488	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		CHEMBL965	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		DB00411	794	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		164612852	188483	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852544	188483	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028161	188483	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		164627387	188606	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874785	188606	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028995	188606	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		162353369	180795	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756442	180795	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
		19021478	192697	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
		CHEMBL5219452	192697	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
		3497	1181	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		5311123	1181	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		CHEMBL1628706	1181	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		457875	5229	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
		CHEMBL106247	5229	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
		44267754	15253	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12115	15253	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267714	97375	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL269645	97375	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		4601	206747	35	None	-2	16	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	206747	35	None	-2	16	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	206747	35	None	-2	16	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		73350398	89798	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377262	89798	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
		15678859	102775	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL305197	102775	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71463061	83795	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205813	83795	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		156015968	178245	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648657	178245	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650620	178245	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		10874119	4907	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
		CHEMBL104574	4907	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
		10862395	5026	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105148	5026	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44312468	204587	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73145	204587	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
		44443732	94238	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL250030	94238	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		15050940	102827	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL305501	102827	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		13773338	79589	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114395	79589	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		13773338	79589	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114395	79589	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		44382125	120416	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL353689	120416	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		164617650	188521	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4860171	188521	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028445	188521	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		156014875	178241	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4640846	178241	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650577	178241	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		46227413	14140	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198087	14140	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL595265	14140	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		44267728	14747	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		CHEMBL12064	14747	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		2028	2979	80	None	-5	10	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		359	2979	80	None	-5	10	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		4634	2979	80	None	-5	10	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		CHEMBL1231	2979	80	None	-5	10	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		DB01062	2979	80	None	-5	10	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		44382652	59026	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169313	59026	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		90645361	112816	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298601	112816	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307123	112816	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		10373706	57409	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		CHEMBL165220	57409	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		154734599	2503	12	None	1	11	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		327	2503	12	None	1	11	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		4108	2503	12	None	1	11	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		CHEMBL27673	2503	12	None	1	11	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		44324848	206780	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90199	206780	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		154734599	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		327	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		4108	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		CHEMBL27673	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		71741394	120835	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	120835	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	120835	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		154734599	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		327	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		4108	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		CHEMBL27673	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		154734599	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		327	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		4108	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		CHEMBL27673	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		164611187	188470	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4851265	188470	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028060	188470	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		6338102	100465	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL290723	100465	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL59587	100465	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		11552283	71690	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
		CHEMBL196481	71690	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
		137630667	161092	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4100938	161092	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116890	161092	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		11796409	38391	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		CHEMBL146351	38391	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		155515982	170010	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	170010	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		170332	160976	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		137629919	161009	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4095626	161009	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116258	161009	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		10386	161168	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4092348	161168	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117554	161168	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		10810094	119560	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL345985	119560	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		9976808	103442	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		CHEMBL3084892	103442	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		156015895	178281	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643290	178281	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650874	178281	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44627742	198377	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL576707	198377	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		44593623	187880	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496503	187880	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539373	187880	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		44450622	95833	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258907	95833	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		167962	4069	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		44274432	80127	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21328	80127	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		58438475	92273	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426677	92273	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		24894635	169807	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL443939	169807	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL527880	169807	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		44443721	94262	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL250203	94262	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		11012653	120820	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355769	120820	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		164617938	188526	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854179	188526	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028470	188526	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10969696	132105	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL369575	132105	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44593621	193297	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524061	193297	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10160219	4930	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104693	4930	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		72190451	92276	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426680	92276	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		24894632	189419	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
		CHEMBL513277	189419	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
		10020614	204767	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
		CHEMBL74736	204767	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
		13773342	79682	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115341	79682	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		302	2977	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	2977	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	2977	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4520788	213975	10	None	-69	25	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		10870954	120310	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL352779	120310	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44384327	59789	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL172646	59789	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		71457690	83798	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205817	83798	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		9976807	103435	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL3084884	103435	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		71455894	83802	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205827	83802	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		71455894	83802	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2205827	83802	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		10336462	103434	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		CHEMBL3084883	103434	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		44295789	189438	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51339	189438	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		14964496	8964	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	8964	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		11561621	201803	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
		CHEMBL606903	201803	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
		9894922	120294	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		CHEMBL352660	120294	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		154734599	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		327	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		4108	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		CHEMBL27673	2503	12	None	-1	11	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		54757332	67924	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
		CHEMBL1910845	67924	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
		410345	89803	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377269	89803	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
		11748799	165411	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL423831	165411	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		10226457	12975	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL1189471	12975	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL538793	12975	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		9909908	13519	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		CHEMBL1193635	13519	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		CHEMBL545077	13519	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		11071537	26496	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL136027	26496	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		174174	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		302	2977	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		4630	2977	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL7634	2977	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		44267695	10724	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11710	10724	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		14964507	114355	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	114355	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		303	2978	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	2978	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	2978	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	2978	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		14685523	37754	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
		CHEMBL14580	37754	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
		15196236	119200	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		CHEMBL343236	119200	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		44415886	79835	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL212141	79835	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		44309108	103094	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL307554	103094	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10830843	203963	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL69383	203963	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		44308799	204029	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69765	204029	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44285557	100153	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL287834	100153	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		137636830	161224	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4061384	161224	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117956	161224	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		73356869	92268	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426672	92268	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		118710660	120831	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	120831	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	120831	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		11740181	103425	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
		CHEMBL3084873	103425	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
		44274468	80606	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21508	80606	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		13773336	79683	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115342	79683	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		10025038	168827	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL437781	168827	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		164626977	188599	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874412	188599	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028969	188599	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		4189	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		72190452	92278	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426682	92278	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		145961126	161553	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128764	161553	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		11523051	96289	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093084	96289	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL261194	96289	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	194916	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	194916	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		23352279	207580	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		CHEMBL94921	207580	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		15105211	172876	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL451542	172876	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		16125398	85117	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL224783	85117	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		9969695	160888	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
		CHEMBL411514	160888	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
		187	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		294	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		65	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		8593	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		CHEMBL667	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		DB03128	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		145961495	161446	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4127373	161446	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		11536903	2397	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		3262	2397	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		CHEMBL3770346	2397	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		16094810	137886	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
		CHEMBL376295	137886	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
		71456285	79595	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
		CHEMBL2114426	79595	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
		24865895	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL259662	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL390842	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		24865895	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL259662	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL390842	96005	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		44274433	99510	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL283320	99510	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894516	172708	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
		CHEMBL450463	172708	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
		15196233	121115	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357404	121115	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
		44378753	120282	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL352607	120282	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		2028	2979	80	None	-8	10	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		359	2979	80	None	-8	10	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		4634	2979	80	None	-8	10	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		CHEMBL1231	2979	80	None	-8	10	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		DB01062	2979	80	None	-8	10	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		3042	1414	35	None	-28	14	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	1414	35	None	-28	14	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	1414	35	None	-28	14	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	1414	35	None	-28	14	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	1414	35	None	-28	14	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		44392933	166303	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
		CHEMBL427145	166303	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
		118710660	120831	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	120831	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	120831	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710662	120830	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	120830	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	120830	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		56965018	77181	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042552	77181	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078967	77181	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		164621443	188554	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4867483	188554	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028653	188554	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015141	178267	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4642045	178267	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650774	178267	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		174174	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	523	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		302	2977	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	2977	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	2977	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		15196236	119200	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		CHEMBL343236	119200	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		199230	163135	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	163135	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		6098192	201801	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606901	201801	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL306462	102965	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	211	2	1	4	1.1	CCO/C(O)=C1\CN2CCCC(C2)C1=O	10.1021/jm020572p
		44318930	106172	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		CHEMBL313738	106172	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		53391301	92274	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426678	92274	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		462902	119853	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL348667	119853	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10660	14416	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	14416	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		24894109	189028	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL509202	189028	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL551563	189028	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		162353376	180427	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4752380	180427	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
		14925759	158038	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4085780	158038	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		46227415	14129	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198050	14129	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL593871	14129	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		16125683	84650	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL222403	84650	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
		939078	63069	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL1788286	63069	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		2562	204599	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL1256696	204599	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL73234	204599	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		462573	29529	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL138502	29529	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		16125506	84779	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223187	84779	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
		463210	164915	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL422326	164915	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		135398737	958	93	None	-22	89	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-22	89	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-22	89	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-22	89	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-22	89	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		9968046	198163	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL57485	198163	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		44450637	155196	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL402473	155196	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		162353379	180962	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4758449	180962	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
		44386115	131438	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL369062	131438	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44295977	192731	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL52203	192731	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267762	15438	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12150	15438	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		9889312	78430	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	78430	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44312066	164381	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL421304	164381	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		302	2977	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		4630	2977	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		CHEMBL7634	2977	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		71459971	79539	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114066	79539	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44627852	14039	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197387	14039	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569712	14039	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10314131	103424	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
		CHEMBL3084872	103424	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
		164627575	188608	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4873979	188608	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029004	188608	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44593625	188130	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498358	188130	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539120	188130	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44383415	120766	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355299	120766	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		11819545	37405	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL145488	37405	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
		11819883	120991	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL356321	120991	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
		46878242	201811	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606962	201811	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		146025727	171685	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44328561	207367	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		CHEMBL93709	207367	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		10105296	205922	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		CHEMBL84113	205922	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		155552185	174061	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	174061	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		45786849	157805	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4083241	157805	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
		10718110	39915	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		CHEMBL147778	39915	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		10671167	121499	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL358289	121499	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		190868	13142	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		CHEMBL1190617	13142	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		CHEMBL541284	13142	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		2200	3131	46	None	-35	12	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		328	3131	46	None	-35	12	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		4848	3131	46	None	-35	12	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		CHEMBL9967	3131	46	None	-35	12	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		DB00670	3131	46	None	-35	12	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		73346332	92535	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432041	92535	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		44299616	195708	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL55698	195708	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		92218234	120827	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		CHEMBL3309718	120827	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		CHEMBL3558072	120827	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		46227411	14121	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198027	14121	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL593443	14121	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		15678857	204032	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL69796	204032	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		156010212	178237	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634066	178237	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650562	178237	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		302	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		137635734	156112	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4063176	156112	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44296007	101964	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL301354	101964	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267703	14958	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12085	14958	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44344029	10120	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115642	10120	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		15050957	203594	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL66914	203594	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		118710660	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		174174	523	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		118710660	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	120831	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		14939895	82119	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201997	82119	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL216629	82119	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		10404824	103431	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084880	103431	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		44392906	12260	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL1184677	12260	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL363895	12260	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		55005	104775	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	104775	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		11610557	72031	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL197588	72031	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		10619926	39802	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL147672	39802	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		176	398	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		10033774	56546	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		CHEMBL163901	56546	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		16125257	144676	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
		CHEMBL390839	144676	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
		57326142	77180	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2042401	77180	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2078965	77180	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		46227457	14134	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL1198075	14134	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL594801	14134	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		16125621	84363	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL221829	84363	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		2200	3131	46	None	-31	12	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		328	3131	46	None	-31	12	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		4848	3131	46	None	-31	12	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		CHEMBL9967	3131	46	None	-31	12	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		DB00670	3131	46	None	-31	12	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		44383064	120307	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352756	120307	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10807270	100457	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
		CHEMBL290675	100457	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
		162667844	182533	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4787283	182533	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		16124707	138146	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL376781	138146	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44382841	59402	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170977	59402	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		43815	186920	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL1708	186920	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL490	186920	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		5648	78411	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2107687	78411	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2111176	78411	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		16086063	80562	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL214898	80562	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		71741394	120835	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	120835	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	120835	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		164613685	188489	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4861655	188489	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028207	188489	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		15157138	99625	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL284137	99625	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		155557119	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4555411	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4596899	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		155557119	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4555411	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596899	176511	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		10155850	96742	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL264414	96742	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44627860	14035	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197371	14035	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL568870	14035	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10789183	104367	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL310132	104367	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319009	106936	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL314831	106936	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44318782	206133	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85996	206133	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		154734599	2503	12	None	-1	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		327	2503	12	None	-1	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		4108	2503	12	None	-1	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		CHEMBL27673	2503	12	None	-1	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		44318851	104726	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL310558	104726	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		164608958	188460	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846447	188460	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027936	188460	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964511	12101	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1183954	12101	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL325473	12101	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		10465050	36187	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144493	36187	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
		162353393	179439	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
		CHEMBL4740422	179439	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
		137661377	159209	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4098720	159209	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		24894630	188969	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL508347	188969	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL555475	188969	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		156016047	178260	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4647816	178260	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650722	178260	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		44267758	12380	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11856	12380	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44400218	67629	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL190459	67629	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
		73352415	92538	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432044	92538	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		44593622	187796	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL495888	187796	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL556390	187796	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		156015809	178318	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645019	178318	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651096	178318	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11833737	120339	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352966	120339	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		73347725	92270	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426674	92270	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		24894633	176900	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
		CHEMBL461709	176900	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
		73355415	92533	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		CHEMBL2432039	92533	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		10852782	168280	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
		CHEMBL43398	168280	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
		5281825	107548	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
		CHEMBL318849	107548	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
		44329347	208088	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
		CHEMBL97765	208088	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
		11504244	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		3652	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		156010398	178236	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633895	178236	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650561	178236	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		156011112	178275	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633679	178275	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650842	178275	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		145960427	161450	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4127428	161450	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		42853214	206454	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL88078	206454	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		25025581	201996	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		CHEMBL608151	201996	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		10663237	147227	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
		CHEMBL39284	147227	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
		71459909	78615	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL2112313	78615	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		73350846	92266	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426670	92266	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		46227455	14170	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198609	14170	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL608985	14170	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		44406573	72974	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200693	72974	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406690	74993	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL203249	74993	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9871871	120758	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355169	120758	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		9843814	127249	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
		CHEMBL36583	127249	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
		44431383	88022	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234439	88022	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16125370	84646	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222387	84646	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
		155522355	176409	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	176409	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	176409	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44295965	189580	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51459	189580	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		10470	2488	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		1689	2488	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		4057	2488	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		CHEMBL524004	2488	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		DB04843	2488	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		140844422	176441	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4452706	176441	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596309	176441	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10104167	2059	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	2059	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	2059	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44311704	204201	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL70848	204201	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311704	204201	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL70848	204201	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		688566	195883	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL558910	195883	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		10107360	78907	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
		CHEMBL2112939	78907	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
		164614388	188497	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4848683	188497	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028251	188497	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44343736	110586	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL325451	110586	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		134272561	176427	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4540604	176427	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596189	176427	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44627858	14038	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197382	14038	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569307	14038	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		16125642	142010	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL387546	142010	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		154734599	2503	12	None	1	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		327	2503	12	None	1	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		4108	2503	12	None	1	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		CHEMBL27673	2503	12	None	1	11	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		14939891	169364	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL442014	169364	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44296054	189156	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51096	189156	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		10119364	43250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	43250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		44431381	149021	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394254	149021	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		164616974	188518	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4857722	188518	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028407	188518	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44378765	56544	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL163887	56544	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44344030	10153	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115807	10153	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		174174	523	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10104167	2059	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	2059	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	2059	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		10109563	158540	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL409151	158540	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		16094788	141915	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL386983	141915	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		10606253	157273	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL407678	157273	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		13981865	112812	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3289391	112812	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3306998	112812	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		1201549	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		333	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		7601	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		CHEMBL1201203	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		CHEMBL438151	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		DB00245	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		44378862	58119	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
		CHEMBL167629	58119	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
		16065268	67928	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
		CHEMBL1910849	67928	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
		155542840	176393	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4521993	176393	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595947	176393	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		9815331	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL64000	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		9815331	203107	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
		CHEMBL64000	203107	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
		154417	93260	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
		CHEMBL2449003	93260	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
		155538050	172349	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4475862	172349	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44295618	165127	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL422763	165127	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		44267706	163249	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL418530	163249	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		10119364	43250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	43250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		9889312	78430	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	78430	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		2705	3842	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		360	3842	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		443879	3842	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		CHEMBL1382	3842	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		DB01036	3842	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		2705	3842	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		360	3842	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		443879	3842	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		CHEMBL1382	3842	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		DB01036	3842	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		16115796	137217	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375073	137217	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		16115951	141643	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL385328	141643	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		12872437	12058	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		CHEMBL1183585	12058	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		CHEMBL306182	12058	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		9889312	78430	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2111540	78430	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		154417	93260	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	93260	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		118710664	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710664	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	120832	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		57326235	77185	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042405	77185	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079009	77185	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		9871136	207115	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL92110	207115	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		164621814	188556	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4867301	188556	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028667	188556	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44311835	204537	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72787	204537	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311835	204537	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72787	204537	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44267725	11324	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11794	11324	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267772	15794	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL12228	15794	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		10269504	134373	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL371734	134373	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406268	140796	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381878	140796	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44213237	101921	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL300998	101921	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		9889312	78430	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	78430	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		2551	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		298	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		488	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		CHEMBL965	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		DB00411	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		15050956	102928	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL306201	102928	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		2551	794	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	794	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		10557581	21774	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202001	21774	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL131913	21774	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		10398843	36407	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
		CHEMBL144693	36407	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
		137629935	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		10622033	42782	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		CHEMBL150219	42782	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		208598	35928	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL144247	35928	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
		6075	150108	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	150108	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		16125529	137206	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374987	137206	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		463892	31877	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		CHEMBL140706	31877	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		44392898	123088	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL360988	123088	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		71575027	86223	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL2312389	86223	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		463616	32050	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		CHEMBL140827	32050	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		2335	11848	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	11848	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	11848	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	11848	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		306	3456	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		3536	3456	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		53930639	3456	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		9577995	3456	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		CHEMBL134641	3456	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		11504244	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	106519	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		10236758	115772	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
		CHEMBL3354065	115772	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
		137655636	158736	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4093527	158736	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44437249	11872	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182436	11872	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		CHEMBL238825	11872	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		137629935	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	161020	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		16125372	84654	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222424	84654	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		118719927	115781	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354074	115781	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
		6603753	108702	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL320820	108702	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
		44422692	11853	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182296	11853	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL228144	11853	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		24865895	96005	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL259662	96005	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL390842	96005	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		44383595	166115	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		CHEMBL426032	166115	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		10476118	123827	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
		CHEMBL362438	123827	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
		134271233	176539	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4591883	176539	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597134	176539	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		118710664	120832	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	120832	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	120832	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		164622170	188560	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863723	188560	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028687	188560	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44593626	187853	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496306	187853	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539121	187853	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		15050953	102339	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303684	102339	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		101676031	97328	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		16175987	97328	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201998	97328	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL269272	97328	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		16664965	84902	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223668	84902	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		44308733	102190	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL302809	102190	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		611037	203694	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL67532	203694	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
		14956862	13735	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		CHEMBL1195116	13735	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		CHEMBL553865	13735	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		14964513	11419	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	11419	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	11419	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		14964497	14291	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	14291	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10622718	38402	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL146359	38402	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		15086397	13720	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1195036	13720	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL553755	13720	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		3652	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		118719928	115782	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354075	115782	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
		156013536	178311	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4639297	178311	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651058	178311	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		108993439	179860	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4745429	179860	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		71452382	83794	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205812	83794	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		44593617	187431	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493795	187431	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		11048067	5579	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL107679	5579	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		135430667	4958	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
		CHEMBL104803	4958	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
		11143997	5022	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105122	5022	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		10225881	107621	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL318995	107621	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		58438451	92285	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426689	92285	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		44437298	11887	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1182460	11887	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL239436	11887	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		9998202	69166	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	69166	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44267749	12948	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11893	12948	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267693	169184	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL440601	169184	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11595794	135701	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		CHEMBL372983	135701	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		44313630	204819	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL75217	204819	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		10525412	41974	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
		CHEMBL149486	41974	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
		15050961	203822	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68446	203822	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		155525065	176554	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4456524	176554	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597243	176554	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		1935	3734	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		2551	3734	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		6687	3734	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		CHEMBL95	3734	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		DB00382	3734	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		44568347	191651	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL519609	191651	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		155518181	170261	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4446039	170261	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		16085999	80292	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL214029	80292	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		10646906	119233	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
		CHEMBL343449	119233	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
		44309089	103010	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL306903	103010	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10061123	36890	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145081	36890	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
		44207909	16699	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		CHEMBL1242923	16699	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		44328540	207782	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		CHEMBL96042	207782	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		14964499	169389	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	169389	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		137630043	161037	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4099667	161037	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116455	161037	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44400185	69326	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192885	69326	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44295977	192731	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		CHEMBL52203	192731	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		1273944	202595	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		CHEMBL612034	202595	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		73352329	92265	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426669	92265	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		156015719	178258	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4646457	178258	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650699	178258	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		156011605	178283	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4638067	178283	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650888	178283	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		10101246	9546	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	9546	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		9998202	69166	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	69166	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44382865	120281	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352596	120281	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		16125620	84647	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL222388	84647	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		15105209	103619	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL308707	103619	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		16125371	84759	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		CHEMBL223017	84759	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		53324553	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		53324553	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	56855	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		11013666	59432	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL171102	59432	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44593616	193214	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL523518	193214	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		162649767	180102	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4748337	180102	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
		44448500	12334	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185248	12334	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL402282	12334	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		145961152	161591	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129382	161591	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		162658112	181071	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4759774	181071	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		73347827	92544	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432052	92544	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		14964494	11957	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	11957	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL5287315	194379	0	None	-12	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	460	8	1	3	6.5	C#CCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		1734	116	10	None	-9	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		307	116	10	None	-9	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL168067	116	10	None	-9	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		214124	169691	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL443780	169691	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		164619478	188539	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872882	188539	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028552	188539	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		14210083	156712	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	156712	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		137629887	161010	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4065555	161010	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116259	161010	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		14964507	114355	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	114355	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		2551	794	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	794	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	794	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	794	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	794	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		13326	1052	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
		167312460	1052	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
		CHEMBL5279691	1052	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
		10716120	38283	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
		CHEMBL146249	38283	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
		44364174	121985	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
		CHEMBL359220	121985	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
		2726	919	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		10880435	59059	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169494	59059	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		11015312	5274	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106505	5274	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44448538	12419	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185855	12419	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL436850	12419	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		44267740	98322	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		CHEMBL274999	98322	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		1353	1911	93	None	-338	83	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		3559	1911	93	None	-338	83	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		86	1911	93	None	-338	83	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		CHEMBL54	1911	93	None	-338	83	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		DB00502	1911	93	None	-338	83	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		155565286	176266	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4579642	176266	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595003	176266	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		156012936	178296	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4639004	178296	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650969	178296	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		11092603	4861	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104332	4861	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		73355325	92267	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426671	92267	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		137642607	158518	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4091231	158518	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		9817231	158236	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		CHEMBL4088272	158236	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		10693031	120987	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
		CHEMBL356305	120987	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
		15678851	102673	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL304582	102673	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		15888010	203846	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68584	203846	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964498	13887	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	13887	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15050941	203667	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL67381	203667	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
		2230	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		296	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		CHEMBL7303	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		DB04365	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		137630995	161141	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4102555	161141	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117268	161141	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44328347	207551	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
		CHEMBL94772	207551	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
		44318817	169114	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL440138	169114	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		10836338	39333	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147105	39333	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		10573458	119262	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
		CHEMBL343659	119262	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
		14537192	100224	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		CHEMBL288482	100224	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		44267796	98101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL273439	98101	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44326538	13266	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL1191560	13266	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		164622564	188561	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862221	188561	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028706	188561	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		2230	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		296	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL7303	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		DB04365	465	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		164614732	188498	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4860752	188498	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028266	188498	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		162353371	181650	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4775999	181650	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		10916286	5102	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
		CHEMBL105593	5102	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
		15157141	92801	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL24369	92801	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		71449188	79685	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
		CHEMBL2115359	79685	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
		15157140	99874	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL285898	99874	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		1210	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	918	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		9880462	72904	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		CHEMBL200416	72904	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		9308	17754	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL1255785	17754	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL12587	17754	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL292911	17754	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		10066369	120258	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	120258	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		10269504	134373	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL371734	134373	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44319342	205718	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL82512	205718	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		511332	109628	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		CHEMBL322251	109628	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		44267694	12727	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11877	12727	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		511332	109628	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL322251	109628	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		135409468	2035	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		333	2035	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		CHEMBL845	2035	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		464036	9746	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		CHEMBL113436	9746	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		14964506	113316	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	113316	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		464036	9746	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL113436	9746	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10012596	189014	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL50898	189014	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		1353	1911	93	None	-338	83	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		3559	1911	93	None	-338	83	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		86	1911	93	None	-338	83	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		CHEMBL54	1911	93	None	-338	83	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		DB00502	1911	93	None	-338	83	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		15050947	102597	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL304109	102597	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		44406572	72842	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200208	72842	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406346	136150	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL373256	136150	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2200	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		328	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		4848	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		CHEMBL9967	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		DB00670	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		164611279	188473	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854472	188473	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028067	188473	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44319010	205826	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83363	205826	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		50898777	56440	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		CHEMBL1632158	56440	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		15050950	204057	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70003	204057	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44267715	14544	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12029	14544	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		462989	33104	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL141699	33104	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		44267750	15248	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12112	15248	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267697	16317	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12268	16317	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11011757	59223	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
		CHEMBL170221	59223	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
		10104167	2059	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	2059	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	2059	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44448496	11912	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182637	11912	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257547	11912	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		15157139	99811	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL285440	99811	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		44267751	98386	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		CHEMBL275347	98386	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		154734599	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		327	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		4108	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		CHEMBL27673	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		44383065	120380	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL353311	120380	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
		44312152	204146	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL70531	204146	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL5268503	193567	0	None	-10	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.7	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		CHEMBL5283759	194228	0	None	-7	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1024	19	1	13	9.4	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		15678850	103008	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL306875	103008	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		15157137	99895	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL286008	99895	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		71741394	120835	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	120835	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	120835	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44267799	16350	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12291	16350	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		14964499	169389	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	169389	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10421982	206041	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		CHEMBL85190	206041	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		10812455	39787	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147653	39787	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		15196354	119270	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		CHEMBL343697	119270	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		23352285	96779	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		CHEMBL264747	96779	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		137628850	160969	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4097248	160969	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4115965	160969	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		10957754	59044	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL169401	59044	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		46905988 91930079	10416	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL1162964	10416	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		15050946	102646	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL304391	102646	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		1212	1662	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		2200	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		328	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		4848	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		CHEMBL9967	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		DB00670	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		2200	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		328	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		4848	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		CHEMBL9967	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		DB00670	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		2200	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		328	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		4848	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		CHEMBL9967	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		DB00670	3131	46	None	-31	12	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		13773340	79590	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114396	79590	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		16125698	84556	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222054	84556	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		70682037	75881	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048820	75881	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		3652	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		24894637	188719	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL504733	188719	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL553434	188719	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		44296020	194835	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL53965	194835	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		154734599	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		327	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		4108	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		CHEMBL27673	2503	12	None	1	11	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		156578	141489	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
		CHEMBL38441	141489	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
		16125335	138158	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL376900	138158	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		462772	102311	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL303503	102311	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		44385809	61466	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL177040	61466	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		2200	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		328	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		4848	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		CHEMBL9967	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		DB00670	3131	46	None	-35	12	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		9991939	119352	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL344327	119352	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		11796509	40697	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		CHEMBL148450	40697	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		10354430	37171	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145301	37171	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		9839491	163209	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		CHEMBL41830	163209	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		CHEMBL554874	163209	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		10035281	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL294273	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		10035281	100982	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		CHEMBL294273	100982	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		10035281	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		CHEMBL294273	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		14964506	113316	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	113316	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		15196232	165371	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL423746	165371	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
		137628858	160971	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4074319	160971	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115967	160971	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		3055	1433	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		313	1433	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		7163	1433	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		CHEMBL936	1433	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		DB01231	1433	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		44384258	128674	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		CHEMBL366819	128674	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		3652	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60138186	120836	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	120836	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	120836	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	120836	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		11504244	106519	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	106519	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	106519	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	106519	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		44448646	11908	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182612	11908	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL254586	11908	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		10035281	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
		CHEMBL294273	100982	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
		46227483	14125	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198039	14125	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593685	14125	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		9868297	94114	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249205	94114	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		1016	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		73347826	92542	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
		CHEMBL2432049	92542	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
		3191	102858	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		44308861	203528	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66400	203528	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		44404147	169090	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL439867	169090	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL5282659	194167	0	None	-14	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	465	9	2	4	5.8	NCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		11968014	12758	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	12758	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		24936155	94622	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
		CHEMBL252258	94622	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
		44309151	203583	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66820	203583	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10103909	203304	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL64779	203304	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
		275176	89813	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
		CHEMBL2377388	89813	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
		3055	1433	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		313	1433	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		7163	1433	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL936	1433	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		DB01231	1433	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		67407161	92284	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426688	92284	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		57326237	77183	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042407	77183	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078985	77183	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		44384326	59876	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
		CHEMBL172969	59876	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
		109013312	180134	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4748774	180134	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		11530307	78342	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093082	78342	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109993	78342	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		7141654	175789	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
		CHEMBL458416	175789	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
		180	401	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		44627739	198372	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL576663	198372	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		44308818	102081	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
		CHEMBL302145	102081	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
		14964495	12613	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	12613	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		199230	163135	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	163135	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		137630127	161049	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4084607	161049	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116537	161049	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		16125443	84649	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
		CHEMBL222402	84649	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
		44274400	98938	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL279520	98938	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		3675988	176835	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
		CHEMBL461087	176835	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
		16125437	84348	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL221713	84348	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		16125568	97330	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
		CHEMBL269280	97330	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
		7333	99357	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
		CHEMBL282433	99357	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
		1530	2182	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10410916	94070	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249007	94070	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44378598	58137	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL167838	58137	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
		156014820	178305	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4646116	178305	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650998	178305	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		11968014	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		10225340	204334	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71531	204334	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		174174	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		25034182	172584	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		CHEMBL448870	172584	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		CHEMBL540359	172584	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		25010559	96769	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL264676	96769	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		9936450	35155	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
		CHEMBL143469	35155	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
		44406597	72909	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200432	72909	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406686	140911	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL382213	140911	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44382699	59140	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169876	59140	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		129989	451	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		8584	451	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		CHEMBL43383	451	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		44292486	181511	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL47650	181511	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		11968014	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		11968014	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		118710670	120833	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	120833	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	120833	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		16115801	12295	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL1184882	12295	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375851	12295	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		9883040	100537	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL291339	100537	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL542622	100537	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		156011965	177292	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
		CHEMBL4636528	177292	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
		70685504	74454	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		CHEMBL2021478	74454	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		CHEMBL2027846	74454	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		11968014	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	12758	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		164625419	188590	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862087	188590	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028881	188590	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		71461681	79540	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114067	79540	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		59291461	112775	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298334	112775	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305613	112775	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		23983764	10333	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
		CHEMBL1162116	10333	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
		154417	93260	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	93260	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		1201549	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	597	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		9892600	58496	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
		CHEMBL168329	58496	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
		14939897	96549	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201994	96549	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL262913	96549	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44311761	102850	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL305607	102850	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		9889312	78430	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	78430	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		9798900	63136	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL1779047	63136	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL1789446	63136	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		44311761	102850	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL305607	102850	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		1734	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		307	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		CHEMBL168067	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		69058946	106475	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084658	106475	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3140110	106475	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		44233192	106482	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084643	106482	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3140141	106482	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		70687661	74453	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021476	74453	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027845	74453	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		1734	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		307	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		CHEMBL168067	116	10	None	-12	12	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		11039424	78916	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112955	78916	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		155529196	171410	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		CHEMBL4462631	171410	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		155554149	175447	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4576768	175447	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		10500741	38546	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL146464	38546	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		10104	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		6604866	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		CHEMBL1493369	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		132712	171798	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4468100	171798	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
		73353378	89802	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377268	89802	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
		44309231	169498	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL443267	169498	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44308913	203967	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69402	203967	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		155511167	169558	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4435641	169558	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		10105296	205922	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		CHEMBL84113	205922	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		10244370	121525	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL358505	121525	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		16086003	80431	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL214642	80431	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		14964497	14291	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	14291	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15749863	154611	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL39922	154611	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		156009611	178257	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634605	178257	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650698	178257	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		156015730	178316	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4644389	178316	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651081	178316	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		16125508	84332	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
		CHEMBL221660	84332	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
		16125680	136637	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL373994	136637	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44593621	193297	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524061	193297	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		611101	203879	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68771	203879	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		10315426	101048	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL294663	101048	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		118710666	120829	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	120829	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	120829	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		155559291	176659	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4563530	176659	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598099	176659	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		24894514	172734	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL450729	172734	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
		463493	203636	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL67172	203636	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		44400323	68669	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		CHEMBL192065	68669	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		9859365	8497	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL109405	8497	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		16125589	84699	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222636	84699	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		167962	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		44449463	96105	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL260228	96105	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44627744	14040	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL1197389	14040	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL569729	14040	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		167962	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		6472	202747	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
		CHEMBL61946	202747	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
		44318736	107021	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		CHEMBL315428	107021	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		16086066	139235	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL378872	139235	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		10503358	38686	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL146567	38686	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		10647703	120968	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
		CHEMBL356181	120968	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
		44318851	104726	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL310558	104726	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		10984804	98476	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL275914	98476	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		10835518	40327	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL148129	40327	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		44383554	120790	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
		CHEMBL355475	120790	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
		44406476	140524	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381020	140524	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9913892	205837	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83459	205837	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319006	206172	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL86309	206172	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10044685	206333	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL87302	206333	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10109893	82165	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		CHEMBL216983	82165	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		CHEMBL544840	82165	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		44406342	72170	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL197973	72170	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		11536903	2397	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		3262	2397	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		CHEMBL3770346	2397	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		10164480	43345	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL150707	43345	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		6472	202747	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL61946	202747	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		9985181	120358	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		CHEMBL353140	120358	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		44383653	120851	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL355854	120851	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10969390	59677	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL172233	59677	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		9843967	155458	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
		CHEMBL40391	155458	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
		10092649	193073	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
		CHEMBL522460	193073	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
		11794901	119583	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL346194	119583	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		611066	157509	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL407975	157509	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
		10043954	82278	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21716	82278	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		302	2977	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		4630	2977	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		CHEMBL7634	2977	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		3652	4097	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		164624458	188583	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863121	188583	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028823	188583	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164625211	188588	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869865	188588	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028864	188588	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		171578	12304	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		CHEMBL1184962	12304	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		CHEMBL380759	12304	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		162353374	180043	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4747590	180043	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		118719925	115779	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
		CHEMBL3354072	115779	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
		44627856	197489	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569953	197489	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		290	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		4022	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		5926	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		CHEMBL40554	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		CHEMBL74300	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		7141656	176837	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
		CHEMBL461089	176837	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
		290	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		4022	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		5926	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		CHEMBL40554	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		CHEMBL74300	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		290	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		4022	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		5926	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		CHEMBL40554	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		CHEMBL74300	2473	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		156015484	178291	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645254	178291	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650952	178291	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		11101362	5125	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
		CHEMBL105674	5125	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
		16125567	84758	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL223016	84758	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		16125507	166179	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL426393	166179	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
		44312464	204656	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73661	204656	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		11759212	57892	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL167223	57892	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		10316726	12028	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL1183364	12028	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL292857	12028	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		155554262	176555	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582069	176555	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597244	176555	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		57326233	77186	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042406	77186	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079010	77186	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		145960466	161523	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128341	161523	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		10058649	36125	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL144434	36125	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		10670917	165064	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL422665	165064	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		14964495	12613	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	12613	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10739662	42276	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL149769	42276	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		10066972	98754	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL278074	98754	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		109035013	180475	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
		CHEMBL4752973	180475	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
		162353383	182577	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
		CHEMBL4787944	182577	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
		71449073	78582	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
		CHEMBL2112217	78582	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
		631645	164876	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL422053	164876	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44443731	94212	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249830	94212	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		24882532	95117	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
		CHEMBL255523	95117	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
		10160073	111189	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL326450	111189	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		156015465	178324	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4640926	178324	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651115	178324	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		46227485	14123	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198034	14123	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593620	14123	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		10160073	111189	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
		CHEMBL326450	111189	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
		10381417	68668	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192061	68668	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44312460	204621	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73410	204621	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
		44382247	30501	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		CHEMBL139311	30501	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		44325051	111697	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328659	111697	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10623721	38351	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL146307	38351	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		237	204865	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	204865	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	204865	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	204865	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		15050951	164925	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL422407	164925	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		162353381	180029	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
		CHEMBL4747438	180029	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
		462395	115202	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		CHEMBL334470	115202	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		422063	196077	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377384	196077	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL560649	196077	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		44443724	93989	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL248614	93989	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
		456319	204076	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL70124	204076	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44296053	189656	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51515	189656	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		205895	11868	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	11868	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		155565770	175624	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
		CHEMBL4580590	175624	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
		11567493	201802	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606902	201802	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		461838	203648	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL67281	203648	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		44382858	59216	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170205	59216	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		145963288	161615	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129723	161615	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		56672197	66562	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		CHEMBL1824785	66562	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		CHEMBL1852489	66562	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		44450621	95832	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258906	95832	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		57664406	2398	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	2398	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	2398	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		162353375	179895	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4745885	179895	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		44448575	11917	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182650	11917	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL258161	11917	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		73355419	92549	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		CHEMBL2432059	92549	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		44400800	165810	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL424832	165810	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		44312455	204560	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL72956	204560	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		154734599	2503	12	None	1	11	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		327	2503	12	None	1	11	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		4108	2503	12	None	1	11	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		CHEMBL27673	2503	12	None	1	11	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		1687	104409	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL310310	104409	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL540034	104409	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		44318736	107021	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		CHEMBL315428	107021	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		44318766	205751	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		CHEMBL82754	205751	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		44308798	204047	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL69904	204047	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10925451	58772	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
		CHEMBL168707	58772	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
		25067048	12333	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185245	12333	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL402207	12333	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		44627855	197371	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569212	197371	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		162353377	181165	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4760904	181165	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		162353372	181387	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4763422	181387	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
		71450996	79687	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2115361	79687	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		10408304	103444	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		CHEMBL3084896	103444	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		13773342	79682	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115341	79682	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		44312081	204247	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
		CHEMBL71088	204247	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
		2774	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		5593	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		7319	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		CHEMBL1200604	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB00809	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB01199	3868	95	None	-1	9	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		10646948	37882	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL145913	37882	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44379281	57546	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		CHEMBL166385	57546	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		10041771	103432	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084881	103432	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		16086004	139237	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL378885	139237	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		25070031	65385	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
		CHEMBL1829335	65385	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
		10397468	188964	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL50831	188964	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		10501523	40521	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		CHEMBL148310	40521	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		10951142	5222	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106219	5222	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		24894628	179123	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL471942	179123	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL554532	179123	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		1273	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	1754	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		24865895	96005	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL259662	96005	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL390842	96005	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		1224	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	1432	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		44382840	120738	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
		CHEMBL354934	120738	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
		2200	3131	46	None	-31	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		328	3131	46	None	-31	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		4848	3131	46	None	-31	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		CHEMBL9967	3131	46	None	-31	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		DB00670	3131	46	None	-31	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		44437227	11878	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182447	11878	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL239017	11878	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		124087	1389	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	1389	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	1389	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	1389	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	1389	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		100	3805	58	None	-19	55	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-19	55	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-19	55	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-19	55	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-19	55	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2733638	11914	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		6508731	11914	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		8030329	11914	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL1182640	11914	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL257643	11914	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		2551	794	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		298	794	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		488	794	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		CHEMBL965	794	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		DB00411	794	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		44593620	187936	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496915	187936	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10248845	122771	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL360491	122771	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		3652	4097	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		14964507	114355	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	114355	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		10443767	13882	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		CHEMBL1196108	13882	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		CHEMBL555955	13882	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		9911615	99031	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
		CHEMBL280220	99031	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
		44286172	144473	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL39067	144473	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
		135	2532	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		2284	3182	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		108993425	181758	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4777543	181758	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		44274477	165568	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
		CHEMBL424214	165568	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
		11595794	135701	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		CHEMBL372983	135701	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		59291324	112778	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298593	112778	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305622	112778	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		44443730	94033	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL248811	94033	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		10340096	103433	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		CHEMBL3084882	103433	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		10269809	159381	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL410061	159381	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44593616	193214	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL523518	193214	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		167962	4069	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	4069	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	4069	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		44418764	82159	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
		CHEMBL216928	82159	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
		16094791	83257	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL218755	83257	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		16094783	136567	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL373888	136567	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		15196234	118505	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL341476	118505	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
		3941250	13337	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1192187	13337	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		CHEMBL543382	13337	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		44309090	203749	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL67873	203749	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		137644950	158492	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091032	158492	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		11099206	120787	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355455	120787	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44319008	205762	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL82850	205762	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44339685	110464	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL324725	110464	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		9978073	94068	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249005	94068	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44448385	11910	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182633	11910	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257174	11910	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		44318781	106978	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL315127	106978	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		11759058	120849	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL355851	120849	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		57326146	77187	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042403	77187	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079020	77187	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		2551	794	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	794	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	794	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	794	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	794	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		55005	104775	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	104775	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		2705	3842	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		360	3842	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		443879	3842	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		CHEMBL1382	3842	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		DB01036	3842	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		44406662	166283	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL427013	166283	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44378914	120030	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		CHEMBL350332	120030	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		155560013	176300	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4564922	176300	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595198	176300	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44593618	187459	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493979	187459	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10073079	101520	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		CHEMBL298085	101520	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		16115798	137878	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376255	137878	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155516383	176673	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4443219	176673	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598230	176673	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		129989	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		8584	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		CHEMBL43383	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		14939893	9534	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL112244	9534	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44267730	16487	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12354	16487	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44383653	120851	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL355854	120851	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		44378982	57580	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL166685	57580	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		16115799	83442	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL219825	83442	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		156015254	178287	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4649420	178287	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650938	178287	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		70681307	74456	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021479	74456	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027890	74456	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		10365639	120859	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		CHEMBL355874	120859	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		324	1925	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		6436265	1925	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		CHEMBL277642	1925	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		11968014	12758	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
		CHEMBL1187846	12758	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
		154417	93260	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	93260	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		44627853	197681	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL571121	197681	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		324	1925	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		6436265	1925	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		CHEMBL277642	1925	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		44378599	58138	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL167839	58138	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
		44344075	110489	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324832	110489	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		16115950	136382	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL373515	136382	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		14210083	156712	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4070155	156712	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		174174	523	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10104167	2059	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		6937	2059	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL3121473	2059	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		44400180	69008	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL192337	69008	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		44296022	194924	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL54155	194924	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267734	10530	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11690	10530	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44406316	72722	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		CHEMBL199821	72722	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		44406689	141285	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL383248	141285	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44299477	100717	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
		CHEMBL292574	100717	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
		18342968	167969	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL431787	167969	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44437270	12328	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1185211	12328	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL398043	12328	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		2230	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		296	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		CHEMBL7303	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		DB04365	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		2230	465	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		296	465	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		CHEMBL7303	465	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		DB04365	465	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		2230	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		296	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		CHEMBL7303	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		DB04365	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		2230	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		296	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		CHEMBL7303	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		DB04365	465	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		118710666	120829	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	120829	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	120829	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		164627658	188609	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4875268	188609	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029013	188609	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10242813	36477	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144751	36477	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		15169865	11263	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL1179079	11263	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL59085	11263	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		68764898	672	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		9430	672	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		CHEMBL3577945	672	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		167962	4069	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		72190450	92275	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426679	92275	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		109032820	182875	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4791819	182875	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		156015045	178265	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648218	178265	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650765	178265	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		11729182	5231	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106259	5231	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		162353387	181231	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4761549	181231	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		162353380	182494	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4786868	182494	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		44437303	12326	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		CHEMBL1185162	12326	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		CHEMBL394329	12326	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		44308899	204006	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69648	204006	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		2683	102888	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	102888	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	102888	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		44431376	87317	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233200	87317	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44593623	187880	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496503	187880	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539373	187880	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		10428089	103447	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
		CHEMBL3084899	103447	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
		10330893	121121	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357444	121121	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL69452	203974	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
		2551	794	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		298	794	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		488	794	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL965	794	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB00411	794	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		16125505	84778	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223186	84778	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
		6726	1280	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	1280	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	1280	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	1280	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	1280	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9998508	80110	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21321	80110	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		54816802	181272	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4762056	181272	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		118719929	115783	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354076	115783	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
		156015051	178328	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4643329	178328	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651139	178328	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		156009660	178329	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634475	178329	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651150	178329	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		10982070	5166	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105945	5166	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		137636308	156202	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4064222	156202	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		44274317	83372	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21937	83372	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894631	176764	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL460470	176764	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
		10404406	100201	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
		CHEMBL288285	100201	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
		10381417	68668	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192061	68668	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		14537189	162643	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		CHEMBL416974	162643	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		10066369	120258	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	120258	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44309135	96568	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL263040	96568	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10467755	121100	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357200	121100	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		137628855	160970	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4103087	160970	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115966	160970	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		9998202	69166	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	69166	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		145961981	161531	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128497	161531	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		4715419	188741	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
		CHEMBL505086	188741	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
		44392960	66301	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL184843	66301	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		15050959	204082	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70154	204082	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		164627253	188603	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4876651	188603	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028989	188603	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015390	178242	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648229	178242	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650585	178242	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		14964494	11957	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	11957	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		14964494	11957	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	11957	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		14956867	204828	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
		CHEMBL75380	204828	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
		12739458	66551	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		CHEMBL1824784	66551	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		CHEMBL1852447	66551	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		15086396	13292	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1191773	13292	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL542915	13292	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		49783209	17609	0	None	-218	26	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-218	26	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		164614364	188495	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4847458	188495	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028248	188495	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44448380	11915	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182644	11915	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257804	11915	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		156011518	178338	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4637731	178338	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651208	178338	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		162353394	180770	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756237	180770	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		11828362	78920	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112959	78920	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44431372	87315	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		CHEMBL233198	87315	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		21855	84246	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
		CHEMBL22108	84246	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
		11834199	58771	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL168704	58771	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		10651844	115489	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		CHEMBL335115	115489	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		11695960	72395	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL198669	72395	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
		10024068	131350	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
		CHEMBL368792	131350	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
		137630891	161129	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4085451	161129	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4117201	161129	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		10035281	100982	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL294273	100982	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		574989	204070	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70082	204070	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		73353884	92322	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		CHEMBL2429890	92322	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		44378600	56527	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
		CHEMBL163686	56527	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
		15730	71118	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	71118	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		164616776	188516	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4852133	188516	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5028394	188516	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		3652	4097	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	4097	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	4097	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	4097	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	4097	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		44392967	65607	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
		CHEMBL183331	65607	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
		164620290	188543	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4870729	188543	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028589	188543	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164621861	188557	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4868124	188557	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028673	188557	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964511	12101	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1183954	12101	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL325473	12101	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		16086060	168943	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL438822	168943	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		70693619	73143	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
		CHEMBL2011502	73143	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
		483747	105409	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL311795	105409	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10139614	5031	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105160	5031	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		441383	20333	57	None	-7	16	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-7	16	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		135398737	958	93	None	-6	89	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		38	958	93	None	-6	89	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		722	958	93	None	-6	89	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		CHEMBL42	958	93	None	-6	89	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		DB00363	958	93	None	-6	89	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		155552923	176307	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4544820	176307	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595245	176307	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44379080	58165	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		CHEMBL168149	58165	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		3072504	5812	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	5812	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10429011	36128	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
		CHEMBL144435	36128	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
		9910802	121010	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL356505	121010	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44312132	102302	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL303443	102302	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
		10572657	40539	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL148328	40539	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		137639541	156703	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4070061	156703	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		9906447	195577	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031738	195577	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL555146	195577	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		1273	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	1754	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		2719	917	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		5535	917	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		607	917	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		CHEMBL76	917	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		DB00608	917	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		46227487	14127	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198047	14127	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593861	14127	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		319	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		321	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		444031	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		784	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		CHEMBL1346	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		DB00496	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		3042	1414	35	None	-12	14	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		355	1414	35	None	-12	14	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		868	1414	35	None	-12	14	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		CHEMBL1123	1414	35	None	-12	14	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		DB00804	1414	35	None	-12	14	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		16125585	84752	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222976	84752	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		73352330	92185	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2424680	92185	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		118710666	120829	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	120829	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	120829	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		16125619	84723	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
		CHEMBL222804	84723	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
		14964506	113316	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	113316	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		66561966	74703	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
		CHEMBL2030625	74703	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
		44437308	12327	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		CHEMBL1185188	12327	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		CHEMBL396845	12327	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		73350931	92534	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432040	92534	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		118719930	115784	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354077	115784	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
		10474335	194692	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		CHEMBL53325	194692	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		162658421	181101	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4760150	181101	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		137644962	158493	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4091058	158493	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44448457	11913	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182638	11913	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL257586	11913	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		24894515	176870	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL461502	176870	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
		44267709	16642	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12419	16642	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44431369	87983	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		CHEMBL234253	87983	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		324	1925	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		6436265	1925	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		CHEMBL277642	1925	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		3929516	107370	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		CHEMBL317757	107370	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		11610557	72031	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL197588	72031	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		10551354	39757	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147611	39757	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44304818	203306	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64788	203306	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		44304818	203306	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64788	203306	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		137629673	161159	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4094819	161159	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117396	161159	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		456293	204058	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL70010	204058	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44383489	128473	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL366640	128473	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		73346336	92545	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432054	92545	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		9308	17754	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL1255785	17754	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL12587	17754	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL292911	17754	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		11809446	59679	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL172234	59679	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44422692	11853	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182296	11853	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL228144	11853	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		44446841	12338	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL1185281	12338	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL404557	12338	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		162657652	180985	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
		CHEMBL4758742	180985	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
		44431375	87316	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233199	87316	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44431370	87984	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234254	87984	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		9308	17754	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL1255785	17754	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL12587	17754	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL292911	17754	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		16086059	80775	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
		CHEMBL215180	80775	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
		16125618	168677	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
		CHEMBL436492	168677	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
		16086059	80775	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL215180	80775	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		9821459	200443	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		CHEMBL59836	200443	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		15105207	169195	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL440686	169195	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		14537191	147989	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
		CHEMBL39342	147989	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
		474465	203071	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL63757	203071	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		44420791	84704	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
		CHEMBL222689	84704	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
		44325013	207194	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		CHEMBL92569	207194	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		44295954	162895	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL417369	162895	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44295712	189509	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51400	189509	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44406521	73906	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL201933	73906	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10199963	141315	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL383389	141315	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10299489	204141	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL70464	204141	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
		129989	451	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		8584	451	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		CHEMBL43383	451	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		129989	451	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		8584	451	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		CHEMBL43383	451	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		154417	93260	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	93260	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		10049361	206121	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85892	206121	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44325013	207194	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL92569	207194	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44431391	146421	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL392186	146421	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
		118710662	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		119357	304	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		3264	304	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		368	304	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		CHEMBL279453	304	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		118710662	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	120830	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		155548586	176597	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4537517	176597	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597611	176597	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		70683405	74475	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021477	74475	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027984	74475	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		315401	89812	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377387	89812	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		44420795	11850	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL1182222	11850	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223055	11850	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		14537188	136546	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
		CHEMBL37372	136546	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
		10770914	25061	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		CHEMBL134692	25061	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		42596929	77188	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042404	77188	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079021	77188	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		688567	63034	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL1788199	63034	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		425249	89797	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
		CHEMBL2377261	89797	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
		CHEMBL5277670	193943	0	None	-2	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	930	19	2	5	13.0	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		319	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		321	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		444031	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		784	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		CHEMBL1346	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		DB00496	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		44406406	133537	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL370862	133537	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406520	135258	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL372566	135258	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406395	140280	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL380583	140280	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		24809738	11889	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182466	11889	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL239655	11889	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		15050958	203796	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68292	203796	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		57	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		60809	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		CHEMBL21536	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		DB15357	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		118710668	120834	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	120834	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	120834	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		44319043	206059	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85391	206059	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		3652	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		57	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		60809	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		CHEMBL21536	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		DB15357	4097	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		5387	94879	31	None	-19	5	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
		CHEMBL253978	94879	31	None	-19	5	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
		44313489	204630	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL73501	204630	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		2551	794	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	794	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	794	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	794	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	794	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		15196235	119193	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
		CHEMBL343182	119193	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
		15749864	100463	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL290715	100463	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		137629259	161004	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4092769	161004	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116203	161004	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44406387	72843	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200209	72843	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2247	505	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		71455896	83805	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205832	83805	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
		11819782	95886	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL259131	95886	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		6604789	101047	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL294649	101047	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		10337773	101585	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL298612	101585	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		162670602	182937	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4792675	182937	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		4735	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	195115	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		11057	176149	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44344077	10450	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116404	10450	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9974229	120286	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352618	120286	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		11808947	59453	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL171216	59453	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		10203251	5224	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
		CHEMBL106224	5224	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
		11004046	5454	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL107444	5454	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		15678856	103781	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL308893	103781	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	46244	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		CHEMBL1535	46244	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		162353388	180979	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4758633	180979	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
		162353384	181090	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4760037	181090	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
		11515739	78332	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092736	78332	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2109804	78332	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		16124705	84629	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL222207	84629	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		2812	4779	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		107867	2974	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		309	2974	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		CHEMBL17045	2974	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		137645406	157902	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4084262	157902	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		164628906	188616	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4877107	188616	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029079	188616	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44382974	59513	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL171520	59513	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		16124708	137336	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
		CHEMBL375277	137336	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
		14964513	11419	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	11419	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	11419	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		2200	3131	46	None	-35	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		328	3131	46	None	-35	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		4848	3131	46	None	-35	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		CHEMBL9967	3131	46	None	-35	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		DB00670	3131	46	None	-35	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		44450620	95831	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258905	95831	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		44422697	11852	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182277	11852	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL227429	11852	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		12259685	201548	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
		CHEMBL60542	201548	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
		44378769	120042	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL350404	120042	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
		156009698	178336	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4634575	178336	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651200	178336	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		9846311	204011	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
		CHEMBL69678	204011	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
		9846311	204011	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		CHEMBL69678	204011	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		44309107	102175	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
		CHEMBL302720	102175	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
		10176401	154968	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL40121	154968	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		10344314	94113	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		CHEMBL249204	94113	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		11498	3019	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		4995951	3019	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		CHEMBL59898	3019	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		11011332	120802	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL355560	120802	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		156010362	178332	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633296	178332	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651171	178332	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11112362	4959	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
		CHEMBL104804	4959	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
		9998829	103419	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
		CHEMBL3084866	103419	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
		118710660	120831	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	120831	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	120831	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		46682613	181156	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4760823	181156	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
		156014205	178292	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635385	178292	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650957	178292	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		71575652	86198	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		CHEMBL2312352	86198	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		44308831	204395	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71933	204395	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44593627	193299	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524071	193299	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL541671	193299	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44448417	11909	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182629	11909	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL256923	11909	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		57664406	2398	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		6938	2398	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089376	2398	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		44308832	203813	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68384	203813	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964495	12613	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	12613	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		2733619	11911	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		6508725	11911	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL1182634	11911	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL257431	11911	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		10475156	121523	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		CHEMBL358493	121523	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		15086393	13291	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1191772	13291	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL542914	13291	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		71457691	83799	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205823	83799	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		16125640	84742	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222917	84742	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		205895	11868	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	11868	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		10457079	10030	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	10030	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		137645938	157583	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4080675	157583	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		44593617	187431	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493795	187431	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		44443733	154784	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL400167	154784	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		202119	12035	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL1183388	12035	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL294470	12035	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		71461700	79594	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
		CHEMBL2114425	79594	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
		15678860	102383	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303876	102383	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44593627	193299	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524071	193299	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL541671	193299	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		145961161	161606	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129580	161606	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		44382880	120760	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
		CHEMBL355193	120760	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
		137629744	161175	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL4071109	161175	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL4117602	161175	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		44392984	12257	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL1184654	12257	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL362864	12257	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		483747	105409	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL311795	105409	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10066369	120258	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	120258	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		133640439	181373	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4763304	181373	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		611107	203944	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL69287	203944	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71458134	79688	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2115362	79688	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		11120347	120729	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		CHEMBL354841	120729	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		15678858	102149	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302544	102149	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		59291578	112785	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298594	112785	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305763	112785	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		1726	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	2497	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	2497	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	2497	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	2497	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	2497	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		44383305	59353	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL170739	59353	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		4098	32505	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	32505	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	32505	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		44383373	59390	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170922	59390	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		44295953	189036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50927	189036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44382739	120396	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL353465	120396	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		9905731	168508	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL435353	168508	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		119357	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		3264	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		368	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		CHEMBL279453	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		44428745	92177	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
		CHEMBL242345	92177	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
		119357	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		3264	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		368	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		CHEMBL279453	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		46188794	178319	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645580	178319	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651099	178319	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44267747	10061	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		CHEMBL11527	10061	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		118710670	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		11531644	176413	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		CHEMBL4560341	176413	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		CHEMBL4596085	176413	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		44431382	88021	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234438	88021	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		199230	163135	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	163135	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		10086238	78908	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
		CHEMBL2112940	78908	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
		66875589	103390	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084662	103390	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		10155225	95840	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL258959	95840	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		14210083	156712	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	156712	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		118710670	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	120833	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		10163651	163233	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	163233	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL5273907	193785	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	945	20	2	5	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		44627740	198758	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL583051	198758	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10497101	70469	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
		CHEMBL194628	70469	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
		13773336	79683	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115342	79683	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		9894136	166236	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL426761	166236	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		939077	195068	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL549577	195068	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		2705	3842	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		360	3842	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		443879	3842	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		CHEMBL1382	3842	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		DB01036	3842	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		118710668	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		2028	2979	80	None	-5	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		359	2979	80	None	-5	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		4634	2979	80	None	-5	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		CHEMBL1231	2979	80	None	-5	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		DB01062	2979	80	None	-5	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		302	2977	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	2977	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	2977	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		303	2978	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	2978	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	2978	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	2978	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		44627854	197709	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL571341	197709	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		156015971	178282	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648444	178282	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650880	178282	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		9991979	119158	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL342958	119158	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		14964507	114355	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	114355	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		75356563	156957	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
		CHEMBL4072787	156957	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
		118719926	115780	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354073	115780	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
		11001809	59081	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169594	59081	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		46227461	14136	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198077	14136	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL594803	14136	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		631644	204077	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70133	204077	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		118710664	120832	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	120832	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	120832	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		60138186	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		145960827	161380	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4126290	161380	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		2200	3131	46	None	-31	12	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		328	3131	46	None	-31	12	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		4848	3131	46	None	-31	12	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		CHEMBL9967	3131	46	None	-31	12	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		DB00670	3131	46	None	-31	12	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		1353	1911	93	None	-338	83	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		3559	1911	93	None	-338	83	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		86	1911	93	None	-338	83	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		CHEMBL54	1911	93	None	-338	83	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		DB00502	1911	93	None	-338	83	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		502259	116798	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL337820	116798	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		909982	202094	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		CHEMBL608828	202094	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		162353390	180949	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4758316	180949	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
		109035056	181323	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
		CHEMBL4762755	181323	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
		164609373	188464	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4846035	188464	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5027958	188464	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		162353378	182911	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4792360	182911	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
		44446841	12338	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1185281	12338	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL404557	12338	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		11819882	17443	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL125764	17443	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
		16124769	84780	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
		CHEMBL223188	84780	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
		319	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		321	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		444031	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		784	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		CHEMBL1346	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		DB00496	1324	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		10125445	76028	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		CHEMBL205654	76028	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		164615651	188511	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852079	188511	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028329	188511	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		16094793	83322	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
		CHEMBL219118	83322	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
		9799291	160120	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL410890	160120	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964497	14291	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	14291	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		3013846	188239	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		CHEMBL499519	188239	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		137631178	161204	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4081662	161204	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117768	161204	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44443728	94032	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL248809	94032	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		44318969	206080	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85568	206080	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319016	206137	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL86012	206137	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319017	206309	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL87132	206309	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10418420	70273	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
		CHEMBL194216	70273	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
		11169365	112512	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
		CHEMBL3298986	112512	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
		137630084	161045	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4070055	161045	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116507	161045	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		57326140	77179	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2042400	77179	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2078962	77179	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		44406451	72942	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200566	72942	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		542182	102161	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302604	102161	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71460014	79686	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
		CHEMBL2115360	79686	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
		44400887	70998	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		CHEMBL195169	70998	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		60138186	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	120836	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44627741	197682	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL571123	197682	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		44593619	187460	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493980	187460	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44308746	203851	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68609	203851	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10572658	121980	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL359197	121980	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		167962	4069	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		162675053	183258	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
		CHEMBL4796491	183258	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
		44578707	182141	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
		CHEMBL478227	182141	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
		57664406	2398	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	2398	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	2398	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		164618644	188531	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4872142	188531	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5028508	188531	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		57326144	77191	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042402	77191	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079061	77191	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		10457079	10030	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	10030	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		162353389	181524	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
		CHEMBL4765133	181524	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
		44443735	94383	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL250834	94383	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		9998202	69166	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	69166	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44420821	84288	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
		CHEMBL221400	84288	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
		44383352	59692	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL172272	59692	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10096017	103445	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		CHEMBL3084897	103445	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		118719920	115773	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354066	115773	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44593620	187936	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496915	187936	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		302	2977	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		4630	2977	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		CHEMBL7634	2977	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		2551	794	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		298	794	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		488	794	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		CHEMBL965	794	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		DB00411	794	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		71450550	83807	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		156017826	177858	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4644285	177858	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		10408160	13050	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL1190020	13050	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL540013	13050	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		44299589	196397	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL56275	196397	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		44450624	95936	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL259344	95936	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		11045444	59189	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL170088	59189	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		11000399	59095	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169680	59095	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		463209	121132	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL357557	121132	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		134272502	176308	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4514058	176308	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595246	176308	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44392974	64540	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL181447	64540	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		16086062	80791	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL215189	80791	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		44308809	204381	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71799	204381	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		56963799	74895	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031737	74895	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		132060812	162036	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4160064	162036	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		4011	82408	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		44593622	187796	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL495888	187796	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL556390	187796	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		10647553	39718	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147554	39718	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44422699	11851	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182272	11851	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL227378	11851	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		10473919	204731	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
		CHEMBL74305	204731	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
		16125571	85150	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL225074	85150	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		66561967	74704	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
		CHEMBL2030626	74704	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
		44295888	188257	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL49975	188257	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		9815331	203107	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL64000	203107	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		174174	523	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	523	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	523	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	523	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	523	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		118710668	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		118710668	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	120834	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		140844410	176392	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4436947	176392	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595946	176392	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		71454562	79654	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115126	79654	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44431387	87318	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233201	87318	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		164609510	188465	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846562	188465	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027965	188465	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		10204457	204403	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71971	204403	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		174174	523	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		260	523	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		320	523	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		CHEMBL517712	523	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		DB00572	523	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		13567081	11234	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1178839	11234	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL45454	11234	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		44292563	187780	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		CHEMBL49576	187780	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		71449148	79538	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114064	79538	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		155523889	176524	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4454134	176524	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597014	176524	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		14939893	9534	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL112244	9534	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL5270925	193660	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.9	C#CCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		24846938	89801	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377267	89801	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
		10030021	169879	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4440484	169879	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		9913341	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL216927	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL553058	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		156014269	177216	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635500	177216	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44319071	206019	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL84993	206019	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		9913341	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL216927	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL553058	82158	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		9818955	9343	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL111224	9343	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		205895	11868	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	11868	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		55005	104775	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	104775	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		199230	163135	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	163135	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		10262466	98344	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL275104	98344	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
		10621363	121690	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		CHEMBL358726	121690	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		44593625	188130	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498358	188130	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539120	188130	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10449632	103446	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084898	103446	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		71458105	79596	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2114427	79596	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		145962050	161632	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4130037	161632	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		10949838	5221	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106218	5221	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		73346226	92264	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426668	92264	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		164621361	188553	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4865137	188553	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028648	188553	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964498	13887	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	13887	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10405613	202518	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
		CHEMBL611476	202518	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
		14964496	8964	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	8964	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10354969	13572	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		CHEMBL1194009	13572	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		CHEMBL545506	13572	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		1273	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		3450	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		356	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		6172	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		67425	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		CHEMBL360055	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		DB00483	1754	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		10088338	103438	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
		CHEMBL3084888	103438	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
		44400375	69174	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192537	69174	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		11767229	78917	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112956	78917	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		9308	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL1255785	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL12587	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL292911	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		57339144	92238	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
		CHEMBL2426364	92238	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
		3652	4097	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	4097	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	4097	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	4097	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	4097	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		162353391	180821	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
		CHEMBL4756873	180821	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
		44448606	11918	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182652	11918	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL258385	11918	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		10114698	4833	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104210	4833	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		46227481	14139	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198081	14139	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL595022	14139	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		16086001	139214	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL378772	139214	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		16125373	84790	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223267	84790	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		44318930	106172	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		CHEMBL313738	106172	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		16086000	80356	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		CHEMBL214342	80356	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		9802631	111997	1	None	-3467	5	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
		CHEMBL328866	111997	1	None	-3467	5	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
		130442480	175270	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		44400762	70568	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL194870	70568	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		3028236	102599	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377383	102599	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL3041159	102599	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		10336882	103448	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
		CHEMBL3084900	103448	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
		939078	63069	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL1788286	63069	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		44313626	204568	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL73017	204568	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		164611347	188474	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856090	188474	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028070	188474	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44576913	193314	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524186	193314	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL557808	193314	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44274441	99093	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL280684	99093	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894625	9778	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL113580	9778	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL553155	9778	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		156014813	178284	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4649668	178284	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650897	178284	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		5282593	55258	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1319362	55258	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1618018	55258	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		9308	17754	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		9308	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	17754	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		11504244	106519	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	106519	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	106519	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	106519	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		164623530	188573	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872632	188573	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028763	188573	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		2750	204061	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		44627958	14036	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197374	14036	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569089	14036	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		11718570	72202	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
		CHEMBL198065	72202	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
		456292	96749	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL264442	96749	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44309153	203514	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66322	203514	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44378888	56845	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL164385	56845	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44593626	187853	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496306	187853	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539121	187853	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		4212	198679	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL1417019	198679	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL58	198679	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		75201901	166425	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		71720489	86959	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323447	86959	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		11588241	155739	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092735	155739	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL405612	155739	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		45266385	195492	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL553241	195492	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		7047822	176836	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
		CHEMBL461088	176836	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
		10026270	94115	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249206	94115	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44295668	188955	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50822	188955	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		10336644	161673	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
		CHEMBL41313	161673	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
		14956860	13702	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL1194903	13702	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL553520	13702	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		44406480	72844	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200210	72844	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10834711	121410	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL358193	121410	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		155551903	176457	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4569929	176457	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596435	176457	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		118719931	115785	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
		CHEMBL3354078	115785	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
		44319339	205907	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83982	205907	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		137631026	161150	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4093215	161150	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117321	161150	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		2200	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		328	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		4848	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		CHEMBL9967	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		DB00670	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		12310489	208394	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
		CHEMBL99618	208394	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
		2200	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		328	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		4848	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		CHEMBL9967	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		DB00670	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		137640201	156961	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4072818	156961	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		42853213	104344	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL310016	104344	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		2396803	206126	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85950	206126	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		2200	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		328	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		4848	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		CHEMBL9967	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		DB00670	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		2200	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		328	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		4848	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		CHEMBL9967	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		DB00670	3131	46	None	-31	12	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		9818955	9343	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL111224	9343	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		2736067	87530	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
		CHEMBL2335158	87530	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
		57326239	77182	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042551	77182	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078974	77182	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		2551	794	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		298	794	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		488	794	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		CHEMBL965	794	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		DB00411	794	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		350	3556	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		9867750	3556	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		CHEMBL73341	3556	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		2028	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		359	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		4634	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		CHEMBL1231	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		DB01062	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		164619081	188537	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872720	188537	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028531	188537	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		118710668	120834	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	120834	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	120834	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		3652	4097	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		57	4097	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		60809	4097	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		CHEMBL21536	4097	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		DB15357	4097	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		118710664	120832	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	120832	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	120832	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		10963509	18496	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		CHEMBL127273	18496	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		44267744	15448	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12153	15448	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11155732	10547	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL1169543	10547	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		10104167	2059	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	2059	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	2059	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44431386	149025	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394255	149025	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16125587	84763	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223028	84763	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		118710670	120833	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	120833	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	120833	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		55005	104775	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	104775	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		14964496	8964	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	8964	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL69452	203974	0	None	2	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
		11718536	137845	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL376000	137845	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		574784	103595	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
		CHEMBL308650	103595	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
		10354968	13075	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		CHEMBL1190173	13075	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		CHEMBL540310	13075	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		107867	2974	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		309	2974	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		CHEMBL17045	2974	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		164614830	188500	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4858774	188500	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028275	188500	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		130442572	171908	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		10365534	154960	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
		CHEMBL401154	154960	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
		11530307	78342	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093082	78342	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109993	78342	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	194916	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	194916	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		44286173	144487	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL39068	144487	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		16125223	168899	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		CHEMBL438427	168899	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		44308900	203996	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69582	203996	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44318929	106862	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL314493	106862	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL5092328	215359	5	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N	10.1021/acs.jmedchem.1c00935
		3236	67609	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		CHEMBL1902981	67609	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		36381	12942	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
		CHEMBL1189234	12942	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
		36381	12942	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
		CHEMBL1189234	12942	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
		302	2977	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		4630	2977	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		CHEMBL7634	2977	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		15050954	204003	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL69620	204003	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		71718048	86955	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323443	86955	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		9948957	204492	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL72506	204492	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		118719924	115778	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354071	115778	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44593624	188129	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498357	188129	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL554916	188129	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		9842753	201812	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606963	201812	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		10101246	9546	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	9546	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		44299564	199087	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL58824	199087	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		11759379	120777	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355392	120777	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		167962	4069	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	4069	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	4069	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		302	2977	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	2977	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	2977	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		123603	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		2684	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		584	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		9658	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		CHEMBL168815	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		2398	954	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		10574041	39822	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147695	39822	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL308924	103787	0	None	-2	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	268	4	1	5	1.0	CCO/C(O)=C1\CN2CC(CCC2CN(C)C)C1=O	10.1021/jm020572p
		71716225	86957	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323445	86957	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		16125325	84573	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222090	84573	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		2229	464	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		295	464	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		CHEMBL128365	464	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		44627956	14034	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197362	14034	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL568775	14034	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		1687	104409	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL310310	104409	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL540034	104409	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		3072501	107269	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	107269	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		53390181	92271	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426675	92271	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		53390538	92277	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426681	92277	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		44448421	12337	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185269	12337	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL403773	12337	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		156013387	178261	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4638935	178261	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650725	178261	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		156012563	178248	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4637485	178248	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650635	178248	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		156013998	178269	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635148	178269	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650787	178269	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11672895	77805	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092737	77805	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		71452384	83797	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205816	83797	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
		71452384	83797	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
		CHEMBL2205816	83797	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
		44437295	11893	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1182472	11893	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		CHEMBL239866	11893	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		16125704	84664	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222450	84664	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		71720488	86953	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323441	86953	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		15050952	203496	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL66177	203496	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		16125531	84356	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL221775	84356	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		73355416	92537	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432043	92537	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		15050955	102598	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL304112	102598	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		164622017	188558	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4871563	188558	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028681	188558	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		109014373	179802	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4744856	179802	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		118719923	115777	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354070	115777	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		14964498	13887	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	13887	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		11694119	115487	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL3351105	115487	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		46227417	14128	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198048	14128	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL593864	14128	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		44296096	101897	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL300845	101897	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44295763	188815	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL50618	188815	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		44296006	189731	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51574	189731	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		15407072	56866	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL164397	56866	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		9889312	78430	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	78430	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44455198	97657	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
		CHEMBL271108	97657	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
		44455198	97657	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
		CHEMBL271108	97657	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
		44292834	101456	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		CHEMBL297683	101456	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		44325003	111642	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328550	111642	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10865439	20625	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		CHEMBL130835	20625	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		140844398	176361	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4470924	176361	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595692	176361	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		71128	96810	25	None	-17	7	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
		CHEMBL26505	96810	25	None	-17	7	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
		CHEMBL5265833	193457	0	None	-28	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	488	10	1	3	7.1	C#CCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155543345	176686	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4543584	176686	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598362	176686	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		101720828	97120	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		16147087	97120	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202002	97120	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL267643	97120	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		4841	67427	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1889399	67427	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1909073	67427	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		11968014	12758	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
		CHEMBL1187846	12758	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
		10302719	43508	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL150845	43508	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL5271406	193681	0	None	-10	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1159	27	3	10	12.8	CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21	10.1021/acs.jmedchem.2c01376
		2028	2979	80	None	-8	10	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	2979	80	None	-8	10	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	2979	80	None	-8	10	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	2979	80	None	-8	10	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	2979	80	None	-8	10	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		118710662	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710662	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	120830	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		57326326	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042553	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078942	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		57326326	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2042553	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2078942	77178	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL5267836	193538	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.8	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		CHEMBL5289083	194458	0	None	-5	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1002	24	3	6	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		16125591	84698	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222634	84698	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		14964494	11957	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	11957	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		155672	5037	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL105198	5037	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL56734	5037	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		44431367	87982	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234252	87982	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44318766	205751	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		CHEMBL82754	205751	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		16124710	85185	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL225387	85185	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		60138186	120836	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	120836	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	120836	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	120836	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		11504244	106519	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	106519	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	106519	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	106519	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		303	2978	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	2978	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	2978	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	2978	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		170332	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		11024241	120301	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352723	120301	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		73346227	92269	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426673	92269	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		162353382	181734	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
		CHEMBL4777127	181734	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
		44274417	98894	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL279225	98894	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		57664406	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		170332	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	160976	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		3158	56267	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL5274390	193813	0	None	-32	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	366	3	2	3	4.6	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OC1CCNCC1	10.1021/acs.jmedchem.2c01376
		44318929	106862	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL314493	106862	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		10105880	37451	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145533	37451	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		137628800	160994	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4089027	160994	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116151	160994	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		44267699	13675	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11947	13675	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		199230	163135	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL41779	163135	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		16125509	169342	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
		CHEMBL441873	169342	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
		11501540	133603	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		CHEMBL371293	133603	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		137628788	160992	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4085150	160992	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116149	160992	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		10670961	40632	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
		CHEMBL148404	40632	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
		14964498	13887	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	13887	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		191	403	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		44275807	98970	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		CHEMBL27979	98970	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		11653112	78333	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2092820	78333	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109828	78333	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	194916	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	194916	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		57664406	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	2398	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		11110049	58240	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL168223	58240	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		13773340	79590	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114396	79590	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		3823	50221	42	None	-44	10	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	50221	42	None	-44	10	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	50221	42	None	-44	10	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		16086005	139231	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL378859	139231	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		16125646	136971	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374513	136971	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		10598540	38329	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL146291	38329	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		44443722	154920	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL400953	154920	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
		10360219	102010	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL301670	102010	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		57326325	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042554	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078987	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		44593624	188129	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498357	188129	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL554916	188129	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		57326325	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2042554	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2078987	77184	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		145960592	161361	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4126071	161361	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		17621	60597	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL176012	60597	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		3072504	5812	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	5812	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		71718668	86799	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2321893	86799	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		300	2510	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		4141	2510	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		CHEMBL92387	2510	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		2904292	183580	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4800495	183580	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
		46227459	14135	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198076	14135	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL594802	14135	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		16125681	84768	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL223079	84768	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		10243426	121916	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL359027	121916	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		16125374	84732	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222860	84732	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		15050948	102817	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL305403	102817	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		10451634	204450	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
		CHEMBL72219	204450	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
		11808946	120636	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL354678	120636	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		47358375	180762	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756164	180762	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
		87934	98081	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL273308	98081	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL542883	98081	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		21862266	142013	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL38756	142013	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		10468535	98129	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
		CHEMBL273586	98129	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
		14964513	11419	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	11419	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	11419	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		289	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		9948320	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		CHEMBL1242950	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		137628799	160993	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4064668	160993	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116150	160993	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		2166	3123	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		305	3123	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		5910	3123	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		CHEMBL550	3123	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		DB01085	3123	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		71716836	86954	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323442	86954	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		68617	205527	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	205527	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	205527	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		462571	118795	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		CHEMBL342137	118795	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		10466231	36075	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144385	36075	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		10421689	35791	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144123	35791	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
		1935	3734	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2551	3734	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		6687	3734	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		CHEMBL95	3734	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		DB00382	3734	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		154059	3637	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		2457	3637	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		7483	3637	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		CHEMBL1734	3637	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		DB01591	3637	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		306	3456	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		3536	3456	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		53930639	3456	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		9577995	3456	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		CHEMBL134641	3456	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		2745	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	3861	42	None	-46	8	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		3652	4097	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2824	3993	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		345	3993	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		71203	3993	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		CHEMBL1892145	3993	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		DB13793	3993	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		92112	21705	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
		CHEMBL1318553	21705	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
		2360	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		2484	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		347	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		441071	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		CHEMBL227934	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		DB15954	3693	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		15376	3994	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		349	3994	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		3643	3994	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		CHEMBL1165342	3994	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		DB13374	3994	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		21158560	112793	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
		CHEMBL3305985	112793	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
		2381	663	48	None	-15	8	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	663	48	None	-15	8	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	663	48	None	-15	8	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	663	48	None	-15	8	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	663	48	None	-15	8	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		11968014	12758	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		CHEMBL1187846	12758	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		656598	12732	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1187724	12732	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL516476	12732	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		13637	579	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity for for [<sup>3</sup>H]-BAY2413555 determined in an radioligand equilibrium dissociation binding assay.Binding affinity for for [<sup>3</sup>H]-BAY2413555 determined in an radioligand equilibrium dissociation binding assay.	Guide to Pharmacology	584	5	3	7	2.8	C[C@H](NC(=O)C1=CN(C2=NC(N3C[C@@H](O)[C@H](O)C3)=C(F)C=C2C1=O)C4=C(F)C=C(F)C=C4F)C(F)(F)C(F)(F)F	39463278
		367	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		5487427	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		8592	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL1900528	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL3305968	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL4650755	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		DB01409	3824	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		23056	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		23056	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		318	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		318	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		3260	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		3260	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		CHEMBL12980	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		CHEMBL12980	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		11536903	2397	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		3262	2397	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		CHEMBL3770346	2397	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		57664406	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		57664406	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		6938	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		6938	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		CHEMBL4089376	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		CHEMBL4089376	2398	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		1273	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		1273	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		3450	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		3450	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		356	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		356	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		6172	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		6172	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		67425	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		67425	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		CHEMBL360055	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		CHEMBL360055	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		DB00483	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		DB00483	1754	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		341	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
		341	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
		341	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
		5311001	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
		5311001	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
		5311001	340	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
		167962	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		167962	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		362	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		362	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		CHEMBL31599	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		CHEMBL31599	4069	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		168057	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		168057	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		7634	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		7634	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		CHEMBL28407	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		CHEMBL28407	1212	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		2381	663	48	None	-15	8	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		374	663	48	None	-15	8	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		7128	663	48	None	-15	8	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		CHEMBL1101	663	48	None	-15	8	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		DB00810	663	48	None	-15	8	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		10350027	1428	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		364	1428	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		365	1428	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		303	2978	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		4629	2978	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		8595	2978	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		CHEMBL44674	2978	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		187	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		294	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		65	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		8593	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		CHEMBL667	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		DB03128	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		119357	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		119357	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		119357	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		3264	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		3264	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		3264	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		368	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		368	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		368	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		CHEMBL279453	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		CHEMBL279453	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		CHEMBL279453	304	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		316	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		317	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		71183	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		CHEMBL3140030	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		CHEMBL376897	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		DB00462	2835	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		21123938	733	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
		343	733	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
		348	3803	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
		66706	3803	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
		2824	3993	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		345	3993	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		71203	3993	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		CHEMBL1892145	3993	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		DB13793	3993	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		342	732	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		442021	732	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		CHEMBL501756	732	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		342	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		342	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		442021	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		442021	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		CHEMBL501756	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		CHEMBL501756	732	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		344	2749	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		44358908	2749	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		CHEMBL139677	2749	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		332	2034	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		44358893	2034	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		CHEMBL343796	2034	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		2360	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		2360	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		2360	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		2484	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		2484	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		2484	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		347	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		347	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		347	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		441071	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		441071	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		441071	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		CHEMBL227934	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		CHEMBL227934	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		CHEMBL227934	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		DB15954	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		DB15954	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		DB15954	3693	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		335	1836	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		3500	1836	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		CHEMBL157822	1836	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		346	3689	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		44259	3689	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		CHEMBL388978	3689	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		DB02010	3689	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		15376	3994	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		349	3994	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		3643	3994	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		CHEMBL1165342	3994	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		DB13374	3994	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		15118529	4083	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		340	4083	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		CHEMBL1256845	4083	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		108152	2201	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
		338	2201	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
		339	4081	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		9803245	4081	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		CHEMBL2206331	4081	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		2784	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		351	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		366	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		676	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		CHEMBL620	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		DB00771	952	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		316	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		317	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		71183	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		CHEMBL3140030	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		CHEMBL376897	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		DB00462	2835	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		2784	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		351	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		366	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		676	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		CHEMBL620	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		DB00771	952	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		23056	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		318	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		3260	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		CHEMBL12980	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		23056	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		318	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		3260	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		CHEMBL12980	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		44431393	88024	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
		CHEMBL234440	88024	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
		1427	2013	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		132947	3864	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		361	3864	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		CHEMBL265256	3864	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		325	2062	0	3H-NMS	1	8	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		3746	2062	0	3H-NMS	1	8	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		657308	2062	0	3H-NMS	1	8	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		CHEMBL1615433	2062	0	3H-NMS	1	8	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		DB00332	2062	0	3H-NMS	1	8	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		187	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		131632304	216037	0	3H-QNB	-6	12	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		12057539	208041	42	3H-MQNB(-)	-2	20	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MQNB(-)	-2	20	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MQNB(-)	-2	20	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		44431384	148860	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
		CHEMBL394137	148860	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
		12057539	208041	42	3H-PIRENZEPINE	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-PIRENZEPINE	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-PIRENZEPINE	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-MQNB(-)	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MQNB(-)	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MQNB(-)	-2	20	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-NMS	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-NMSP	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-QNB	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-NMS	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-NMSP	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-QNB	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-NMS	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-NMSP	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-QNB	-2	20	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-NMS	-2	20	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-NMS	-2	20	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-NMS	-2	20	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-MQNB(-)	-2	20	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MQNB(-)	-2	20	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MQNB(-)	-2	20	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-Arachidonic Acid	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-NMS	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-Arachidonic Acid	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-NMS	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-Arachidonic Acid	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-NMS	-2	20	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		24835791	216104	0	3H-MQNB(-)	1	2	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		5831	215963	0	3H-QNB	-29	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		42470	216183	0	3H-NMS	-2	5	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	345	10	0	3	4.9	CCN(CCCC(=O)C1CCCCC1)C(C)CC2=CC=C(C=C2)OC	None
		3246155	215962	0	3H-QNB	-6	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		131632304	216037	0	3H-NMS	-10	12	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		325	2062	0	3H-NMS	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		3746	2062	0	3H-NMS	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		657308	2062	0	3H-NMS	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		CHEMBL1615433	2062	0	3H-NMS	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		DB00332	2062	0	3H-NMS	-1	8	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		12057539	208041	42	3H-NMS	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-QNB	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	3H-MQNB(-)	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-NMS	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-QNB	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-MQNB(-)	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-NMS	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-QNB	-2	20	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-MQNB(-)	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		24835791	216104	0	3H-MQNB(-)	-1	2	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		12057539	208041	42	3H-QNB	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-QNB	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-QNB	-2	20	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		16721019	87986	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
		CHEMBL234258	87986	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
		44431389	146151	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
		CHEMBL391977	146151	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
		1734	116	10	3H-PIRENZEPINE	-12	12	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-PIRENZEPINE	-12	12	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-PIRENZEPINE	-12	12	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		135398737	958	93	3H-NMS	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-QNB	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-NMS	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-QNB	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-NMS	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-QNB	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-NMS	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-QNB	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-NMS	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-QNB	-6	89	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		154825138	216038	0	3H-4-DAMP	-1	11	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	216038	0	3H-NMS	-1	11	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		11434515	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		11519741	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		4484	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		7449	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		CHEMBL1194325	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		DB08897	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		154825138	216038	0	3H-MQNB(-)	-1	11	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		2381	663	48	3H-NMS	-19	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	663	48	3H-NMS	-19	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	663	48	3H-NMS	-19	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	663	48	3H-NMS	-19	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	663	48	3H-NMS	-19	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		71202	216372	0	3H-NMS	-3	4	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	340	3	0	3	4.9	CC1(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)SCCN(C)C)C	None
		202	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	UNDEFINED	-9	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		5656	203066	87	UNDEFINED	-25	40	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	UNDEFINED	-25	40	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	203127	52	UNDEFINED	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	UNDEFINED	-1	27	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		11957621	216039	0	3H-NMS	-12	10	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
		11957621	216039	0	3H-NMS	-12	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
		3075702	217332	0	3H-AF-DX384	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		145	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		179	400	115	3H-QNB	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-QNB	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-QNB	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-QNB	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-QNB	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		141	1427	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	1427	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	1427	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	1427	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		119376	1841	48	3H-NMS	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	1841	48	3H-NMS	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	1841	48	3H-NMS	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		1353	1911	93	3H-QNB	-5011	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-QNB	-5011	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-QNB	-5011	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-QNB	-5011	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-QNB	-5011	83	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1588	2325	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		290	2473	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		4022	2473	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		5926	2473	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		CHEMBL40554	2473	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		CHEMBL74300	2473	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		15897	2862	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		2166	3123	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		305	3123	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		5910	3123	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		CHEMBL550	3123	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		DB01085	3123	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		2200	3131	46	3H-NMS	-35	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-35	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-35	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-35	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-35	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		119570	3159	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2389	3331	118	3H-QNB	-2818	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-QNB	-2818	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-QNB	-2818	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-QNB	-2818	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-QNB	-2818	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		128563	3464	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	3464	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	3464	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	3464	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		6917970	3691	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		1267	3804	49	3H-NMS	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-NMS	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-NMS	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		213	3853	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		185	4006	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		2865	4143	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		103	4153	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2662	11384	131	3H-QNB	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-QNB	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	15561	106	3H-QNB	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	3H-QNB	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		10297	27112	30	3H-QNB	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-QNB	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	46800	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		115237	55585	119	3H-QNB	-42657	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-QNB	-42657	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		10624	70300	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		1979	77326	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	77326	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		2244	94233	100	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		3025067	99382	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	99382	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	99382	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		3663	99967	83	3H-QNB	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	99967	83	3H-QNB	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		37632	111592	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		CHEMBL328250	111592	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		3452843	119525	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		CHEMBL345686	119525	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		446220	133521	14	3H-QNB	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-QNB	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		44208932	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		1615	167791	24	3H-QNB	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-QNB	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		5280343	188275	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	188275	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	188275	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	192533	136	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	193615	112	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	193615	112	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		4495	196535	92	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	200551	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	202274	22	3H-QNB	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-QNB	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-QNB	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5281600	203025	92	3H-QNB	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-QNB	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-QNB	-25	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-QNB	-25	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1973	203483	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	203483	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	203483	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		202478	204687	20	3H-QNB	-97	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		CHEMBL7393	204687	20	3H-QNB	-97	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		5311189	204841	11	3H-QNB	-194	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		CHEMBL7549	204841	11	3H-QNB	-194	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		4158	205341	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	205501	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		119607	206203	113	3H-QNB	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-QNB	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	206367	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		444	206666	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	206666	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		16231	207509	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	207509	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		5831	215963	0	3H-NMS	-29	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		11954259	215979	0	3H-QNB	-15135	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		104911	216019	0	3H-QNB	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	216027	0	3H-NMS	-10	12	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		24835791	216104	0	3H-MQNB(-)	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		None	216135	0	3H-QNB	-10471	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		40589	216144	0	3H-QNB	-407	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
		25137849	216179	0	3H-QNB	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-QNB	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	216239	0	3H-QNB	-95499	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		None	216311	0	3H-QNB	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-QNB	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-QNB	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-QNB	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-QNB	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-QNB	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216318	0	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	216325	0	3H-QNB	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	216326	0	3H-QNB	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		None	216327	0	3H-QNB	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	216328	0	3H-QNB	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	216329	0	3H-QNB	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	216330	0	3H-QNB	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	216331	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		135269	216389	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	216391	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		119828	216394	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-QNB	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216489	0	3H-QNB	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		None	216493	0	3H-NMS	-10471285	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
		None	216494	0	3H-NMS	-1	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
		20980871	216430	0	3H-QNB	-27	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
		367	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		5487427	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		8592	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL1900528	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3305968	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL4650755	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB01409	3824	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		9399	216106	0	3H-MQNB(-)	-	1	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	493	3	2	4	-1.1	C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-]	None
		180	401	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1971	2866	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		44431388	87319	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
		CHEMBL233202	87319	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
		44431380	87985	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
		CHEMBL234257	87985	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
		154825138	216038	0	3H-MQNB(-)	-1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	216038	0	3H-NMS	-1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	216038	0	3H-NMS	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154734599	2503	12	3H-4-DAMP	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		154734599	2503	12	3H-PIRENZEPINE	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-4-DAMP	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-PIRENZEPINE	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-4-DAMP	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-PIRENZEPINE	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-4-DAMP	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-PIRENZEPINE	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		1224	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		310	1922	0	3H-NMS	-25	10	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	1922	0	3H-NMS	-25	10	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	1922	0	3H-NMS	-25	10	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		1353	1911	93	3H-NMS	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-QNB	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-NMS	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-QNB	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-NMS	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-QNB	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-NMS	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-QNB	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-NMS	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-QNB	-338	83	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3652	4097	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		None	216257	0	3H-4-DAMP	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
		1734	116	10	3H-NMS	-12	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-NMS	-12	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-NMS	-12	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		154734599	2503	12	3H-NMS	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-NMS	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-NMS	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-NMS	1	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		2745	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	3861	42	3H-NMS	-18	8	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		None	216257	0	3H-NMS	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
		2337	3256	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	958	93	3H-QNB	-22	89	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-QNB	-22	89	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-QNB	-22	89	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-QNB	-22	89	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-QNB	-22	89	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	3H-QNB	-19	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-QNB	-19	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-QNB	-19	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-QNB	-19	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-QNB	-19	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		4066	204626	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	204626	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		154825138	216038	0	3H-MQNB(-)	-1	11	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154734599	2503	12	3H-NMS	1	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-NMS	1	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-NMS	1	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-NMS	1	11	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		103	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		103	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		4601	206747	35	3H-NMS	-6	16	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	3H-NMS	-6	16	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	3H-NMS	-6	16	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		4839	216375	0	3H-NMS	-2	4	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	323	5	0	3	3.8	CCN1CCCC(C1)OC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	None
		2274	3173	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1712	2492	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		154825138	216038	0	3H-NMS	-1	11	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		2270	3171	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4811	3171	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4913	3171	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		CHEMBL640	3171	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		DB01035	3171	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		2726	919	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		3012003	216145	0	3H-QNB	-1	12	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		308	2060	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	2060	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	2060	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		154734599	2503	12	3H-QNB	-1	11	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-QNB	-1	11	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-QNB	-1	11	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-QNB	-1	11	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		5387	94879	31	3H-NMS	-19	5	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
		CHEMBL253978	94879	31	3H-NMS	-19	5	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
		1225	1471	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		73707487	216374	0	3H-NMS	-23	8	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
		1273	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	1754	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		308	2060	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	2060	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	2060	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		277	1301	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135398745	2914	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		101	3822	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		55752	3822	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL35057	3822	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		2448	99323	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		2448	99323	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		5831	215963	0	3H-MQNB(-)	-29	12	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		3337	206367	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		154734599	2503	12	3H-NMS	-1	11	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-NMS	-1	11	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-NMS	-1	11	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-NMS	-1	11	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		None	216254	0	3H-NMS	-1659	19	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		2200	3131	46	3H-4-DAMP	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-4-DAMP	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-4-DAMP	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-4-DAMP	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-4-DAMP	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		44431383	88022	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
		CHEMBL234439	88022	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
		131632304	216037	0	3H-QNB	-6	12	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		2230	465	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		296	465	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		CHEMBL7303	465	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		DB04365	465	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		44431381	149021	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
		CHEMBL394254	149021	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
		None	216256	0	3H-NMS	-5	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
		124226	1921	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		322	1921	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		5831	215963	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		135398737	958	93	3H-NMS	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-NMSP	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-NMS	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-NMSP	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-NMS	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-NMSP	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-NMS	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-NMSP	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-NMS	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-NMSP	-22	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5831	215963	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		68617	205527	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		11954259	215979	0	3H-QNB	-15135	43	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		4601	206747	35	3H-QNB	-2	16	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	3H-QNB	-2	16	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	3H-QNB	-2	16	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		2726	919	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1212	1662	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		214	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2200	3131	46	3H-QNB	-31	12	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-QNB	-31	12	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-QNB	-31	12	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-QNB	-31	12	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-QNB	-31	12	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2200	3131	46	3H-NMS	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-35	12	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1979	77326	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	77326	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		302	2977	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	2977	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	2977	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		15387	45822	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		15387	45822	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		3042	1414	35	3H-NMS	-28	14	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	1414	35	3H-NMS	-28	14	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	1414	35	3H-NMS	-28	14	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	1414	35	3H-NMS	-28	14	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	1414	35	3H-NMS	-28	14	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		5831	215963	0	3H-cAMP	-190	12	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		310	1922	0	3H-NMS	-56	10	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	1922	0	3H-NMS	-56	10	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	1922	0	3H-NMS	-56	10	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		10921	13045	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		2968	13045	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		CHEMBL1190	13045	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		4919	206234	23	3H-QNB	-3	8	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	206234	23	3H-QNB	-3	8	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		2865	4143	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		100	3805	58	3H-QNB	-19	55	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-QNB	-19	55	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-QNB	-19	55	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-QNB	-19	55	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-QNB	-19	55	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1273	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	1754	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		2905	14498	50	3H-NMS	-16	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
		CHEMBL1201338	14498	50	3H-NMS	-16	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
		2200	3131	46	3H-QNB	-35	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-QNB	-35	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-QNB	-35	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-QNB	-35	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-QNB	-35	12	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1209	1658	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2726	919	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		11976	920	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		209	3057	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		302	2977	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	2977	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	2977	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		1192	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		2028	2979	80	3H-NMS	-5	10	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	2979	80	3H-NMS	-5	10	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	2979	80	3H-NMS	-5	10	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	2979	80	3H-NMS	-5	10	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	2979	80	3H-NMS	-5	10	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		154734599	2503	12	3H-NMS	1	11	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-NMS	1	11	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-NMS	1	11	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-NMS	1	11	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		1734	116	10	3H-QNB	-12	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-QNB	-12	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-QNB	-12	12	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		1734	116	10	3H-NMS	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-NMS	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-NMS	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		3246155	215962	0	3H-NMS	-16	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		1734	116	10	3H-4-DAMP	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-4-DAMP	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-4-DAMP	-9	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		308	2060	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	2060	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	2060	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		1613	2348	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2865	4143	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3042	1414	35	3H-NMS	-12	14	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	1414	35	3H-NMS	-12	14	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	1414	35	3H-NMS	-12	14	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	1414	35	3H-NMS	-12	14	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	1414	35	3H-NMS	-12	14	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		7534	216373	0	3H-NMS	-3	4	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	291	3	1	4	2.5	CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O	None
		3947	206395	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		114743	216101	0	3H-QNB	-1	8	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	291	1	1	1	4.9	C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N	None
		2200	3131	46	3H-NMS	-31	12	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-31	12	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-31	12	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-31	12	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-31	12	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		5831	215963	0	3H-cAMP	-29	12	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		3294	2006	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		15897	2862	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		187	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		43815	186920	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		187	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		130169	3605	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
		331	3605	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
		242	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2389	3331	118	3H-QNB	-2818	67	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-QNB	-2818	67	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-QNB	-2818	67	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-QNB	-2818	67	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-QNB	-2818	67	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2200	3131	46	3H-MQNB(-)	-35	12	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-MQNB(-)	-35	12	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-MQNB(-)	-35	12	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-MQNB(-)	-35	12	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-MQNB(-)	-35	12	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		3337	206367	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		442108	84636	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		CHEMBL222287	84636	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		2370	623	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		297	623	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		358	623	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		CHEMBL1482	623	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		DB01019	623	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		5831	215963	0	3H-NMS	-29	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		129989	451	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		8584	451	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		CHEMBL43383	451	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		10938	1702	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		299	1702	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		3256	1702	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		CHEMBL2110739	1702	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		154734599	2503	12	3H-NMS	-1	11	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-NMS	-1	11	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-NMS	-1	11	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-NMS	-1	11	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		154825138	216038	0	3H-NMS	-1	11	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		1734	116	10	3H-MQNB(-)	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-MQNB(-)	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-MQNB(-)	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		71128	96810	25	3H-NMS	-3	7	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
		CHEMBL26505	96810	25	3H-NMS	-3	7	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
		44431376	87317	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
		CHEMBL233200	87317	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
		135409468	2035	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		2200	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		62865	1274	0	3H-Methoctramine	-6	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	3H-Methoctramine	-6	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	3H-Methoctramine	-6	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	3H-Methoctramine	-6	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	3H-Methoctramine	-6	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		154734599	2503	12	3H-MQNB(-)	1	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-MQNB(-)	1	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-MQNB(-)	1	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-MQNB(-)	1	11	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4919	206234	23	3H-NMS	-9	8	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	206234	23	3H-NMS	-9	8	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		187	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		2726	919	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1979	77326	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	77326	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		154734599	2503	12	3H-MQNB(-)	-1	11	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-MQNB(-)	-1	11	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-MQNB(-)	-1	11	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-MQNB(-)	-1	11	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		44431372	87315	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		CHEMBL233198	87315	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		2200	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-MQNB(-)	-31	12	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1830	2590	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		5831	215963	0	3H-MQNB(-)	-190	12	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		208	2863	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		4541	2863	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL1494	2863	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2200	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		None	216228	0	3H-NMS	-56	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
		135398745	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2200	3131	46	3H-NMS	-35	12	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-35	12	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-35	12	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-35	12	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-35	12	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		10090005	215986	0	3H-QNB	-588	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
		135398737	958	93	3H-QNB	-22	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-QNB	-22	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-QNB	-22	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-QNB	-22	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-QNB	-22	89	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398745	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		44431369	87983	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		CHEMBL234253	87983	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		302	2977	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	2977	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	2977	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		2745	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	3861	42	3H-NMS	-46	8	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		154734599	2503	12	3H-MQNB(-)	-1	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-MQNB(-)	-1	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-MQNB(-)	-1	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-MQNB(-)	-1	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		44431375	87316	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
		CHEMBL233199	87316	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
		44431370	87984	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
		CHEMBL234254	87984	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
		2166	3123	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		305	3123	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		5910	3123	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		CHEMBL550	3123	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		DB01085	3123	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		3823	50221	42	None	-44	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		76973198	50221	42	None	-44	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL157101	50221	42	None	-44	10	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		44431391	146421	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
		CHEMBL392186	146421	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
		3389	217711	0	None	1	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		2812	4779	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	4779	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		2719	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		5535	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		607	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		CHEMBL76	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		DB00608	917	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		441383	20333	57	None	-7	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	20333	57	None	-7	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		2389	3331	118	None	-2818	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-2818	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-2818	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-2818	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-2818	67	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		242	470	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		3294	2006	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1016	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	3747	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		1209	1658	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1212	1662	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66265	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	94013	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		1210	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	918	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1273	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	1754	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		15387	45822	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	45822	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		212	3806	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	3806	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	3806	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	3806	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	3806	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		68617	205527	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		176	398	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	398	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	398	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	398	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	398	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2448	99323	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		4189	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	206922	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1548955	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	88581	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		3198	205513	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	205513	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	205513	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		2274	3173	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		3652	46244	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		CHEMBL1535	46244	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		72064	78401	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
		CHEMBL2110892	78401	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
		2774	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		5593	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		7319	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		CHEMBL1200604	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB00809	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB01199	3868	95	3H-NMS	-3	9	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		310	1922	0	3H-QNB	-25	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	1922	0	3H-QNB	-25	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	1922	0	3H-QNB	-25	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		2200	3131	46	3H-PIRENZEPINE	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-PIRENZEPINE	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-PIRENZEPINE	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-PIRENZEPINE	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-PIRENZEPINE	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		183782	3398	20	3H-NMS	-870	13	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	3398	20	3H-NMS	-870	13	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	3398	20	3H-NMS	-870	13	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		2200	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1613	2348	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		1353	1911	93	3H-QNB	-5011	83	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-QNB	-5011	83	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-QNB	-5011	83	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-QNB	-5011	83	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-QNB	-5011	83	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2230	465	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		296	465	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		CHEMBL7303	465	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		DB04365	465	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		2200	3131	46	3H-MQNB(-)	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-MQNB(-)	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-MQNB(-)	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-MQNB(-)	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-MQNB(-)	-31	12	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2995	204405	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		15897	2862	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		108107	79944	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	79944	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	79944	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	79944	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		1613	2348	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		9905731	168508	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
		CHEMBL435353	168508	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
		191	403	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		None	216258	0	3H-NMS	1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	574	9	3	7	4.0	CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.CS(=O)(=O)O	None
		2337	3256	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		3236	67609	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
		CHEMBL1902981	67609	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
		1273	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	1754	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		4011	82408	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		44431382	88021	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
		CHEMBL234438	88021	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
		4098	32505	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	32505	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	32505	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		2995	204405	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		11057	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	176149	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		4735	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL361506	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL55	195115	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		2247	505	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2381	663	48	3H-QNB	-15	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	663	48	3H-QNB	-15	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	663	48	3H-QNB	-15	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	663	48	3H-QNB	-15	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	663	48	3H-QNB	-15	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		1530	2182	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		6726	1280	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	1280	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	1280	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	1280	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	1280	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		1613	2348	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		6918558	14514	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
		CHEMBL1201764	14514	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
		2284	3182	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		135	2532	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		237	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL546257	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL554190	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL7568	204865	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		3947	206395	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		187	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		3191	102858	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		3055	1433	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		313	1433	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		7163	1433	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		CHEMBL936	1433	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		DB01231	1433	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		3042	1414	35	None	-28	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	1414	35	None	-28	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	1414	35	None	-28	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	1414	35	None	-28	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	1414	35	None	-28	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		1353	1911	93	None	-338	83	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-338	83	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-338	83	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-338	83	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-338	83	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1935	3734	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2551	3734	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		6687	3734	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		CHEMBL95	3734	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		DB00382	3734	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2335	11848	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		8478	11848	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL1182210	11848	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL221753	11848	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		6075	150108	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	150108	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		26987	949	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		1734	116	10	3H-MQNB(-)	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-MQNB(-)	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-MQNB(-)	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		43815	186920	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		2726	919	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2200	3131	46	None	-35	12	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	None	-35	12	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	None	-35	12	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	None	-35	12	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	None	-35	12	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2562	204599	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL1256696	204599	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL73234	204599	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		1225	1471	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	1471	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	1471	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	1471	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	1471	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		103	4153	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		4601	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	206747	35	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		4976	203579	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		CHEMBL668	203579	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		154059	3637	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		2457	3637	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		7483	3637	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		CHEMBL1734	3637	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		DB01591	3637	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		3652	4097	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	4097	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	4097	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	4097	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	4097	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2200	3131	46	None	-31	12	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	None	-31	12	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	None	-31	12	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	None	-31	12	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	None	-31	12	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1224	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	1432	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1971	2866	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		5284550	41721	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		CHEMBL1492500	41721	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		134688371	14429	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		13765	14429	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		CHEMBL1200623	14429	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		134	2514	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1979	77326	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	77326	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		2389	3331	118	3H-QNB	-2818	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-QNB	-2818	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-QNB	-2818	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-QNB	-2818	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-QNB	-2818	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6450478	216012	0	3H-QNB	-1	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
		135398745	2914	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2337	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1712	2492	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		277	1301	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2745	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	3861	42	3H-QNB	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		129894468	216105	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
		2398	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		1734	116	10	3H-NMS	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	116	10	3H-NMS	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	116	10	3H-NMS	-12	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		2745	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	3861	42	3H-NMS	-46	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		135398745	2914	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		4212	198679	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		CHEMBL1417019	198679	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		CHEMBL58	198679	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		73707487	216374	0	None	1	8	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
		319	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		321	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		444031	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		784	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		CHEMBL1346	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		DB00496	1324	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		44431387	87318	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
		CHEMBL233201	87318	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
		1726	2497	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1993	2497	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		7438	2497	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		CHEMBL978	2497	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		DB06709	2497	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1726	2497	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1993	2497	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		7438	2497	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		CHEMBL978	2497	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		DB06709	2497	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		135398737	958	93	None	-22	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-22	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-22	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-22	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-22	89	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		3042	1414	35	None	-12	14	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	1414	35	None	-12	14	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	1414	35	None	-12	14	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	1414	35	None	-12	14	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	1414	35	None	-12	14	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		135398737	958	93	None	-6	89	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-6	89	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-6	89	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-6	89	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-6	89	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		21855	84246	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		CHEMBL22108	84246	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		62865	1274	0	None	-6	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	None	-6	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	None	-6	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	None	-6	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	None	-6	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		2774	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		5593	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		7319	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		CHEMBL1200604	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB00809	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB01199	3868	95	None	-1	9	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		6472	202747	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL61946	202747	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
		24096961	216107	0	3H-MQNB(-)	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
		319	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		321	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		444031	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		784	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		CHEMBL1346	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		DB00496	1324	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		124087	1389	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	1389	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	1389	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	1389	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	1389	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		1371	1923	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		24199	1923	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		323	1923	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		CHEMBL1201325	1923	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		DB06787	1923	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		10921	13045	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		2968	13045	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		CHEMBL1190	13045	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		4919	206234	23	None	-3	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	206234	23	None	-3	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		5648	78411	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		CHEMBL2107687	78411	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		CHEMBL2111176	78411	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		2270	3171	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4811	3171	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4913	3171	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		CHEMBL640	3171	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		DB01035	3171	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		1712	2492	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		100	3805	58	None	-19	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-19	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-19	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-19	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-19	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2286	3183	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		154825138	216038	0	3H-PIRENZEPINE	-1	11	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		187	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		279	1661	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		49381	1661	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		CHEMBL63756	1661	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		1212	1662	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	216256	0	3H-NMS	-5	5	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
		154734599	2503	12	3H-QNB	1	11	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	2503	12	3H-QNB	1	11	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	2503	12	3H-QNB	1	11	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	2503	12	3H-QNB	1	11	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		135398745	2914	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	920	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		2200	3131	46	3H-NMS	-31	12	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-31	12	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-31	12	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-31	12	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-31	12	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		277	1301	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1427	2013	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		2028	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	2979	80	None	-8	10	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		5831	215963	0	None	-1	12	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		180	401	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2028	2979	80	UNDEFINED	-8	10	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	2979	80	UNDEFINED	-8	10	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	2979	80	UNDEFINED	-8	10	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	2979	80	UNDEFINED	-8	10	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	2979	80	UNDEFINED	-8	10	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		1086	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		3290	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		7181	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		CHEMBL1206	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		DB00392	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		4904	155521	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
		CHEMBL404215	155521	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
		2028	2979	80	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	2979	80	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	2979	80	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	2979	80	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	2979	80	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		2705	3842	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		360	3842	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		443879	3842	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		CHEMBL1382	3842	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		DB01036	3842	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		5831	215963	0	None	-190	12	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		2705	3842	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		360	3842	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		443879	3842	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		CHEMBL1382	3842	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		DB01036	3842	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		1201549	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	597	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		24835791	216104	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		44431386	149025	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
		CHEMBL394255	149025	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
		25897919	55652	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		657309	55652	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1464005	55652	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1621597	55652	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		1201549	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	597	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		11968014	12758	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		CHEMBL1187846	12758	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		24835791	216104	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		123134663	217728	0	None	-1	3	Dog	8.1	pKi	=	8.1	Binding	radioligand ([3H]QNB) displacement assayradioligand ([3H]QNB) displacement assay	Drug Central	330	2	0	2	5.4	C[N@+]12CCCC[C@@H]1CCC(C2)=C(C1=CC=CS1)C1=CC=CS1	None
		12057539	208041	42	None	-2	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	None	-2	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	None	-2	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		135398737	958	93	3H-QNB	-22	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-QNB	-22	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-QNB	-22	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-QNB	-22	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-QNB	-22	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	3H-QNB	-19	55	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-QNB	-19	55	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-QNB	-19	55	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-QNB	-19	55	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-QNB	-19	55	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1427	2013	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		25897919	55652	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		657309	55652	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1464005	55652	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1621597	55652	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		12057539	208041	42	None	-2	20	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	None	-2	20	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	None	-2	20	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		10470	2488	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		1689	2488	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		4057	2488	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		CHEMBL524004	2488	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		DB04843	2488	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		11693	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		3494	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		4302	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		7459	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		CHEMBL1201335	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		DB00986	1827	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		154417	23181	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
		CHEMBL1331216	23181	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
		12057539	208041	42	None	-17	20	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	None	-17	20	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	None	-17	20	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		2293	3186	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		329	3186	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		4934	3186	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		CHEMBL1180725	3186	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		DB00782	3186	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		10129	3322	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		11753673	3322	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		5303	3322	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		CHEMBL3833319	3322	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		DB11855	3322	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		316	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		317	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		71183	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3140030	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL376897	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB00462	2835	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		367	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		5487427	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		8592	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL1900528	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3305968	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL4650755	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB01409	3824	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		11519069	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		11519070	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		4816	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		7354	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		CHEMBL1187833	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		DB09076	3939	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		44431367	87982	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
		CHEMBL234252	87982	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
		2200	3131	46	3H-NMS	-35	12	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	3131	46	3H-NMS	-35	12	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	3131	46	3H-NMS	-35	12	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	3131	46	3H-NMS	-35	12	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	3131	46	3H-NMS	-35	12	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		24835791	216104	0	3H-MQNB(-)	1	2	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		11954224	215953	0	3H-QNB	-1047	58	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		46780481	107531	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		135398745	2914	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		129894468	216105	0	3H-MQNB(-)	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
		10104	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		6604866	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		CHEMBL1493369	3566	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		10129	3322	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		11753673	3322	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		5303	3322	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		CHEMBL3833319	3322	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		DB11855	3322	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		1201549	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		333	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		7601	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		CHEMBL1201203	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		CHEMBL438151	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		DB00245	597	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		1086	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		3290	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		7181	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		CHEMBL1206	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		DB00392	1590	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		123603	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		2684	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		584	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		9658	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		CHEMBL168815	883	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		367	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		367	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		367	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		367	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		5487427	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		5487427	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		5487427	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		5487427	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		8592	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		8592	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		8592	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		8592	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL1900528	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL1900528	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL1900528	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL1900528	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL3305968	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL3305968	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL3305968	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL3305968	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL4650755	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL4650755	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL4650755	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL4650755	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		DB01409	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		DB01409	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		DB01409	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		DB01409	3824	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		8598	1272	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		91827377	1272	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		2370	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		2370	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		297	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		297	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		358	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		358	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		CHEMBL1482	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		CHEMBL1482	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		DB01019	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		DB01019	623	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		2166	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		2166	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		305	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		305	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		5910	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		5910	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		CHEMBL550	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		CHEMBL550	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		DB01085	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		DB01085	3123	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		2551	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		2551	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		298	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		298	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		488	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		488	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		CHEMBL965	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		CHEMBL965	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		DB00411	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		DB00411	794	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		2230	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		2230	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		2230	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		296	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		296	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		296	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		CHEMBL7303	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		CHEMBL7303	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		CHEMBL7303	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		DB04365	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		DB04365	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		DB04365	465	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		129786	1891	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
		3276	1891	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
		187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		302	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		302	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		4630	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		4630	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		CHEMBL7634	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		CHEMBL7634	2977	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		24768606	4030	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		3274	4030	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		CHEMBL1628667	4030	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		2200	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		328	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		4848	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		CHEMBL9967	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		DB00670	3131	46	None	-35	12	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		1273	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		1273	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		1273	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		3450	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		3450	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		3450	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		356	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		356	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		356	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		6172	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		6172	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		6172	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		67425	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		67425	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		67425	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		CHEMBL360055	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		CHEMBL360055	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		CHEMBL360055	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		DB00483	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		DB00483	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		DB00483	1754	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		107867	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		107867	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		309	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		309	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		CHEMBL17045	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		CHEMBL17045	2974	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		5282426	1466	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		7549	1466	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		CHEMBL108947	1466	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		154059	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		154059	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		2457	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		2457	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		7483	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		7483	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		CHEMBL1734	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		CHEMBL1734	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		DB01591	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		DB01591	3637	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		3652	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		3652	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		3652	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		57	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		57	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		57	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		60809	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		60809	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		60809	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		CHEMBL21536	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		CHEMBL21536	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		CHEMBL21536	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		DB15357	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		DB15357	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		DB15357	4097	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		2774	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		5593	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		7319	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		CHEMBL1200604	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		DB00809	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		DB01199	3868	95	None	-1	9	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		1726	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		1726	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		1993	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		1993	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		7438	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		7438	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		CHEMBL978	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		CHEMBL978	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		DB06709	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		DB06709	2497	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		319	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		319	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		319	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		321	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		321	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		321	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		444031	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		444031	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		444031	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		784	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		784	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		784	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		CHEMBL1346	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		CHEMBL1346	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		CHEMBL1346	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		DB00496	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		DB00496	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		DB00496	1324	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		129140	3934	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
		129140	3934	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
		8583	3934	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
		8583	3934	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		154734599	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		327	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		4108	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		CHEMBL27673	2503	12	None	1	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		180	401	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		200	401	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		2160	401	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		CHEMBL629	401	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		DB00321	401	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		2028	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		359	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		4634	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		CHEMBL1231	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		DB01062	2979	80	None	-8	10	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		2028	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		2028	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		359	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		359	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		4634	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		4634	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		CHEMBL1231	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		CHEMBL1231	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		DB01062	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		DB01062	2979	80	None	-8	10	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		324	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		324	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		324	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		324	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		6436265	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		6436265	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		6436265	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		6436265	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		CHEMBL277642	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		CHEMBL277642	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		CHEMBL277642	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		CHEMBL277642	1925	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		119357	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		119357	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		3264	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		3264	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		368	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		368	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		CHEMBL279453	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		CHEMBL279453	304	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		1734	116	10	None	-9	12	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		307	116	10	None	-9	12	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		CHEMBL168067	116	10	None	-9	12	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		129989	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		129989	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		8584	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		8584	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		CHEMBL43383	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		CHEMBL43383	451	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		2705	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		2705	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		360	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		360	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		443879	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		443879	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		CHEMBL1382	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		CHEMBL1382	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		DB01036	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		DB01036	3842	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		174174	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		174174	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		174174	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		174174	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		260	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		260	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		260	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		260	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		320	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		320	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		320	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		320	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		CHEMBL517712	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		CHEMBL517712	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		CHEMBL517712	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		CHEMBL517712	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		DB00572	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		DB00572	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		DB00572	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		DB00572	523	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		8586	301	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
		9862598	301	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
		3000322	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		3000322	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		330	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		330	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		CHEMBL569713	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		CHEMBL569713	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		DB00747	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		DB00747	3562	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		8600	342	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		91827379	342	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		30843	1402	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		354	1402	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		831	1402	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		CHEMBL1908364	1402	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		DB08997	1402	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		10470	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		1689	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		4057	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		CHEMBL524004	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		DB04843	2488	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		2293	3186	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		329	3186	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		4934	3186	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		CHEMBL1180725	3186	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		DB00782	3186	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		11354367	3816	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
		3255	3816	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
		325	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		325	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		3746	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		3746	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		657308	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		657308	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		CHEMBL1615433	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		CHEMBL1615433	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		DB00332	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		DB00332	2062	0	None	-1	8	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		132947	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		361	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		CHEMBL265256	3864	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		11519069	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		11519069	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		11519070	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		11519070	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		4816	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		4816	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		7354	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		7354	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		CHEMBL1187833	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		CHEMBL1187833	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		DB09076	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		DB09076	3939	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		42519285	2577	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		8591	2577	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		CHEMBL3185781	2577	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		314	2692	0	None	-1122018	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10799315
		313	2691	0	None	-407	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7925952
		134	2514	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2865	4143	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3337	206367	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		46780481	107531	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		11954224	215953	0	None	-1047	58	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		3012003	216145	0	None	-1	12	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		2895	203592	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		CHEMBL669	203592	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		11976	920	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		4066	204626	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	204626	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		24096961	216107	0	None	-	1	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
		11757797	2842	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		292	2842	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		10938	1702	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		299	1702	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		3256	1702	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		CHEMBL2110739	1702	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		30844	2310	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		358	2310	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		300	2510	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		4141	2510	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		CHEMBL92387	2510	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		303	2978	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		4629	2978	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		8595	2978	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		CHEMBL44674	2978	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		30844	2310	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		358	2310	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		290	2473	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		4022	2473	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		5926	2473	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		CHEMBL40554	2473	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		CHEMBL74300	2473	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		22991950	2328	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
		326	2328	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
		1273	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		3450	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		356	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		6172	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		67425	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		CHEMBL360055	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		DB00483	1754	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		2229	464	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		295	464	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		CHEMBL128365	464	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		2551	794	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		298	794	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		488	794	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		CHEMBL965	794	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		DB00411	794	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		107867	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		107867	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		107867	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		309	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		309	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		309	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		CHEMBL17045	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		CHEMBL17045	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		CHEMBL17045	2974	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		2200	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		2200	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		2200	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		328	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		328	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		328	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		4848	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		4848	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		4848	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		CHEMBL9967	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		CHEMBL9967	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		CHEMBL9967	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		DB00670	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		DB00670	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		DB00670	3131	46	None	-31	12	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		308	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		308	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		3603	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		3603	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		CHEMBL1256682	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		CHEMBL1256682	2060	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		187	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		294	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		65	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		8593	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		CHEMBL667	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		DB03128	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		302	2977	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		4630	2977	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		CHEMBL7634	2977	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		3042	1414	35	None	-28	14	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		355	1414	35	None	-28	14	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		868	1414	35	None	-28	14	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		CHEMBL1123	1414	35	None	-28	14	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		DB00804	1414	35	None	-28	14	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		310	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		310	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		310	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		3602	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		3602	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		3602	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		CHEMBL3545990	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		CHEMBL3545990	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		CHEMBL3545990	1922	0	None	-56	10	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		124226	1921	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		322	1921	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		310	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		310	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		3602	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		3602	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		CHEMBL3545990	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		CHEMBL3545990	1922	0	None	-25	10	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		1427	2013	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		357	2013	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		3696	2013	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		CHEMBL11	2013	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		DB00458	2013	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		10259588	4079	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
		363	4079	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
		10426487	2841	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		291	2841	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		CHEMBL99521	2841	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		154734599	2503	12	None	-1	11	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		327	2503	12	None	-1	11	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		4108	2503	12	None	-1	11	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		CHEMBL27673	2503	12	None	-1	11	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		130169	3605	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
		331	3605	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
		1371	1923	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		24199	1923	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		323	1923	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		CHEMBL1201325	1923	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		DB06787	1923	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		167962	4069	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		362	4069	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		CHEMBL31599	4069	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		324	1925	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		6436265	1925	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		CHEMBL277642	1925	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		10062394	3047	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		304	3047	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		CHEMBL130715	3047	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		1734	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		1734	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		307	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		307	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		CHEMBL168067	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		CHEMBL168067	116	10	None	-12	12	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		293	2843	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		9985526	2843	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		10350027	1428	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		364	1428	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		365	1428	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		350	3556	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		9867750	3556	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		CHEMBL73341	3556	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		30843	1402	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		354	1402	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		831	1402	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		CHEMBL1908364	1402	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		DB08997	1402	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		174174	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		174174	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		260	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		260	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		320	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		320	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		CHEMBL517712	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		CHEMBL517712	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		DB00572	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		DB00572	523	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)